Author results

3OXZ
  • Download 3oxz
  • View 3oxz
Molmil generated image of 3oxz
CRYSTAL STRUCTURE OF ABL KINASE DOMAIN BOUND WITH A DFG-OUT INHIBITOR AP24534
分子名称:Tyrosine-protein kinase ABL1, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide
著者Zhou, T., Huang, W.S., Wang, Y., Thomas, M., Keats, J., Xu, Q., Rivera, V., Shakespeare, W.C., Clackson, T., Dalgarno, D.C., Zhu, X.
登録日2010-09-22
公開日2010-12-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance.
Chem.Biol.Drug Des., 77, 2011
3OY3
  • Download 3oy3
  • View 3oy3
Molmil generated image of 3oy3
CRYSTAL STRUCTURE OF ABL T315I MUTANT KINASE DOMAIN BOUND WITH A DFG-OUT INHIBITOR AP24589
分子名称:Tyrosine-protein kinase ABL1, 5-[(5-{[4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-3-(trifluoromethyl)phenyl]carbamoyl}-2-methylphenyl)ethynyl]-1-methyl-1H-imidazole-2-carboxamide
著者Zhou, T., Commodore, L., Huang, W.S., Wang, Y., Thomas, M., Keats, J., Xu, Q., Rivera, V., Shakespeare, W.C., Clackson, T., Dalgarno, D.C., Zhu, X.
登録日2010-09-22
公開日2010-12-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance.
Chem.Biol.Drug Des., 77, 2011
4RX4
  • Download 4rx4
  • View 4rx4
Molmil generated image of 4rx4
CRYSTAL STRUCTURE OF VH1-46 GERMLINE-DERIVED CD4-BINDING SITE-DIRECTED ANTIBODY 8ANC134 IN COMPLEX WITH HIV-1 CLADE A Q842.D12 GP120
分子名称:HIV-1 Clade A Q842.d12 gp120, 8ANC134 Heavy chain, 8ANC134 Light Chain, ...
著者Zhou, T., Acharya, P., Moquin, S., Kwong, P.D.
登録日2014-12-08
公開日2015-07-01
最終更新日2015-07-08
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell(Cambridge,Mass.), 161, 2015
4YDI
  • Download 4ydi
  • View 4ydi
Molmil generated image of 4ydi
CRYSTAL STRUCTURE OF BROAD AND POTENTLY NEUTRALIZING VRC01-CLASS ANTIBODY Z258-VRC27.01, ISOLATED FROM HUMAN DONOR Z258, IN COMPLEX WITH HIV-1 GP120 FROM CLADE A STRAIN Q23.17
分子名称:Envelope glycoprotein gp160, HEAVY CHAIN OF ANTIBODY Z258-VRC27.01, LIGHT CHAIN OF ANTIBODY Z258-VRC27.01, ...
著者Zhou, T., Srivatsan, S., Kwong, P.D.
登録日2015-02-22
公開日2015-06-03
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (3.452 Å)
主引用文献Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell, 161, 2015
4YDJ
  • Download 4ydj
  • View 4ydj
Molmil generated image of 4ydj
CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY 44-VRC13.01 IN COMPLEX WITH HIV-1 CLADE AE STRAIN 93TH057 GP120
分子名称:Envelope glycoprotein gp160,Envelope glycoprotein gp160, HEAVY CHAIN OF ANTIBODY 44-VRC13.01, LIGHT CHAIN OF ANTIBODY 44-VRC13.01, ...
著者Zhou, T., Moquin, S., Kwong, P.D.
登録日2015-02-22
公開日2015-06-03
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (2.308 Å)
主引用文献Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell, 161, 2015
4YDK
  • Download 4ydk
  • View 4ydk
Molmil generated image of 4ydk
CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY C38-VRC16.01 IN COMPLEX WITH HIV-1 CLADE AE STRAIN 93TH057 GP120
分子名称:Envelope glycoprotein gp160,Envelope glycoprotein gp160, HEAVY CHAIN OF ANTIBODY C38-VRC16.01, LIGHT CHAIN OF ANTIBODY C38-VRC16.01, ...
著者Zhou, T., Moquin, S., Zheng, A., Kwong, P.D.
登録日2015-02-22
公開日2015-06-03
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (2.051 Å)
主引用文献Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell, 161, 2015
4YDL
  • Download 4ydl
  • View 4ydl
Molmil generated image of 4ydl
CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY C38-VRC18.02 IN COMPLEX WITH HIV-1 CLADE AE STRAIN 93TH057GP120
分子名称:Envelope glycoprotein gp160,Envelope glycoprotein gp160, HEAVY CHAIN OF ANTIBODY C38-VRC18.02, LIGHT CHAIN OF ANTIBODY C38-VRC18.02, ...
著者Zhou, T., Srivatsan, S., Kwong, P.D.
登録日2015-02-22
公開日2015-06-03
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell, 161, 2015
3KF4
  • Download 3kf4
  • View 3kf4
Molmil generated image of 3kf4
STRUCTURAL ANALYSIS OF DFG-IN AND DFG-OUT DUAL SRC-ABL INHIBITORS SHARING A COMMON VINYL PURINE TEMPLATE
分子名称:Tyrosine-protein kinase ABL1, N-[4-(dimethylphosphoryl)phenyl]-9-[(E)-2-(5-methyl-1H-indazol-4-yl)ethenyl]-9H-purin-6-amine
著者Zhou, T.
登録日2009-10-27
公開日2009-12-22
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template.
Chem.Biol.Drug Des., 75, 2010
3KFA
  • Download 3kfa
  • View 3kfa
Molmil generated image of 3kfa
STRUCTURAL ANALYSIS OF DFG-IN AND DFG-OUT DUAL SRC-ABL INHIBITORS SHARING A COMMON VINYL PURINE TEMPLATE
分子名称:Tyrosine-protein kinase ABL1, 3-{(E)-2-[6-(cyclopropylamino)-9H-purin-9-yl]ethenyl}-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide
著者Zhou, T.
登録日2009-10-27
公開日2009-12-22
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.22 Å)
主引用文献Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template.
Chem.Biol.Drug Des., 75, 2010
4LSP
  • Download 4lsp
  • View 4lsp
Molmil generated image of 4lsp
CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC-CH31 IN COMPLEX WITH HIV-1 CLADE A/E GP120 93TH057
分子名称:HIV-1 CLADE A/E STRAIN 93TH057 GP120, HEAVY CHAIN OF ANTIBODY VRC-CH31, LIGHT CHAIN OF ANTIBODY VRC-CH31, ...
著者Zhou, T., Moquin, S., Kwong, P.D.
登録日2013-07-23
公開日2013-09-04
最終更新日2014-05-07
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LSQ
  • Download 4lsq
  • View 4lsq
Molmil generated image of 4lsq
CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC-CH31 IN COMPLEX WITH HIV-1 CLADE A/E GP120 93TH057 WITH LOOP D AND LOOP V5 FROM CLADE A STRAIN 3415_V1_C1
分子名称:ENVELOPE GLYCOPROTEIN GP120 WITH LOOP D AND V5 FROM STRAIN 3415_V1_C1, HEAVY CHAIN OF ANTIBODY VRC-CH31, LIGHT CHAIN OF ANTIBODY VRC-CH31 WITH N70D MUTATION, ...
著者Zhou, T., Moquin, S., Kwong, P.D.
登録日2013-07-23
公開日2013-08-21
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LSR
  • Download 4lsr
  • View 4lsr
Molmil generated image of 4lsr
CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC-CH31 IN COMPLEX WITH HIV-1 CLADE A/E STRAN 93TH057 GP120 WITH LOOP D AND LOOP V5 FROM CLADE A STRAIN KER_2018_11
分子名称:ENVELOPE GLYCOPROTEIN GP120 WITH LOOP D AND V5 FROM STRAIN ker_2018_11, HEAVY CHAIN OF ANTIBODY VRC-CH31, LIGHT CHAIN OF ANTIBODY VRC-CH31 (N70D MUTATION), ...
著者Zhou, T., Moquin, S., Kwong, P.D.
登録日2013-07-23
公開日2013-08-21
最終更新日2014-05-07
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LSS
  • Download 4lss
  • View 4lss
Molmil generated image of 4lss
CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC01 IN COMPLEX WITH HIV-1 CLADE A STRAIN KER_2018_11 GP120
分子名称:envelope glycoprotein GP120, HEAVY CHAIN OF ANTIBODY VRC01, LIGHT CHAIN OF ANTIBODY VRC01 with N72T mutation, ...
著者Zhou, T., Moquin, S., Kwong, P.D.
登録日2013-07-23
公開日2013-08-21
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LST
  • Download 4lst
  • View 4lst
Molmil generated image of 4lst
CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC01 IN COMPLEX WITH HIV-1 CLADE C STRAIN ZM176.66 GP120
分子名称:ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C, HEAVY CHAIN OF ANTIBODY VRC01, LIGHT CHAIN OF ANTIBODY VRC01, ...
著者Zhou, T., Moquin, S., Kwong, P.D.
登録日2013-07-23
公開日2013-08-21
最終更新日2014-05-07
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LSU
  • Download 4lsu
  • View 4lsu
Molmil generated image of 4lsu
CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC-PG20 IN COMPLEX WITH HIV-1 CLADE A/E 93TH057 GP120
分子名称:HIV-1 CLADE A/E STRAIN 93TH057 GP120, HEAVY CHAIN OF ANTIBODY VRC-PG20, LIGHT CHAIN OF ANTIBODY VRC-PG20, ...
著者Zhou, T., Moquin, S., Kwong, P.D.
登録日2013-07-23
公開日2013-08-21
最終更新日2014-05-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LSV
  • Download 4lsv
  • View 4lsv
Molmil generated image of 4lsv
CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY 3BNC117 IN COMPLEX WITH HIV-1 CLADE C C1086 GP120
分子名称:envelope glycoprotein GP120, HEAVY CHAIN OF ANTIBODY 3BNC117, LIGHT CHAIN OF ANTIBODY 3BNC117, ...
著者Zhou, T., Moquin, S., Kwong, P.D.
登録日2013-07-23
公開日2013-08-21
最終更新日2014-05-07
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
1F48
  • Download 1f48
  • View 1f48
Molmil generated image of 1f48
CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE
分子名称:ARSENITE-TRANSLOCATING ATPASE, ANTIMONY (III) ION, MAGNESIUM ION, ...
著者Zhou, T., Radaev, S., Rosen, B.P., Gatti, D.L.
登録日2000-06-07
公開日2000-09-13
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pump.
EMBO J., 19, 2000
1FWK
  • Download 1fwk
  • View 1fwk
Molmil generated image of 1fwk
CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH ADP
分子名称:HOMOSERINE KINASE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Zhou, T., Daugherty, M., Grishin, N.V., Osterman, A.L., Zhang, H.
登録日2000-09-22
公開日2000-12-20
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily.
Structure Fold.Des., 8, 2000
1FWL
  • Download 1fwl
  • View 1fwl
Molmil generated image of 1fwl
CRYSTAL STRUCTURE OF HOMOSERINE KINASE
分子名称:HOMOSERINE KINASE
著者Zhou, T., Daugherty, M., Grishin, N.V., Osterman, A.L., Zhang, H.
登録日2000-09-22
公開日2000-12-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily.
Structure Fold.Des., 8, 2000
1IHU
  • Download 1ihu
  • View 1ihu
Molmil generated image of 1ihu
CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE IN COMPLEX WITH MG-ADP-ALF3
分子名称:ARSENICAL PUMP-DRIVING ATPASE, MAGNESIUM ION, CADMIUM ION, ...
著者Zhou, T., Radaev, S., Rosen, B.P., Gatti, D.L.
登録日2001-04-20
公開日2001-09-12
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Conformational changes in four regions of the Escherichia coli ArsA ATPase link ATP hydrolysis to ion translocation.
J.Biol.Chem., 276, 2001
1II0
  • Download 1ii0
  • View 1ii0
Molmil generated image of 1ii0
CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE
分子名称:ARSENICAL PUMP-DRIVING ATPASE, CADMIUM ION, CHLORIDE ION, ...
著者Zhou, T., Radaev, S., Rosen, B.P., Gatti, D.L.
登録日2001-04-20
公開日2001-09-12
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Conformational changes in four regions of the Escherichia coli ArsA ATPase link ATP hydrolysis to ion translocation.
J.Biol.Chem., 276, 2001
1II9
  • Download 1ii9
  • View 1ii9
Molmil generated image of 1ii9
CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE IN COMPLEX WITH AMP-PNP
分子名称:ARSENICAL PUMP-DRIVING ATPASE, MAGNESIUM ION, CADMIUM ION, ...
著者Zhou, T., Radaev, S., Gatti, D.L., Rosen, B.P.
登録日2001-04-21
公開日2001-09-12
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Conformational changes in four regions of the Escherichia coli ArsA ATPase link ATP hydrolysis to ion translocation.
J.Biol.Chem., 276, 2001
1KQN
  • Download 1kqn
  • View 1kqn
Molmil generated image of 1kqn
CRYSTAL STRUCTURE OF NMN/NAMN ADENYLYLTRANSFERASE COMPLEXED WITH NAD
分子名称:NICOTINAMIDE MONONUCLEOTIDE ADENYLYL TRANSFERASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, XENON
著者Zhou, T., Kurnasov, O., Tomchick, D.R., Binns, D.D., Grishin, N.V., Marquez, V.E., Osterman, A.L., Zhang, H.
登録日2002-01-07
公開日2003-01-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of Human Nicotinamide/Nicotonic Acid Mononucleotide Adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
J.Biol.Chem., 277, 2003
1KQO
  • Download 1kqo
  • View 1kqo
Molmil generated image of 1kqo
CRYSTAL STRUCTURE OF NMN/NAMN ADENYLYLTRANSFERASE COMPLEXED WITH DEAMIDO-NAD
分子名称:NICOTINAMIDE MONONUCLEOTIDE ADENYLYL TRANSFERASE, NICOTINIC ACID ADENINE DINUCLEOTIDE
著者Zhou, T., Kurnasov, O., Tomchick, D.R., Binns, D.D., Grishin, N.V., Marquez, V.E., Osterman, A.L., Zhang, H.
登録日2002-01-07
公開日2003-01-07
最終更新日2014-10-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of Hhuman of Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
J.Biol.Chem., 277, 2002
1KR2
  • Download 1kr2
  • View 1kr2
Molmil generated image of 1kr2
CRYSTAL STRUCTURE OF HUMAN NMN/NAMN ADENYLYL TRANSFERASE COMPLEXED WITH TIAZOFURIN ADENINE DINUCLEOTIDE (TAD)
分子名称:NICOTINAMIDE MONONUCLEOTIDE ADENYLYL TRANSFERASE, BETA-METHYLENE-THIAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE
著者Zhou, T., Kurnasov, O., Tomchick, D.R., Binns, D.D., Grishin, N.V., Marquez, V.E., Osterman, A.L., Zhang, H.
登録日2002-01-08
公開日2003-01-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of Hhuman of Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
J.Biol.Chem., 277, 2002