1JM4
 
 | | NMR Structure of P/CAF Bromodomain in Complex with HIV-1 Tat Peptide | | Descriptor: | HIV-1 Tat Peptide, P300/CBP-associated Factor | | Authors: | Mujtaba, S, He, Y, Zeng, L, Farooq, A, Carlson, J.E, Ott, M, Verdin, E, Zhou, M.-M. | | Deposit date: | 2001-07-17 | | Release date: | 2002-07-17 | | Last modified: | 2023-11-15 | | Method: | SOLUTION NMR | | Cite: | Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain
Mol.Cell, 9, 2002
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1R4K
 | | Solution Structure of the Drosophila Argonaute 1 PAZ Domain | | Descriptor: | Argonaute 1 | | Authors: | Yan, K.S, Yan, S, Farooq, A, Han, A, Zeng, L, Zhou, M.-M. | | Deposit date: | 2003-10-07 | | Release date: | 2003-12-09 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Structure and conserved RNA binding of the PAZ domain
Nature, 426, 2003
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1BVH
 | | SOLUTION STRUCTURE OF A LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE | | Descriptor: | ACID PHOSPHATASE | | Authors: | Logan, T.M, Zhou, M.-M, Nettesheim, D.G, Meadows, R.P, Van Etten, R.L, Fesik, S.W. | | Deposit date: | 1994-05-03 | | Release date: | 1994-07-31 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | Solution structure of a low molecular weight protein tyrosine phosphatase.
Biochemistry, 33, 1994
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1XR0
 | | Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors | | Descriptor: | Basic fibroblast growth factor receptor 1, FGFR signalling adaptor SNT-1 | | Authors: | Dhalluin, C, Yan, K.S, Plotnikova, O, Lee, K.W, Zeng, L, Kuti, M, Mujtaba, S, Goldfarb, M.P, Zhou, M.-M. | | Deposit date: | 2004-10-13 | | Release date: | 2004-11-02 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors
Mol.Cell, 6, 2000
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2AQE
 | | Structural and functional analysis of ada2 alpha swirm domain | | Descriptor: | Transcriptional adaptor 2, Ada2 alpha | | Authors: | Qian, C, Zhang, Q, Zeng, L, Zhou, M.-M. | | Deposit date: | 2005-08-17 | | Release date: | 2005-12-13 | | Last modified: | 2022-03-09 | | Method: | SOLUTION NMR | | Cite: | Structure and chromosomal DNA binding of the SWIRM domain
Nat.Struct.Mol.Biol., 12, 2005
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1M3G
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1N3H
 | | Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc | | Descriptor: | SHC Transforming protein | | Authors: | Farooq, A, Zeng, L, Yan, K.S, Ravichandran, K.S, Zhou, M.-M. | | Deposit date: | 2002-10-28 | | Release date: | 2003-10-28 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc
Structure, 11, 2003
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1N3J
 | | Structure and Substrate of a Histone H3 Lysine Methyltransferase from Paramecium Bursaria Chlorella Virus 1 | | Descriptor: | Histone H3 Lysine Methyltransferase | | Authors: | Manzur, K.L, Farooq, A, Zeng, L, Plotnikova, O, Sachchidanand, Koch, A.W, Zhou, M.-M. | | Deposit date: | 2002-10-28 | | Release date: | 2003-01-28 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3.
Nat.Struct.Biol., 10, 2003
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1N72
 | | Structure and Ligand of a Histone Acetyltransferase Bromodomain | | Descriptor: | HISTONE ACETYLTRANSFERASE | | Authors: | Dhalluin, C, Carlson, J.E, Zeng, L, He, C, Aggarwal, A.K, Zhou, M.-M. | | Deposit date: | 2002-11-12 | | Release date: | 2002-12-11 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Structure and Ligand of a Histone Acetyltransferase Bromodomain
Nature, 399, 1999
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1OP4
 | | Solution Structure of Neural Cadherin Prodomain | | Descriptor: | Neural-cadherin | | Authors: | Koch, A.W, Farooq, A, Shan, W, Zeng, L, Colman, D.R, Zhou, M.-M. | | Deposit date: | 2003-03-04 | | Release date: | 2004-03-16 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Structure of the Neural (N-) Cadherin Prodomain Reveals a Cadherin Extracellular Domain-like Fold without Adhesive Characteristics
Structure, 12, 2004
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7XFG
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7XEZ
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1OY2
 | | Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc | | Descriptor: | SHC transforming protein | | Authors: | Farooq, A, Zeng, L, Yan, K.S, Ravichandran, K.S, Zhou, M.-M. | | Deposit date: | 2003-04-03 | | Release date: | 2004-04-06 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc
Structure, 11, 2003
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4NUC
 | | Crystal structure of the first bromodomain of human BRD4 in complex with MS435 inhibitor | | Descriptor: | 1,2-ETHANEDIOL, 4-[(E)-(4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, Bromodomain-containing protein 4 | | Authors: | Plotnikov, A.N, Joshua, J, Zhou, M.-M. | | Deposit date: | 2013-12-03 | | Release date: | 2014-04-02 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
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4NUE
 | | Crystal structure of the first bromodomain of human BRD4 in complex with MS267 inhibitor | | Descriptor: | 1,2-ETHANEDIOL, 4-[(E)-(2-amino-4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, Bromodomain-containing protein 4 | | Authors: | Plotnikov, A.N, Joshua, J, Zhou, M.-M. | | Deposit date: | 2013-12-03 | | Release date: | 2014-04-02 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
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4NUD
 | | Crystal structure of the first bromodomain of human BRD4 in complex with MS436 inhibitor | | Descriptor: | 1,2-ETHANEDIOL, 4-[(E)-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, Bromodomain-containing protein 4 | | Authors: | Plotnikov, A.N, Joshua, J, Zhou, M.-M. | | Deposit date: | 2013-12-03 | | Release date: | 2014-04-02 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
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1SHC
 | | SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE | | Descriptor: | SHC, TRKA RECEPTOR PHOSPHOPEPTIDE | | Authors: | Zhou, M.-M, Ravichandran, K.S, Olejniczak, E.T, Petros, A.M, Meadows, R.P, Sattler, M, Harlan, J.E, Wade, W.S, Burakoff, S.J, Fesik, S.W. | | Deposit date: | 1996-03-27 | | Release date: | 1997-05-15 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
Nature, 378, 1995
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1IRS
 | | IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE | | Descriptor: | IL-4 RECEPTOR PHOSPHOPEPTIDE, IRS-1 | | Authors: | Zhou, M.-M, Huang, B, Olejniczak, E.T, Meadows, R.P, Shuker, S.B, Miyazaki, M, Trub, T, Shoelson, S.E, Feisk, S.W. | | Deposit date: | 1996-03-22 | | Release date: | 1997-05-15 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.
Nat.Struct.Biol., 3, 1996
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1TCE
 | | SOLUTION NMR STRUCTURE OF THE SHC SH2 DOMAIN COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDE FROM THE T-CELL RECEPTOR, MINIMIZED AVERAGE STRUCTURE | | Descriptor: | PHOSPHOPEPTIDE OF THE ZETA CHAIN OF T CELL RECEPTOR, SHC | | Authors: | Zhou, M.-M, Meadows, R.P, Logan, T.M, Yoon, H.S, Wade, W.R, Ravichandran, K.S, Burakoff, S.J, Feisk, S.W. | | Deposit date: | 1996-03-27 | | Release date: | 1997-05-15 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.
Proc.Natl.Acad.Sci.USA, 92, 1995
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8I60
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2LSP
 | | solution structures of BRD4 second bromodomain with NF-kB-K310ac peptide | | Descriptor: | Bromodomain-containing protein 4, NF-kB-K310ac peptide | | Authors: | Zhang, G, Liu, R, Zhong, Y, Plotnikov, A.N, Zhang, W, Rusinova, E, Gerona-Nevarro, G, Moshkina, N, Joshua, J, Chuang, P.Y, Ohlmeyer, M, He, J, Zhou, M.-M. | | Deposit date: | 2012-05-03 | | Release date: | 2012-07-18 | | Last modified: | 2023-11-15 | | Method: | SOLUTION NMR | | Cite: | Down-regulation of NF-kappa B transcriptional activity in HIV-associated kidney disease by BRD4 inhibition.
J.Biol.Chem., 287, 2012
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4F3I
 | | Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor | | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate | | Authors: | Joshua, J, Zhou, M.-M, Plotnikov, A.N. | | Deposit date: | 2012-05-09 | | Release date: | 2012-09-12 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Down-regulation of NF-{kappa}B Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition.
J.Biol.Chem., 287, 2012
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1HZM
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1JSP
 | | NMR Structure of CBP Bromodomain in complex with p53 peptide | | Descriptor: | CREB-BINDING PROTEIN, tumor protein p53 | | Authors: | He, Y, Mujtaba, S, Zeng, L, Yan, S, Zhou, M.-M. | | Deposit date: | 2001-08-17 | | Release date: | 2002-08-17 | | Last modified: | 2023-11-15 | | Method: | SOLUTION NMR | | Cite: | Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
Mol.Cell, 13, 2004
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4QB3
 | | Crystal structure of the first bromodomain of human BRD4 in complex with Olinone | | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-[4-(1-oxo-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)butyl]acetamide | | Authors: | Plotnikov, A.N, Joshua, J, Zhou, M.-M. | | Deposit date: | 2014-05-06 | | Release date: | 2015-04-22 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (0.94 Å) | | Cite: | Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression.
Chem.Biol., 21, 2014
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