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7XNA
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BU of 7xna by Molmil
Crystal structure of somatostatin receptor 2 (SSTR2) with peptide antagonist CYN 154806
Descriptor: CYN 154806, Somatostatin receptor type 2,Endo-1,4-beta-xylanase
Authors:Zhao, W, Han, S, Qiu, N, Feng, W, Lu, M, Yang, D, Wang, M.-W, Wu, B, Zhao, Q.
Deposit date:2022-04-28
Release date:2022-08-03
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural insights into ligand recognition and selectivity of somatostatin receptors.
Cell Res., 32, 2022
7XN9
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BU of 7xn9 by Molmil
Crystal structure of SSTR2 and L-054,522 complex
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Somatostatin receptor type 2,Endo-1,4-beta-xylanase, tert-butyl (2S)-6-azanyl-2-[[(2R,3S)-3-(1H-indol-3-yl)-2-[[4-(2-oxidanylidene-3H-benzimidazol-1-yl)piperidin-1-yl]carbonylamino]butanoyl]amino]hexanoate
Authors:Zhao, W, Han, S, Qiu, N, Feng, W, Lu, M, Yang, D, Wang, M.-W, Wu, B, Zhao, Q.
Deposit date:2022-04-28
Release date:2022-08-03
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insights into ligand recognition and selectivity of somatostatin receptors.
Cell Res., 32, 2022
7XK8
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BU of 7xk8 by Molmil
Cryo-EM structure of the Neuromedin U receptor 2 (NMUR2) in complex with G Protein and its endogeneous Peptide-Agonist NMU25
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Zhao, W, Wenru, Z, Mu, W, Minmin, L, Shutian, C, Tingting, T, Gisela, S, Holger, W, Albert, B, Cuiying, Y, Xiaojing, C, Han, S, Wu, B, Zhao, Q.
Deposit date:2022-04-19
Release date:2023-02-22
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Ligand recognition and activation of neuromedin U receptor 2.
Nat Commun, 13, 2022
5JCB
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BU of 5jcb by Molmil
Microtubule depolymerizing agent podophyllotoxin derivative YJTSF1
Descriptor: (5R,5aR,8aS,9R)-9-[(4H-1,2,4-triazol-3-yl)sulfanyl]-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Guan, Z, Zhao, W, Yin, P.
Deposit date:2016-04-14
Release date:2017-09-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Insights into the Inhibition of Tubulin by the Antitumor Agent 4 beta-(1,2,4-triazol-3-ylthio)-4-deoxypodophyllotoxin.
ACS Chem. Biol., 12, 2017
4UX5
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BU of 4ux5 by Molmil
Structure of DNA complex of PCG2
Descriptor: 5'-D(*CP*AP*AP*TP*GP*AP*CP*GP*CP*GP*TP*AP*AP*GP)-3', 5'-D(*CP*TP*TP*AP*CP*GP*CP*GP*TP*CP*AP*TP*TP*GP)-3', TRANSCRIPTION FACTOR MBP1
Authors:Liu, J, Huang, J, Zhao, Y, Liu, H, Wang, D, Yang, J, Zhao, W, Taylor, I.A, Peng, Y.
Deposit date:2014-08-19
Release date:2015-01-14
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis of DNA Recognition by Pcg2 Reveals a Novel DNA Binding Mode for Winged Helix-Turn-Helix Domains.
Nucleic Acids Res., 43, 2015
6PKM
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BU of 6pkm by Molmil
MicroED structure of proteinase K from an uncoated, single lamella at 2.17A resolution (#8)
Descriptor: Proteinase K
Authors:Martynowycz, M.W, Zhao, W, Hattne, J, Jensen, G.J, Gonen, T.
Deposit date:2019-06-29
Release date:2019-09-04
Last modified:2019-12-18
Method:ELECTRON CRYSTALLOGRAPHY (2.17 Å)
Cite:Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED.
Structure, 27, 2019
6PKQ
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BU of 6pkq by Molmil
MicroED structure of proteinase K from a platinum-coated, polished, single lamella at 1.85A resolution (#11)
Descriptor: Proteinase K
Authors:Martynowycz, M.W, Zhao, W, Hattne, J, Jensen, G.J, Gonen, T.
Deposit date:2019-06-29
Release date:2019-09-04
Last modified:2019-12-18
Method:ELECTRON CRYSTALLOGRAPHY (1.85 Å)
Cite:Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED.
Structure, 27, 2019
6PKS
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BU of 6pks by Molmil
MicroED structure of proteinase K from low-dose merged lamellae that were not pre-coated with platinum 2.16A resolution (LD)
Descriptor: Proteinase K
Authors:Martynowycz, M.W, Zhao, W, Hattne, J, Jensen, G.J, Gonen, T.
Deposit date:2019-06-29
Release date:2019-09-04
Last modified:2019-12-18
Method:ELECTRON CRYSTALLOGRAPHY (2.16 Å)
Cite:Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED.
Structure, 27, 2019
6PKL
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BU of 6pkl by Molmil
MicroED structure of proteinase K from an uncoated, single lamella at 2.59A resolution (#7)
Descriptor: Proteinase K
Authors:Martynowycz, M.W, Zhao, W, Hattne, J, Jensen, G.J, Gonen, T.
Deposit date:2019-06-29
Release date:2019-09-04
Last modified:2019-12-18
Method:ELECTRON CRYSTALLOGRAPHY (2.59 Å)
Cite:Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED.
Structure, 27, 2019
6PKT
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BU of 6pkt by Molmil
MicroED structure of proteinase K from merging low-dose, platinum pre-coated lamellae at 1.85A resolution (LDPT)
Descriptor: Proteinase K
Authors:Martynowycz, M.W, Zhao, W, Hattne, J, Jensen, G.J, Gonen, T.
Deposit date:2019-06-29
Release date:2019-09-04
Last modified:2019-12-18
Method:ELECTRON CRYSTALLOGRAPHY (1.85 Å)
Cite:Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED.
Structure, 27, 2019
6PKN
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BU of 6pkn by Molmil
MicroED structure of proteinase K from an unpolished, platinum-coated, single lamella at 2.08A resolution (#9)
Descriptor: Proteinase K
Authors:Martynowycz, M.W, Zhao, W, Hattne, J, Jensen, G.J, Gonen, T.
Deposit date:2019-06-29
Release date:2019-09-04
Last modified:2019-12-18
Method:ELECTRON CRYSTALLOGRAPHY (2.08 Å)
Cite:Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED.
Structure, 27, 2019
6PKJ
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BU of 6pkj by Molmil
MicroED structure of proteinase K from an uncoated, single lamella at 2.17A resolution (#2)
Descriptor: Proteinase K
Authors:Martynowycz, M.W, Zhao, W, Hattne, J, Jensen, G.J, Gonen, T.
Deposit date:2019-06-29
Release date:2019-09-04
Last modified:2019-12-18
Method:ELECTRON CRYSTALLOGRAPHY (2.176 Å)
Cite:Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED.
Structure, 27, 2019
6PKO
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BU of 6pko by Molmil
MicroED structure of proteinase K from a platinum coated, unpolished, single lamella at 2.07A resolution (#12)
Descriptor: Proteinase K
Authors:Martynowycz, M.W, Zhao, W, Hattne, J, Jensen, G.J, Gonen, T.
Deposit date:2019-06-29
Release date:2019-09-04
Last modified:2019-12-18
Method:ELECTRON CRYSTALLOGRAPHY (2.07 Å)
Cite:Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED.
Structure, 27, 2019
6PKK
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BU of 6pkk by Molmil
MicroED structure of proteinase K from an uncoated, single lamella at 2.18A resolution (#5)
Descriptor: Proteinase K
Authors:Martynowycz, M.W, Zhao, W, Hattne, J, Jensen, G.J, Gonen, T.
Deposit date:2019-06-29
Release date:2019-09-04
Last modified:2019-12-18
Method:ELECTRON CRYSTALLOGRAPHY (2.176 Å)
Cite:Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED.
Structure, 27, 2019
6PKP
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BU of 6pkp by Molmil
MicroED structure of proteinase K from a platinum-coated, polished, single lamella at 1.91A resolution (#10)
Descriptor: Proteinase K
Authors:Martynowycz, M.W, Zhao, W, Hattne, J, Jensen, G.J, Gonen, T.
Deposit date:2019-06-29
Release date:2019-09-04
Last modified:2019-12-18
Method:ELECTRON CRYSTALLOGRAPHY (1.91 Å)
Cite:Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED.
Structure, 27, 2019
6PKR
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BU of 6pkr by Molmil
MicroED structure of proteinase K from a platinum-coated, polished, single lamella at 1.79A resolution (#13)
Descriptor: Proteinase K
Authors:Martynowycz, M.W, Zhao, W, Hattne, J, Jensen, G.J, Gonen, T.
Deposit date:2019-06-29
Release date:2019-09-04
Last modified:2019-12-18
Method:ELECTRON CRYSTALLOGRAPHY (1.79 Å)
Cite:Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED.
Structure, 27, 2019
5H1B
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BU of 5h1b by Molmil
Human RAD51 presynaptic complex
Descriptor: DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA repair protein RAD51 homolog 1, MAGNESIUM ION, ...
Authors:Xu, J, Zhao, L, Xu, Y, Zhao, W, Sung, P, Wang, H.W.
Deposit date:2016-10-08
Release date:2016-12-21
Last modified:2022-03-23
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange
Nat. Struct. Mol. Biol., 24, 2017
5H1C
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BU of 5h1c by Molmil
Human RAD51 post-synaptic complexes
Descriptor: DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA repair protein RAD51 homolog 1, ...
Authors:Xu, J, Zhao, L, Xu, Y, Zhao, W, Sung, P, Wang, H.W.
Deposit date:2016-10-08
Release date:2016-12-21
Last modified:2022-03-23
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange
Nat. Struct. Mol. Biol., 24, 2017
8H1D
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BU of 8h1d by Molmil
Solid-state NMR Structure of Aquaporin Z in its Native Cellular Membranes
Descriptor: Aquaporin Z
Authors:Xie, H, Zhao, Y, Zhao, W, Chen, Y, Liu, M, Yang, J.
Deposit date:2022-10-02
Release date:2022-11-09
Last modified:2023-11-15
Method:SOLID-STATE NMR
Cite:Solid-state NMR structure determination of a membrane protein in E. coli cellular inner membrane.
Sci Adv, 9, 2023
6U5G
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BU of 6u5g by Molmil
MicroED structure of a FIB-milled CypA Crystal
Descriptor: Peptidyl-prolyl cis-trans isomerase A
Authors:Wolff, A.M, Martynowycz, M.W, Zhao, W, Gonen, T, Fraser, J.S, Thompson, M.C.
Deposit date:2019-08-27
Release date:2020-01-29
Last modified:2023-10-11
Method:ELECTRON CRYSTALLOGRAPHY (2.5 Å)
Cite:Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals
Iucrj, 7, 2020
7RSP
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BU of 7rsp by Molmil
Structure of the VPS34 kinase domain with compound 14
Descriptor: (7R,8R)-2-[(3R)-3-methylmorpholin-4-yl]-7-(propan-2-yl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one, GLYCEROL, Phosphatidylinositol 3-kinase catalytic subunit type 3
Authors:Hu, D.X, Patel, S, Chen, H, Wang, S, Staben, S, Dimitrova, Y.N, Wallweber, H.A, Lee, J.Y, Chan, G.K.Y, Sneeringer, C.J, Prangley, M.S, Moffat, J.G, Wu, C, Schutt, L.K, Salphati, L, Pang, J, McNamara, E, Huang, H, Chen, Y, Wang, Y, Zhao, W, Lim, J, Murthy, A, Siu, M.
Deposit date:2021-08-11
Release date:2021-11-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors.
J.Med.Chem., 65, 2022
7RSV
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BU of 7rsv by Molmil
Structure of the VPS34 kinase domain with compound 5
Descriptor: (5aS,8aR,9S)-2-[(3R)-3-methylmorpholin-4-yl]-5,5a,6,7,8,8a-hexahydro-4H-cyclopenta[e]pyrazolo[1,5-a]pyrazin-4-one, GLYCEROL, Phosphatidylinositol 3-kinase catalytic subunit type 3, ...
Authors:Hu, D.X, Patel, S, Chen, H, Wang, S, Staben, S, Dimitrova, Y.N, Wallweber, H.A, Lee, J.Y, Chan, G.K.Y, Sneeringer, C.J, Prangley, M.S, Moffat, J.G, Wu, C, Schutt, L.K, Salphati, L, Pang, J, McNamara, E, Huang, H, Chen, Y, Wang, Y, Zhao, W, Lim, J, Murthy, A, Siu, M.
Deposit date:2021-08-11
Release date:2021-11-24
Last modified:2022-09-14
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors.
J.Med.Chem., 65, 2022
7RSJ
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BU of 7rsj by Molmil
Structure of the VPS34 kinase domain with compound 14
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, N-{4-[(7R,8R)-4-oxo-7-(propan-2-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl]pyridin-2-yl}cyclopropanecarboxamide, ...
Authors:Hu, D.X, Patel, S, Chen, H, Wang, S, Staben, S, Dimitrova, Y.N, Wallweber, H.A, Lee, J.Y, Chan, G.K.Y, Sneeringer, C.J, Prangley, M.S, Moffat, J.G, Wu, C, Schutt, L.K, Salphati, L, Pang, J, McNamara, E, Huang, H, Chen, Y, Wang, Y, Zhao, W, Lim, J, Murthy, A, Siu, M.
Deposit date:2021-08-11
Release date:2021-11-24
Last modified:2022-09-14
Method:X-RAY DIFFRACTION (1.881 Å)
Cite:Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors.
J.Med.Chem., 65, 2022
4EJS
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BU of 4ejs by Molmil
Structure of yeast elongator subcomplex Elp456
Descriptor: Elongator complex protein 4, Elongator complex protein 5, Elongator complex protein 6
Authors:Lin, Z, Zhao, W, Long, J, Shen, Y.
Deposit date:2012-04-07
Release date:2012-05-02
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.606 Å)
Cite:Crystal structure of elongator subcomplex Elp4-6
J.Biol.Chem., 287, 2012
1YOP
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BU of 1yop by Molmil
The solution structure of Kti11p
Descriptor: Kti11p, ZINC ION
Authors:Sun, J, Zhang, J, Wu, F, Xu, C, Li, S, Zhao, W, Wu, Z, Wu, J, Zhou, C.-Z, Shi, Y.
Deposit date:2005-01-28
Release date:2005-04-05
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of Kti11p from Saccharomyces cerevisiae reveals a novel zinc-binding module.
Biochemistry, 44, 2005

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