Author results

1G2C
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HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION PROTEIN CORE
Descriptor:FUSION PROTEIN (F)
Authors:Zhao, X., Singh, M., Malashkevich, V.N., Kim, P.S.
Deposit date:2000-10-18
Release date:2001-01-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural characterization of the human respiratory syncytial virus fusion protein core.
Proc.Natl.Acad.Sci.USA, 97, 2000
1K1F
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STRUCTURE OF THE BCR-ABL ONCOPROTEIN OLIGOMERIZATION DOMAIN
Descriptor:BREAKPOINT CLUSTER REGION PROTEIN
Authors:Zhao, X., Ghaffari, S., Lodish, H., Malashkevich, V.N., Kim, P.S.
Deposit date:2001-09-25
Release date:2002-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the Bcr-Abl oncoprotein oligomerization domain.
Nat.Struct.Biol., 9, 2002
3AKA
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STRUCTURAL BASIS FOR PROKARYOTIC CALCIUM-MEDIATED REGULATION BY A STREPTOMYCES COELICOLOR CALCIUM-BINDING PROTEIN
Descriptor:Putative calcium binding protein, CALCIUM ION
Authors:Zhao, X., Pang, H., Wang, S., Zhou, W., Yang, K., Bartlam, M.
Deposit date:2010-07-09
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for prokaryotic calciummediated regulation by a Streptomyces coelicolor calcium binding protein
Protein Cell, 1, 2010
3AKB
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STRUCTURAL BASIS FOR PROKARYOTIC CALCIUM-MEDIATED REGULATION BY A STREPTOMYCES COELICOLOR CALCIUM-BINDING PROTEIN
Descriptor:Putative calcium binding protein, CALCIUM ION
Authors:Zhao, X., Pang, H., Wang, S., Zhou, W., Yang, K., Bartlam, M.
Deposit date:2010-07-09
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for prokaryotic calciummediated regulation by a Streptomyces coelicolor calcium binding protein
Protein Cell, 1, 2010
4I5I
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CRYSTAL STRUCTURE OF THE SIRT1 CATALYTIC DOMAIN BOUND TO NAD AND AN EX527 ANALOG
Descriptor:NAD-dependent protein deacetylase sirtuin-1, (6S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Zhao, X., Allison, D., Condon, B., Zhang, F., Gheyi, T., Zhang, A., Ashok, S., Russell, M., Macewan, I., Qian, Y., Jamison, J.A., Luz, J.G.
Deposit date:2012-11-28
Release date:2013-01-23
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The 2.5 angstrom crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.
J.Med.Chem., 56, 2013
5H5N
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THE CRYSTAL STRUCTURE OF THE NS1 (H17N10) RNA-BINDING DOMAIN
Descriptor:Non-structural protein 1
Authors:Zhao, X., Qi, J., Xiao, H., Gao, G.F.
Deposit date:2016-11-08
Release date:2016-11-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:The NS1 gene from bat-derived influenza-like virus H17N10 can be rescued in influenza A PR8 backbone
J.Gen.Virol., 97, 2016
2R25
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COMPLEX OF YPD1 AND SLN1-R1 WITH BOUND MG2+ AND BEF3-
Descriptor:Phosphorelay intermediate protein YPD1, Osmosensing histidine protein kinase SLN1, MAGNESIUM ION, ...
Authors:Copeland, D.M., Zhao, X., Soares, A.S., West, A.H.
Deposit date:2007-08-24
Release date:2008-01-15
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of a complex between the phosphorelay protein YPD1 and the response regulator domain of SLN1 bound to a phosphoryl analog
J.Mol.Biol., 375, 2008
4C50
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CRYSTAL STRUCTURE OF THE CATALASE-PEROXIDASE (KATG) D137S MUTANT FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:CATALASE-PEROXIDASE, ALPHA-D-GLUCOSE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Hersleth, H.-P., Zhao, X., Magliozzo, R.S., Andersson, K.K.
Deposit date:2013-09-10
Release date:2013-11-13
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Access Channel Residues Ser315 and Asp137 in Mycobacterium Tuberculosis Catalase-Peroxidase (Katg) Control Peroxidatic Activation of the Pro-Drug Isoniazid.
Chem.Commun.(Camb.), 49, 2013
4C51
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CRYSTAL STRUCTURE OF THE CATALASE-PEROXIDASE (KATG) R418L MUTANT FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:CATALASE-PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE, ALPHA-D-GLUCOSE
Authors:Hersleth, H.-P., Zhao, X., Magliozzo, R.S., Andersson, K.K.
Deposit date:2013-09-10
Release date:2013-11-13
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Access Channel Residues Ser315 and Asp137 in Mycobacterium Tuberculosis Catalase-Peroxidase (Katg) Control Peroxidatic Activation of the Pro-Drug Isoniazid.
Chem.Commun.(Camb.), 49, 2013
5T7Q
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TIRAP PHOSPHOINOSITIDE-BINDING MOTIF
Descriptor:Toll/interleukin-1 receptor domain-containing adapter protein
Authors:Capelluto, D.G.S., Ellena, J.F., Armstrong, G., Zhao, X., Xiao, S.
Deposit date:2016-09-05
Release date:2017-03-08
Last modified:2018-08-29
Method:SOLUTION NMR
Cite:Membrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif.
Sci Rep, 7, 2017
3HTK
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CRYSTAL STRUCTURE OF MMS21 AND SMC5 COMPLEX
Descriptor:Structural maintenance of chromosomes protein 5, E3 SUMO-protein ligase MMS21, ZINC ION
Authors:Duan, X., Sarangi, P., Liu, X., Rangi, G.K., Zhao, X., Ye, H.
Deposit date:2009-06-11
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural and functional insights into the roles of the Mms21 subunit of the Smc5/6 complex.
Mol.Cell, 35, 2009
5MV1
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CRYSTAL STRUCTURE OF THE E PROTEIN OF THE JAPANESE ENCEPHALITIS VIRULENT VIRUS
Descriptor:E protein
Authors:Liu, X., Zhao, X., Na, R., Li, L., Warkentin, E., Witt, J., Lu, X., Wei, Y., Peng, G., Li, Y., Wang, J.
Deposit date:2017-01-14
Release date:2018-05-23
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The structure differences of Japanese encephalitis virus SA14 and SA14-14-2 E proteins elucidate the virulence attenuation mechanism.
Protein Cell, 10, 2019
5MV2
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CRYSTAL STRUCTURE OF THE E PROTEIN OF THE JAPANESE ENCEPHALITIS LIVE ATTENUATED VACCINE VIRUS
Descriptor:E protein
Authors:Liu, X., Zhao, X., Na, R., Li, L., Warkentin, E., Witt, J., Lu, X., Wei, Y., Peng, G., Li, Y., Wang, J.
Deposit date:2017-01-14
Release date:2018-05-23
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure differences of Japanese encephalitis virus SA14 and SA14-14-2 E proteins elucidate the virulence attenuation mechanism.
Protein Cell, 10, 2019
1DKX
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THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 1 SELENOMETHIONYL CRYSTALS
Descriptor:SUBSTRATE BINDING DOMAIN OF DNAK, SUBSTRATE PEPTIDE (7 RESIDUES)
Authors:Zhu, X., Zhao, X., Burkholder, W.F., Gragerov, A., Ogata, C.M., Gottesman, M.E., Hendrickson, W.A.
Deposit date:1996-06-03
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of substrate binding by the molecular chaperone DnaK.
Science, 272, 1996
1DKY
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THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 2 NATIVE CRYSTALS
Descriptor:DNAK, PEPTIDE SUBSTRATE
Authors:Zhu, X., Zhao, X., Burkholder, W.F., Gragerov, A., Ogata, C.M., Gottesman, M.E., Hendrickson, W.A.
Deposit date:1996-06-03
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural analysis of substrate binding by the molecular chaperone DnaK.
Science, 272, 1996
1DKZ
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THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 1 NATIVE CRYSTALS
Descriptor:SUBSTRATE BINDING DOMAIN OF DNAK, SUBSTRATE PEPTIDE (7 RESIDUES)
Authors:Zhu, X., Zhao, X., Burkholder, W.F., Gragerov, A., Ogata, C.M., Gottesman, M.E., Hendrickson, W.A.
Deposit date:1996-06-03
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of substrate binding by the molecular chaperone DnaK.
Science, 272, 1996
1XKE
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SOLUTION STRUCTURE OF THE SECOND RAN-BINDING DOMAIN FROM HUMAN RANBP2
Descriptor:Ran-binding protein 2
Authors:Geyer, J.P., Doeker, R., Kremer, W., Zhao, X., Kuhlmann, J., Kalbitzer, H.R.
Deposit date:2004-09-28
Release date:2005-04-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the Ran-binding domain 2 of RanBP2 and its interaction with the C terminus of Ran.
J.Mol.Biol., 348, 2005
2PZE
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MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A HEAD-TO-TAIL DIMER
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
Deposit date:2007-05-17
Release date:2007-10-09
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
2PZF
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MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A HEAD-TO-TAIL DIMER WITH DELTA F508
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
Deposit date:2007-05-18
Release date:2007-10-09
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
2PZG
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MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A MONOMER
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
Deposit date:2007-05-18
Release date:2007-10-09
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
1OWD
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SUBSTITUTED 2-NAPHTHAMIDINE INHIBITORS OF UROKINASE
Descriptor:Urokinase-type plasminogen activator, 6-[AMINO(IMINO)METHYL]-N-[(4R)-4-ETHYL-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL]-2-NAPHTHAMIDE
Authors:Wendt, M.D., Rockway, T.W., Geyer, A., McClellan, W., Weitzberg, M., Zhao, X., Mantei, R., Nienaber, V.L., Stewart, K., Klinghofer, V., Giranda, V.L.
Deposit date:2003-03-28
Release date:2003-09-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution.
J.Med.Chem., 47, 2004
1OWE
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SUBSTITUTED 2-NAPHTHAMIDINE INHIBITORS OF UROKINASE
Descriptor:Urokinase-type plasminogen activator, SULFATE ION, 6-[(Z)-AMINO(IMINO)METHYL]-N-PHENYL-2-NAPHTHAMIDE
Authors:Wendt, M.D., Rockway, T.W., Geyer, A., McClellan, W., Weitzberg, M., Zhao, X., Mantei, R., Nienaber, V.L., Stewart, K., Klinghofer, V., Giranda, V.L.
Deposit date:2003-03-28
Release date:2003-09-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution.
J.Med.Chem., 47, 2004
1OWH
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SUBSTITUTED 2-NAPHTHAMIDINE INHIBITORS OF UROKINASE
Descriptor:Urokinase-type plasminogen activator, SULFATE ION, 6-[(Z)-AMINO(IMINO)METHYL]-N-[4-(AMINOMETHYL)PHENYL]-2-NAPHTHAMIDE
Authors:Wendt, M.D., Rockway, T.W., Geyer, A., McClellan, W., Weitzberg, M., Zhao, X., Mantei, R., Nienaber, V.L., Stewart, K., Klinghofer, V., Giranda, V.L.
Deposit date:2003-03-28
Release date:2003-09-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution.
J.Med.Chem., 47, 2004
1OWI
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SUBSTITUTED 2-NAPHTHAMIDINE INHIBITORS OF UROKINASE
Descriptor:Urokinase-type plasminogen activator, 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE
Authors:Wendt, M.D., Rockway, T.W., Geyer, A., McClellan, W., Weitzberg, M., Zhao, X., Mantei, R., Nienaber, V.L., Stewart, K., Klinghofer, V., Giranda, V.L.
Deposit date:2003-03-28
Release date:2003-09-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution.
J.Med.Chem., 47, 2004
1OWJ
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SUBSTITUTED 2-NAPHTHAMIDINE INHIBITORS OF UROKINASE
Descriptor:Urokinase-type plasminogen activator, 6-[(Z)-AMINO(IMINO)METHYL]-N-(1-ISOPROPYL-3,4-DIHYDROISOQUINOLIN-7-YL)-2-NAPHTHAMIDE
Authors:Wendt, M.D., Rockway, T.W., Geyer, A., McClellan, W., Weitzberg, M., Zhao, X., Mantei, R., Nienaber, V.L., Stewart, K., Klinghofer, V., Giranda, V.L.
Deposit date:2003-03-28
Release date:2003-09-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution.
J.Med.Chem., 47, 2004