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1JIA
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BU of 1jia by Molmil
STRUCTURE OF A BASIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS AT 2.13A RESOLUTION
Descriptor: CALCIUM ION, PHOSPHOLIPASE A2
Authors:Zhao, K, Lin, Z.
Deposit date:1997-06-09
Release date:1998-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structure of a basic phospholipase A2 from Agkistrodon halys Pallas at 2.13 A resolution.
Acta Crystallogr.,Sect.D, 54, 1998
1HU8
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BU of 1hu8 by Molmil
CRYSTAL STRUCTURE OF THE MOUSE P53 CORE DNA-BINDING DOMAIN AT 2.7A RESOLUTION
Descriptor: CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Zhao, K, Chai, X, Johnston, K, Clements, A, Marmorstein, R.
Deposit date:2001-01-04
Release date:2001-07-04
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the mouse p53 core DNA-binding domain at 2.7 A resolution.
J.Biol.Chem., 276, 2001
1SZD
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BU of 1szd by Molmil
Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2 histone/protein deacetylases
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, CHLORIDE ION, GLYCEROL, ...
Authors:Zhao, K, Harshaw, R, Chai, X, Marmorstein, R.
Deposit date:2004-04-05
Release date:2004-06-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases.
Proc.Natl.Acad.Sci.Usa, 101, 2004
1SZC
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BU of 1szc by Molmil
Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2 histone/protein deacetylases
Descriptor: CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, CHLORIDE ION, GLYCEROL, ...
Authors:Zhao, K, Harshaw, R, Chai, X, Marmorstein, R.
Deposit date:2004-04-05
Release date:2004-06-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases.
Proc.Natl.Acad.Sci.Usa, 101, 2004
1NFJ
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BU of 1nfj by Molmil
Structure of a Sir2 substrate, alba, reveals a mechanism for deactylation-induced enhancement of DNA-binding
Descriptor: conserved hypothetical protein AF1956
Authors:Zhao, K, Chai, X, Marmorstein, R.
Deposit date:2002-12-15
Release date:2003-08-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a Sir2 substrate, alba, reveals a mechanism for deacetylation-induced enhancement of DNA-binding
J.Biol.Chem., 278, 2003
1NFH
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BU of 1nfh by Molmil
Structure of a Sir2 substrate, alba, reveals a mechanism for deactylation-induced enhancement of DNA-binding
Descriptor: conserved hypothetical protein AF1956
Authors:Zhao, K, Chai, X, Marmorstein, R.
Deposit date:2002-12-15
Release date:2003-08-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of a Sir2 substrate, Alba, reveals a mechanism for deacetylation-induced enhancement of DNA-binding
J.Biol.Chem., 278, 2003
1Q1A
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BU of 1q1a by Molmil
Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and histone peptide
Descriptor: 2'-O-ACETYL ADENOSINE-5-DIPHOSPHORIBOSE, HST2 protein, Histone H4, ...
Authors:Zhao, K, Chai, X, Marmorstein, R.
Deposit date:2003-07-18
Release date:2003-11-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-Acetyl ADP ribose and histone peptide.
Structure, 11, 2003
1Q17
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BU of 1q17 by Molmil
Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and histone peptide
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, CHLORIDE ION, HST2 protein, ...
Authors:Zhao, K, Chai, X, Marmorstein, R.
Deposit date:2003-07-18
Release date:2003-11-18
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the Yeast Hst2 Protein Deacetylase in Ternary Complex with 2'-O-Acetyl ADP Ribose and Histone Peptide.
Structure, 11, 2003
1Q14
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BU of 1q14 by Molmil
Structure and autoregulation of the yeast Hst2 homolog of Sir2
Descriptor: CHLORIDE ION, HST2 protein, ZINC ION
Authors:Zhao, K, Chai, X, Clements, A, Marmorstein, R.
Deposit date:2003-07-18
Release date:2003-09-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and autoregulation of the Yeast Hst2 homolog of Sir2
Nat.Struct.Biol., 10, 2003
1S5P
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BU of 1s5p by Molmil
Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Eschericia coli.
Descriptor: HISTONE H4 (RESIDUES 12-19), NAD-dependent deacetylase, ZINC ION
Authors:Zhao, K, Chai, X, Marmorstein, R.
Deposit date:2004-01-21
Release date:2004-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structure and Substrate Binding Properties of cobB, a Sir2 Homolog Protein Deacetylase from Eschericia coli.
J.Mol.Biol., 337, 2004
6LO2
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BU of 6lo2 by Molmil
Crystal structure of EED in complex with EZH2 peptide and compound 11#
Descriptor: 8-[4-[(dimethylamino)methyl]phenyl]-N-[(2-methoxyphenyl)methyl]-[1,2,4]triazolo[4,3-a]pyridin-5-amine, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED
Authors:Zhao, K, Zhao, M, Luo, X, Zhang, H, Chen, Z.
Deposit date:2020-01-02
Release date:2021-07-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structure of EED in complex with EZH2 peptide and cmpd20
To Be Published
7QK4
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BU of 7qk4 by Molmil
EED in complex with PRC2 allosteric inhibitor compound 22 (MAK683)
Descriptor: CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ...
Authors:Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C.
Deposit date:2021-12-17
Release date:2022-04-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.602 Å)
Cite:Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J.Med.Chem., 65, 2022
7QJG
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BU of 7qjg by Molmil
EED in complex with PRC2 allosteric inhibitor compound 6
Descriptor: CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-(2,3-dihydro-1-benzofuran-7-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ...
Authors:Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C.
Deposit date:2021-12-16
Release date:2022-04-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J.Med.Chem., 65, 2022
7QJU
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BU of 7qju by Molmil
EED in complex with PRC2 allosteric inhibitor compound 7
Descriptor: CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ...
Authors:Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C.
Deposit date:2021-12-17
Release date:2022-04-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J.Med.Chem., 65, 2022
5H19
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BU of 5h19 by Molmil
EED in complex with PRC2 allosteric inhibitor EED162
Descriptor: 5-(furan-2-ylmethylamino)-9-(phenylmethyl)-8,10-dihydro-7H-[1,2,4]triazolo[3,4-a][2,7]naphthyridine-6-carbonitrile, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED
Authors:Zhao, K, Zhao, M, Luo, X, Zhang, H.
Deposit date:2016-10-08
Release date:2017-01-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
5H14
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BU of 5h14 by Molmil
EED in complex with an allosteric PRC2 inhibitor EED666
Descriptor: 2-[3-(3,5-dimethylpyrazol-1-yl)-4-nitro-phenyl]-3,4-dihydro-1H-isoquinoline, GLYCEROL, Histone-lysine N-methyltransferase EZH2, ...
Authors:Zhao, K, Zhao, M, Luo, X, Zhang, H.
Deposit date:2016-10-08
Release date:2017-01-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
5H25
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BU of 5h25 by Molmil
EED in complex with PRC2 allosteric inhibitor compound 11
Descriptor: 5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED
Authors:Zhao, K, Zhao, M, Luo, X, Zhang, H.
Deposit date:2016-10-14
Release date:2017-01-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
5H15
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BU of 5h15 by Molmil
EED in complex with PRC2 allosteric inhibitor EED709
Descriptor: (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED
Authors:Zhao, K, Zhao, M, Luo, X, Zhang, H.
Deposit date:2016-10-08
Release date:2017-01-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
5H24
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BU of 5h24 by Molmil
EED in complex with PRC2 allosteric inhibitor compound 8
Descriptor: 5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED
Authors:Zhao, K, Zhao, M, Luo, X, Zhang, H.
Deposit date:2016-10-14
Release date:2017-01-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
5GSA
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BU of 5gsa by Molmil
EED in complex with an allosteric PRC2 inhibitor
Descriptor: Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, Polycomb protein EED
Authors:Zhao, K, Zhao, M, Luo, X, Zhang, H.
Deposit date:2016-08-15
Release date:2017-02-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of
Nat. Chem. Biol., 13, 2017
5H13
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BU of 5h13 by Molmil
EED in complex with PRC2 allosteric inhibitor EED396
Descriptor: 4-azanylidene-2-(3-methoxy-4-propan-2-yloxy-phenyl)-6,7-dihydro-[1,3]benzodioxolo[6,5-a]quinolizine-3-carbonitrile, GLYCEROL, PRASEODYMIUM ION, ...
Authors:Zhao, K, Zhao, M, Luo, X, Zhang, H.
Deposit date:2016-10-08
Release date:2017-01-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
5H17
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BU of 5h17 by Molmil
EED in complex with PRC2 allosteric inhibitor EED210
Descriptor: (3R,4aS,10aS)-6-methoxy-3-[(3-methoxyphenyl)methyl]-1-methyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinoline, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED
Authors:Zhao, K, Zhao, M, Luo, X, Zhang, H.
Deposit date:2016-10-08
Release date:2017-01-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
3TG5
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BU of 3tg5 by Molmil
Structure of SMYD2 in complex with p53 and SAH
Descriptor: Cellular tumor antigen p53, GLYCEROL, N-lysine methyltransferase SMYD2, ...
Authors:Zhao, K, Wang, L.
Deposit date:2011-08-17
Release date:2011-08-31
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of human SMYD2 reveals the basis of p53 tumor suppressor methylation
J.Biol.Chem., 2011
3TG4
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BU of 3tg4 by Molmil
Structure of SMYD2 in complex with SAM
Descriptor: GLYCEROL, N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ...
Authors:Zhao, K, Wang, L.
Deposit date:2011-08-17
Release date:2011-08-31
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of human SMYD2 reveals the basis of p53 tumor suppressor methylation
J.Biol.Chem., 2011
6L1T
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BU of 6l1t by Molmil
Cryo-EM structure of phosphorylated Tyr39 a-synuclein amyloid fibril
Descriptor: Alpha-synuclein
Authors:Liu, C, Li, Y.M, Zhao, K, Lim, Y.J, Liu, Z.Y.
Deposit date:2019-09-30
Release date:2020-08-12
Last modified:2020-09-02
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Parkinson's disease-related phosphorylation at Tyr39 rearranges alpha-synuclein amyloid fibril structure revealed by cryo-EM.
Proc.Natl.Acad.Sci.USA, 117, 2020

 

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