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5IKW
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CRYSTAL STRUCTURE OF BMP-2-INDUCIBLE KINASE IN COMPLEX WITH AN INDAZOLE INHIBITOR
Descriptor:BMP-2-inducible protein kinase, N-(6-{3-[(cyclopropylsulfonyl)amino]phenyl}-1H-indazol-3-yl)cyclopropanecarboxamide
Authors:Counago, R.M., Sorrell, F.J., Krojer, T., Savitsky, P., Elkins, J.M., Axtman, A., Drewry, D., Wells, C., Zhang, C., Zuercher, W., Willson, T.M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Arruda, P., Gileadi, O., Structural Genomics Consortium (SGC)
Deposit date:2016-03-04
Release date:2016-06-29
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Crystal Structure of BMP-2-inducible kinase in complex with a 3-acylaminoindazole inhibitor GSK3236425A
To Be Published
5UKF
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CRYSTAL STRUCTURE OF THE HUMAN VACCINIA-RELATED KINASE 1 BOUND TO AN OXINDOLE INHIBITOR
Descriptor:Serine/threonine-protein kinase VRK1, 4-{[(Z)-(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}benzene-1-sulfonamide, PHOSPHATE ION, ...
Authors:Counago, R.M., Wells, C., Zuercher, W., Willson, T.M., Bountra, C., Edwards, A.M., Arruda, P., Gileadi, O., Structural Genomics Consortium (SGC)
Deposit date:2017-01-22
Release date:2017-03-29
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.
Sci Rep, 7, 2017
168D
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STABILIZING EFFECTS OF THE RNA 2'-SUBSTITUENT: CRYSTAL STRUCTURE OF AN OLIGODEOXYNUCLEOTIDE DUPLEX CONTAINING 2'-O-METHYLATED ADENOSINES
Descriptor:DNA/RNA (5'-D(*GP*CP*GP*TP*)-R(*(A2M)P*)-D(*TP*AP*CP*GP*C)-3')
Authors:Lubini, P., Zuercher, W., Egli, M.
Deposit date:1994-04-08
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Stabilizing effects of the RNA 2'-substituent: crystal structure of an oligodeoxynucleotide duplex containing 2'-O-methylated adenosines.
Chem.Biol., 1, 1994
5I3O
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CRYSTAL STRUCTURE OF BMP-2-INDUCIBLE KINASE IN COMPLEX WITH AN INDAZOLE INHIBITOR
Descriptor:BMP-2-inducible protein kinase, N-(6-{3-[(dimethylsulfamoyl)amino]phenyl}-1H-indazol-3-yl)cyclopropanecarboxamide, SULFATE ION
Authors:Counago, R.M., Sorrell, F.J., Krojer, T., Savitsky, P., Elkins, J.M., Axtman, A., Drewry, D., Wells, C., Zhang, C., Zuercher, W., Willson, T.M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Arruda, P., Gileadi, O., Structural Genomics Consortium (SGC)
Deposit date:2016-02-10
Release date:2016-03-09
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor
To Be Published
5I3R
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CRYSTAL STRUCTURE OF BMP-2-INDUCIBLE KINASE IN COMPLEX WITH AN INDAZOLE INHIBITOR
Descriptor:BMP-2-inducible protein kinase, N-[6-(3-{[(cyclopropylmethyl)sulfonyl]amino}phenyl)-1H-indazol-3-yl]cyclopropanecarboxamide, PHOSPHATE ION
Authors:Counago, R.M., Sorrell, F.J., Krojer, T., Savitsky, P., Elkins, J.M., Axtman, A., Drewry, D., Wells, C., Zhang, C., Zuercher, W., Willson, T.M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Arruda, P., Gileadi, O., Structural Genomics Consortium (SGC)
Deposit date:2016-02-10
Release date:2016-03-09
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor
To Be Published
5U94
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CRYSTAL STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS PASTA KINASE PKNB IN COMPLEX WITH THE POTENTIAL THERAPUTIC KINASE INHIBITOR GSK690693.
Descriptor:Serine/threonine-protein kinase PknB, 4-{2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methylbut-3-yn-2-ol, GLYCEROL, ...
Authors:Wlodarchak, N., Satyshur, K., Striker, R.
Deposit date:2016-12-15
Release date:2017-12-20
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:In Silico Screen and Structural Analysis Identifies Bacterial Kinase Inhibitors which Act with beta-Lactams To Inhibit Mycobacterial Growth.
Mol. Pharm., 15, 2018