Author results

3NWN
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CRYSTAL STRUCTURE OF THE HUMAN KIF9 MOTOR DOMAIN IN COMPLEX WITH ADP
Descriptor:Kinesin-like protein KIF9, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Zhu, H., Tempel, W., He, H., Shen, Y., Wang, J., Brothers, G., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2010-07-09
Release date:2010-07-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the human KIF9 motor domain in complex with ADP
To be Published
2O52
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CRYSTAL STRUCTURE OF HUMAN RAB4B IN COMPLEX WITH GDP
Descriptor:Ras-related protein Rab-4B, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Zhu, H., Tempel, W., Wang, J., Shen, Y., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2006-12-05
Release date:2006-12-19
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of human RAB4B in complex with GDP
To be Published
2OIL
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CRYSTAL STRUCTURE OF HUMAN RAB25 IN COMPLEX WITH GDP
Descriptor:Ras-related protein Rab-25, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Zhu, H., Wang, J., Shen, Y., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-01-11
Release date:2007-01-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of human RAB25 in complex with GDP
To be Published
2P5S
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RAB DOMAIN OF HUMAN RASEF IN COMPLEX WITH GDP
Descriptor:RAS and EF-hand domain containing, GUANOSINE-5'-DIPHOSPHATE, UNKNOWN ATOM OR ION
Authors:Zhu, H., Wang, J., Shen, Y., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-03-16
Release date:2007-03-27
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:RAB domain of human RASEF in complex with GDP
To be Published
2PMY
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EF-HAND DOMAIN OF HUMAN RASEF
Descriptor:RAS and EF-hand domain-containing protein, CALCIUM ION, SULFATE ION, ...
Authors:Zhu, H., Shen, Y., Wang, J., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-04-23
Release date:2007-05-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:EF-hand domain of human RASEF
To be Published
3B6U
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CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF HUMAN KINESIN FAMILY MEMBER 3B IN COMPLEX WITH ADP
Descriptor:Kinesin-like protein KIF3B, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Zhu, H., Shen, Y., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-10-29
Release date:2007-11-13
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Motor domain of human kinesin family member 3B in complex with ADP.
To be Published
3B6V
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CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF HUMAN KINESIN FAMILY MEMBER 3C IN COMPLEX WITH ADP
Descriptor:Kinesin-like protein KIF3C, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Zhu, H., Tempel, W., Shen, Y., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-10-29
Release date:2007-11-13
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Motor domain of human kinesin family member 3C in complex with ADP.
To be Published
3CEQ
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THE TPR DOMAIN OF HUMAN KINESIN LIGHT CHAIN 2 (HKLC2)
Descriptor:Kinesin light chain 2
Authors:Zhu, H., Shen, Y., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-02-29
Release date:2008-08-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The TPR domain of Human Kinesin Light Chain 2 (hKLC2)
To be Published
3EDT
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CRYSTAL STRUCTURE OF THE MUTATED S328N HKLC2 TPR DOMAIN
Descriptor:Kinesin light chain 2, UNKNOWN ATOM OR ION
Authors:Zhu, H., Shen, Y., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-09-03
Release date:2009-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of mutated S328N TPR domain of human kinesin light chain 2
To be published
1R1N
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TRI-NUCLEAR OXO-IRON CLUSTERS IN THE FERRIC BINDING PROTEIN FROM N. GONORRHOEAE
Descriptor:Ferric-iron Binding Protein, OXO-IRON CLUSTER 1, OXO-IRON CLUSTER 2, ...
Authors:Zhu, H., Alexeev, D., Hunter, D.J., Campopiano, D.J., Sadler, P.J.
Deposit date:2003-09-24
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif.
Biochem.J., 376, 2003
2FAO
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LIGD POLYMERASE DOMAIN
Descriptor:probable ATP-dependent DNA ligase, SULFATE ION
Authors:Zhu, H., Nandakumar, J., Aniukwu, J., Wang, L.K., Glickman, M.S., Lima, C.D., Shuman, S.
Deposit date:2005-12-07
Release date:2006-05-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D
Proc.Natl.Acad.Sci.USA, 103, 2006
2FAQ
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LIGD POLYMERASE DOMAIN WITH ATP AND MANGANESE
Descriptor:probable ATP-dependent DNA ligase, MANGANESE (II) ION, SULFATE ION, ...
Authors:Zhu, H., Nandakumar, J., Aniukwu, J., Wang, L.K., Glickman, M.S., Lima, C.D., Shuman, S.
Deposit date:2005-12-07
Release date:2006-05-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D
Proc.Natl.Acad.Sci.USA, 103, 2006
2FAR
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LIGD POLYMERASE DOMAIN WITH DATP AND MANGANESE
Descriptor:probable ATP-dependent DNA ligase, MANGANESE (II) ION, SULFATE ION, ...
Authors:Zhu, H., Nandakumar, J., Aniukwu, J., Wang, L.K., Glickman, M.S., Lima, C.D., Shuman, S.
Deposit date:2005-12-07
Release date:2006-05-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D
Proc.Natl.Acad.Sci.USA, 103, 2006
2IA5
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T4 POLYNUCLEOTIDE KINASE/PHOSPHATASE WITH BOUND SULFATE AND MAGNESIUM.
Descriptor:Polynucleotide kinase, MAGNESIUM ION, SULFATE ION, ...
Authors:Zhu, H., Smith, P.C., Wang, L.K., Lima, C.D., Shuman, S.
Deposit date:2006-09-07
Release date:2007-06-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-function analysis of the 3' phosphatase component of T4 polynucleotide kinase/phosphatase.
Virology, 366, 2007
6JLQ
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CRYSTAL STRUCTURE OF HUMAN USP46-WDR48-WDR20 COMPLEX
Descriptor:Ubiquitin carboxyl-terminal hydrolase 46, WD repeat-containing protein 48, WD repeat-containing protein 20,highly similar to WD repeat protein 20,WD repeat-containing protein 20, ...
Authors:Zhu, H., Zhang, T., Ding, J.
Deposit date:2019-03-06
Release date:2019-07-10
Method:X-RAY DIFFRACTION (3.101 Å)
Cite:Crystal structure of human USP46-WDR48-WDR20 complex
To Be Published
5WDH
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MOTOR DOMAIN OF HUMAN KINESIN FAMILY MEMBER C1
Descriptor:Kinesin-like protein KIFC1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Zhu, H., Tempel, W., He, H., Shen, Y., Wang, J., Brothers, G., Landry, R., Arrowsmith, C.H., Edwards, A.M., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2017-07-05
Release date:2017-08-09
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (2.248 Å)
Cite:Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
Sci Rep, 7, 2017
4XH7
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CRYSTAL STRUCTURE OF MUPP1 PDZ4
Descriptor:Multiple PDZ domain protein, IMIDAZOLE
Authors:Liu, Z., Zhu, H., Liu, W.
Deposit date:2015-01-05
Release date:2015-03-04
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Biochemical and structural characterization of MUPP1-PDZ4 domain from Mus musculus.
Acta Biochim.Biophys.Sin., 47, 2015
5FZQ
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DESIGNED TPR PROTEIN M4N
Descriptor:DESIGNED TPR PROTEIN, SULFATE ION
Authors:Albrecht, R., Zhu, H., Hartmann, M.D.
Deposit date:2016-03-15
Release date:2016-10-12
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.148 Å)
Cite:Origin of a folded repeat protein from an intrinsically disordered ancestor.
Elife, 5, 2016
5FZR
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DESIGNED TPR PROTEIN M4N DELTA C (CF I)
Descriptor:DESIGNED TPR PROTEIN
Authors:Albrecht, R., Zhu, H., Hartmann, M.D.
Deposit date:2016-03-15
Release date:2016-10-12
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.045 Å)
Cite:Origin of a folded repeat protein from an intrinsically disordered ancestor.
Elife, 5, 2016
5FZS
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DESIGNED TPR PROTEIN M4N DELTA C (CF II)
Descriptor:DESIGNED TPR PROTEIN
Authors:Albrecht, R., Zhu, H., Hartmann, M.D.
Deposit date:2016-03-15
Release date:2016-10-12
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (1.652 Å)
Cite:Origin of a folded repeat protein from an intrinsically disordered ancestor.
Elife, 5, 2016
5HSI
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CRYSTAL STRUCTURE OF TYROSINE DECARBOXYLASE AT 1.73 ANGSTROMS RESOLUTION
Descriptor:Putative decarboxylase, MAGNESIUM ION
Authors:Ni, Y., Zhou, J., Zhu, H., Zhang, K.
Deposit date:2016-01-25
Release date:2016-09-21
Method:X-RAY DIFFRACTION (1.732 Å)
Cite:Crystal structure of tyrosine decarboxylase and identification of key residues involved in conformational swing and substrate binding
Sci Rep, 6, 2016
6DCG
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DISCOVERY OF MK-8353: AN ORALLY BIOAVAILABLE DUAL MECHANISM ERK INHIBITOR FOR ONCOLOGY
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, (3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)-N-(3-{6-[(propan-2-yl)oxy]pyridin-3-yl}-1H-indazol-5-yl)pyrrolidine-3-carboxamide
Authors:Boga, S.B., Deng, Y., Zhu, L., Nan, Y., Cooper, A., Shipps Jr., G.W., Doll, R., Shih, N., Zhu, H., Sun, R., Wang, T., Paliwal, S., Tsui, H., Gao, X., Yao, X., Desai, J., Wang, J., Alhassan, A.B., Kelly, J., Patel, M., Muppalla, K., Gudipati, S., Zhang, L., Buevich, A., Hesk, D., Carr, D., Dayananth, P., Mei, H., Cox, K., Sherborne, B., Hruza, A.W., Xiao, L., Jin, W., Long, B., Liu, G., Taylor, S.A., Kirschmeier, P., Windsor, W.T., Bishop, R., Samatar, A.A.
Deposit date:2018-05-06
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.
ACS Med Chem Lett, 9, 2018
1XC1
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OXO ZIRCONIUM(IV) CLUSTER IN THE FERRIC BINDING PROTEIN (FBP)
Descriptor:periplasmic iron-binding protein, OXO ZIRCONIUM(IV) CLUSTER
Authors:Zhong, W., Alexeev, D., Harvey, I., Guo, M., Hunter, D.J.B., Zhu, H., Campopiano, D.J., Sadler, P.J.
Deposit date:2004-08-31
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Assembly of an Oxo-Zirconium(IV) Cluster in a Protein Cleft
Angew.Chem.Int.Ed.Engl., 43, 2004
2PXX
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HUMAN PUTATIVE METHYLTRANSFERASE MGC2408
Descriptor:Uncharacterized protein MGC2408, UNKNOWN ATOM OR ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Tempel, W., Wu, H., Dombrovsky, L., Zeng, H., Zhu, H., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2007-05-14
Release date:2007-05-22
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene.
Proteins, 74, 2009
2NZT
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CRYSTAL STRUCTURE OF HUMAN HEXOKINASE II
Descriptor:Hexokinase-2, ALPHA-D-GLUCOSE, BETA-D-GLUCOSE-6-PHOSPHATE, ...
Authors:Rabeh, W.M., Zhu, H., Nedyalkova, L., Tempel, W., Wasney, G., Landry, R., Vedadi, M., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2006-11-25
Release date:2006-12-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of human hexokinase II
To be Published