Author results

3JBL
  • Download 3jbl
  • View 3jbl
Molmil generated image of 3jbl
CRYO-EM STRUCTURE OF THE ACTIVATED NAIP2/NLRC4 INFLAMMASOME REVEALS NUCLEATED POLYMERIZATION
分子名称:NLR family CARD domain-containing protein 4
著者Zhang, L., Chen, S., Ruan, J., Wu, J., Tong, A.B., Yin, Q., Li, Y., David, L., Lu, A., Wang, W.L., Marks, C., Ouyang, Q., Zhang, X., Mao, Y., Wu, H.
登録日2015-09-05
公開日2015-10-21
最終更新日2018-07-18
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.
Science, 350, 2015
4ZJB
  • Download 4zjb
  • View 4zjb
Molmil generated image of 4zjb
CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE(FABZ) IN COMPLEX WITH HOLO-ACP FROM HELICOBACTER PYLORI
分子名称:3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, Acyl carrier protein, CITRIC ACID, ...
著者Zhang, L., Zhang, L., Shen, X., Jiang, H.
登録日2015-04-29
公開日2016-11-02
最終更新日2018-06-20
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis.
Cell Res., 26, 2016
5H9G
  • Download 5h9g
  • View 5h9g
Molmil generated image of 5h9g
APO-ACP FROM HELICOBACTER PYLORI
分子名称:Acyl carrier protein
著者Zhang, L., Zhang, L., Shen, X., Jiang, H.
登録日2015-12-28
公開日2016-12-28
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献apo-ACP from Helicobacter pylori
To Be Published
5H9H
  • Download 5h9h
  • View 5h9h
Molmil generated image of 5h9h
HOLO ACYL CARRIER PROTEIN (HOLO-ACP) FROM HELICOBACTER PYLORI
分子名称:Acyl carrier protein
著者Zhang, L., Zhang, L., Shen, X., Jiang, H.
登録日2015-12-28
公開日2016-12-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献holo acyl carrier protein (holo-ACP) from Helicobacter pylori
To Be Published
3CF8
  • Download 3cf8
  • View 3cf8
Molmil generated image of 3cf8
CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH QUERCETIN
分子名称:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
著者Zhang, L., Wu, D., Liu, W., Shen, X., Jiang, H.
登録日2008-03-03
公開日2008-12-09
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay
Protein Sci., 17, 2008
3CF9
  • Download 3cf9
  • View 3cf9
Molmil generated image of 3cf9
CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH APIGENIN
分子名称:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, ...
著者Zhang, L., Wu, D., Liu, W., Shen, X., Jiang, H.
登録日2008-03-03
公開日2008-12-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay
Protein Sci., 17, 2008
3D04
  • Download 3d04
  • View 3d04
Molmil generated image of 3d04
CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH SAKURANETIN
分子名称:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
著者Zhang, L., Kong, Y., Wu, D., Shen, X., Jiang, H.
登録日2008-05-01
公開日2008-12-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay
Protein Sci., 17, 2008
4I5X
  • Download 4i5x
  • View 4i5x
Molmil generated image of 4i5x
CRYSTAL STRUCTURE OF AKR1B10 COMPLEXED WITH NADP+ AND FLUFENAMIC ACID
分子名称:Aldo-keto reductase family 1 member B10, 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Zhang, L., Zheng, X., Chen, S., Zhai, J., Zhang, H., Zhao, Y.
登録日2012-11-29
公開日2013-10-23
最終更新日2013-12-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111)
Febs Lett., 587, 2013
4JIH
  • Download 4jih
  • View 4jih
Molmil generated image of 4jih
CRYSTAL STRUCTURE OF AKR1B10 COMPLEXED WITH NADP+ AND EPALRESTAT
分子名称:Aldo-keto reductase family 1 member B10, {5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Zhang, L., Zheng, X., Zhang, H., Zhao, Y., Chen, K., Zhai, J., Hu, X., Structural Genomics Consortium (SGC)
登録日2013-03-06
公開日2013-10-23
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111).
Febs Lett., 587, 2013
4JII
  • Download 4jii
  • View 4jii
Molmil generated image of 4jii
CRYSTAL STRUCTURE OF AKR1B10 COMPLEXED WITH NADP+ AND ZOPOLRESTAT
分子名称:Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, ...
著者Zhang, L., Zheng, X., Zhang, H., Zhao, Y., Chen, K., Zhai, J., Hu, X., Structural Genomics Consortium (SGC)
登録日2013-03-06
公開日2013-10-23
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111).
Febs Lett., 587, 2013
4JIR
  • Download 4jir
  • View 4jir
Molmil generated image of 4jir
CRYSTAL STRUCTURE OF ALDOSE REDUCTASE (AKR1B1) COMPLEXED WITH NADP+ AND EPALRESTAT
分子名称:Aldose reductase, {5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid, SULFATE ION, ...
著者Zhang, L., Zheng, X., Zhang, H., Zhao, Y., Chen, K., Zhai, J., Hu, X.
登録日2013-03-06
公開日2013-10-23
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111).
Febs Lett., 587, 2013
5ZB9
  • Download 5zb9
  • View 5zb9
Molmil generated image of 5zb9
CRYSTAL STRUCTURE OF RTT109 FROM ASPERGILLUS FUMIGATUS
分子名称:DNA damage response protein Rtt109, putative, GLYCEROL
著者Zhang, L., Serra-Cardona, A., Zhou, H., Wang, M., Yang, N., Zhang, Z., Xu, R.M.
登録日2018-02-10
公開日2018-07-25
最終更新日2018-08-22
実験手法X-RAY DIFFRACTION (2.502 Å)
主引用文献Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109.
Cell, 174, 2018
5ZBA
  • Download 5zba
  • View 5zba
Molmil generated image of 5zba
CRYSTAL STRUCTURE OF RTT109-ASF1-H3-H4-COA COMPLEX
分子名称:DNA damage response protein Rtt109, putative, Histone chaperone asf1, ...
著者Zhang, L., Serra-Cardona, A., Zhou, H., Wang, M., Yang, N., Zhang, Z., Xu, R.M.
登録日2018-02-10
公開日2018-07-25
最終更新日2018-08-22
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109.
Cell, 174, 2018
5ZBB
  • Download 5zbb
  • View 5zbb
Molmil generated image of 5zbb
CRYSTAL STRUCTURE OF RTT109-ASF1-H3-H4 COMPLEX
分子名称:DNA damage response protein Rtt109, putative, Histone chaperone asf1, ...
著者Zhang, L., Serra-Cardona, A., Zhou, H., Wang, M., Yang, N., Zhang, Z., Xu, R.M.
登録日2018-02-10
公開日2018-07-25
最終更新日2018-08-22
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109.
Cell, 174, 2018
3QAE
  • Download 3qae
  • View 3qae
Molmil generated image of 3qae
3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE OF STREPTOCOCCUS PNEUMONIAE
分子名称:3-hydroxy-3-methylglutaryl-coenzyme a reductase, CITRIC ACID, GLYCEROL, ...
著者Zhang, L., Feng, L., Zhou, L., Gui, J., Wan, J.
登録日2011-01-10
公開日2011-01-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献3-hydroxy-3-methylglutaryl-coenzyme A reductase of Streptococcus pneumoniae
To be Published
3QAU
  • Download 3qau
  • View 3qau
Molmil generated image of 3qau
3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE FROM STREPTOCOCCUS PNEUMONIAE
分子名称:3-hydroxy-3-methylglutaryl-coenzyme a reductase, GLYCEROL, SULFATE ION, ...
著者Zhang, L., Feng, L., Zhou, L., Gui, J., Wan, J.
登録日2011-01-11
公開日2011-01-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献3-Hydroxy-3-MethylGlutaryl-Coenzyme A Reductase from Streptococcus pneumoniae
To be Published
3R21
  • Download 3r21
  • View 3r21
Molmil generated image of 3r21
DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF PYRAZOLOPYRIDINE-SULFONAMIDES AS POTENT MULTIPLE-MITOTIC KINASE (MMK) INHIBITORS (PART I)
分子名称:Serine/threonine-protein kinase 6, N-(2-aminoethyl)-N-{5-[(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]pyridin-2-yl}methanesulfonamide, MAGNESIUM ION
著者Zhang, L., Fan, J., Chong, J.-H., Cesena, A., Tam, B., Gilson, C., Boykin, C., Wang, D., Marcotte, D., Le Brazidec, J.-Y., Aivazian, D., Piao, J., Lundgren, K., Hong, K., Vu, K., Nguyen, K.
登録日2011-03-11
公開日2011-08-10
最終更新日2012-02-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).
Bioorg.Med.Chem.Lett., 21, 2011
3R22
  • Download 3r22
  • View 3r22
Molmil generated image of 3r22
DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF PYRAZOLOPYRIDINE-SULFONAMIDES AS POTENT MULTIPLE-MITOTIC KINASE (MMK) INHIBITORS (PART I)
分子名称:Serine/threonine-protein kinase 6, N-{5-[(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]pyridin-2-yl}methanesulfonamide
著者Zhang, L., Fan, J., Chong, J.-H., Cesana, A., Tam, B., Gilson, C., Boykin, C., Wang, D., Marcotte, D., Le Brazidec, J.-Y., Aivazian, D., Piao, J., Lundgren, K., Hong, K., Vu, K., Nguyen, K.
登録日2011-03-11
公開日2011-08-10
最終更新日2012-02-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).
Bioorg.Med.Chem.Lett., 21, 2011
4GQG
  • Download 4gqg
  • View 4gqg
Molmil generated image of 4gqg
CRYSTAL STRUCTURE OF AKR1B10 COMPLEXED WITH NADP+
分子名称:Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Zhang, L., Zheng, X., Chen, S., Zhai, J., Hu, X.
登録日2012-08-23
公開日2013-08-28
最終更新日2013-12-11
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111)
Febs Lett., 587, 2013
2GLL
  • Download 2gll
  • View 2gll
Molmil generated image of 2gll
CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE(FABZ) FROM HELICOBACTER PYLORI
分子名称:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE
著者Zhang, L., Liu, W., Shen, X., Jiang, H.
登録日2006-04-05
公開日2007-03-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ).
J.Biol.Chem., 283, 2008
2GLM
  • Download 2glm
  • View 2glm
Molmil generated image of 2glm
CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE(FABZ) FROM HELICOBACTER PYLORI COMPLEXED WITH COMPOUND 2
分子名称:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
著者Zhang, L., Liu, W., Shen, X., Jiang, H.
登録日2006-04-05
公開日2007-03-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ).
J.Biol.Chem., 283, 2008
2GLP
  • Download 2glp
  • View 2glp
Molmil generated image of 2glp
CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE(FABZ) FROM HELICOBACTER PYLORI COMPLEXED WITH COMPOUND 1
分子名称:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
著者Zhang, L., Liu, W., Shen, X., Jiang, H.
登録日2006-04-05
公開日2007-03-13
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ).
J.Biol.Chem., 283, 2008
2GLV
  • Download 2glv
  • View 2glv
Molmil generated image of 2glv
CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE(FABZ) MUTANT(Y100A) FROM HELICOBACTER PYLORI
分子名称:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION
著者Zhang, L., Liu, W., Shen, X., Jiang, H.
登録日2006-04-05
公開日2007-03-13
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ).
J.Biol.Chem., 283, 2008
5C1U
  • Download 5c1u
  • View 5c1u
Molmil generated image of 5c1u
CRYSTAL STRUCTURE OF EV71 3C PROTEINASE IN COMPLEX WITH COMPOUND XB
分子名称:3C proteinase, Nalpha-{(2E)-3-[4-(dimethylamino)phenyl]prop-2-enoyl}-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide
著者Zhang, L., Huang, G., Cai, Q., Zhao, C., Ren, H., Li, P., Li, N., Chen, S., Li, J., Lin, T.
登録日2015-06-15
公開日2016-06-01
最終更新日2016-10-26
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71
J.Mol.Recognit., 29, 2016
5C1X
  • Download 5c1x
  • View 5c1x
Molmil generated image of 5c1x
CRYSTAL STRUCTURE OF EV71 3C PROTEINASE IN COMPLEX WITH COMPOUND VIII
分子名称:3C proteinase, Nalpha-[(benzyloxy)carbonyl]-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide
著者Zhang, L., Huang, G., Cai, Q., Zhao, C., Ren, H., Li, P., Li, N., Chen, S., Li, J., Lin, T.
登録日2015-06-15
公開日2016-06-01
最終更新日2016-10-26
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71
J.Mol.Recognit., 29, 2016