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5WWP
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BU of 5wwp by Molmil
Crystal structure of Middle East respiratory syndrome coronavirus helicase (MERS-CoV nsp13)
Descriptor: ORF1ab, SULFATE ION, ZINC ION
Authors:Hao, W, Wojdyla, J.A, Zhao, R, Han, R, Das, R, Zlatev, I, Manoharan, M, Wang, M, Cui, S.
Deposit date:2017-01-03
Release date:2017-07-05
Last modified:2021-09-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of Middle East respiratory syndrome coronavirus helicase
PLoS Pathog., 13, 2017
8SKQ
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BU of 8skq by Molmil
RNA oligonucleotide containing an alpha-(L)-threofuranosyl nucleic acid (TNA)
Descriptor: TNA-containing RNA oligonucleotide
Authors:Harp, J.M, Egli, M.
Deposit date:2023-04-20
Release date:2024-02-14
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Shorter Is Better: The alpha-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.
J.Am.Chem.Soc., 145, 2023
6VEM
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BU of 6vem by Molmil
Structure of RNA octamer
Descriptor: COBALT HEXAMMINE(III), Modified Octamer RNA
Authors:Pallan, P.S, Egli, M.
Deposit date:2020-01-02
Release date:2020-11-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5'-(R)- and 5'-(S)-C-methyl-guanosine.
Nucleic Acids Res., 48, 2020
5DER
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BU of 5der by Molmil
RNA oligonucleotide containing (R)-C5'-ME-2'F U
Descriptor: RNA oligonucleotide containing (R)-C5'-Me-2'-FU
Authors:Harp, J.M, Egli, M.
Deposit date:2015-08-25
Release date:2016-06-29
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
J.Org.Chem., 81, 2016
5D8T
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BU of 5d8t by Molmil
RNA octamer containing (S)-5' methyl, 2'-F U.
Descriptor: COBALT HEXAMMINE(III), RNA oligonucleotide containing (S)-C5'-Me-2'-FU
Authors:Harp, J.M, Egli, M.
Deposit date:2015-08-17
Release date:2016-06-29
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
J.Org.Chem., 81, 2016
5DEK
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BU of 5dek by Molmil
RNA octamer containing dT
Descriptor: COBALT HEXAMMINE(III), RNA oligonucleotide containing dT
Authors:Harp, J.M, Egli, M.
Deposit date:2015-08-25
Release date:2016-07-20
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.993 Å)
Cite:Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
J.Org.Chem., 81, 2016
6CY2
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BU of 6cy2 by Molmil
RNA octamer containing 2'-OMe, 4'Calpha-OMe U.
Descriptor: RNA (5'-R(*(CBV)P*GP*AP*AP*(UOA)P*UP*CP*G)-3')
Authors:Harp, J.M, Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CXZ
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BU of 6cxz by Molmil
RNA octamer containing 2'-F, 4'-Calpha-Me U.
Descriptor: CACODYLATE ION, COBALT HEXAMMINE(III), RNA (5'-R(*CP*GP*AP*AP*(U4M)P*UP*CP*G)-3')
Authors:Harp, J.M, Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CY0
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BU of 6cy0 by Molmil
RNA octamer containing 2'-F, 4'-Cbeta-OMe U.
Descriptor: RNA (5'-R(*(CBV)P*GP*AP*AP*(UFB)P*UP*CP*G)-3')
Authors:Harp, J.M, Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CY4
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BU of 6cy4 by Molmil
RNA octamer containing 2'-OMe, 4'- Cbeta-OMe U.
Descriptor: RNA (5'-R(*(CBV)P*GP*AP*AP*(UOB)P*UP*CP*G)-3')
Authors:Harp, J.M, Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
5V2H
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BU of 5v2h by Molmil
RNA octamer containing glycol nucleic acid, SgnT
Descriptor: COBALT HEXAMMINE(III), MAGNESIUM ION, RNA (5'-R(*(CBV)P*GP*AP*AP*(ZTH)P*UP*CP*G)-3')
Authors:Harp, J.M, Egli, M.
Deposit date:2017-03-04
Release date:2017-06-14
Last modified:2022-06-22
Method:X-RAY DIFFRACTION (1.080013 Å)
Cite:Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
5V1L
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BU of 5v1l by Molmil
Structure of S-GNA dodecamer
Descriptor: RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*(ZTH)P*AP*GP*CP*G)-3'), SPERMINE, STRONTIUM ION
Authors:Pallan, P.S, Egli, M.
Deposit date:2017-03-02
Release date:2017-06-14
Last modified:2022-06-22
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
5V1K
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BU of 5v1k by Molmil
Structure of R-GNA dodecamer
Descriptor: RNA (5'-R(*CP*GP*CP*GP*AP*AP*(5BU)P*(8RJ)P*AP*GP*CP*G)-3')
Authors:Pallan, P.S, Egli, M.
Deposit date:2017-03-02
Release date:2017-06-21
Last modified:2022-06-22
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 2017
5VR4
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BU of 5vr4 by Molmil
RNA octamer containing 2'-F-4'-OMe U.
Descriptor: COBALT TETRAAMMINE ION, RNA (5'-R(*CP*GP*AP*AP*(UMO)P*UP*CP*G)-3')
Authors:Harp, J.M, Egli, M.
Deposit date:2017-05-10
Release date:2017-10-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.
J. Am. Chem. Soc., 139, 2017

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PDB entries from 2024-03-27

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