Author results

1CMK
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CRYSTAL STRUCTURES OF THE MYRISTYLATED CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE REVEAL OPEN AND CLOSED CONFORMATIONS
Descriptor:cAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT, cAMP-dependent protein kinase inhibitor, alpha form, ...
Authors:Zheng, J., Knighton, D.R., Xuong, N.-H., Taylor, S.S., Sowadski, J.M., Ten Eyck, L.F.
Deposit date:1993-11-18
Release date:1994-05-31
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations.
Protein Sci., 2, 1993
1ATP
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2.2 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH MNATP AND A PEPTIDE INHIBITOR
Descriptor:cAMP-DEPENDENT PROTEIN KINASE, PEPTIDE INHIBITOR PKI(5-24), MANGANESE (II) ION, ...
Authors:Zheng, J., Trafny, E.A., Knighton, D.R., Xuong, N.-H., Taylor, S.S., Teneyck, L.F., Sowadski, J.M.
Deposit date:1993-01-08
Release date:1993-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor.
Acta Crystallogr.,Sect.D, 49, 1993
5LVX
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CRYSTAL STRUCTURE OF GLUCOCEREBROSIDASE WITH AN INHIBITORY QUINAZOLINE MODULATOR
Descriptor:Glucosylceramidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Zheng, J., Chen, L., Skinner, O.S., Lansbury, P., Skerlj, R., Mrosek, M., Heunisch, U., Krapp, S., Weigand, S., Charrow, J., Schwake, M., Kelleher, N.L., Silverman, R.B., Krainc, D.
Deposit date:2016-09-14
Release date:2017-10-25
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:beta-Glucocerebrosidase Modulators Promote Dimerization of beta-Glucocerebrosidase and Reveal an Allosteric Binding Site.
J. Am. Chem. Soc., 140, 2018
4P0U
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YHDE E33A P4 SPACE GROUP
Descriptor:Maf-like protein YceF
Authors:Zheng, J., Jin, J., Wang, N., Jia, Z.
Deposit date:2014-02-23
Release date:2014-05-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:YhdE E33A p4 space group
To Be Published
4PT1
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CRYSTAL STRUCTURE OF LOCUSTA MIGRATORIA ODORANT BINDING PROTEINS LMIGOBP1
Descriptor:Odorant-binding protein 1d, 2-(2-METHOXYETHOXY)ETHANOL
Authors:Zheng, J., Li, J., Chen, Z.
Deposit date:2014-03-10
Release date:2014-12-31
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of the Locusta migratoria odorant binding protein.
Biochem.Biophys.Res.Commun., 456, 2015
4XXB
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CRYSTAL STRUCTURE OF HUMAN MDM2-RPL11
Descriptor:60S ribosomal protein L11, E3 ubiquitin-protein ligase Mdm2, IMIDAZOLE, ...
Authors:Zheng, J., Chen, Z.
Deposit date:2015-01-30
Release date:2015-08-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation
Genes Dev., 29, 2015
1AWE
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HUMAN SOS1 PLECKSTRIN HOMOLOGY (PH) DOMAIN, NMR, 20 STRUCTURES
Descriptor:SOS1
Authors:Zheng, J., Cowburn, D.
Deposit date:1997-10-01
Release date:1998-02-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains.
J.Biol.Chem., 272, 1997
1U5W
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CRYSTAL STRUCTURE OF HYPOTHETICAL PROTEIN YJJX FROM ESCHERICHIA COLI
Descriptor:Hypothetical UPF0244 protein yjjX, SULFATE ION
Authors:Zheng, J., Singh, V.K., Jia, Z., Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI)
Deposit date:2004-07-28
Release date:2005-08-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification of an ITPase/XTPase in Escherichia coli by Structural and Biochemical Analysis
Structure, 13, 2005
1ZYL
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CRYSTAL STRUCTURE OF HYPOTHETICAL PROTEIN YIHE FROM ESCHERICHIA COLI
Descriptor:Hypothetical protein yihE
Authors:Zheng, J., Jia, Z., Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI)
Deposit date:2005-06-10
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of a novel prokaryotic Ser/Thr kinase and its implication in the Cpx stress response pathway.
Mol.Microbiol., 63, 2007
2QKA
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STRUCTURAL AND KINETIC STUDY OF THE DIFFERENCES BETWEEN HUMAN AND E.COLI MANGANESE SUPEROXIDE DISMUTASES
Descriptor:Superoxide dismutase [Mn], MANGANESE (II) ION
Authors:Zheng, J., Domsic, J.F., Cabelli, D., McKenna, R., Silverman, D.N.
Deposit date:2007-07-10
Release date:2008-07-29
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and kinetic study of differences between human and Escherichia coli manganese superoxide dismutases.
Biochemistry, 46, 2007
2QKC
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STRUCTURAL AND KINETIC STUDY OF THE DIFFERENCES BETWEEN HUMAN AND E.COLI MANGANESE SUPEROXIDE DISMUTASES
Descriptor:Superoxide dismutase [Mn], MANGANESE (II) ION
Authors:Zheng, J., Domsic, J.F., Cabelli, D., McKenna, R., Silverman, D.N.
Deposit date:2007-07-10
Release date:2008-07-29
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and kinetic study of differences between human and Escherichia coli manganese superoxide dismutases.
Biochemistry, 46, 2007
3EPS
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THE CRYSTAL STRUCTURE OF ISOCITRATE DEHYDROGENASE KINASE/PHOSPHATASE FROM E. COLI
Descriptor:Isocitrate dehydrogenase kinase/phosphatase, ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Zheng, J., Jia, Z., Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI)
Deposit date:2008-09-29
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase.
Nature, 465, 2010
3FRQ
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STRUCTURE OF THE MACROLIDE BIOSENSOR PROTEIN, MPHR(A), WITH ERYTHROMCYIN
Descriptor:Repressor protein MphR(A), ERYTHROMYCIN A, GLYCEROL, ...
Authors:Zheng, J., Sagar, V., Smolinsky, A., Bourke, C., LaRonde-LeBlanc, N., Cropp, T.A.
Deposit date:2009-01-08
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structure and function of the macrolide biosensor protein, MphR(A), with and without erythromycin
J.Mol.Biol., 387, 2009
3G56
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STRUCTURE OF THE MACROLIDE BIOSENSOR PROTEIN, MPHR(A)
Descriptor:Regulator of macrolide 2'-phosphotransferase I, 1,2-ETHANEDIOL, GLYCEROL
Authors:Zheng, J., Sagar, V., Smolinsky, A., Bourke, C., LaRonde-LeBlanc, N., Cropp, T.A.
Deposit date:2009-02-04
Release date:2009-03-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and function of the macrolide biosensor protein, MphR(A), with and without erythromycin
J.Mol.Biol., 387, 2009
3LC6
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THE ALTERNATIVE CONFORMATION STRUCTURE OF ISOCITRATE DEHYDROGENASE KINASE/PHOSPHATASE FROM E. COLI
Descriptor:Isocitrate dehydrogenase kinase/phosphatase, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Zheng, J., Jia, Z.
Deposit date:2010-01-09
Release date:2010-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase.
Nature, 465, 2010
3LCB
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THE CRYSTAL STRUCTURE OF ISOCITRATE DEHYDROGENASE KINASE/PHOSPHATASE IN COMPLEX WITH ITS SUBSTRATE, ISOCITRATE DEHYDROGENASE, FROM ESCHERICHIA COLI.
Descriptor:Isocitrate dehydrogenase kinase/phosphatase, Isocitrate dehydrogenase [NADP], ADENOSINE MONOPHOSPHATE, ...
Authors:Zheng, J., Jia, Z.
Deposit date:2010-01-10
Release date:2010-04-21
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase.
Nature, 465, 2010
3MJC
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STRUCTURE OF A-TYPE KETOREDUCTASES FROM MODULAR POLYKETIDE SYNTHASE
Descriptor:AmphB, GLYCEROL
Authors:Zheng, J., Taylor, C.A., Piasecki, S.K., Keatinge-Clay, A.T.
Deposit date:2010-04-12
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Structural and Functional Analysis of A-Type Ketoreductases from the Amphotericin Modular Polyketide Synthase.
Structure, 18, 2010
3MJE
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STRUCTURE OF A-TYPE KETOREDUCTASES FROM MODULAR POLYKETIDE SYNTHASE
Descriptor:AmphB, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL
Authors:Zheng, J., Taylor, C.A., Piasecki, S.K., Keatinge-Clay, A.T.
Deposit date:2010-04-12
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Structural and Functional Analysis of A-Type Ketoreductases from the Amphotericin Modular Polyketide Synthase.
Structure, 18, 2010
3MJS
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STRUCTURE OF A-TYPE KETOREDUCTASES FROM MODULAR POLYKETIDE SYNTHASE
Descriptor:AmphB, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2S)-2-hydroxybutanedioic acid, ...
Authors:Zheng, J., Taylor, C.A., Piasecki, S.K., Keatinge-Clay, A.T.
Deposit date:2010-04-13
Release date:2010-08-18
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and Functional Analysis of A-Type Ketoreductases from the Amphotericin Modular Polyketide Synthase.
Structure, 18, 2010
3MJT
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STRUCTURE OF A-TYPE KETOREDUCTASES FROM MODULAR POLYKETIDE SYNTHASE
Descriptor:AmphB, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL
Authors:Zheng, J., Taylor, C.A., Piasecki, S.K., Keatinge-Clay, A.T.
Deposit date:2010-04-13
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and Functional Analysis of A-Type Ketoreductases from the Amphotericin Modular Polyketide Synthase.
Structure, 18, 2010
3MJV
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STRUCTURE OF A-TYPE KETOREDUCTASES FROM MODULAR POLYKETIDE SYNTHASE
Descriptor:AmphB, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zheng, J., Taylor, C.A., Piasecki, S.K., Keatinge-Clay, A.T.
Deposit date:2010-04-13
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Structural and Functional Analysis of A-Type Ketoreductases from the Amphotericin Modular Polyketide Synthase.
Structure, 18, 2010
3QP9
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THE STRUCTURE OF A C2-TYPE KETOREDUCTASE FROM A MODULAR POLYKETIDE SYNTHASE
Descriptor:Type I polyketide synthase PikAII
Authors:Zheng, J., Keatinge-Clay, A.T.
Deposit date:2011-02-11
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural and functional analysis of c2-type ketoreductases from modular polyketide synthases.
J.Mol.Biol., 410, 2011
3SLK
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STRUCTURE OF KETOREDUCTASE AND ENOYLREDUCTASE DIDOMAIN FROM MODULAR POLYKETIDE SYNTHASE
Descriptor:Polyketide synthase extender module 2, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION
Authors:Zheng, J., Gay, D.C., Keatinge-Clay, A.T.
Deposit date:2011-06-24
Release date:2012-05-30
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:Divergence of multimodular polyketide synthases revealed by a didomain structure.
Nat.Chem.Biol., 8, 2012
4DIF
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STRUCTURE OF A1-TYPE KETOREDUCTASE
Descriptor:AmphB, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL
Authors:Zheng, J., Keatinge-Clay, A.T.
Deposit date:2012-01-30
Release date:2013-02-13
Method:X-RAY DIFFRACTION (1.521 Å)
Cite:Structure and mutagenesis of A2-type ketoreductase from modular polyketide synthase reveals insights into stereospecificity
To be Published
4IMP
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THE MISSING LINKER: A DIMERIZATION MOTIF LOCATED WITHIN POLYKETIDE SYNTHASE MODULES
Descriptor:Polyketide synthase extender modules 3-4, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zheng, J., Keatinge-Clay, A.T.
Deposit date:2013-01-03
Release date:2013-03-27
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:The missing linker: a dimerization motif located within polyketide synthase modules.
Acs Chem.Biol., 8, 2013