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3T3M
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A NOVEL HIGH AFFINITY INTEGRIN ALPHAIIBBETA3 RECEPTOR ANTAGONIST THAT UNEXPECTEDLY DISPLACES MG2+ FROM THE BETA3 MIDAS
分子名称:Integrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, ...
著者Zhu, J., Zhu, J., Springer, T.A.
登録日2011-07-25
公開日2012-03-28
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
Sci Transl Med, 4, 2012
3T3P
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A NOVEL HIGH AFFINITY INTEGRIN ALPHAIIBBETA3 RECEPTOR ANTAGONIST THAT UNEXPECTEDLY DISPLACES MG2+ FROM THE BETA3 MIDAS
分子名称:Integrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, ...
著者Zhu, J., Zhu, J., Springer, T.A.
登録日2011-07-25
公開日2012-03-28
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
Sci Transl Med, 4, 2012
4UIK
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CRYSTAL STRUCTURE OF QUININE-DEPENDENT FAB 314.1
分子名称:FAB 314.1
著者Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A.
登録日2015-03-30
公開日2015-09-02
最終更新日2015-11-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for Quinine-Dependent Antibody Binding to Platelet Integrin Alphaiib Beta3
Blood, 126, 2015
4UIL
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CRYSTAL STRUCTURE OF QUININE-DEPENDENT FAB 314.1 WITH QUININE
分子名称:FAB 314.1, Quinine
著者Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A.
登録日2015-03-30
公開日2015-09-02
最終更新日2015-11-11
実験手法X-RAY DIFFRACTION (2.853 Å)
主引用文献Structural Basis for Quinine-Dependent Antibody Binding to Platelet Integrin Alphaiib Beta3
Blood, 126, 2015
4UIM
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CRYSTAL STRUCTURE OF QUININE-DEPENDENT FAB 314.3
分子名称:FAB 314.3, SULFATE ION
著者Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A.
登録日2015-03-30
公開日2015-09-02
最終更新日2015-11-11
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Basis for Quinine-Dependent Antibody Binding to Platelet Integrin Alphaiib Beta3
Blood, 126, 2015
4UIN
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CRYSTAL STRUCTURE OF QUININE-DEPENDENT FAB 314.3 WITH QUININE
分子名称:FAB 314.3, Quinine
著者Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A.
登録日2015-03-30
公開日2015-09-02
最終更新日2017-04-19
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis for Quinine-Dependent Antibody Binding to Platelet Integrin Alphaiib Beta3
Blood, 126, 2015
5YPR
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CRYSTAL STRUCTURE OF PSD-95 SH3-GK DOMAIN IN COMPLEX WITH A SYNTHESIZED INHIBITOR
分子名称:Disks large homolog 4, Synthesized GK inhibitor
著者Zhu, J., Zhou, Q., Shang, Y., Weng, Z., Zhu, R., Zhang, M.
登録日2017-11-02
公開日2018-03-14
実験手法X-RAY DIFFRACTION (2.349 Å)
主引用文献Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs.
Cell Rep, 21, 2017
5MME
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXD WITH US46C
分子名称:CREB-binding protein, dimethyl 5-[(5-ethanoyl-2-ethoxy-phenyl)amino]benzene-1,3-dicarboxylate
著者Zhu, J., Caflisch, A.
登録日2016-12-09
公開日2017-12-20
最終更新日2019-10-16
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
5EWD
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CRYSTAL STRUCTURE OF THE HUMAN BRPF1 BROMODOMAIN IN COMPLEX WITH SEED18
分子名称:Peregrin, 4-phenylpyridine, NITRATE ION
著者Zhu, J., Caflisch, A.
登録日2015-11-20
公開日2016-05-25
最終更新日2016-06-22
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
2IEL
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CRYSTAL STRUCTURE OF TT0030 FROM THERMUS THERMOPHILUS
分子名称:Hypothetical Protein TT0030
著者Zhu, J., Huang, J., Stepanyuk, G., Chen, L., Chang, J., Zhao, M., Xu, H., Liu, Z.J., Rose, J.P., Wang, B.C., Southeast Collaboratory for Structural Genomics (SECSG)
登録日2006-09-19
公開日2006-11-14
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献CRYSTAL STRUCTURE OF TT0030 from Thermus Thermophilus AT 1.6 ANGSTROMS RESOLUTION
To be Published
2QVO
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CRYSTAL STRUCTURE OF AF1382 FROM ARCHAEOGLOBUS FULGIDUS
分子名称:Uncharacterized protein AF_1382
著者Zhu, J., Zhao, M., Fu, Z.-Q., Yang, H., Chang, J., Hao, X., Chen, L., Liu, Z.J., Rose, J.P., Wang, B.C., Southeast Collaboratory for Structural Genomics (SECSG)
登録日2007-08-08
公開日2007-09-04
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structure of AF1382 from Archaeoglobus fulgidus.
To be Published
3WP0
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CRYSTAL STRUCTURE OF DLG GK IN COMPLEX WITH A PHOSPHOR-LGL2 PEPTIDE
分子名称:Disks large homolog 4, Lethal(2) giant larvae protein homolog 2, GLYCEROL
著者Zhu, J., Shang, Y., Wan, Q., Xia, Y., Chen, J., Du, Q., Zhang, M.
登録日2014-01-08
公開日2014-03-19
最終更新日2014-04-30
実験手法X-RAY DIFFRACTION (2.039 Å)
主引用文献Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl
Cell Res., 24, 2014
3WP1
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PHOSPHORYLATION-DEPENDENT INTERACTION BETWEEN TUMOR SUPPRESSORS DLG AND LGL
分子名称:Disks large homolog 4, Lethal(2) giant larvae protein homolog 2, SULFATE ION
著者Zhu, J., Shang, Y., Wan, Q., Xia, Y., Chen, J., Du, Q., Zhang, M.
登録日2014-01-08
公開日2014-03-19
最終更新日2014-04-30
実験手法X-RAY DIFFRACTION (2.804 Å)
主引用文献Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl
Cell Res., 24, 2014
5COD
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BOVINE HEART COMPLEX I MEMBRANE DOMAIN
分子名称:NADH-ubiquinone oxidoreductase chain 5, NADH-ubiquinone oxidoreductase chain 4, Unknown structure, ...
著者Zhu, J., Hirst, J., King, M.S., Yu, M., Leslie, A.G.W., Klipcan, L.
登録日2015-07-20
公開日2015-09-23
最終更新日2015-10-07
実験手法X-RAY DIFFRACTION (6.74 Å)
主引用文献Structure of subcomplex I beta of mammalian respiratory complex I leads to new supernumerary subunit assignments.
Proc.Natl.Acad.Sci.USA, 112, 2015
1ZNN
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STRUCTURE OF THE SYNTHASE SUBUNIT OF PLP SYNTHASE
分子名称:PLP SYNTHASE, SULFATE ION, (4R)-2-METHYLPENTANE-2,4-DIOL
著者Zhu, J., Burgner, J.W., Harms, E., Belitsky, B.R., Smith, J.L.
登録日2005-05-11
公開日2005-05-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A New Arrangement of (beta/alpha)8 Barrels in the Synthase Subunit of PLP Synthase.
J.Biol.Chem., 280, 2005
2KBH
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SOLUTION STRUCTURE OF BMKALPHATX11 (MAJOR CONFORMATION)
分子名称:Toxin Bmka2
著者Zhu, J., Wu, H.
登録日2008-11-28
公開日2009-12-08
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of BmKalphaTx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch
Biochem.Biophys.Res.Commun., 391, 2010
2KBJ
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SOLUTION STRUCTURE OF BMKALPHATX11 (MINOR CONFORMATION)
分子名称:Toxin Bmka2
著者Zhu, J., Wu, H.
登録日2008-11-28
公開日2009-12-08
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of BmKalphaTx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch
Biochem.Biophys.Res.Commun., 391, 2010
2KBK
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SOLUTION STRUCTURE OF BMK-M10
分子名称:Neurotoxin BmK-M10
著者Zhu, J., Wu, H.
登録日2008-11-28
公開日2009-12-22
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution Structure of BmK-M10
To be Published
2P17
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CRYSTAL STRUCTURE OF GK1651 FROM GEOBACILLUS KAUSTOPHILUS
分子名称:Pirin-like protein, FE (III) ION
著者Zhu, J., Swindell II, J.T., Chen, L., Ebihara, A., Shinkai, A., Kuramitsu, S., Yokoyama, S., Fu, Z.-Q., Rose, J.P., Wang, B.C., Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-02
公開日2007-05-01
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Crystal structure of GK1651 from Geobacillus kaustophilus
To be Published
2P3E
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CRYSTAL STRUCTURE OF AQ1208 FROM AQUIFEX AEOLICUS
分子名称:Diaminopimelate decarboxylase
著者Zhu, J., Swindell II, J.T., Chen, L., Ebihara, A., Shinkai, A., Kuramitsu, S., Yokoyama, S., Fu, Z.-Q., Rose, J.P., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-08
公開日2007-05-01
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献To be Published
To be Published
3FCS
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STRUCTURE OF COMPLETE ECTODOMAIN OF INTEGRIN AIIBB3
分子名称:Integrin, alpha 2b, Integrin beta-3, ...
著者Zhu, J., Luo, B.-H., Xiao, T., Zhang, C., Nishida, N., Springer, T.A.
登録日2008-11-22
公開日2009-01-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
Mol.Cell, 32, 2008
3FCU
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STRUCTURE OF HEADPIECE OF INTEGRIN AIIBB3 IN OPEN CONFORMATION
分子名称:Integrin, alpha 2b, Integrin beta-3, ...
著者Zhu, J., Luo, B.-H., Xiao, T., Zhang, C., Nishida, N., Springer, T.A.
登録日2008-11-22
公開日2009-01-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
Mol.Cell, 32, 2008
3RO3
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CRYSTAL STRUCTURE OF LGN/MINSCUTEABLE COMPLEX
分子名称:G-protein-signaling modulator 2, peptide of Protein inscuteable homolog, GLYCEROL, ...
著者Zhu, J., Wen, W., Shang, Y., Wei, Z., Pan, Z., Wang, W., Zhang, M.
登録日2011-04-25
公開日2012-03-07
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and G[alpha]i/LGN/NuMA pathways
Mol.Cell, 43, 2011
4HTX
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CRYSTAL STRUCTURE OF PDE2 CATALYTIC DOMAIN IN COMPLEX WITH BAY60-7550
分子名称:cGMP-dependent 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
著者Zhu, J., Huang, Q.
登録日2012-11-02
公開日2013-08-28
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献X-ray Crystal Structure of Phosphodiesterase 2 in Complex with a Highly Selective, Nanomolar Inhibitor Reveals a Binding-Induced Pocket Important for Selectivity.
J.Am.Chem.Soc., 135, 2013
4HTZ
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CRYSTAL STRUCTURE OF PDE2 CATALYTIC DOMAIN IN SPACE GROUP P1
分子名称:cGMP-dependent 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION
著者Zhu, J., Huang, Q.
登録日2012-11-02
公開日2013-08-28
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray Crystal Structure of Phosphodiesterase 2 in Complex with a Highly Selective, Nanomolar Inhibitor Reveals a Binding-Induced Pocket Important for Selectivity.
J.Am.Chem.Soc., 135, 2013