Author results

3H3B
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CRYSTAL STRUCTURE OF THE SINGLE-CHAIN FV (SCFV) FRAGMENT OF AN ANTI-ERBB2 ANTIBODY CHA21 IN COMPLEX WITH RESIDUES 1-192 OF ERBB2 EXTRACELLULAR DOMAIN
分子名称:Receptor tyrosine-protein kinase erbB-2, anti-ErbB2 antibody chA21
著者Zhou, H., Liu, Y., Niu, L., Zhu, J., Teng, M.
登録日2009-04-16
公開日2010-04-28
最終更新日2011-09-28
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structural Insights into the Down-regulation of Overexpressed p185her2/neu Protein of Transformed Cells by the Antibody chA21.
J.Biol.Chem., 286, 2011
2HGF
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HAIRPIN LOOP CONTAINING DOMAIN OF HEPATOCYTE GROWTH FACTOR, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称:HEPATOCYTE GROWTH FACTOR
著者Zhou, H., Mazzulla, M.J., Kaufman, J.D., Stahl, S.J., Wingfield, P.T., Rubin, J.S., Bottaro, D.P., Byrd, R.A.
登録日1997-12-18
公開日1998-06-24
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site.
Structure, 6, 1998
1T2M
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SOLUTION STRUCTURE OF THE PDZ DOMAIN OF AF-6
分子名称:AF-6 protein
著者Zhou, H., Wu, J.H., Xu, Y.Q., Huang, A.D., Shi, Y.Y.
登録日2004-04-22
公開日2005-02-08
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution Structure of AF-6 PDZ Domain and Its Interaction with the C-terminal Peptides from Neurexin and Bcr
J.Biol.Chem., 280, 2005
3PSM
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.98A CRYSTAL STRUCTURE OF A DIMERIC PLANT DEFENSIN SPE10
分子名称:Defensin
著者Zhou, H., Song, X., Gong, W.
登録日2010-12-01
公開日2010-12-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (0.98 Å)
主引用文献0.98A crystal structure of a dimeric plant defensin SPE10
To be Published
3Q18
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HUMAN GLUTATHIONE TRANSFERASE O2
分子名称:Glutathione S-transferase omega-2, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Zhou, H., Board, P.G., Oakley, A.J.
登録日2010-12-16
公開日2012-01-25
最終更新日2013-09-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases.
J.Mol.Biol., 420, 2012
3Q19
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HUMAN GLUTATHIONE TRANSFERASE O2
分子名称:Glutathione S-transferase omega-2, GLUTATHIONE, CHLORIDE ION
著者Zhou, H., Board, P.G., Oakley, A.J.
登録日2010-12-16
公開日2012-01-25
最終更新日2013-09-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases.
J.Mol.Biol., 420, 2012
3QAG
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HUMAN GLUTATHIONE TRANSFERASE O2 WITH GLUTATHIONE -NEW CRYSTAL FORM
分子名称:Glutathione S-transferase omega-2, GLUTATHIONE, DI(HYDROXYETHYL)ETHER, ...
著者Zhou, H., Board, P.G., Oakley, A.J.
登録日2011-01-11
公開日2012-01-11
最終更新日2013-06-26
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases.
J.Mol.Biol., 420, 2012
4E5Y
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STRUCTURE OF HUMAN FX PROTEIN, THE KEY ENZYME IN THE BIOSYNTHESIS OF GDP-L-FUCOSE
分子名称:GDP-L-fucose synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Zhou, H., He, J.H.
登録日2012-03-15
公開日2013-04-17
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Structure of human FX protein, the key enzyme in the biosynthesis of GDP-L-fucose
To be Published
4HVC
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CRYSTAL STRUCTURE OF HUMAN PROLYL-TRNA SYNTHETASE IN COMPLEX WITH HALOFUGINONE AND ATP ANALOGUE
分子名称:Bifunctional glutamate/proline--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ...
著者Zhou, H., Sun, L., Yang, X.L., Schimmel, P.
登録日2012-11-06
公開日2013-01-02
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
Nature, 494, 2012
4XEM
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CRYSTAL STRUCTURE OF WILD TYPE HUMAN ALARS CATALYTIC DOMAIN
分子名称:Alanine--tRNA ligase, cytoplasmic, '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, ...
著者Zhou, H., He, W., Yang, X.L.
登録日2014-12-24
公開日2016-02-17
実験手法X-RAY DIFFRACTION (1.278 Å)
主引用文献Crystal structure of wild type human AlaRS catalytic domain
To Be Published
6A68
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THE CRYSTAL STRUCTURE OF RAT CALCIUM-DEPENDENT ACTIVATOR PROTEIN FOR SECRETION (CAPS) DAMH DOMAIN
分子名称:Calcium-dependent secretion activator 1, POTASSIUM ION
著者Zhou, H., Wei, Z.Q., Yao, D.Q., Zhang, R.G., Ma, C.
登録日2018-06-26
公開日2019-03-13
最終更新日2019-03-27
実験手法X-RAY DIFFRACTION (2.901 Å)
主引用文献Structural and Functional Analysis of the CAPS SNARE-Binding Domain Required for SNARE Complex Formation and Exocytosis
Cell Rep, 26, 2019
5WXB
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CRYSTAL STRUCTURE OF ZIKV MTASE IN COMPLEX WITH SAH
分子名称:MRNA cap 0-1 NS5-type MT, S-ADENOSYL-L-HOMOCYSTEINE
著者Yang, H., Wang, L., Zhou, H.
登録日2017-01-07
公開日2017-05-17
実験手法X-RAY DIFFRACTION (1.762 Å)
主引用文献The conformational changes of Zika virus methyltransferase upon converting SAM to SAH
Oncotarget, 8, 2017
5HXW
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L-AMINO ACID DEAMINASE FROM PROTEUS VULGARIS
分子名称:L-amino acid deaminase, FLAVIN-ADENINE DINUCLEOTIDE, CETYL-TRIMETHYL-AMMONIUM
著者Zhou, H., Ju, Y., Niu, L., Teng, M.
登録日2016-01-31
公開日2016-08-03
最終更新日2016-08-24
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Crystal structure of a membrane-bound l-amino acid deaminase from Proteus vulgaris
J.Struct.Biol., 195, 2016
5I39
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HIGH RESOLUTION STRUCTURE OF L-AMINO ACID DEAMINASE FROM PROTEUS VULGARIS WITH THE DELETION OF THE SPECIFIC INSERTION SEQUENCE
分子名称:L-amino acid deaminase, FLAVIN-ADENINE DINUCLEOTIDE, 1,2-ETHANEDIOL
著者Zhou, H., Ju, Y., Niu, L., Teng, M.
登録日2016-02-10
公開日2016-08-03
最終更新日2016-08-24
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal structure of a membrane-bound l-amino acid deaminase from Proteus vulgaris
J.Struct.Biol., 195, 2016
5V58
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CRYSTAL STRUCTURE OF HUMAN PROLYL-TRNA SYNTHETASE IN COMPLEX WITH AZE-SA
分子名称:Bifunctional glutamate/proline--tRNA ligase, 5'-O-{[(2S)-azetidine-2-carbonyl]sulfamoyl}adenosine, ZINC ION
著者Zhou, H., Song, Y., Schimmel, P.
登録日2017-03-13
公開日2018-01-10
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.
Nat Commun, 8, 2017
5V59
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CRYSTAL STRUCTURE OF CATALYTIC FRAGMENT OF HUMAN ALARS IN COMPLEX WITH AZE-SA
分子名称:Alanine--tRNA ligase, cytoplasmic, 5'-O-{[(2S)-azetidine-2-carbonyl]sulfamoyl}adenosine
著者Zhou, H., Song, Y., Schimmel, P.
登録日2017-03-13
公開日2018-01-10
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.
Nat Commun, 8, 2017
6IPX
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CRYSTAL STRUCTURE OF THE APO FORM TRANSCRIPTION FACTOR
分子名称:AimR transcriptional regulator
著者Oy, S.Y., Zhen, X., Zhou, H., Ding, W.
登録日2018-11-05
公開日2019-01-23
最終更新日2019-02-06
実験手法X-RAY DIFFRACTION (2.634 Å)
主引用文献Structural basis of AimP signaling molecule recognition by AimR in Spbeta group of bacteriophages.
Protein Cell, 10, 2019
6IDE
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CRYSTAL STRUCTURE OF THE VIBRIO CHOLERA VQMA-LIGAND-DNA COMPLEX PROVIDES MOLECULAR MECHANISMS FOR DRUG DESIGN
分子名称:Transcriptional regulator LuxR family, DNA (5'-D(*AP*GP*GP*GP*GP*GP*GP*AP*AP*AP*TP*CP*CP*CP*CP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*GP*GP*GP*GP*AP*TP*TP*TP*CP*CP*CP*CP*CP*CP*T)-3'), ...
著者Wu, H., Li, M.J., Guo, H.J., Zhou, H., Li, B., Xu, Q., Xu, C.Y., Yu, F., He, J.H.
登録日2018-09-09
公開日2019-01-16
最終更新日2019-03-06
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Crystal structure of theVibrio choleraeVqmA-ligand-DNA complex provides insight into ligand-binding mechanisms relevant for drug design.
J. Biol. Chem., 294, 2019
3CYV
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CRYSTAL STRUCTURE OF UROPORPHYRINOGEN DECARBOXYLASE FROM SHIGELLA FLEXINERI: NEW INSIGHTS INTO ITS CATALYTIC MECHANISM
分子名称:Uroporphyrinogen decarboxylase
著者Liu, H., Zhou, H., Bi, R.
登録日2008-04-26
公開日2009-04-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of uroporphyrinogen III decarboxylase from Shigella flexineri: new insights into its catalytic mechanism
To be Published
5X8Y
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A MUTATION IDENTIFIED IN NEONATAL MICROCEPHALY DESTABILIZES ZIKA VIRUS NS1 ASSEMBLY IN VITRO
分子名称:ZIKV NS1
著者Wang, D., Chen, C., Liu, S., Zhou, H., Yang, K., Zhao, Q., Ji, X., Chen, C., Xie, W., Wang, Z., Mi, L.Z., Yang, H.
登録日2017-03-03
公開日2017-05-17
実験手法X-RAY DIFFRACTION (2.817 Å)
主引用文献A Mutation Identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in Vitro
Sci Rep, 7, 2017
6A9W
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STRUCTURE OF THE BIFUNCTIONAL DNA PRIMASE-POLYMERASE FROM PHAGE NRS-1
分子名称:Primase
著者Guo, H.J., Li, M.J., Wang, T.L., Wu, H., Zhou, H., Xu, C.Y., Liu, X.P., Yu, F., He, J.H.
登録日2018-07-16
公開日2019-03-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure and biochemical studies of the bifunctional DNA primase-polymerase from phage NrS-1.
Biochem. Biophys. Res. Commun., 510, 2019
6DXK
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GLUCOCORTICOID RECEPTOR IN COMPLEX WITH COMPOUND 11
分子名称:Glucocorticoid receptor, (8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-(3,3-dimethylbut-1-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name)
著者Rew, Y., Du, X., Eksterowicz, J., Zhou, H., Jahchan, N., Zhu, L., Yan, X., Kawai, H., McGee, L.R., Medina, J.C., Huang, T., Chen, C., Zavorotinskaya, T., Sutimantanapi, D., Waszczuk, J., Jackson, E., Huang, E., Ye, Q., Fantin, V.R., Daqing, S.
登録日2018-06-29
公開日2018-10-03
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101).
J. Med. Chem., 61, 2018
5GM1
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CRYSTAL STRUCTURE OF METHYLTRANSFERASE TLED COMPLEXED WITH SAH
分子名称:O-methylransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者Yu, F., Li, M.J., Xu, C.Y., Zhou, H., Sun, B., Wang, Z.J., Xu, Q., Xie, M.Y., Zuo, G., Huang, P., Wang, Q.S., He, J.H.
登録日2016-07-12
公開日2016-09-28
最終更新日2016-12-07
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Crystal structure and enantioselectivity of terpene cyclization in SAM-dependent methyltransferase TleD
Biochem.J., 473, 2016
5GM2
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CRYSTAL STRUCTURE OF METHYLTRANSFERASE TLED COMPLEXED WITH SAH AND TELEOCIDIN A1
分子名称:O-methylransferase, S-ADENOSYL-L-HOMOCYSTEINE, (2S,5S)-9-[(3R)-3,7-dimethylocta-1,6-dien-3-yl]-5-(hydroxymethyl)-1-methyl-2-(propan-2-yl)-1,2,4,5,6,8-hexahydro-3H-[1,4]diazonino[7,6,5-cd]indol-3-one
著者Yu, F., Li, M.J., Xu, C.Y., Zhou, H., Sun, B., Wang, Z.J., Xu, Q., Xie, M.Y., Zuo, G., Huang, P., Wang, Q.S., He, J.H.
登録日2016-07-12
公開日2016-09-28
最終更新日2016-12-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure and enantioselectivity of terpene cyclization in SAM-dependent methyltransferase TleD
Biochem.J., 473, 2016
5ZYP
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STRUCTURE OF THE YEAST CTR9/PAF1 COMPLEX
分子名称:RNA polymerase-associated protein CTR9,RNA polymerase II-associated protein 1, NICKEL (II) ION
著者Xie, Y., Zheng, M., Zhou, H., Long, J.
登録日2018-05-28
公開日2018-09-26
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (2.532 Å)
主引用文献Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation.
Nat Commun, 9, 2018