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1CF7
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BU of 1cf7 by Molmil
STRUCTURAL BASIS OF DNA RECOGNITION BY THE HETERODIMERIC CELL CYCLE TRANSCRIPTION FACTOR E2F-DP
Descriptor: DNA (5'-D(*AP*TP*TP*TP*TP*CP*GP*CP*GP*CP*GP*GP*TP*TP*TP*T)-3'), DNA (5'-D(*TP*AP*AP*AP*AP*CP*CP*GP*CP*GP*CP*GP*AP*AP*AP*A)-3'), PROTEIN (TRANSCRIPTION FACTOR DP-2), ...
Authors:Zheng, N, Fraenkel, E, Pabo, C.O, Pavletich, N.P.
Deposit date:1999-03-24
Release date:1999-04-02
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP.
Genes Dev., 13, 1999
1FBV
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BU of 1fbv by Molmil
STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES
Descriptor: SIGNAL TRANSDUCTION PROTEIN CBL, SULFATE ION, UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7, ...
Authors:Zheng, N, Wang, P, Jeffrey, P.D, Pavletich, N.P.
Deposit date:2000-07-17
Release date:2000-08-30
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.
Cell(Cambridge,Mass.), 102, 2000
1LDD
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BU of 1ldd by Molmil
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex
Descriptor: Anaphase Promoting Complex
Authors:Zheng, N, Schulman, B.A, Song, L, Miller, J.J, Jeffrey, P.D, Wang, P, Chu, C, Koepp, D.M, Elledge, S.J, Pagano, M, Conaway, R.C, Conaway, J.W, Harper, J.W, Pavletich, N.P.
Deposit date:2002-04-08
Release date:2002-05-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature, 416, 2002
1LDK
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BU of 1ldk by Molmil
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex
Descriptor: CULLIN HOMOLOG, CYCLIN A/CDK2-ASSOCIATED PROTEIN P19, SKP2-like protein type gamma, ...
Authors:Zheng, N, Schulman, B.A, Song, L, Miller, J.J, Jeffrey, P.D, Wang, P, Chu, C, Koepp, D.M, Elledge, S.J, Pagano, M, Conaway, R.C, Conaway, J.W, Harper, J.W, Pavletich, N.P.
Deposit date:2002-04-08
Release date:2002-05-08
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature, 416, 2002
1LDJ
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BU of 1ldj by Molmil
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex
Descriptor: Cullin homolog 1, ZINC ION, ring-box protein 1
Authors:Zheng, N, Schulman, B.A, Song, L, Miller, J.J, Jeffrey, P.D, Wang, P, Chu, C, Koepp, D.M, Elledge, S.J, Pagano, M, Conaway, R.C, Conaway, J.W, Harper, J.W, Pavletich, N.P.
Deposit date:2002-04-08
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature, 416, 2002
8T6L
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BU of 8t6l by Molmil
Cryo-EM structure of rat cardiac sodium channel NaV1.5 with batrachotoxin analog BTX-B
Descriptor: (1R)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-9,12-dihydroxy-2,11a-dimethyl-1,2,3,4,7a,8,9,10,11,11a,12,13-dodecahydro-7H-9,11b-epoxy-13a,5a-prop[1]enophenanthro[2,1-f][1,4]oxazepin-14-yl]ethyl benzoate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, ...
Authors:Tonggu, L, Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A.
Deposit date:2023-06-16
Release date:2024-03-06
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin.
Nat Commun, 15, 2024
1MIU
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BU of 1miu by Molmil
Structure of a BRCA2-DSS1 complex
Descriptor: Breast Cancer type 2 susceptibility protein, Deleted in split hand/split foot protein 1, MERCURY (II) ION
Authors:Yang, H, Jeffrey, P.D, Miller, J, Kinnucan, E, Sun, Y, Thoma, N.H, Zheng, N, Chen, P.L, Lee, W.H, Pavletich, N.P.
Deposit date:2002-08-23
Release date:2002-09-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure
Science, 297, 2002
1MJE
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BU of 1mje by Molmil
STRUCTURE OF A BRCA2-DSS1-SSDNA COMPLEX
Descriptor: 5'-D(P*TP*TP*TP*TP*TP*T)-3', Deleted in split hand/split foot protein 1, breast cancer 2
Authors:Yang, H, Jeffrey, P.D, Miller, J, Kinnucan, E, Sun, Y, Thoma, N.H, Zheng, N, Chen, P.L, Lee, W.H, Pavletich, N.P.
Deposit date:2002-08-27
Release date:2002-09-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.
Science, 297, 2002
7TE8
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BU of 7te8 by Molmil
CA14-CBD-DB21 ternary complex
Descriptor: CA14, DB21, cannabidiol
Authors:Cao, S, Zheng, N.
Deposit date:2022-01-04
Release date:2022-01-12
Last modified:2022-07-06
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Defining molecular glues with a dual-nanobody cannabidiol sensor.
Nat Commun, 13, 2022
7T1Y
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BU of 7t1y by Molmil
Structure of the Fbw7-Skp1-MycCdegron complex
Descriptor: F-box/WD repeat-containing protein 7, Myc proto-oncogene protein C terminal degron, S-phase kinase-associated protein 1, ...
Authors:Wang, B, Rusnac, D.V, Clurman, B.E, Zheng, N.
Deposit date:2021-12-02
Release date:2022-02-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor.
Sci Adv, 8, 2022
7T1Z
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BU of 7t1z by Molmil
Structure of the Fbw7-Skp1-MycNdegron complex
Descriptor: F-box/WD repeat-containing protein 7, Myc proto-oncogene N terminal degron, S-phase kinase-associated protein 1, ...
Authors:Wang, B, Rusnac, D.V, Clurman, B.E, Zheng, N.
Deposit date:2021-12-02
Release date:2022-02-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor.
Sci Adv, 8, 2022
4U8H
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BU of 4u8h by Molmil
Crystal Structure of Mammalian Period-Cryptochrome Complex
Descriptor: Cryptochrome-2, Period circadian protein homolog 2, ZINC ION
Authors:Nangle, S.N, Rosensweig, C, Koike, N, Tei, H, Takahashi, J.S, Green, C.B, Zheng, N.
Deposit date:2014-08-03
Release date:2014-10-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.798 Å)
Cite:Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex.
Elife, 3, 2014
6O60
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BU of 6o60 by Molmil
Crystal structure of GGTase3-FBXL2-SKP1 complex
Descriptor: F-box/LRR-repeat protein 2, Geranylgeranyl transferase type-2 subunit beta, Protein prenyltransferase alpha subunit repeat-containing protein 1, ...
Authors:Wang, H, Zheng, N.
Deposit date:2019-03-04
Release date:2019-06-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase.
Nat.Struct.Mol.Biol., 26, 2019
4EKW
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BU of 4ekw by Molmil
Crystal structure of the NavAb voltage-gated sodium channel (wild-type, 3.2 A)
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein, PHOSPHATE ION
Authors:Payandeh, J, Gamal El-Din, T.M, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2012-04-10
Release date:2012-05-16
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Crystal structure of a voltage-gated sodium channel in two potentially inactivated states.
Nature, 486, 2012
6BRT
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BU of 6brt by Molmil
F-box protein CTH with hydrolase
Descriptor: (5R)-5-hydroxy-3-methylfuran-2(5H)-one, D3-CTH-D14-D-ring
Authors:Shabek, N, Zheng, N, Mao, H, Hinds, T.R, Ticchiarelli, F, Leyser, O.
Deposit date:2017-12-01
Release date:2018-11-21
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.393 Å)
Cite:Structural plasticity of D3-D14 ubiquitin ligase in strigolactone signalling.
Nature, 563, 2018
6BRO
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BU of 6bro by Molmil
Crystal structure of ASK1-D3 ubiquitin ligase form1
Descriptor: F-box/LRR-repeat MAX2 homolog, SKP1-like protein 1A
Authors:Shabek, N, Zheng, N.
Deposit date:2017-11-30
Release date:2018-11-21
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural plasticity of D3-D14 ubiquitin ligase in strigolactone signalling.
Nature, 563, 2018
6DSZ
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BU of 6dsz by Molmil
Crystal structure of DDB1 in complex with DET1- and DDB1-associated protein 1 (DDA1)
Descriptor: DET1- and DDB1-associated protein 1, DNA damage-binding protein 1
Authors:Shabek, N, Zheng, N.
Deposit date:2018-06-14
Release date:2018-12-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.093 Å)
Cite:Structural insights into DDA1 function as a core component of the CRL4-DDB1 ubiquitin ligase.
Cell Discov, 4, 2018
6C1P
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BU of 6c1p by Molmil
HypoPP mutant
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHAPSO, Ion transport protein, ...
Authors:Catterall, W.A, Zheng, N, Jiang, D, Gamal El-Din, T.M.
Deposit date:2018-01-05
Release date:2018-05-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for gating pore current in periodic paralysis.
Nature, 557, 2018
5K16
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BU of 5k16 by Molmil
Crystal structure of free Ubiquitin-specific protease 12
Descriptor: GLYCEROL, Ubiquitin carboxyl-terminal hydrolase 12, ZINC ION
Authors:Li, H, D'Andrea, A.D, Zheng, N.
Deposit date:2016-05-17
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.599 Å)
Cite:Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Mol.Cell, 63, 2016
5K1B
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BU of 5k1b by Molmil
Crystal structure of the UAF1/USP12 complex in F222 space group
Descriptor: Ubiquitin carboxyl-terminal hydrolase 12, WD repeat-containing protein 48, ZINC ION
Authors:Li, H, D'Andrea, A.D, Zheng, N.
Deposit date:2016-05-18
Release date:2016-07-20
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Mol.Cell, 63, 2016
5KMD
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BU of 5kmd by Molmil
Structure of CavAb in complex with amlodipine
Descriptor: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein, ...
Authors:Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2016-06-26
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
Nature, 537, 2016
5KLS
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BU of 5kls by Molmil
Structure of CavAb in complex with Br-dihydropyridine derivative UK-59811
Descriptor: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein, ...
Authors:Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2016-06-25
Release date:2016-08-31
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.299 Å)
Cite:Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
Nature, 537, 2016
5KLB
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BU of 5klb by Molmil
Crystal structure of the CavAb voltage-gated calcium channel(wild-type, 2.7A)
Descriptor: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, CALCIUM ION, ...
Authors:Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2016-06-23
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
Nature, 537, 2016
5KMH
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BU of 5kmh by Molmil
Structure of CavAb in complex with Br-verapamil
Descriptor: (2~{R})-2-(2-bromophenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-propan-2-yl-pentanenitrile, 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, ...
Authors:Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2016-06-27
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
Nature, 537, 2016
5KMF
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BU of 5kmf by Molmil
Structure of CavAb in complex with nimodipine
Descriptor: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein, ...
Authors:Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2016-06-26
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
Nature, 537, 2016

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