Author results

1XC1
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OXO ZIRCONIUM(IV) CLUSTER IN THE FERRIC BINDING PROTEIN (FBP)
Descriptor:periplasmic iron-binding protein, OXO ZIRCONIUM(IV) CLUSTER
Authors:Zhong, W., Alexeev, D., Harvey, I., Guo, M., Hunter, D.J.B., Zhu, H., Campopiano, D.J., Sadler, P.J.
Deposit date:2004-08-31
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Assembly of an Oxo-Zirconium(IV) Cluster in a Protein Cleft
Angew.Chem.Int.Ed.Engl., 43, 2004
4HYV
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PYRUVATE KINASE (PYK) FROM TRYPANOSOMA BRUCEI IN THE PRESENCE OF MAGNESIUM, PEP AND F26BP
Descriptor:Pyruvate kinase 1, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Zhong, W., Morgan, H.P., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2012-11-14
Release date:2013-09-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase.
Acta Crystallogr.,Sect.D, 69, 2013
4HYW
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PYRUVATE KINASE (PYK) FROM TRYPANOSOMA BRUCEI IN THE PRESENCE OF MAGNESIUM AND F26BP
Descriptor:Pyruvate kinase 1, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Zhong, W., Morgan, H.P., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2012-11-14
Release date:2013-09-11
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase.
Acta Crystallogr.,Sect.D, 69, 2013
4KCT
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PYRUVATE KINASE (PYK) FROM TRYPANOSOMA BRUCEI SOAKED WITH OXALOACETATE
Descriptor:Pyruvate kinase 1, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Zhong, W., Morgan, H.P., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2013-04-24
Release date:2014-01-08
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Pyruvate kinases have an intrinsic and conserved decarboxylase activity.
Biochem.J., 458, 2014
4KCU
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PYRUVATE KINASE (PYK) FROM TRYPANOSOMA BRUCEI SOAKED WITH D-MALATE
Descriptor:Pyruvate kinase 1, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Zhong, W., Morgan, H.P., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2013-04-24
Release date:2014-01-08
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Pyruvate kinases have an intrinsic and conserved decarboxylase activity.
Biochem.J., 458, 2014
4KCV
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PYRUVATE KINASE (PYK) FROM TRYPANOSOMA BRUCEI SOAKED WITH 2-OXOGLUTARIC ACID
Descriptor:Pyruvate kinase 1, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Zhong, W., Morgan, H.P., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2013-04-24
Release date:2014-01-08
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Pyruvate kinases have an intrinsic and conserved decarboxylase activity.
Biochem.J., 458, 2014
4KCW
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PYRUVATE KINASE (PYK) FROM TRYPANOSOMA BRUCEI SOAKED WITH OXALATE
Descriptor:Pyruvate kinase 1, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Zhong, W., Morgan, H.P., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2013-04-24
Release date:2014-01-08
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Pyruvate kinases have an intrinsic and conserved decarboxylase activity.
Biochem.J., 458, 2014
5WRP
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T-STATE CRYSTAL STRUCTURE OF PYRUVATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Pyruvate kinase, PHOSPHATE ION
Authors:Zhong, W., Cai, Q., El Sahili, A., Lescar, J., Dedon, P.C.
Deposit date:2016-12-02
Release date:2017-11-15
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Nat Commun, 8, 2017
5WS8
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PYRUVATE KINASE (PYK) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH OXALATE
Descriptor:Pyruvate kinase, MAGNESIUM ION, OXALATE ION
Authors:Zhong, W., Cai, Q., El Sahili, A., Lescar, J., Dedon, P.C.
Deposit date:2016-12-06
Release date:2017-11-15
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Nat Commun, 8, 2017
5WS9
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PYRUVATE KINASE (PYK) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH OXALATE, ATP AND ALLOSTERIC ACTIVATOR AMP
Descriptor:Pyruvate kinase, MAGNESIUM ION, OXALATE ION, ...
Authors:Zhong, W., Cai, Q., El Sahili, A., Lescar, J., Dedon, P.C.
Deposit date:2016-12-06
Release date:2017-11-15
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Nat Commun, 8, 2017
5WSA
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PYRUVATE KINASE (PYK) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH OXALATE AND ALLOSTERIC ACTIVATOR GLUCOSE 6-PHOSPHATE
Descriptor:Pyruvate kinase, ALPHA-D-GLUCOSE-6-PHOSPHATE, MAGNESIUM ION, ...
Authors:Zhong, W., Cai, Q., El Sahili, A., Lescar, J., Dedon, P.C.
Deposit date:2016-12-06
Release date:2017-11-15
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Nat Commun, 8, 2017
5WSB
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PYRUVATE KINASE (PYK) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH OXALATE, ALLOSTERIC ACTIVATORS AMP AND GLUCOSE 6-PHOSPHATE
Descriptor:Pyruvate kinase, ADENOSINE MONOPHOSPHATE, ALPHA-D-GLUCOSE-6-PHOSPHATE, ...
Authors:Zhong, W., Cai, Q., El Sahili, A., Lescar, J., Dedon, P.C.
Deposit date:2016-12-06
Release date:2017-11-15
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Nat Commun, 8, 2017
5WSC
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CRYSTAL OF PYRUVATE KINASE (PYK) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH OXALATE, SOAKED WITH ALLOSTERIC ACTIVATORS AMP AND GLUCOSE 6-PHOSPHATE
Descriptor:Pyruvate kinase, ADENOSINE MONOPHOSPHATE, ALPHA-D-GLUCOSE-6-PHOSPHATE, ...
Authors:Zhong, W., Cai, Q., El Sahili, A., Lescar, J., Dedon, P.C.
Deposit date:2016-12-06
Release date:2017-11-15
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Nat Commun, 8, 2017
5ZHI
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APO CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:tRNA (guanine-N(1)-)-methyltransferase
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Apo crystal structure of TrmD from Mycobacterium tuberculosis
To Be Published
5ZHJ
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH S-ADENOSYL HOMOCYSTEINE (SAH)
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, GLYCEROL
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of TrmD from Mycobacterium tuberculosis in complex with S-adenosyl homocysteine (SAH)
To Be Published
5ZHK
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-[(4-{[cyclohexyl(ethyl)amino]methyl}phenyl)methyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of TrmD from Mycobacterium tuberculosis in complex with active-site inhibitor
To Be Published
5ZHL
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-({4-[(octylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of TrmD from Mycobacterium tuberculosis in complex with active-site inhibitor
To Be Published
5ZHM
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CRYSTAL STRUCTURE OF TRMD FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-({4-[(diethylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide, S-ADENOSYLMETHIONINE
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Crystal structure of TrmD from Pseudomonas aeruginosa in complex with active-site inhibitor
To Be Published
5ZHN
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CRYSTAL STRUCTURE OF TRMD FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-({4-[(octylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal structure of TrmD from Pseudomonas aeruginosa in complex with active-site inhibitor
To Be Published
4KRZ
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APO CRYSTAL STRUCTURE OF PYRUVATE KINASE (PYK) FROM TRYPANOSOMA CRUZI
Descriptor:Pyruvate kinase, POTASSIUM ION, GLYCEROL
Authors:Zhong, W., Morgan, H.P., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2013-05-17
Release date:2014-11-19
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of pyruvate kinases display evolutionarily divergent allosteric strategies.
R Soc Open Sci, 1, 2014
1O7T
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METAL NANOCLUSTERS BOUND TO THE FERRIC BINDING PROTEIN FROM NEISSERIA GONORRHOEAE.
Descriptor:IRON BINDING PROTEIN, HF OXO CLUSTER HF5, SMALLEST HF-OXO-PHOSPHATE CLUSTER HF3, ...
Authors:Alexeev, D., Zu, H., Guo, M., Zhong, W., Hunter, D.J.B., Yang, W., Campopiano, D.J., Sadler, P.J.
Deposit date:2002-11-12
Release date:2003-02-27
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A novel protein-mineral interface.
Nat. Struct. Biol., 10, 2003
5JIE
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CRYSTAL STRUCTURE OF THE ORSAY VIRUS DELTA PROTEIN N-TERMINAL FRAGMENT (AA 1~66)
Descriptor:Protein delta
Authors:Fan, Y., Guo, Y., Zhong, W., Tao, Y.J.
Deposit date:2016-04-22
Release date:2017-02-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.1374 Å)
Cite:Structure of a pentameric virion-associated fiber with a potential role in Orsay virus entry to host cells.
PLoS Pathog., 13, 2017
1TP7
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CRYSTAL STRUCTURE OF THE RNA-DEPENDENT RNA POLYMERASE FROM HUMAN RHINOVIRUS 16
Descriptor:Genome polyprotein, SULFATE ION, 3-[BENZYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE
Authors:Appleby, T.C., Luecke, H., Shim, J.H., Wu, J.Z., Cheney, I.W., Zhong, W., Vogeley, L., Hong, Z., Yao, N.
Deposit date:2004-06-15
Release date:2005-06-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of complete rhinovirus RNA polymerase suggests front loading of protein primer.
J.Virol., 79, 2005
1WBX
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CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 DB AND KB MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE
Descriptor:H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B ALPHA CHAIN, BETA-2MICROGLOBULIN, ...
Authors:Meijers, R., Lai, C., Yang, Y., Liu, J., Zhong, W., Wang, J., Reinherz, E.L.
Deposit date:2004-11-05
Release date:2005-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of Murine Mhc Class I H-2 D(B) and K(B) Molecules in Complex with Ctl Epitopes from Influenza a Virus: Implications for Tcr Repertoire Selection and Immunodominance
J.Mol.Biol., 345, 2005
1WBY
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CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 DB AND KB MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE
Descriptor:H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B ALPHA CHAIN, BETA-2MICROGLOBULIN, ...
Authors:Meijers, R., Lai, C., Yang, Y., Liu, J., Zhong, W., Wang, J., Reinherz, E.L.
Deposit date:2004-11-05
Release date:2005-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of Murine Mhc Class I H-2 D(B) and K(B) Molecules in Complex with Ctl Epitopes from Influenza a Virus: Implications for Tcr Repertoire Selection and Immunodominance
J.Mol.Biol., 345, 2005
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