Author results

1CEH
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STRUCTURE AND FUNCTION OF THE CATALYTIC SITE MUTANT ASP99ASN OF PHOSPHOLIPASE A2: ABSENCE OF CONSERVED STRUCTURAL WATER
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION
Authors:Kumar, A., Sekharudu, C., Ramakrishnan, B., Dupureur, C.M., Zhu, H., Tsai, M.-D., Sundaralingam, M.
Deposit date:1994-11-16
Release date:1995-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and function of the catalytic site mutant Asp 99 Asn of phospholipase A2: absence of the conserved structural water.
Protein Sci., 3, 1994
1EJ8
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CRYSTAL STRUCTURE OF DOMAIN 2 OF THE YEAST COPPER CHAPERONE FOR SUPEROXIDE DISMUTASE (LYS7) AT 1.55 A RESOLUTION
Descriptor:LYS7, CALCIUM ION
Authors:Hall, L.T., Sanchez, R.J., Holloway, S.P., Zhu, H., Stine, J.E., Lyons, T.J., Demeler, B., Schirf, V., Hansen, J.C., Nersissian, A.M., Valentine, J.S., Hart, P.J.
Deposit date:2000-03-01
Release date:2000-04-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:X-ray crystallographic and analytical ultracentrifugation analyses of truncated and full-length yeast copper chaperones for SOD (LYS7): a dimer-dimer model of LYS7-SOD association and copper delivery.
Biochemistry, 39, 2000
1O7T
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METAL NANOCLUSTERS BOUND TO THE FERRIC BINDING PROTEIN FROM NEISSERIA GONORRHOEAE.
Descriptor:IRON BINDING PROTEIN, HF OXO CLUSTER HF5, SMALLEST HF-OXO-PHOSPHATE CLUSTER HF3, ...
Authors:Alexeev, D., Zu, H., Guo, M., Zhong, W., Hunter, D.J.B., Yang, W., Campopiano, D.J., Sadler, P.J.
Deposit date:2002-11-12
Release date:2003-02-27
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A novel protein-mineral interface.
Nat. Struct. Biol., 10, 2003
1R1N
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TRI-NUCLEAR OXO-IRON CLUSTERS IN THE FERRIC BINDING PROTEIN FROM N. GONORRHOEAE
Descriptor:Ferric-iron Binding Protein, OXO-IRON CLUSTER 1, OXO-IRON CLUSTER 2, ...
Authors:Zhu, H., Alexeev, D., Hunter, D.J., Campopiano, D.J., Sadler, P.J.
Deposit date:2003-09-24
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif.
Biochem.J., 376, 2003
1XC1
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OXO ZIRCONIUM(IV) CLUSTER IN THE FERRIC BINDING PROTEIN (FBP)
Descriptor:periplasmic iron-binding protein, OXO ZIRCONIUM(IV) CLUSTER
Authors:Zhong, W., Alexeev, D., Harvey, I., Guo, M., Hunter, D.J.B., Zhu, H., Campopiano, D.J., Sadler, P.J.
Deposit date:2004-08-31
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Assembly of an Oxo-Zirconium(IV) Cluster in a Protein Cleft
Angew.Chem.Int.Ed.Engl., 43, 2004
2FAO
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LIGD POLYMERASE DOMAIN
Descriptor:probable ATP-dependent DNA ligase, SULFATE ION
Authors:Zhu, H., Nandakumar, J., Aniukwu, J., Wang, L.K., Glickman, M.S., Lima, C.D., Shuman, S.
Deposit date:2005-12-07
Release date:2006-05-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D
Proc.Natl.Acad.Sci.USA, 103, 2006
2FAQ
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LIGD POLYMERASE DOMAIN WITH ATP AND MANGANESE
Descriptor:probable ATP-dependent DNA ligase, MANGANESE (II) ION, SULFATE ION, ...
Authors:Zhu, H., Nandakumar, J., Aniukwu, J., Wang, L.K., Glickman, M.S., Lima, C.D., Shuman, S.
Deposit date:2005-12-07
Release date:2006-05-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D
Proc.Natl.Acad.Sci.USA, 103, 2006
2FAR
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LIGD POLYMERASE DOMAIN WITH DATP AND MANGANESE
Descriptor:probable ATP-dependent DNA ligase, MANGANESE (II) ION, SULFATE ION, ...
Authors:Zhu, H., Nandakumar, J., Aniukwu, J., Wang, L.K., Glickman, M.S., Lima, C.D., Shuman, S.
Deposit date:2005-12-07
Release date:2006-05-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D
Proc.Natl.Acad.Sci.USA, 103, 2006
2IA5
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T4 POLYNUCLEOTIDE KINASE/PHOSPHATASE WITH BOUND SULFATE AND MAGNESIUM.
Descriptor:Polynucleotide kinase, MAGNESIUM ION, SULFATE ION, ...
Authors:Zhu, H., Smith, P.C., Wang, L.K., Lima, C.D., Shuman, S.
Deposit date:2006-09-07
Release date:2007-06-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-function analysis of the 3' phosphatase component of T4 polynucleotide kinase/phosphatase.
Virology, 366, 2007
2LUZ
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SOLUTION NMR STRUCTURE OF CALU16 FROM MICROMONOSPORA ECHINOSPORA, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET MIR12
Descriptor:CalU16
Authors:Ramelot, T.A., Yang, Y., Lee, H., Pederson, K., Lee, D., Kohan, E., Janjua, H., Xiao, R., Acton, T.B., Everett, J.K., Wrobel, R.L., Bingman, C.A., Singh, S., Thorson, J.S., Prestegard, J.H., Montelione, G.T., Phillips Jr., G.N., Kennedy, M.A., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Northeast Structural Genomics Consortium (NESG)
Deposit date:2012-06-22
Release date:2012-10-03
Last modified:2014-11-12
Method:SOLUTION NMR
Cite:Structure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19.
Acs Chem.Biol., 9, 2014
2MJV
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SOLUTION STRUCTURES OF SECOND BROMODOMAIN OF BRD4 WITH DI-ACETYLATED TWIST PEPTIDE
Descriptor:Twist-related protein 1, Bromodomain-containing protein 4
Authors:Zeng, L., Zhou, M.
Deposit date:2014-01-16
Release date:2014-03-19
Method:SOLUTION NMR
Cite:Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer.
Cancer Cell, 25, 2014
2MKZ
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SOLUTION STRUCTURE OF A PROTEIN C-TERMINAL DOMAIN
Descriptor:Proteasomal ubiquitin receptor ADRM1
Authors:Feng, Y., Jiao, L.
Deposit date:2014-02-17
Release date:2014-12-31
Method:SOLUTION NMR
Cite:Mechanism of the Rpn13-induced activation of Uch37
Protein Cell, 5, 2014
2MOQ
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SOLUTION STRUCTURE AND MOLECULAR DETERMINANTS OF HEMOGLOBIN BINDING OF THE FIRST NEAT DOMAIN OF ISDB IN STAPHYLOCOCCUS AUREUS
Descriptor:Iron-regulated surface determinant protein B
Authors:Fonner, B.A., Tripet, B.P., Eilers, B.J., Stanisich, J., Sullivan-Springhetti, R.K., Moore, R., Lui, M., Lei, B., Copie, V.
Deposit date:2014-04-29
Release date:2014-07-02
Last modified:2014-08-20
Method:SOLUTION NMR
Cite:Solution Structure and Molecular Determinants of Hemoglobin Binding of the First NEAT Domain of IsdB in Staphylococcus aureus.
Biochemistry, 53, 2014
2NZT
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CRYSTAL STRUCTURE OF HUMAN HEXOKINASE II
Descriptor:Hexokinase-2, ALPHA-D-GLUCOSE, BETA-D-GLUCOSE-6-PHOSPHATE, ...
Authors:Rabeh, W.M., Zhu, H., Nedyalkova, L., Tempel, W., Wasney, G., Landry, R., Vedadi, M., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2006-11-25
Release date:2006-12-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of human hexokinase II
To be Published
2O52
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CRYSTAL STRUCTURE OF HUMAN RAB4B IN COMPLEX WITH GDP
Descriptor:Ras-related protein Rab-4B, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Zhu, H., Tempel, W., Wang, J., Shen, Y., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2006-12-05
Release date:2006-12-19
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of human RAB4B in complex with GDP
To be Published
2OIL
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CRYSTAL STRUCTURE OF HUMAN RAB25 IN COMPLEX WITH GDP
Descriptor:Ras-related protein Rab-25, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Zhu, H., Wang, J., Shen, Y., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-01-11
Release date:2007-01-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of human RAB25 in complex with GDP
To be Published
2P57
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GAP DOMAIN OF ZNF289, AN ID1-REGULATED ZINC FINGER PROTEIN
Descriptor:GTPase-activating protein ZNF289, ZINC ION, UNKNOWN ATOM OR ION
Authors:Tong, Y., Dimov, S., Shen, L., Zhu, H., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-03-14
Release date:2007-03-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:GAP domain of ZNF289, an ID1-regulated zinc finger protein
To be Published
2P5S
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RAB DOMAIN OF HUMAN RASEF IN COMPLEX WITH GDP
Descriptor:RAS and EF-hand domain containing, GUANOSINE-5'-DIPHOSPHATE, UNKNOWN ATOM OR ION
Authors:Zhu, H., Wang, J., Shen, Y., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-03-16
Release date:2007-03-27
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:RAB domain of human RASEF in complex with GDP
To be Published
2PH6
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CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH INHIBITOR
Descriptor:Beta-secretase 1, SULFATE ION, 3-({[(1R)-1-(4-FLUOROPHENYL)ETHYL]AMINO}CARBONYL)-5-[METHYL(METHYLSULFONYL)AMINO]BENZYL ALPHA-METHYL-D-PHENYLALANINATE
Authors:Munshi, S.
Deposit date:2007-04-10
Release date:2007-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
2PH8
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CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH INHIBITOR
Descriptor:Beta-secretase 1, SULFATE ION, N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDE
Authors:Munshi, S.
Deposit date:2007-04-10
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
2PMY
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EF-HAND DOMAIN OF HUMAN RASEF
Descriptor:RAS and EF-hand domain-containing protein, CALCIUM ION, SULFATE ION, ...
Authors:Zhu, H., Shen, Y., Wang, J., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-04-23
Release date:2007-05-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:EF-hand domain of human RASEF
To be Published
2PXX
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HUMAN PUTATIVE METHYLTRANSFERASE MGC2408
Descriptor:Uncharacterized protein MGC2408, UNKNOWN ATOM OR ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Tempel, W., Wu, H., Dombrovsky, L., Zeng, H., Zhu, H., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2007-05-14
Release date:2007-05-22
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene.
Proteins, 74, 2009
2PZ9
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CRYSTAL STRUCTURE OF PUTATIVE TRANSCRIPTIONAL REGULATOR SCO4942 FROM STREPTOMYCES COELICOLOR
Descriptor:Putative regulatory protein, SULFATE ION
Authors:Filippova, E.V., Chruszcz, M., Xu, X., Zheng, H., Cymborowski, M., Savchenko, A., Edwards, A., Joachimiak, A., Minor, W., Midwest Center for Structural Genomics (MCSG)
Deposit date:2007-05-17
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:In situ proteolysis for protein crystallization and structure determination.
Nat.Methods, 4, 2007
2QZK
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CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH I21
Descriptor:Beta-secretase 1, 2-[(5R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-3-oxa-15-azatricyclo[15.3.1.1~7,11~]docosa-1(21),7(22),8,10,12,14,17,19-octaen-19-yl]benzonitrile
Authors:Munshi, S.
Deposit date:2007-08-16
Release date:2008-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
2R13
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CRYSTAL STRUCTURE OF HUMAN MITONEET REVEALS A NOVEL [2FE-2S] CLUSTER COORDINATION
Descriptor:Zinc finger CDGSH domain-containing protein 1, CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER
Authors:Hou, X., Liu, R., Ross, S., Smart, E.J., Zhu, H., Gong, W.
Deposit date:2007-08-22
Release date:2007-09-11
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystallographic studies of human MitoNEET
J.Biol.Chem., 282, 2007