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6AKK
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CRYSTAL STRUCTURE OF THE SECOND COILED-COIL DOMAIN OF SIKE1
Descriptor:Suppressor of IKBKE 1, GLYCEROL
Authors:Zhou, L., Chen, M., Zhou, Z.C.
Deposit date:2018-09-02
Release date:2019-01-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.
Cell Discov, 5, 2019
6AKL
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CRYSTAL STRUCTURE OF STRIATIN3 IN COMPLEX WITH SIKE1 COILED-COIL DOMAIN
Descriptor:Suppressor of IKBKE 1, Striatin-3
Authors:Zhou, L., Chen, M., Zhou, Z.C.
Deposit date:2018-09-02
Release date:2019-01-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.
Cell Discov, 5, 2019
6AKM
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CRYSTAL STRUCTURE OF SLMAP-SIKE1 COMPLEX
Descriptor:Suppressor of IKBKE 1, Sarcolemmal membrane-associated protein, GLYCEROL
Authors:Ma, J., Chen, M., Zhou, Z.C.
Deposit date:2018-09-02
Release date:2019-01-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.
Cell Discov, 5, 2019
6BMD
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RNA HAIRPIN CONTAINING GPPPG-OLIGO TO MIMIC INTERMEDIATE FORMED BY ACTIVATED MONOMER AND ACTIVATED DOWNSTREAM HELPER
Descriptor:RNA (5'-R(P*GP*AP*GP*GP*UP*GP*(LCC)P*(LCC)P*GP*AP*GP*CP*GP*CP*GP*AP*AP*AP*GP*CP*GP*CP*UP*C)-3'), RNA (5'-D(*(GP3))-R(P*CP*AP*CP*CP*UP*CP*A)-3')
Authors:Zhang, W., Szostak, J.W.
Deposit date:2017-11-14
Release date:2018-02-21
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide.
J. Am. Chem. Soc., 140, 2018
5YP5
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CRYSTAL STRUCTURE OF RORGAMMA COMPLEXED WITH SRC2 AND COMPOUND 5D
Descriptor:Nuclear receptor ROR-gamma, SRC2-2 peptide, 2-[4-(ethylsulfonyl)phenyl]-N-{5-[2-(2-methylpropyl)benzoyl]-4-phenyl-1,3-thiazol-2-yl}acetamide
Authors:Gao, M., Cai, W., Chunwa, C.
Deposit date:2017-11-01
Release date:2018-04-04
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:From ROR gamma t Agonist to Two Types of ROR gamma t Inverse Agonists
ACS Med Chem Lett, 9, 2018
5YP6
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RORGAMMA (263-509) COMPLEXED WITH SRC2 AND COMPOUND 6
Descriptor:Nuclear receptor ROR-gamma, SRC2, N-[3'-cyano-4'-(2-methylpropyl)-2-(trifluoromethyl)biphenyl-4-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide
Authors:Gao, M., Cai, W.
Deposit date:2017-11-01
Release date:2018-02-07
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:From ROR gamma t Agonist to Two Types of ROR gamma t Inverse Agonists
ACS Med Chem Lett, 9, 2018
5YF4
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A KINASE COMPLEX MST4-MOB4
Descriptor:MOB-like protein phocein, Peptide from Serine/threonine-protein kinase 26, ZINC ION
Authors:Chen, M., Zhou, Z.C.
Deposit date:2017-09-20
Release date:2018-08-15
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (1.897 Å)
Cite:The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer.
J. Biol. Chem., 293, 2018
6AZ4
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RNA HAIRPIN COMPLEX WITH GUANOSINE DINUCLEOTIDE LIGAND G(5')PPP(5')G
Descriptor:RNA (32-MER), RNA (5'-R(*CP*AP*GP*CP*AP*GP*CP*AP*G)-3'), DIGUANOSINE-5'-TRIPHOSPHATE
Authors:Zhang, W., Szostak, J.W.
Deposit date:2017-09-09
Release date:2018-02-21
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide.
J. Am. Chem. Soc., 140, 2018
6ASY
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BIP-ATP2
Descriptor:78 kDa glucose-regulated protein, GLYCEROL, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Liu, Q., Yang, J., Zong, Y., Columbus, L., Zhou, L.
Deposit date:2017-08-26
Release date:2017-12-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s.
Nat Commun, 8, 2017
5Y61
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YFIB-YFIR COMPLEXED WITH GMP
Descriptor:YfiR, YfiB, GUANOSINE-5'-MONOPHOSPHATE
Authors:Zhou, L., Xu, M., Jiang, T.
Deposit date:2017-08-10
Release date:2017-09-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structural insights into the functional role of GMP in modulating the YfiBNR system
Biochem. Biophys. Res. Commun., 493, 2017
5Y62
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YFIR COMPLEXED WITH GMP
Descriptor:YfiR, GUANOSINE-5'-MONOPHOSPHATE
Authors:Zhou, L., Xu, M., Jiang, T.
Deposit date:2017-08-10
Release date:2017-09-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into the functional role of GMP in modulating the YfiBNR system
Biochem. Biophys. Res. Commun., 493, 2017
5Y64
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PHOSPHOGLYCERATE MUTASE 1 H11 PHOSPHORYLATED FORM COMPLEXED WITH KH1
Descriptor:Phosphoglycerate mutase 1, CHLORIDE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Zhou, L., Jiang, L.L.
Deposit date:2017-08-10
Release date:2018-12-05
Method:X-RAY DIFFRACTION (2.149 Å)
Cite:Phosphoglycerate mutase 1 H11 phosphorylated form complexed with KH1
To Be Published
5Y65
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PHOSPHOGLYCERATE MUTASE 1 COMPLEXED WITH A SMALL MOLECULE INHIBITOR KH2
Descriptor:Phosphoglycerate mutase 1, CHLORIDE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Jiang, L.L., Zhou, L.
Deposit date:2017-08-10
Release date:2018-12-05
Method:X-RAY DIFFRACTION (2.554 Å)
Cite:Phosphoglycerate mutase 1 complexed with a small molecule inhibitor KH2
To Be Published
5Y2U
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X-RAY STRUCTURE OF PHOSPHOGLYCERATE MUTASE 1(PGAM1) COMPLEXED WITH A SMALL MOLECULE
Descriptor:Phosphoglycerate mutase 1, CHLORIDE ION, ALIZARIN RED, ...
Authors:Jiang, L.L., Zhou, L.
Deposit date:2017-07-27
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:X-ray structure of Phosphoglycerate Mutase 1(PGAM1) complexed with a small molecule
To Be Published
5Y35
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PHOSPHOGLYCERATE MUTASE 1 COMPLEXED WITH A SMALL MOLECULE INHIBITOR KH1
Descriptor:Phosphoglycerate mutase 1, CHLORIDE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Jiang, L.L., Zhou, L.
Deposit date:2017-07-27
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:Phosphoglycerate mutase 1 complexed with a small molecule inhibitor KH1
To Be Published
5Y2I
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PHOSPHOGLYCERATE MUTASE 1 (PGAM1) COMPLEXED WITH ITS INHIBITOR PGMI-004A
Descriptor:Phosphoglycerate mutase 1, 3,4-bis(oxidanyl)-9,10-bis(oxidanylidene)-~{N}-[4-(trifluoromethyl)phenyl]anthracene-2-sulfonamide, CHLORIDE ION, ...
Authors:Jiang, L., Zhou, L.
Deposit date:2017-07-26
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.917 Å)
Cite:Phosphoglycerate mutase 1 (PGAM1) complexed with its inhibitor PGMI-004A
To Be Published
5Y2Q
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X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) COMPLEXED WITH A SMALL MOLECULE
Descriptor:Acetylcholine-binding protein, 3-[[4-[(3,4-dichlorophenyl)methyl]piperidin-4-yl]methoxy]pyridine
Authors:Jiang, L.L., Zhou, L.
Deposit date:2017-07-26
Release date:2018-08-08
Method:X-RAY DIFFRACTION (2.363 Å)
Cite:X-ray structure of acetylcholine binding protein (AChBP) complexed with a small molecule
To Be Published
5WBS
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CRYSTAL STRUCTURE OF FRIZZLED-7 CRD WITH AN INHIBITOR PEPTIDE FZ7-21
Descriptor:Frizzled-7,inhibitor peptide Fz7-21
Authors:Nile, A.H., Mukund, S., Hannoush, R.N., Wang, W.
Deposit date:2017-06-29
Release date:2018-04-18
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Nat. Chem. Biol., 14, 2018
5W96
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SOLUTION STRUCTURE OF PHAGE DERIVED PEPTIDE INHIBITOR OF FRIZZLED 7 RECEPTOR
Descriptor:Fz7 binding peptide
Authors:Nile, A.H., de Sousa e Melo, F., Mukund, S., Piskol, R., Hansen, S., Zhou, L., Zhang, Y., Fu, Y., Gogol, E.B., Komuves, L.G., Modrusan, Z., Angers, S., Franke, Y., Koth, C., Fairbrother, W.J., Wang, W., de Sauvage, F.J., Hannoush, R.N.
Deposit date:2017-06-22
Release date:2018-04-18
Last modified:2018-05-30
Method:SOLUTION NMR
Cite:A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Nat. Chem. Biol., 14, 2018
5VGW
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RNA HAIRPIN STRUCTURE CONTAINING TETRALOOP/RECEPTOR MOTIF
Descriptor:RNA (5'-R(*CP*UP*GP*CP*UP*GP*GP*CP*UP*AP*AP*GP*GP*CP*CP*CP*GP*AP*AP*AP*GP*G)-3'), RNA (5'-R(P*GP*CP*UP*AP*UP*GP*CP*CP*UP*GP*CP*UP*G)-3')
Authors:Zhang, W., Szostak, J.W.
Deposit date:2017-04-11
Release date:2018-02-21
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide.
J. Am. Chem. Soc., 140, 2018
5VCF
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RNA HAIRPIN STRUCTURE CONTAINING TETRALOOP/RECEPTOR MOTIF, COMPLEXED WITH 2-MEIMPG ANALOGUE
Descriptor:RNA (5'-R(*CP*UP*GP*CP*UP*GP*GP*CP*UP*AP*AP*GP*GP*CP*CP*CP*GP*AP*AP*AP*GP*G)-3'), RNA (5'-R(*CP*UP*AP*UP*GP*CP*CP*UP*GP*CP*UP*G)-3'), 5'-O-[(S)-hydroxy(4-methyl-1H-imidazol-5-yl)phosphoryl]guanosine
Authors:Zhang, W., Szostak, J.W.
Deposit date:2017-03-31
Release date:2018-02-21
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide.
J. Am. Chem. Soc., 140, 2018
5VCI
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RNA HAIRPIN STRUCTURE CONTAINING TETRALOOP/RECEPTOR MOTIF, COMPLEXED WITH 2-MEIMPG ANALOGUE
Descriptor:RNA (5'-R(*CP*UP*GP*CP*UP*GP*GP*CP*UP*AP*AP*GP*GP*CP*CP*CP*GP*AP*AP*AP*GP*G)-3'), RNA (5'-R(P*CP*UP*AP*UP*GP*CP*CP*UP*GP*CP*UP*G)-3'), 5'-O-[(S)-hydroxy(4-methyl-1H-imidazol-5-yl)phosphoryl]guanosine
Authors:Szostak, J.W., Zhang, W.
Deposit date:2017-03-31
Release date:2018-02-21
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide.
J. Am. Chem. Soc., 140, 2018
5V9Z
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RNA HAIRPIN STRUCTURE CONTAINING 2-MEIMPG ANALOGUE BOUND
Descriptor:RNA (25-MER), RNA (5'-R(P*GP*CP*AP*CP*CP*UP*CP*A)-3'), 5'-O-[(S)-hydroxy(4-methyl-1H-imidazol-5-yl)phosphoryl]guanosine
Authors:Zhang, W., Szostak, J.W.
Deposit date:2017-03-24
Release date:2018-02-21
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide.
J. Am. Chem. Soc., 140, 2018
5V0H
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RNA DUPLEX WITH 2-MEIMPG ANALOGUE BOUND-ONE BINDING SITE
Descriptor:RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3'), 5'-O-[(S)-hydroxy(4-methyl-1H-imidazol-5-yl)phosphoryl]guanosine, MAGNESIUM ION
Authors:Zhang, W., Tam, C.P., Szostak, J.W.
Deposit date:2017-02-28
Release date:2017-03-08
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide.
J. Am. Chem. Soc., 140, 2018
5V0J
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RNA DUPLEX WITH 2-MEIMPG ANALOGUE BOUND-2 BINDING SITES
Descriptor:RNA (5'-R(*(LCC)P*(LCC)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3'), 5'-O-[(S)-hydroxy(4-methyl-1H-imidazol-5-yl)phosphoryl]guanosine, MAGNESIUM ION
Authors:Zhang, W., Tam, C.P., Szostak, J.W.
Deposit date:2017-02-28
Release date:2017-03-08
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide.
J. Am. Chem. Soc., 140, 2018