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4ZS7
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BU of 4zs7 by Molmil
Structural mimicry of receptor interaction by antagonistic IL-6 antibodies
Descriptor: Interleukin-6, Llama Fab fragment 68F2 heavy chain, Llama Fab fragment 68F2 light chain
Authors:Blanchetot, C, De Jonge, N, Desmyter, A, Ongenae, N, Hofman, E, Klarenbeek, A, Sadi, A, Hultberg, A, Kretz-Rommel, A, Spinelli, S, Loris, R, Cambillau, C, de Haard, H.
Deposit date:2015-05-13
Release date:2016-05-04
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.
J.Biol.Chem., 291, 2016
2XA3
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BU of 2xa3 by Molmil
crystal structure of the broadly neutralizing llama VHH D7 and its mode of HIV-1 gp120 interaction
Descriptor: LLAMA HEAVY CHAIN ANTIBODY D7, SULFATE ION
Authors:Hinz, A, Lutje Hulsik, D, Forsman, A, Koh, W, Belrhali, H, Gorlani, A, de Haard, H, Weiss, R.A, Verrips, T, Weissenhorn, W.
Deposit date:2010-03-29
Release date:2010-05-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the neutralizing Llama V(HH) D7 and its mode of HIV-1 gp120 interaction.
PLoS ONE, 5, 2010
4GRW
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BU of 4grw by Molmil
Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs)
Descriptor: Interleukin-12 subunit beta, Interleukin-23 subunit alpha, Nanobody 124C4, ...
Authors:Desmyter, A, Spinelli, S, Button, C, Saunders, M, de Haard, H, Rommelaere, H, Union, A, Cambillau, C.
Deposit date:2012-08-27
Release date:2014-02-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine-Nanobody Complex.
Front Immunol, 8, 2017
1SJX
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BU of 1sjx by Molmil
Three-Dimensional Structure of a Llama VHH Domain OE7 binding the cell wall protein Malf1
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, immunoglobulin VH domain
Authors:Dolk, E, van der Vaart, M, Hulsik, D.L, Vriend, G, de Haard, H, Spinelli, S, Cambillau, C, Frenken, L, Verrips, T.
Deposit date:2004-03-04
Release date:2005-03-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Isolation of llama antibody fragments for prevention of dandruff by phage display in shampoo.
Appl.Environ.Microbiol., 71, 2005
7PHS
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BU of 7phs by Molmil
highly potent IL6 antagonistic antibody selected from a camelid immune phage display repertoire
Descriptor: Heavy chain of Fab129D3, Light chain of Fab129D3
Authors:Cambillau, C, Pannecoucke, E, De Haard, H.
Deposit date:2021-08-18
Release date:2022-09-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Non-promiscuous pairing in a highly potent IL6 antagonistic antibody selected from a camelid immune phage display repertoire
To Be Published
5M2J
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BU of 5m2j by Molmil
Complex between human TNF alpha and Llama VHH2
Descriptor: Anti-(ED-B) scFV, Tumor necrosis factor
Authors:Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H.
Deposit date:2016-10-13
Release date:2017-08-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.
Front Immunol, 8, 2017
5M2M
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BU of 5m2m by Molmil
Complex between human TNF alpha and Llama VHH3
Descriptor: Llama nanobody VHH3, Tumor necrosis factor
Authors:Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H.
Deposit date:2016-10-13
Release date:2017-08-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.
Front Immunol, 8, 2017
5M2I
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BU of 5m2i by Molmil
Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1
Descriptor: Tumor necrosis factor, VHH1
Authors:Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H.
Deposit date:2016-10-13
Release date:2017-08-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.
Front Immunol, 8, 2017
6GFF
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BU of 6gff by Molmil
Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucine-rich repeat-containing protein 32, MHG-8 Fab heavy chain, ...
Authors:Merceron, R, Lienart, S, Vanderaa, C, Colau, D, Stockis, J, Van Der Woning, B, De Haard, H, Saunders, M, Coulie, P.G, Savvides, S.N, Lucas, S.
Deposit date:2018-04-30
Release date:2018-11-07
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis of latent TGF-beta 1 presentation and activation by GARP on human regulatory T cells.
Science, 362, 2018
4R90
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BU of 4r90 by Molmil
Anti CD70 Llama glama Fab 27B3
Descriptor: Anti CD70 Llama glama Fab 27B3 Heavy chain, Anti CD70 Llama glama Fab 27B3 Light chain, CALCIUM ION, ...
Authors:Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I.
Deposit date:2014-09-03
Release date:2015-06-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.746 Å)
Cite:Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
4R96
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BU of 4r96 by Molmil
Structure of a Llama Glama Fab 48A2 against human cMet
Descriptor: Llama glama Fab 48A2 against human cMet H chain, Llama glama Fab 48A2 against human cMet L chain
Authors:Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I.
Deposit date:2014-09-03
Release date:2015-06-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
6QRN
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BU of 6qrn by Molmil
Galectin-10 complexed with ribose
Descriptor: Galectin-10, beta-D-ribopyranose
Authors:Verstraete, K, Verschueren, K.H.G.
Deposit date:2019-02-19
Release date:2019-06-05
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
1ZRU
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BU of 1zru by Molmil
structure of the lactophage p2 receptor binding protein in complex with glycerol
Descriptor: GLYCEROL, lactophage p2 receptor binding protein
Authors:Spinelli, S, Tremblay, D.M, Tegoni, M, Blangy, S, Huyghe, C, Desmyter, A, Labrie, S, de Haard, H, Moineau, S, Cambillau, C, Structural Proteomics in Europe (SPINE)
Deposit date:2005-05-22
Release date:2006-03-28
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Receptor-binding protein of Lactococcus lactis phages: identification and characterization of the saccharide receptor-binding site.
J.Bacteriol., 188, 2006
6GLX
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BU of 6glx by Molmil
Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 4E8
Descriptor: Fab 4E8 - Heavy chain, Fab 4E8 - Light chain, Galectin-10
Authors:Verstraete, K, Verschueren, K, Savvides, S.N.
Deposit date:2018-05-23
Release date:2019-06-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.396 Å)
Cite:Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
6GKU
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BU of 6gku by Molmil
Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 6F5
Descriptor: CALCIUM ION, Fab 6F5 - Heavy Chain, Fab 6F5 - Light chain, ...
Authors:Verstraete, K, Verschueren, K, Savvides, S.N.
Deposit date:2018-05-21
Release date:2019-06-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
6GLW
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BU of 6glw by Molmil
Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 1D11
Descriptor: ACETATE ION, Fab 1D11 - Heavy chain, Fab 1D11 - Light chain, ...
Authors:Verstraete, K, Verschueren, K, Savvides, S.N.
Deposit date:2018-05-23
Release date:2019-06-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
6GKQ
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BU of 6gkq by Molmil
X-ray structure determined from ex vivo Charcot-Leyden crystal
Descriptor: GLYCEROL, Galectin-10
Authors:Verstraete, K, Verschueren, K, Savvides, S.N.
Deposit date:2018-05-21
Release date:2019-06-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
6GKS
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BU of 6gks by Molmil
X-ray structure determined from recombinant Charcot-Leyden crystal
Descriptor: GLYCEROL, Galectin-10
Authors:Verstraete, K, Verschueren, K, Savvides, S.N.
Deposit date:2018-05-21
Release date:2019-06-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
6GKT
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BU of 6gkt by Molmil
X-ray structure of a non-autocrystallizing galectin-10 variant, Gal10-Tyr69Glu
Descriptor: Galectin-10, HEXAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, ...
Authors:Verstraete, K, Verschueren, K, Savvides, S.N.
Deposit date:2018-05-21
Release date:2019-06-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
7Q15
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BU of 7q15 by Molmil
Crystal structure of FcRn and beta-2-microglobulin in complex with IgG1-Fc-MST-HN (efgartigimod)
Descriptor: Beta-2-microglobulin, IgG receptor FcRn large subunit p51, IgG1-Fc-MST-HN, ...
Authors:Pannecoucke, E, Savvides, S.N.
Deposit date:2021-10-18
Release date:2022-09-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement.
Nat Commun, 13, 2022
7Q3P
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BU of 7q3p by Molmil
Crystal structure of IgG1-Fc-MST-HN (efgartigimod)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Pannecoucke, E, Savvides, S.N.
Deposit date:2021-10-28
Release date:2022-09-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement.
Nat Commun, 13, 2022

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