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3T3M
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A NOVEL HIGH AFFINITY INTEGRIN ALPHAIIBBETA3 RECEPTOR ANTAGONIST THAT UNEXPECTEDLY DISPLACES MG2+ FROM THE BETA3 MIDAS
Descriptor:Integrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, ...
Authors:Zhu, J., Zhu, J., Springer, T.A.
Deposit date:2011-07-25
Release date:2012-03-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
Sci Transl Med, 4, 2012
3T3P
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A NOVEL HIGH AFFINITY INTEGRIN ALPHAIIBBETA3 RECEPTOR ANTAGONIST THAT UNEXPECTEDLY DISPLACES MG2+ FROM THE BETA3 MIDAS
Descriptor:Integrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, ...
Authors:Zhu, J., Zhu, J., Springer, T.A.
Deposit date:2011-07-25
Release date:2012-03-28
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
Sci Transl Med, 4, 2012
4UIK
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CRYSTAL STRUCTURE OF QUININE-DEPENDENT FAB 314.1
Descriptor:FAB 314.1
Authors:Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A.
Deposit date:2015-03-30
Release date:2015-09-02
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Quinine-Dependent Antibody Binding to Platelet Integrin Alphaiib Beta3
Blood, 126, 2015
4UIL
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CRYSTAL STRUCTURE OF QUININE-DEPENDENT FAB 314.1 WITH QUININE
Descriptor:FAB 314.1, Quinine
Authors:Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A.
Deposit date:2015-03-30
Release date:2015-09-02
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (2.853 Å)
Cite:Structural Basis for Quinine-Dependent Antibody Binding to Platelet Integrin Alphaiib Beta3
Blood, 126, 2015
4UIM
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CRYSTAL STRUCTURE OF QUININE-DEPENDENT FAB 314.3
Descriptor:FAB 314.3, SULFATE ION
Authors:Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A.
Deposit date:2015-03-30
Release date:2015-09-02
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for Quinine-Dependent Antibody Binding to Platelet Integrin Alphaiib Beta3
Blood, 126, 2015
4UIN
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CRYSTAL STRUCTURE OF QUININE-DEPENDENT FAB 314.3 WITH QUININE
Descriptor:FAB 314.3, Quinine
Authors:Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A.
Deposit date:2015-03-30
Release date:2015-09-02
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Quinine-Dependent Antibody Binding to Platelet Integrin Alphaiib Beta3
Blood, 126, 2015
5YPR
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CRYSTAL STRUCTURE OF PSD-95 SH3-GK DOMAIN IN COMPLEX WITH A SYNTHESIZED INHIBITOR
Descriptor:Disks large homolog 4, Synthesized GK inhibitor
Authors:Zhu, J., Zhou, Q., Shang, Y., Weng, Z., Zhu, R., Zhang, M.
Deposit date:2017-11-02
Release date:2018-03-14
Method:X-RAY DIFFRACTION (2.349 Å)
Cite:Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs.
Cell Rep, 21, 2017
5EWD
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CRYSTAL STRUCTURE OF THE HUMAN BRPF1 BROMODOMAIN IN COMPLEX WITH SEED18
Descriptor:Peregrin, 4-phenylpyridine, NITRATE ION
Authors:Zhu, J., Caflisch, A.
Deposit date:2015-11-20
Release date:2016-05-25
Last modified:2016-06-22
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5MME
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXD WITH US46C
Descriptor:CREB-binding protein, dimethyl 5-[(5-ethanoyl-2-ethoxy-phenyl)amino]benzene-1,3-dicarboxylate
Authors:Zhu, J., Caflisch, A.
Deposit date:2016-12-09
Release date:2017-12-20
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
2IEL
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CRYSTAL STRUCTURE OF TT0030 FROM THERMUS THERMOPHILUS
Descriptor:Hypothetical Protein TT0030
Authors:Zhu, J., Huang, J., Stepanyuk, G., Chen, L., Chang, J., Zhao, M., Xu, H., Liu, Z.J., Rose, J.P., Wang, B.C., Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2006-09-19
Release date:2006-11-14
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:CRYSTAL STRUCTURE OF TT0030 from Thermus Thermophilus AT 1.6 ANGSTROMS RESOLUTION
To be Published
2QVO
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CRYSTAL STRUCTURE OF AF1382 FROM ARCHAEOGLOBUS FULGIDUS
Descriptor:Uncharacterized protein AF_1382
Authors:Zhu, J., Zhao, M., Fu, Z.-Q., Yang, H., Chang, J., Hao, X., Chen, L., Liu, Z.J., Rose, J.P., Wang, B.C., Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2007-08-08
Release date:2007-09-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of AF1382 from Archaeoglobus fulgidus.
To be Published
3WP0
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CRYSTAL STRUCTURE OF DLG GK IN COMPLEX WITH A PHOSPHOR-LGL2 PEPTIDE
Descriptor:Disks large homolog 4, Lethal(2) giant larvae protein homolog 2, GLYCEROL
Authors:Zhu, J., Shang, Y., Wan, Q., Xia, Y., Chen, J., Du, Q., Zhang, M.
Deposit date:2014-01-08
Release date:2014-03-19
Last modified:2014-04-30
Method:X-RAY DIFFRACTION (2.039 Å)
Cite:Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl
Cell Res., 24, 2014
3WP1
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PHOSPHORYLATION-DEPENDENT INTERACTION BETWEEN TUMOR SUPPRESSORS DLG AND LGL
Descriptor:Disks large homolog 4, Lethal(2) giant larvae protein homolog 2, SULFATE ION
Authors:Zhu, J., Shang, Y., Wan, Q., Xia, Y., Chen, J., Du, Q., Zhang, M.
Deposit date:2014-01-08
Release date:2014-03-19
Last modified:2014-04-30
Method:X-RAY DIFFRACTION (2.804 Å)
Cite:Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl
Cell Res., 24, 2014
5COD
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BOVINE HEART COMPLEX I MEMBRANE DOMAIN
Descriptor:NADH-ubiquinone oxidoreductase chain 5, NADH-ubiquinone oxidoreductase chain 4, Unknown structure, ...
Authors:Zhu, J., Hirst, J., King, M.S., Yu, M., Leslie, A.G.W., Klipcan, L.
Deposit date:2015-07-20
Release date:2015-09-23
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (6.74 Å)
Cite:Structure of subcomplex I beta of mammalian respiratory complex I leads to new supernumerary subunit assignments.
Proc.Natl.Acad.Sci.USA, 112, 2015
5MMG
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXED WITH UT07C
Descriptor:CREB-binding protein, 1-[4-ethoxy-3-[(1-methylsulfonylindol-6-yl)amino]phenyl]ethanone
Authors:Zhu, J., Caflisch, A.
Deposit date:2016-12-09
Release date:2017-12-20
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
5MPK
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXED WITH DK19
Descriptor:CREB-binding protein, ~{N}-(5-ethanoyl-2-ethoxy-phenyl)-3-(2~{H}-1,2,3,4-tetrazol-5-yl)-5-(1,3-thiazol-4-yl)benzamide
Authors:Zhu, J., Caflisch, A.
Deposit date:2016-12-16
Release date:2018-01-17
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
5MPN
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXED WITH FA26
Descriptor:CREB-binding protein, 1-[4-ethoxy-3-[3-(2~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]ethanone, 1,2-ETHANEDIOL
Authors:Zhu, J., Caflisch, A.
Deposit date:2016-12-16
Release date:2018-01-17
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
5OWK
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXED WITH DSPB2A002
Descriptor:CREB-binding protein, ethyl 4-chloranyl-1-methyl-6-oxidanylidene-pyridine-3-carboxylate
Authors:Zhu, J., Spiliotopoulos, D., Caflisch, A.
Deposit date:2017-09-01
Release date:2018-08-29
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
6FQO
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXD WITH DT29
Descriptor:CREB-binding protein, ~{N}-[3-(2,5-dimethyl-3-oxidanylidene-1,2-oxazol-4-yl)-5-(5-ethanoyl-2-ethoxy-phenyl)phenyl]furan-2-carboxamide, 1,2-ETHANEDIOL
Authors:Zhu, J., Caflisch, A.
Deposit date:2018-02-14
Release date:2018-08-29
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
6FQU
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXD WITH DR09
Descriptor:CREB-binding protein, 1-[3-[3-[3,3-bis(fluoranyl)piperidin-1-yl]phenyl]-4-ethoxy-phenyl]ethanone
Authors:Zhu, J., Caflisch, A.
Deposit date:2018-02-14
Release date:2018-08-29
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
6FR0
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXD WITH PB08
Descriptor:CREB-binding protein, ~{N}-[3-(5-ethanoyl-2-ethoxy-phenyl)-5-(2-ethyl-5-methyl-3-oxidanylidene-1,2-oxazol-4-yl)phenyl]furan-2-carboxamide
Authors:Zhu, J., Caflisch, A.
Deposit date:2018-02-15
Release date:2018-08-29
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
6FRF
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXD WITH PA10
Descriptor:CREB-binding protein, ~{N}-[3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-(5-ethanoyl-2-ethoxy-phenyl)phenyl]furan-2-carboxamide
Authors:Zhu, J., Caflisch, A.
Deposit date:2018-02-15
Release date:2018-08-29
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
1ZNN
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STRUCTURE OF THE SYNTHASE SUBUNIT OF PLP SYNTHASE
Descriptor:PLP SYNTHASE, SULFATE ION, (4R)-2-METHYLPENTANE-2,4-DIOL
Authors:Zhu, J., Burgner, J.W., Harms, E., Belitsky, B.R., Smith, J.L.
Deposit date:2005-05-11
Release date:2005-05-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A New Arrangement of (beta/alpha)8 Barrels in the Synthase Subunit of PLP Synthase.
J.Biol.Chem., 280, 2005
2KBH
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SOLUTION STRUCTURE OF BMKALPHATX11 (MAJOR CONFORMATION)
Descriptor:Toxin Bmka2
Authors:Zhu, J., Wu, H.
Deposit date:2008-11-28
Release date:2009-12-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of BmKalphaTx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch
Biochem.Biophys.Res.Commun., 391, 2010
2KBJ
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SOLUTION STRUCTURE OF BMKALPHATX11 (MINOR CONFORMATION)
Descriptor:Toxin Bmka2
Authors:Zhu, J., Wu, H.
Deposit date:2008-11-28
Release date:2009-12-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of BmKalphaTx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch
Biochem.Biophys.Res.Commun., 391, 2010