Author results

2XNI
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PROTEIN-LIGAND COMPLEX OF A NOVEL MACROCYCLIC HCV NS3 PROTEASE INHIBITOR DERIVED FROM AMINO CYCLIC BORONATES
分子名称:NS3 PROTEASE, NS4A COFACTOR, (1-{[(10-tert-butyl-15,15-dimethyl-3,9,12-trioxo-6,7,9,10,11,12,14,15,16,17,18,19,23,23a-tetradecahydro-1H,5H-2,23:5,8-dimethano-4,13,2,8,11-benzodioxatriazacyclohenicosin-7(3H)-yl)carbonyl]amino}-3-hydroxypropyl)(trihydroxy)borate(1-), ...
著者Li, X., Zhang, Y.-K., Liu, Y., Ding, C.Z., Zhou, Y., Li, Q., Plattner, J.J., Baker, S.J., Zhang, S., Kazmierski, W.M., Wright, L.L., Smith, G.K., Grimes, R.M., Crosby, R.M., Creech, K.L., Carballo, L.H., Slater, M.J., Jarvest, R.L., Thommes, P., Hubbard, J.A., Convery, M.A., Nassau, P.M., McDowell, W., Skarzynski, T.J., Qian, X., Fan, D., Liao, L., Ni, Z.-J., Pennicott, L.E., Zou, W., Wright, J.
登録日2010-08-02
公開日2011-08-17
最終更新日2012-09-26
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Novel Macrocyclic Hcv Ns3 Protease Inhibitors Derived from Alpha-Amino Cyclic Boronates.
Bioorg.Med.Chem.Lett., 20, 2010
2XCF
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CRYSTAL STRUCTURE OF HCV NS3 PROTEASE WITH A BORONATE INHIBITOR
分子名称:NS3 PROTEASE, NS4A, ZINC ION, ...
著者Li, X., Zhang, Y.-K., Liu, Y., Ding, C.Z., Li, Q., Zhou, Y., Plattner, J.J., Baker, S.J., Qian, X., Fan, D., Liao, L., Ni, Z.-J., White, G.V., Mordaunt, J.E., Lazarides, L.X., Slater, M.J., Jarvest, R.L., Thommes, P., Ellis, M., Edge, C.M., Hubbard, J.A., Nassau, P., McDowell, B., Skarzynski, T.J., Rowland, P., Somers, D.O., Kazmierski, W.M., Grimes, R.M., Wright, L.L., Smith, G.K., Zou, W., Wright, J., Pennicott, L.E.
登録日2010-04-22
公開日2010-06-02
最終更新日2019-02-06
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Synthesis and Evaluation of Novel Alpha-Amino Cyclic Boronates as Inhibitors of Hcv Ns3 Protease.
Bioorg.Med.Chem.Lett., 20, 2010
2XCN
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CRYSTAL STRUCTURE OF HCV NS3 PROTEASE WITH A BORONATE INHIBITOR
分子名称:NS3 PROTEASE, NS4A, N-[(CYCLOPENTYLOXY)CARBONYL]-3-METHYL-L-VALYL-(4R)-N-{(1R)-3-HYDROXY-1-[HYDROXY(OXIDO)BORANYL]PROPYL}-4-(ISOQUINOLIN-1-YLOXY)-L-PROLINAMIDE, ...
著者Li, X., Zhang, Y.-K., Liu, Y., Ding, C.Z., Li, Q., Zhou, Y., Plattner, J.J., Baker, S.J., Qian, X., Fan, D., Liao, L., Ni, Z.-J., White, G.V., Mordaunt, J.E., Lazarides, L.X., Slater, M.J., Jarvest, R.L., Thommes, P., Ellis, M., Edge, C.M., Hubbard, J.A., Nassau, P., McDowell, B., Skarzynski, T.J., Rowland, P., Somers, D.O., Kazmierski, W.M., Grimes, R.M., Wright, L.L., Smith, G.K., Zou, W., Wright, J., Pennicott, L.E.
登録日2010-04-23
公開日2010-06-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.02 Å)
主引用文献Synthesis and Evaluation of Novel Alpha-Amino Cyclic Boronates as Inhibitors of Hcv Ns3 Protease.
Bioorg.Med.Chem.Lett., 20, 2010
4Y21
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CRYSTAL STRUCTURE OF MUNC13-1 MUN DOMAIN
分子名称:Protein unc-13 homolog A
著者Yang, X.Y., Wang, S., Sheng, Y., Zhang, M., Zou, W.J., Wu, L.J., Kang, L.J., Rizo, J., Zhang, R.G., Xu, T., Ma, C.
登録日2015-02-09
公開日2015-06-10
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming.
Nat.Struct.Mol.Biol., 22, 2015
6HEQ
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PRION NANOBODY 484
分子名称:Prion nanobody 484
著者Soror, S.H., Abskharon, R.N., Wohlkonig, A.
登録日2018-08-20
公開日2019-12-04
最終更新日2019-12-18
実験手法X-RAY DIFFRACTION (1.23 Å)
主引用文献Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion.
Plos Pathog., 15, 2019
6HER
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MOUSE PRION PROTEIN IN COMPLEX WITH NANOBODY 484
分子名称:Major prion protein, Nanobody 484, SULFATE ION, ...
著者Soror, S.H., Abskharon, R., Wohlkonig, A.
登録日2018-08-20
公開日2019-12-04
最終更新日2019-12-18
実験手法X-RAY DIFFRACTION (1.199 Å)
主引用文献Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion.
Plos Pathog., 15, 2019
6HHD
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MOUSE PRION PROTEIN IN COMPLEX WITH NANOBODY 484
分子名称:Major prion protein, Nanobody 484, CHLORIDE ION, ...
著者Soror, S., Abskharon, R., Wohlkonig, A.
登録日2018-08-28
公開日2019-12-11
最終更新日2019-12-18
実験手法X-RAY DIFFRACTION (2.102 Å)
主引用文献Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion.
Plos Pathog., 15, 2019
6MK0
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INTEGRIN ALPHAVBETA3 ECTODOMAIN BOUND TO ANTAGONIST TDI-4161
分子名称:Integrin alpha-V, Integrin beta-3, N-ACETYL-D-GLUCOSAMINE, ...
著者van Agthoven, J., Arnaout, M.A.
登録日2018-09-24
公開日2019-09-25
最終更新日2020-02-12
実験手法X-RAY DIFFRACTION (3.005 Å)
主引用文献Novel Pure alphaVbeta3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations
Acs Pharmacol Transl Sci, 2, 2019
5UE8
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THE CRYSTAL STRUCTURE OF MUNC13-1 C1C2BMUN DOMAIN
分子名称:Protein unc-13 homolog A, ZINC ION, CHLORIDE ION
著者Tomchick, D.R., Rizo, J., Xu, J.
登録日2016-12-29
公開日2017-02-15
最終更新日2018-03-28
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN.
Elife, 6, 2017
5UF7
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CRYSTAL STRUCTURE OF MUNC13-1 MUN DOMAIN
分子名称:Protein unc-13 homolog A
著者Tomchick, D.R., Rizo, J., Xu, J.
登録日2017-01-03
公開日2017-02-15
最終更新日2018-03-28
実験手法X-RAY DIFFRACTION (2.896 Å)
主引用文献Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN.
Elife, 6, 2017