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4L6R
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STRUCTURE OF THE CLASS B HUMAN GLUCAGON G PROTEIN COUPLED RECEPTOR
Descriptor:Soluble cytochrome b562 and Glucagon receptor chimera, DI(HYDROXYETHYL)ETHER
Authors:Siu, F.Y., He, M., de Graaf, C., Han, G.W., Yang, D., Zhang, Z., Zhou, C., Xu, Q., Wacker, D., Joseph, J.S., Liu, W., Lau, J., Cherezov, V., Katritch, V., Wang, M.W., Stevens, R.C., GPCR Network (GPCR)
Deposit date:2013-06-12
Release date:2013-07-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the human glucagon class B G-protein-coupled receptor.
Nature, 499, 2013
5XEZ
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STRUCTURE OF THE FULL-LENGTH GLUCAGON CLASS B G PROTEIN-COUPLED RECEPTOR
Descriptor:Glucagon receptor,Endolysin,Glucagon receptor, Antibody, mAb1, ...
Authors:Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B.
Deposit date:2017-04-06
Release date:2017-05-24
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
5XF1
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STRUCTURE OF THE FULL-LENGTH GLUCAGON CLASS B G PROTEIN-COUPLED RECEPTOR
Descriptor:Glucagon receptor,Endolysin,Glucagon receptor, Antibody mAb1 Heavy chain, Antibody mAb1 Light chain, ...
Authors:Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B.
Deposit date:2017-04-06
Release date:2017-05-24
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
5VEW
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STRUCTURE OF THE HUMAN GLP-1 RECEPTOR COMPLEX WITH PF-06372222
Descriptor:Glucagon-like peptide 1 receptor,Endolysin chimera, N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Song, G., Yang, D., Wang, Y., Graaf, C.D., Zhou, Q., Jiang, S., Liu, K., Cai, X., Dai, A., Lin, G., Liu, D., Wu, F., Wu, Y., Zhao, S., Ye, L., Han, G.W., Lau, J., Wu, B., Hanson, M.A., Liu, Z.-J., Wang, M.-W., Stevens, R.C.
Deposit date:2017-04-05
Release date:2017-05-24
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.
Nature, 546, 2017
5VEX
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STRUCTURE OF THE HUMAN GLP-1 RECEPTOR COMPLEX WITH NNC0640
Descriptor:Glucagon-like peptide 1 receptor, Endolysin chimera, 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide
Authors:Song, G., Yang, D., Wang, Y., Graaf, C.D., Zhou, Q., Jiang, S., Liu, K., Cai, X., Dai, A., Lin, G., Liu, D., Wu, F., Wu, Y., Zhao, S., Ye, L., Han, G.W., Lau, J., Wu, B., Hanson, M.A., Liu, Z.-J., Wang, M.-W., Stevens, R.C.
Deposit date:2017-04-05
Release date:2017-05-17
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.
Nature, 546, 2017
5G2B
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CRYSTAL STRUCTURE OF T. BRUCEI PDE-B1 CATALYTIC DOMAIN WITH INHIBITOR NPD-008
Descriptor:CLASS 1 PHOSPHODIESTERASE PDEB1, ZINC ION, MAGNESIUM ION, ...
Authors:Singh, A.K., Anthonyrajah, E.S., Brown, D.G.
Deposit date:2016-04-07
Release date:2017-11-29
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
J. Med. Chem., 61, 2018
5G57
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CRYSTAL STRUCTURE OF T. BRUCEI PDE-B1 CATALYTIC DOMAIN WITH INHIBITOR NPD-001
Descriptor:PHOSPHODIESTERASE B1, ZINC ION, MAGNESIUM ION, ...
Authors:Singh, A.K., Brown, D.G.
Deposit date:2016-05-22
Release date:2017-11-29
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
J. Med. Chem., 61, 2018
5G5V
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CRYSTAL STRUCTURE OF T. BRUCEI PDE-B1 CATALYTIC DOMAIN WITH INHIBITOR NPD-038
Descriptor:PHOSPHODIESTERASE B1, ZINC ION, MAGNESIUM ION, ...
Authors:Singh, A.K., Brown, D.G.
Deposit date:2016-06-06
Release date:2018-03-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
J. Med. Chem., 61, 2018
5L8C
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CRYSTAL STRUCTURE OF T. BRUCEI PDE-B1 CATALYTIC DOMAIN WITH INHIBITOR NPD-039
Descriptor:Phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Singh, A.K., Anthonyrajah, E.S., Brown, D.G.
Deposit date:2016-06-07
Release date:2018-03-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
J. Med. Chem., 61, 2018
5L8Y
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CRYSTAL STRUCTURE OF T. BRUCEI PDE-B1 CATALYTIC DOMAIN WITH INHIBITOR NPD-937
Descriptor:Phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Singh, A.K., Anthonyrajah, E.S., Brown, D.G.
Deposit date:2016-06-08
Release date:2018-03-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
J. Med. Chem., 61, 2018
5L9H
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CRYSTAL STRUCTURE OF T. BRUCEI PDE-B1 CATALYTIC DOMAIN WITH INHIBITOR NPD-340
Descriptor:Phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Singh, A.K., Brown, D.G.
Deposit date:2016-06-10
Release date:2018-03-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
J. Med. Chem., 61, 2018
5LAQ
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4B CATALYTIC DOMAIN WITH INHIBITOR NPD-001
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B,cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ...
Authors:Singh, A.K., Brown, D.G.
Deposit date:2016-06-14
Release date:2018-03-14
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
J. Med. Chem., 61, 2018
5LBO
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D2 CATALYTIC DOMAIN WITH INHIBITOR NPD-001
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Singh, A.K., Brown, D.G.
Deposit date:2016-06-16
Release date:2018-03-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
J. Med. Chem., 61, 2018
4I15
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CRYSTAL STRUCTURE OF TBRPDEB1
Descriptor:Class 1 phosphodiesterase PDEB1, ZINC ION, MAGNESIUM ION
Authors:Wang, H., Ke, H.
Deposit date:2012-11-20
Release date:2013-03-13
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure.
J.Med.Chem., 56, 2013
2XNT
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ACETYLCHOLINE BINDING PROTEIN (ACHBP) AS TEMPLATE FOR HIERARCHICAL IN SILICO SCREENING PROCEDURES TO IDENTIFY STRUCTURALLY NOVEL LIGANDS FOR THE NICOTINIC RECEPTORS
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, (2S)-2-[(4-CHLOROBENZYL)OXY]-2-PHENYLETHANAMINE, BROMIDE ION
Authors:Rucktooa, P., Akdemir, A., deEsch, I., Sixma, T.K.
Deposit date:2010-08-06
Release date:2011-08-24
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Acetylcholine Binding Protein (Achbp) as Template for Hierarchical in Silico Screening Procedures to Identify Structurally Novel Ligands for the Nicotinic Receptors.
Bioorg.Med.Chem., 19, 2011
2XNU
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ACETYLCHOLINE BINDING PROTEIN (ACHBP) AS TEMPLATE FOR HIERARCHICAL IN SILICO SCREENING PROCEDURES TO IDENTIFY STRUCTURALLY NOVEL LIGANDS FOR THE NICOTINIC RECEPTORS
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, 2-(2-(4-PHENYLPIPERIDIN-1-YL)ETHYL)-1H-INDOLE
Authors:Rucktooa, P., Akdemir, A., deEsch, I., Sixma, T.K.
Deposit date:2010-08-06
Release date:2011-08-24
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Acetylcholine Binding Protein (Achbp) as Template for Hierarchical in Silico Screening Procedures to Identify Structurally Novel Ligands for the Nicotinic Receptors.
Bioorg.Med.Chem., 19, 2011
2XNV
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ACETYLCHOLINE BINDING PROTEIN (ACHBP) AS TEMPLATE FOR HIERARCHICAL IN SILICO SCREENING PROCEDURES TO IDENTIFY STRUCTURALLY NOVEL LIGANDS FOR THE NICOTINIC RECEPTORS
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, 2-(2-(4-PHENYLPIPERIDIN-1-YL)ETHYL)-1H-INDOLE
Authors:Rucktooa, P., Akdemir, A., deEsch, I., Sixma, T.K.
Deposit date:2010-08-06
Release date:2011-08-24
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Acetylcholine Binding Protein (Achbp) as Template for Hierarchical in Silico Screening Procedures to Identify Structurally Novel Ligands for the Nicotinic Receptors.
Bioorg.Med.Chem., 19, 2011