Author results

5T2P
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HEPATITIS B VIRUS CORE PROTEIN Y132A MUTANT IN COMPLEX WITH SULFAMOYLBENZAMIDE (SBA_R01)
分子名称:Core protein, 4-fluoranyl-3-(4-oxidanylpiperidin-1-yl)sulfonyl-~{N}-[3,4,5-tris(fluoranyl)phenyl]benzamide, ISOPROPYL ALCOHOL, ...
著者Zhou, Z., Xu, Z.H.
登録日2016-08-24
公開日2017-02-22
実験手法X-RAY DIFFRACTION (1.693 Å)
主引用文献Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms
Sci Rep, 7, 2017
5WRE
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HEPATITIS B VIRUS CORE PROTEIN Y132A MUTANT IN COMPLEX WITH HETEROARYLDIHYDROPYRIMIDINE (HAP_R01)
分子名称:Core protein, (2S)-1-[[(4R)-4-(2-chloranyl-4-fluoranyl-phenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-4,4-bis(fluoranyl)pyrrolidine-2-carboxylic acid, ISOPROPYL ALCOHOL, ...
著者Zhou, Z., Xu, Z.H.
登録日2016-12-01
公開日2017-02-22
実験手法X-RAY DIFFRACTION (1.946 Å)
主引用文献Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms
Sci Rep, 7, 2017
5WTW
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HEPATITIS B VIRUS CORE PROTEIN Y132A MUTANT IN P 41 21 2 SPACE GROUP
分子名称:Core protein, CHLORIDE ION
著者Zhou, Z., Xu, Z.H.
登録日2016-12-15
公開日2017-02-22
実験手法X-RAY DIFFRACTION (2.623 Å)
主引用文献Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms
Sci Rep, 7, 2017
2L5A
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STRUCTURAL BASIS FOR RECOGNITION OF CENTROMERE SPECIFIC HISTONE H3 VARIANT BY NONHISTONE SCM3
分子名称:Histone H3-like centromeric protein CSE4, Protein SCM3, Histone H4
著者Zhou, Z., Feng, H., Zhou, B., Ghirlando, R., Hu, K., Zwolak, A., Jenkins, L., Xiao, H., Tjandra, N., Wu, C., Bai, Y.
登録日2010-10-28
公開日2011-03-16
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3.
Nature, 472, 2011
6JPJ
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CRYSTAL STRUCTURE OF FGF401 IN COMPLEX OF FGFR4
分子名称:Fibroblast growth factor receptor 4, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide, SULFATE ION
著者Zhou, Z., Chen, X., Chen, Y.
登録日2019-03-27
公開日2019-05-15
最終更新日2019-06-05
実験手法X-RAY DIFFRACTION (2.638 Å)
主引用文献Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4.
Chem.Commun.(Camb.), 55, 2019
1SV2
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CRYSTAL STRUCTURE OF PEPTIDE DEFORMYLASE FROM LEPTOSPIRA INTERROGANS (LIPDF) AT PH7.5
分子名称:Peptide deformylase, ZINC ION, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ...
著者Zhou, Z., Song, X., Li, Y., Gong, W.
登録日2004-03-27
公開日2005-08-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Novel conformational states of peptide deformylase from pathogenic bacterium Leptospira interrogans: implications for population shift
J.Biol.Chem., 280, 2005
1SZZ
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CRYSTAL STRUCTURE OF PEPTIDE DEFORMYLASE FROM LEPTOSPIRA INTERROGANS COMPLEXED WITH INHIBITOR ACTINONIN
分子名称:Peptide deformylase, ZINC ION, ACTINONIN
著者Zhou, Z., Song, X., Li, Y., Gong, W.
登録日2004-04-06
公開日2005-08-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Novel conformational states of peptide deformylase from pathogenic bacterium Leptospira interrogans: implications for population shift
J.Biol.Chem., 280, 2005
1VEV
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CRYSTAL STRUCTURE OF PEPTIDE DEFORMYLASE FROM LEPTOSPIRA INTERROGANS (LIPDF) AT PH6.5
分子名称:Peptide deformylase, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
著者Zhou, Z., Song, X., Li, Y., Gong, W.
登録日2004-04-06
公開日2005-08-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Novel conformational states of peptide deformylase from pathogenic bacterium Leptospira interrogans: implications for population shift
J.Biol.Chem., 280, 2005
1VEY
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CRYSTAL STRUCTURE OF PEPTIDE DEFORMYLASE FROM LEPTOSPIRA INTERROGANS (LIPDF) AT PH7.0
分子名称:Peptide deformylase, ZINC ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
著者Zhou, Z., Song, X., Li, Y., Gong, W.
登録日2004-04-06
公開日2005-08-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Novel conformational states of peptide deformylase from pathogenic bacterium Leptospira interrogans: implications for population shift
J.Biol.Chem., 280, 2005
1VEZ
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CRYSTAL STRUCTURE OF PEPTIDE DEFORMYLASE FROM LEPTOSPIRA INTERROGANS(LIPDF) AT PH8.0
分子名称:Peptide deformylase, ZINC ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
著者Zhou, Z., Song, X., Li, Y., Gong, W.
登録日2004-04-06
公開日2005-08-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Novel conformational states of peptide deformylase from pathogenic bacterium Leptospira interrogans: implications for population shift
J.Biol.Chem., 280, 2005
1Y6H
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CRYSTAL STRUCTURE OF LIPDF
分子名称:Peptide deformylase, ZINC ION, FORMIC ACID, ...
著者Zhou, Z., Song, X., Li, Y., Gong, W.
登録日2004-12-06
公開日2004-12-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Unique structural characteristics of peptide deformylase from pathogenic bacterium Leptospira interrogans
J.Mol.Biol., 339, 2004
2JSS
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NMR STRUCTURE OF CHAPERONE CHZ1 COMPLEXED WITH HISTONE H2A.Z-H2B
分子名称:Chimera of Histone H2B.1 and Histone H2A.Z, Uncharacterized protein YER030W
著者Zhou, Z., Feng, H., Hansen, D.F., Kato, H., Luk, E., Freedberg, D.I., Kay, L.E., Wu, C., Bai, Y.
登録日2007-07-11
公開日2008-05-20
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B.
Nat.Struct.Mol.Biol., 15, 2008
2L5V
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SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OF HRPN13
分子名称:Proteasomal ubiquitin receptor ADRM1
著者Zhou, Z., Hu, H.
登録日2010-11-08
公開日2011-11-09
実験手法SOLUTION NMR
主引用文献Solution structure of the C-terminal domain of hRpn13
To be Published
2QJU
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CRYSTAL STRUCTURE OF AN NSS HOMOLOG WITH BOUND ANTIDEPRESSANT
分子名称:Transporter, B-OCTYLGLUCOSIDE, SODIUM ION, ...
著者Zhou, Z., Karpowich, N.K., Wang, D.N., New York Consortium on Membrane Protein Structure (NYCOMPS)
登録日2007-07-09
公開日2007-08-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.
Science, 317, 2007
2RPI
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THE NMR STRUCTURE OF THE SUBMILLISECOND FOLDING INTERMEDIATE OF THE THERMUS THERMOPHILUS RIBONUCLEASE H
分子名称:Ribonuclease H
著者Zhou, Z., Feng, H., Bai, Y.
登録日2008-05-16
公開日2009-03-31
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献The high-resolution NMR structure of the early folding intermediate of the Thermus thermophilus ribonuclease H
J.Mol.Biol., 384, 2008
3GWU
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LEUCINE TRANSPORTER LEUT IN COMPLEX WITH SERTRALINE
分子名称:Transporter, LEUCINE, SODIUM ION, ...
著者Zhou, Z., Zhen, J., Karpowich, N.K., Law, C.J., Reith, M.E.A., Wang, D.N.
登録日2009-04-01
公開日2009-05-12
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
3GWV
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LEUCINE TRANSPORTER LEUT IN COMPLEX WITH R-FLUOXETINE
分子名称:Transporter, LEUCINE, SODIUM ION, ...
著者Zhou, Z., Zhen, J., Karpowich, N.K., Law, C.J., Reith, M.E.A., Wang, D.N.
登録日2009-04-01
公開日2009-05-12
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
3GWW
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LEUCINE TRANSPORTER LEUT IN COMPLEX WITH S-FLUOXETINE
分子名称:Transporter, SODIUM ION, LEUCINE, ...
著者Zhou, Z., Zhen, J., Karpowich, N.K., Law, C.J., Reith, M.E.A., Wang, D.N.
登録日2009-04-01
公開日2009-05-12
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
5XS2
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CDK8-CYCC IN COMPLEX WITH COMPOUND 17:3-CHLORO-4-(4-PYRIDYL)-1H-PYRROLE-2-CARBOXAMIDE
分子名称:Cyclin-dependent kinase 8, Cyclin-C, GLYCEROL, ...
著者Zhou, Z., Xu, Z.
登録日2017-06-12
公開日2017-08-09
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Discovery of potent and selective CDK8 inhibitors through FBDD approach
Bioorg. Med. Chem. Lett., 27, 2017
5XQX
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HUMAN CDK8-CYCC IN COMPLEX WITH COMPOUND 4: N-METHYL-4-(4-PYRIDYL)-1H-PYRROLE-2-CARBOXAMIDE
分子名称:Cyclin-dependent kinase 8, Cyclin-C, GLYCEROL, ...
著者Zhou, Z., Xu, Z.H.
登録日2017-06-07
公開日2017-08-09
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of potent and selective CDK8 inhibitors through FBDD approach
Bioorg. Med. Chem. Lett., 27, 2017
4RE1
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CRYSTAL STRUCTURE OF HUMAN TEAD1 AND DISULFIDE-ENGINEERED YAP
分子名称:Transcriptional enhancer factor TEF-1, Yorkie homolog, CHLORIDE ION
著者Xu, Z., Zhou, Z.
登録日2014-09-21
公開日2014-11-19
最終更新日2015-09-02
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides.
Faseb J., 29, 2015
5GMZ
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HEPATITIS B VIRUS CORE PROTEIN Y132A MUTANT IN COMPLEX WITH 4-METHYL HETEROARYLDIHYDROPYRIMIDINE
分子名称:Core protein, ISOPROPYL ALCOHOL, (2S)-4,4-difluoro-1-[[(4S)-4-(4-fluorophenyl)-5-methoxycarbonyl-4-methyl-2-(1,3-thiazol-2-yl)-1H-pyrimidin-6-yl]methyl]pyrrolidine-2-carboxylic acid, ...
著者Xu, Z.H., Zhou, Z.
登録日2016-07-18
公開日2016-08-10
最終更新日2016-09-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors
J.Med.Chem., 59, 2016
1UJ1
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO)
分子名称:3C-like proteinase
著者Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z.
登録日2003-07-25
公開日2003-11-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
1UK2
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO) AT PH8.0
分子名称:3C-LIKE PROTEINASE
著者Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z.
登録日2003-08-14
公開日2003-11-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
1UK3
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO) AT PH7.6
分子名称:3C-like proteinase
著者Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z.
登録日2003-08-14
公開日2003-11-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003