Author results

2DHO
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CRYSTAL STRUCTURE OF HUMAN IPP ISOMERASE I IN SPACE GROUP P212121
Descriptor:Isopentenyl-diphosphate delta-isomerase 1, MANGANESE (II) ION, SODIUM ION, ...
Authors:Zhang, C., Wei, Z., Gong, W.
Deposit date:2006-03-24
Release date:2007-06-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of human IPP isomerase: new insights into the catalytic mechanism
J.Mol.Biol., 366, 2007
2I6K
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CRYSTAL STRUCTURE OF HUMAN TYPE I IPP ISOMERASE COMPLEXED WITH A SUBSTRATE ANALOG
Descriptor:Isopentenyl-diphosphate delta-isomerase 1, MANGANESE (II) ION, MAGNESIUM ION, ...
Authors:Zhang, C., Wei, Z., Gong, W.
Deposit date:2006-08-29
Release date:2007-06-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of human IPP isomerase: new insights into the catalytic mechanism
J.Mol.Biol., 366, 2007
3VW7
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CRYSTAL STRUCTURE OF HUMAN PROTEASE-ACTIVATED RECEPTOR 1 (PAR1) BOUND WITH ANTAGONIST VORAPAXAR AT 2.2 ANGSTROM
Descriptor:Proteinase-activated receptor 1, Lysozyme, ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate, ...
Authors:Zhang, C., Srinivasan, Y., Arlow, D.H., Fung, J.J., Palmer, D., Zheng, Y., Green, H.F., Pandey, A., Dror, R.O., Shaw, D.E., Weis, W.I., Coughlin, S.R., Kobilka, B.K.
Deposit date:2012-08-07
Release date:2012-12-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:High-resolution crystal structure of human protease-activated receptor 1
Nature, 492, 2012
4NSX
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CRYSTAL STRUCTURE OF THE UTP21 TANDEM WD DOMAIN
Descriptor:U3 small nucleolar RNA-associated protein 21, CITRATE ANION
Authors:Zhang, C., Ye, K.
Deposit date:2013-11-29
Release date:2014-02-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of Utp21 Tandem WD Domain Provides Insight into the Organization of the UTPB Complex Involved in Ribosome Synthesis
Plos One, 9, 2014
5BOA
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CRYSTAL STRUCTURE OF THE MENINGITIS PATHOGEN STREPTOCOCCUS SUIS ADHESION FHB BOUND TO THE DISACCHARIDE RECEPTOR GB2
Descriptor:Translation initiation factor 2 (IF-2 GTPase), ALPHA D-GALACTOSE, BETA-D-GALACTOSE
Authors:Zhang, C., Yu, Y., Yang, M., Jiang, Y.
Deposit date:2015-05-27
Release date:2016-05-04
Method:X-RAY DIFFRACTION (2.708 Å)
Cite:Structural basis of the interaction between the meningitis pathogen Streptococcus suis adhesin Fhb and its human receptor.
Febs Lett., 590, 2016
5GOZ
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CRYSTAL STRUCTURE OF ZIKV NS5 METHYLTRANSFERASE IN COMPLEX WITH GTP AND SAH
Descriptor:RNA-directed RNA polymerase NS5, GUANOSINE-5'-TRIPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Zhang, C., Jin, T.
Deposit date:2016-07-30
Release date:2016-12-07
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.049 Å)
Cite:Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design
Biochem. Biophys. Res. Commun., 492, 2017
5GP1
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CRYSTAL STRUCTURE OF ZIKV NS5 METHYLTRANSFERASE IN COMPLEX WITH GTP AND SAH
Descriptor:RNA-directed RNA polymerase NS5, SULFATE ION, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, ...
Authors:Zhang, C., Jin, T.
Deposit date:2016-07-30
Release date:2016-12-07
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.444 Å)
Cite:Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design
Biochem. Biophys. Res. Commun., 492, 2017
5IC7
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STRUCTURE OF THE WD DOMAIN OF UTP18
Descriptor:Putative uncharacterized protein, SULFATE ION
Authors:Zhang, C., Ye, K.
Deposit date:2016-02-22
Release date:2016-07-06
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (2.331 Å)
Cite:Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits
Nucleic Acids Res., 44, 2016
5IC8
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STRUCTURE OF UTP6
Descriptor:Putative uncharacterized protein
Authors:Zhang, C., Ye, K.
Deposit date:2016-02-23
Release date:2016-07-06
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits
Nucleic Acids Res., 44, 2016
5IC9
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STRUCTURE OF THE CTD COMPLEX OF UTP12 AND UTP13
Descriptor:Putative uncharacterized protein
Authors:Zhang, C., Ye, K.
Deposit date:2016-02-23
Release date:2016-07-06
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits
Nucleic Acids Res., 44, 2016
5ICA
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STRUCTURE OF THE CTD COMPLEX OF UTP12, UTP13, UTP1 AND UTP21
Descriptor:Putative uncharacterized protein, Putative U3 snoRNP protein, Periodic tryptophan protein 2-like protein
Authors:Zhang, C., Ye, K.
Deposit date:2016-02-23
Release date:2016-07-06
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (3.507 Å)
Cite:Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits
Nucleic Acids Res., 44, 2016
6E9E
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ESCAS13D-CRRNA BINARY COMPLEX
Descriptor:crRNA (52-MER), EsCas13d, MAGNESIUM ION
Authors:Zhang, C., Lyumkis, D.
Deposit date:2018-08-01
Release date:2018-10-03
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d.
Cell, 175, 2018
6E9F
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ESCAS13D-CRRNA-TARGET RNA TERNARY COMPLEX
Descriptor:EsCas13d, crRNA (52-MER), RNA (27-MER), ...
Authors:Zhang, C., Lyumkis, D.
Deposit date:2018-08-01
Release date:2018-10-03
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d.
Cell, 175, 2018
4HVS
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CRYSTAL STRUCTURE OF KIT KINASE DOMAIN WITH A SMALL MOLECULE INHIBITOR, PLX647
Descriptor:Mast/stem cell growth factor receptor Kit, 5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[4-(trifluoromethyl)benzyl]pyridin-2-amine
Authors:Zhang, Y., Zhang, C.
Deposit date:2012-11-06
Release date:2013-03-27
Last modified:2013-04-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HW7
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CRYSTAL STRUCTURE OF FMS KINASE DOMAIN WITH A SMALL MOLECULAR INHIBITOR, PLX647-OME
Descriptor:Macrophage colony-stimulating factor 1 receptor, 5-[(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[4-(trifluoromethyl)benzyl]pyridin-2-amine
Authors:Zhang, Y., Zhang, C.
Deposit date:2012-11-07
Release date:2013-03-27
Last modified:2013-04-17
Method:X-RAY DIFFRACTION (2.9001 Å)
Cite:Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.
Proc.Natl.Acad.Sci.USA, 110, 2013
4XV1
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B-RAF KINASE V600E ONCOGENIC MUTANT IN COMPLEX WITH PLX7904
Descriptor:Serine/threonine-protein kinase B-raf, N'-(3-{[5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)-N-ethyl-N-methylsulfuric diamide
Authors:Zhang, Y., Zhang, C.
Deposit date:2015-01-26
Release date:2015-10-28
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature, 526, 2015
4XV2
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B-RAF KINASE V600E ONCOGENIC MUTANT IN COMPLEX WITH DABRAFENIB
Descriptor:Serine/threonine-protein kinase B-raf, Dabrafenib
Authors:zhang, Y., zhang, c.
Deposit date:2015-01-26
Release date:2015-10-28
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature, 526, 2015
4XV3
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B-RAF KINASE V600E ONCOGENIC MUTANT IN COMPLEX WITH PLX7922
Descriptor:Serine/threonine-protein kinase B-raf, N'-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-N-ethyl-N-methylsulfuric diamide
Authors:Zhang, Y., Zhang, C.
Deposit date:2015-01-26
Release date:2015-10-28
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature, 526, 2015
4XV9
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B-RAF KINASE DOMAIN IN COMPLEX WITH PLX5568
Descriptor:Serine/threonine-protein kinase B-raf, N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}-4-(trifluoromethyl)benzenesulfonamide, SULFATE ION
Authors:zhang, Y., zhang, c., wang, w.
Deposit date:2015-01-26
Release date:2015-10-28
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature, 526, 2015
4RL5
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CRYSTAL STRUCTURE OF THE ARABIDOPSIS EXOCYST SUBUNIT EXO70 FAMILY PROTEIN A1
Descriptor:Exocyst complex component EXO70A1
Authors:Zhang, Z.-M., Zhang, C., Song, J.
Deposit date:2014-10-15
Release date:2015-11-25
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5FBH
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN CALCIUM SENSING RECEPTOR WITH BOUND GD3+
Descriptor:Extracellular calcium-sensing receptor, GADOLINIUM ION, MAGNESIUM ION, ...
Authors:Zhang, T., Zhang, C., Miller, C.L., Zou, J., Moremen, K.W., Brown, E.M., Yang, J.J., Hu, J.
Deposit date:2015-12-14
Release date:2016-06-22
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist.
Sci Adv, 2, 2016
5FBK
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN CALCIUM SENSING RECEPTOR
Descriptor:Extracellular calcium-sensing receptor, CYCLOMETHYLTRYPTOPHAN, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Zhang, T., Zhang, C., Miller, C.L., Zou, J., Moremen, K.W., Brown, E.M., Yang, J.J., Hu, J.
Deposit date:2015-12-14
Release date:2016-06-22
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist.
Sci Adv, 2, 2016
6NT9
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CRYO-EM STRUCTURE OF THE COMPLEX BETWEEN HUMAN TBK1 AND CHICKEN STING
Descriptor:Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein
Authors:Shang, G., Zhang, C., Chen, Z.J., Bai, X., Zhang, X.
Deposit date:2019-01-28
Release date:2019-03-06
Last modified:2019-04-03
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of STING binding with and phosphorylation by TBK1.
Nature, 567, 2019
6EOA
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CRYSTAL STRUCTURE OF HAL3 FROM CRYPTOCOCCUS NEOFORMANS
Descriptor:Phosphopantothenoylcysteine decarboxylase, FLAVIN MONONUCLEOTIDE
Authors:Reverter, D., Zhang, C., Molero, C., Arino, J.
Deposit date:2017-10-09
Release date:2018-10-31
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Characterization of the atypical Ppz/Hal3 phosphatase system from the pathogenic fungus Cryptococcus neoformans.
Mol.Microbiol., 111, 2019
5BOB
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CRYSTAL STRUCTURE OF THE MENINGITIS PATHOGEN STREPTOCOCCUS SUIS ADHESION FHB
Descriptor:Translation initiation factor 2 (IF-2 GTPase), GLYCEROL
Authors:Jiang, Y., Zhang, C., Yu, Y.
Deposit date:2015-05-27
Release date:2015-11-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Expression, purification, crystallization and structure determination of the N terminal domain of Fhb, a factor H binding protein from Streptococcus suis.
Biochem.Biophys.Res.Commun., 466, 2015