Author results

3J6Q
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IDENTIFICATION OF THE ACTIVE SITES IN THE METHYLTRANSFERASES OF A TRANSCRIBING DSRNA VIRUS
Descriptor:Structural protein VP3, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Zhu, B., Yang, C., Liu, H., Cheng, L., Song, F., Zeng, S., Huang, X., Ji, G., Zhu, P.
Deposit date:2014-03-20
Release date:2014-10-08
Last modified:2014-10-22
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Identification of the active sites in the methyltransferases of a transcribing dsRNA virus.
J.Mol.Biol., 426, 2014
6AKS
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CRYO-EM STRUCTURE OF CVA10 MATURE VIRUS
Descriptor:VP1, VP2, VP3, ...
Authors:Zhu, L., Sun, Y., Fan, J.Y., Zhu, B., Cao, L., Gao, Q., Zhang, Y.J., Liu, H.R., Rao, Z.H., Wang, X.X.
Deposit date:2018-09-03
Release date:2019-01-16
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structures of Coxsackievirus A10 unveil the molecular mechanisms of receptor binding and viral uncoating.
Nat Commun, 9, 2018
6AKT
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CRYO-EM STRUCTURE OF CVA10 A-PARTICLE
Descriptor:VP1, VP2, VP3
Authors:Zhu, L., Sun, Y., Fan, J.Y., Zhu, B., Cao, L., Gao, Q., Zhang, Y.J., Liu, H.R., Rao, Z.H., Wang, X.X.
Deposit date:2018-09-03
Release date:2019-01-16
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structures of Coxsackievirus A10 unveil the molecular mechanisms of receptor binding and viral uncoating.
Nat Commun, 9, 2018
6AKU
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CRYO-EM STRUCTURE OF CVA10 EMPTY PARTICLE
Descriptor:VP1, VP2, VP3
Authors:Zhu, L., Sun, Y., Fan, J.Y., Zhu, B., Cao, L., Gao, Q., Zhang, Y.J., Liu, H.R., Rao, Z.H., Wang, X.X.
Deposit date:2018-09-03
Release date:2019-01-16
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structures of Coxsackievirus A10 unveil the molecular mechanisms of receptor binding and viral uncoating.
Nat Commun, 9, 2018
5H0R
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RNA DEPENDENT RNA POLYMERASE ,VP4,DSRNA
Descriptor:RNA-dependent RNA polymerase, VP4 protein, RNA (42-MER)
Authors:Li, X., Zhou, N., Chen, W., Zhu, B., Wang, X., Xu, B., Wang, J., Liu, H., Cheng, L.
Deposit date:2016-10-06
Release date:2017-01-25
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Near-Atomic Resolution Structure Determination of a Cypovirus Capsid and Polymerase Complex Using Cryo-EM at 200kV
J. Mol. Biol., 429, 2017
5H0S
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EM STRUCTURE OF VP1A AND VP1B
Descriptor:VP1
Authors:Li, X., Zhou, N., Xu, B., Chen, W., Zhu, B., Wang, X., Wang, J., Liu, H., Cheng, L.
Deposit date:2016-10-06
Release date:2017-01-25
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Near-Atomic Resolution Structure Determination of a Cypovirus Capsid and Polymerase Complex Using Cryo-EM at 200kV
J. Mol. Biol., 429, 2017
2AJG
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CRYSTAL STRUCTURE OF THE EDITING DOMAIN OF E. COLI LEUCYL-TRNA SYNTHETASE
Descriptor:Leucyl-tRNA synthetase
Authors:Liu, Y., Liao, J., Zhu, B., Wang, E.D., Ding, J.
Deposit date:2005-08-01
Release date:2006-01-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination
Biochem.J., 394, 2006
2AJH
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CRYSTAL STRUCTURE OF THE EDITING DOMAIN OF E. COLI LEUCYL-TRNA SYNTHETASE COMPLEXES WITH METHIONINE
Descriptor:Leucyl-tRNA synthetase, METHIONINE
Authors:Liu, Y., Liao, J., Zhu, B., Wang, E.D., Ding, J.
Deposit date:2005-08-02
Release date:2006-01-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination
Biochem.J., 394, 2006
2AJI
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CRYSTAL STRUCTURE OF THE EDITING DOMAIN OF E. COLI LEUCYL-TRNA SYNTHETASE COMPLEXES WITH ISOLEUCINE
Descriptor:Leucyl-tRNA synthetase, ISOLEUCINE
Authors:Liu, Y., Liao, J., Zhu, B., Wang, E.D., Ding, J.
Deposit date:2005-08-02
Release date:2006-01-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination
Biochem.J., 394, 2006
4H75
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CRYSTAL STRUCTURE OF HUMAN SPINDLIN1 IN COMPLEX WITH A HISTONE H3K4(ME3) PEPTIDE
Descriptor:Spindlin-1, Histone H3, GLYCEROL, ...
Authors:Yang, N., Wang, W., Wang, Y., Wang, M., Zhao, Q., Rao, Z., Zhu, B., Xu, R.M.
Deposit date:2012-09-20
Release date:2012-10-03
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (2.098 Å)
Cite:Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1.
Proc.Natl.Acad.Sci.USA, 109, 2012
4NFT
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CRYSTAL STRUCTURE OF HUMAN LNKH2B-H2A.Z-ANP32E
Descriptor:Histone H2B type 2-E, Histone H2A.Z, Acidic leucine-rich nuclear phosphoprotein 32 family member E
Authors:Shan, S., Pan, L., Mao, Z., Wang, W., Sun, J., Dong, Q., Liang, X., Ding, X., Chen, S., Dai, L., Zhang, Z., Zhu, B., Zhou, Z.
Deposit date:2013-11-01
Release date:2014-04-09
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z
Cell Res., 24, 2014
4PW5
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STRUCTURE OF UHRF2-SRA IN COMPLEX WITH A 5HMC-CONTAINING DNA, COMPLEX I
Descriptor:E3 ubiquitin-protein ligase UHRF2, 5hmC-containing DNA1, 5hmC-containing DNA2
Authors:ZHou, T., Xiong, J., Wang, M., Yang, N., Wong, J., Zhu, B., Xu, R.M.
Deposit date:2014-03-18
Release date:2014-05-07
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (2.204 Å)
Cite:Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2.
Mol.Cell, 54, 2014
4PW6
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STRUCTURE OF UHRF2-SRA IN COMPLEX WITH A 5HMC-CONTAINING DNA, COMPLEX II
Descriptor:E3 ubiquitin-protein ligase UHRF2, 5hmC-containing DNA1, 5hmC-containing DNA2
Authors:Zhou, T., Xiong, J., Wang, M., Yang, N., Wong, J., Zhu, B., Xu, R.M.
Deposit date:2014-03-18
Release date:2014-05-07
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (3.789 Å)
Cite:Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2.
Mol.Cell, 54, 2014
4PW7
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STRUCTURE OF UHRF2-SRA IN COMPLEX WITH A 5MC-CONTAINING DNA
Descriptor:E3 ubiquitin-protein ligase UHRF2, 5mC-containing DNA1, 5mC-containing DNA2
Authors:ZHou, T., Xiong, J., Wang, M., Yang, N., Wong, J., Zhu, B., Xu, R.M.
Deposit date:2014-03-19
Release date:2014-05-07
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2.
Mol.Cell, 54, 2014
5EX0
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CRYSTAL STRUCTURE OF HUMAN SMYD3 IN COMPLEX WITH A MAP3K2 PEPTIDE
Descriptor:Histone-lysine N-methyltransferase SMYD3, MAP3K2 peptide, ZINC ION, ...
Authors:Fu, W., Liu, N., Qiao, Q., Wang, M., Min, J., Zhu, B., Xu, R.M., Yang, N.
Deposit date:2015-11-23
Release date:2016-03-09
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase
J.Biol.Chem., 291, 2016
5EX3
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CRYSTAL STRUCTURE OF HUMAN SMYD3 IN COMPLEX WITH A VEGFR1 PEPTIDE
Descriptor:Histone-lysine N-methyltransferase SMYD3, VEGFR1 peptide, ZINC ION, ...
Authors:Qiao, Q., Fu, W., Liu, N., Wang, M., Min, J., Zhu, B., Xu, R.M., Yang, N.
Deposit date:2015-11-23
Release date:2016-03-09
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.408 Å)
Cite:Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase
J.Biol.Chem., 291, 2016
6INE
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CRYSTAL STRUCTURE OF HUMAN ASH1L-MRG15 COMPLEX
Descriptor:Histone-lysine N-methyltransferase ASH1L, Mortality factor 4-like protein 1, ZINC ION, ...
Authors:Hou, P., Huang, C., Liu, C.P., Yu, T., Yin, Y., Zhu, B., Xu, R.M.
Deposit date:2018-10-25
Release date:2019-03-20
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Insights into Stimulation of Ash1L's H3K36 Methyltransferase Activity through Mrg15 Binding.
Structure, 27, 2019
4MZF
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CRYSTAL STRUCTURE OF HUMAN SPINDLIN1 BOUND TO HISTONE H3(K4ME3-R8ME2A) PEPTIDE
Descriptor:Peptide from Histone H3.2, Spindlin-1, CHLORIDE ION, ...
Authors:Su, X., Ding, X., Li, H.
Deposit date:2013-09-30
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2.098 Å)
Cite:Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1
Genes Dev., 28, 2014
4MZG
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CRYSTAL STRUCTURE OF HUMAN SPINDLIN1 BOUND TO HISTONE H3K4ME3 PEPTIDE
Descriptor:Peptide from Histone H3.2, Spindlin-1, (4R)-2-METHYLPENTANE-2,4-DIOL, ...
Authors:Su, X., Ding, X., Li, H.
Deposit date:2013-09-30
Release date:2014-03-26
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1
Genes Dev., 28, 2014
4MZH
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CRYSTAL STRUCTURE OF HUMAN SPINDLIN1 BOUND TO HISTONE H3(K4ME3-R8ME2S) PEPTIDE
Descriptor:Spindlin-1, Peptide from Histone H3.2, MAGNESIUM ION
Authors:Su, X., Ding, X., Li, H.
Deposit date:2013-09-30
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2.204 Å)
Cite:Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1
Genes Dev., 28, 2014
2FJP
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HUMAN DIPEPTIDYL PEPTIDASE IV/CD26 IN COMPLEX WITH AN INHIBITOR
Descriptor:Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, 6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM
Authors:Scapin, G., Patel, S.B., Becker, J.W.
Deposit date:2006-01-03
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
J.Med.Chem., 49, 2006
3T8M
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RATIONAL DESIGN OF PI3K-ALPHA INHIBITORS THAT EXHIBIT SELECTIVITY OVER THE PI3K-BETA ISOFORM
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, N~2~-{2-chloro-4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-N~2~,N~8~-dimethyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamide
Authors:Murray, J.M., Wiesmann, C.
Deposit date:2011-08-01
Release date:2011-11-16
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Rational Design of PI3K-alpha Inhibitors that Exhibit Selectivity Over the PI3K-beta Isoform
To be Published
3HAB
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THE STRUCTURE OF DPP4 IN COMPLEX WITH PIPERIDINE FUSED BENZIMIDAZOLE 25
Descriptor:Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Scapin, G.
Deposit date:2009-05-01
Release date:2009-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors
Bioorg.Med.Chem.Lett., 19, 2009
3HAC
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THE STRUCTURE OF DPP-4 IN COMPLEX WITH PIPERIDINE FUSED IMIDAZOPYRIDINE 34
Descriptor:Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Scapin, G.
Deposit date:2009-05-01
Release date:2009-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors
Bioorg.Med.Chem.Lett., 19, 2009
4RGY
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STRUCTURAL AND FUNCTIONAL ANALYSIS OF A LOW-TEMPERATURE-ACTIVE ALKALINE ESTERASE FROM SOUTH CHINA SEA MARINE SEDIMENT MICROBIAL METAGENOMIC LIBRARY
Descriptor:Esterase
Authors:Liu, Y.
Deposit date:2014-10-01
Release date:2015-09-16
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and functional analysis of a low-temperature-active alkaline esterase from South China Sea marine sediment microbial metagenomic library.
J Ind Microbiol Biotechnol, 42, 2015
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