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6AJF
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJG
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH SQ109
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, N-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.604 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJH
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH AU1235
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, 1-(2-adamantyl)-3-[2,3,4-tris(fluoranyl)phenyl]urea, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside, ...
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.818 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJI
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH RIMONABANT
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside, ...
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJJ
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH ICA38
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside, ...
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.794 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6A5F
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THE STRUCTURE OF [4+2] AND [6+4] CYCLASE IN THE BIOSYNTHETIC PATHWAY OF NARGENICIN
Descriptor:NgnD
Authors:Zhang, B., Ge, H.M.
Deposit date:2018-06-23
Release date:2019-02-06
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products.
Nature, 568, 2019
6A5G
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THE STRUCTURE OF [4+2] AND [6+4] CYCLASE IN THE BIOSYNTHETIC PATHWAY OF STREPTOSEOMYCIN
Descriptor:[4+2] and [4+6] cyclase StmD
Authors:Zhang, B., Ge, H.M.
Deposit date:2018-06-23
Release date:2019-02-06
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products.
Nature, 568, 2019
6A5H
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THE STRUCTURE OF [4+2] AND [6+4] CYCLASE IN THE BIOSYNTHETIC PATHWAY OF UNIDENTIFIED NATURAL PRODUCT
Descriptor:101015D
Authors:Zhang, B., Ge, H.M.
Deposit date:2018-06-23
Release date:2019-02-06
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (1.618 Å)
Cite:Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products.
Nature, 568, 2019
3VBC
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CRYSTAL STRUCTURE OF IL-17 RECEPTOR B SEFIR DOMAIN
Descriptor:Interleukin-17 receptor B
Authors:Zhang, B., Liu, C., Li, X., Deng, J.
Deposit date:2012-01-02
Release date:2013-02-06
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of IL-17 Receptor B SEFIR Domain.
J.Immunol., 190, 2013
4L1W
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CRYSTAL STRUCTUER OF HUMAN 3-ALPHA HYDROXYSTEROID DEHYDROGENASE TYPE 3 IN COMPLEX WITH NADP+ AND PROGESTERONE
Descriptor:Aldo-keto reductase family 1 member C2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROGESTERONE, ...
Authors:Zhang, B., Hu, X.-J., Lin, S.-X.
Deposit date:2013-06-03
Release date:2014-04-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Human 3-alpha hydroxysteroid dehydrogenase type 3 (3 alpha-HSD3): The V54L mutation restricting the steroid alternative binding and enhancing the 20 alpha-HSD activity
J.Steroid Biochem.Mol.Biol., 141, 2014
4L1X
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CRYSTAL STRUCTUER OF HUMAN 3-ALPHA HYDROXYSTEROID DEHYDROGENASE TYPE 3 V54L MUTANT IN COMPLEX WITH NADP+ AND PROGESTERONE
Descriptor:Aldo-keto reductase family 1 member C2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROGESTERONE, ...
Authors:Zhang, B., Hu, X.-J., Lin, S.-X.
Deposit date:2013-06-03
Release date:2014-04-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human 3-alpha hydroxysteroid dehydrogenase type 3 (3 alpha-HSD3): The V54L mutation restricting the steroid alternative binding and enhancing the 20 alpha-HSD activity
J.Steroid Biochem.Mol.Biol., 141, 2014
4NUX
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STRUCTURE OF RECEPTOR A
Descriptor:Interleukin-17 receptor A
Authors:Zhang, B., Han, Y., Deng, J.
Deposit date:2013-12-04
Release date:2014-05-14
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2.295 Å)
Cite:Structure of the unique SEFIR domain from human interleukin 17 receptor A reveals a composite ligand-binding site containing a conserved alpha-helix for Act1 binding and IL-17 signaling.
Acta Crystallogr.,Sect.D, 70, 2014
4XO6
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CRYSTAL STRUCTURE OF HUMAN 3-ALPHA HYDROXYSTEROID DEHYDROGENASE TYPE 3 IN COMPLEX WITH NADP+, 5ALPHA-ANDROSTAN-3,17-DIONE AND (3BETA, 5ALPHA)-3-HYDROXYANDROSTAN-17-ONE
Descriptor:Aldo-keto reductase family 1 member C2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5ALPHA-ANDROSTAN-3,17-DIONE, ...
Authors:Zhang, B., Hu, X.-J., Lin, S.-X.
Deposit date:2015-01-16
Release date:2016-02-17
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Human 3 alpha-hydroxysteroid dehydrogenase type 3: structural clues of 5 alpha-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth.
Biochem.J., 473, 2016
4XO7
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CRYSTAL STRUCTURE OF HUMAN 3-ALPHA HYDROXYSTEROID DEHYDROGENASE TYPE 3 IN COMPLEX WITH NADP+, 5ALPHA-ANDROSTAN-3,17-DIONE AND (3BETA, 5ALPHA)-3-HYDROXYANDROSTAN-17-ONE
Descriptor:Aldo-keto reductase family 1 member C2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-ANDROSTENE-3-17-DIONE, ...
Authors:Zhang, B., Hu, X.-J., Lin, S.-X.
Deposit date:2015-01-16
Release date:2016-02-17
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Human 3 alpha-hydroxysteroid dehydrogenase type 3: structural clues of 5 alpha-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth.
Biochem.J., 473, 2016
1L3Q
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H. RUFESCENS ABALONE SHELL LUSTRIN A CONSENSUS REPEAT, FPGKNVNCTSGE, PH 7.4, 1-H NMR STRUCTURE
Descriptor:Lustrin A
Authors:Evans, J.S., Wustman, B.A., Zhang, B., Morse, D.E.
Deposit date:2002-02-28
Release date:2002-03-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Model peptide studies of sequence regions in the elastomeric biomineralization protein, Lustrin A. I. The C-domain consensus-PG-, -NVNCT-motif
Biopolymers, 63, 2002
4IMA
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THE STRUCTURE OF C436M-HLPYK IN COMPLEX WITH CITRATE/MN/ATP/FRU-1,6-BP
Descriptor:Pyruvate kinase, MANGANESE (II) ION, CITRATE ANION, ...
Authors:Zhang, B., Holyoak, T., Fenton, A.W., Tang, Q.L., Prasannan, C.B., Deng, J.P.
Deposit date:2013-01-02
Release date:2013-01-23
Last modified:2013-02-06
Method:X-RAY DIFFRACTION (1.954 Å)
Cite:Energetic Coupling between an Oxidizable Cysteine and the Phosphorylatable N-Terminus of Human Liver Pyruvate Kinase.
Biochemistry, 52, 2013
5TDG
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CRYSTAL STRUCTURE OF PREFUSION-STABILIZED BOVINE RSV F (DS-CAV1 VARIANT: STRAIN ATUE51908)
Descriptor:Fusion glycoprotein F0,Fibritin, N-ACETYL-D-GLUCOSAMINE
Authors:Chen, L., Zhang, B., Kwong, P.D.
Deposit date:2016-09-19
Release date:2017-08-16
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Protection of calves by a prefusion-stabilized bovine RSV F vaccine.
NPJ Vaccines, 2, 2017
5TDL
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CRYSTAL STRUCTURE OF PREFUSION-STABILIZED BOVINE RSV FUSION GLYCOPROTEIN (SINGLE-CHAIN DS2-V1 VARIANT: STRAIN 391-2 SC9 DS-CAV1 Q98C Q361C)
Descriptor:Bovine prefusion RSV F glycoprotein, N-ACETYL-D-GLUCOSAMINE
Authors:Chen, L., Zhang, B., Kwong, P.D.
Deposit date:2016-09-19
Release date:2017-08-16
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Protection of calves by a prefusion-stabilized bovine RSV F vaccine.
NPJ Vaccines, 2, 2017
6A4X
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OXIDASE CHAP-H2
Descriptor:Bleomycin resistance protein, FE (II) ION
Authors:Zhang, B., Wang, Y.S., Ge, H.M.
Deposit date:2018-06-21
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis.
J. Am. Chem. Soc., 140, 2018
6A4Z
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OXIDASE CHAP
Descriptor:ChaP protein, FE (II) ION
Authors:Zhang, B., Ge, H.M.
Deposit date:2018-06-21
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis.
J. Am. Chem. Soc., 140, 2018
6A52
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OXIDASE CHAP-H1
Descriptor:dioxidase ChaP-H1, FE (II) ION
Authors:Zhang, B., Ge, H.M.
Deposit date:2018-06-21
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis.
J. Am. Chem. Soc., 140, 2018
6DF6
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CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR ALPHA IN COMPLEX WITH RECEPTOR DEGRADER 16AB
Descriptor:Estrogen receptor, (8R)-8-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-1,8-dihydro-2H-[1]benzopyrano[4,3-d][1]benzoxepine-5,11-diol, GLYCEROL
Authors:Kiefer, J.R., Vinogradova, M., Liang, J., Zhang, B., Ortwine, D.F., Nettles, K.W., Nwachukwu, J.C.
Deposit date:2018-05-14
Release date:2019-02-20
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha.
Bioorg. Med. Chem. Lett., 29, 2019
6DFN
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CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR ALPHA IN COMPLEX WITH RECEPTOR DEGRADER 16AA
Descriptor:Estrogen receptor, (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, NICKEL (II) ION, ...
Authors:Kiefer, J.R., Vinogradova, M., Liang, J., Zhang, B., Ortwine, D.F., Nettles, K.W., Nwachukwu, J.C.
Deposit date:2018-05-15
Release date:2019-02-20
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha.
Bioorg. Med. Chem. Lett., 29, 2019
5Z9Y
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THIAZOLE SYNTHASE (THIG) COMPLEXED WITH DXP
Descriptor:Thiazole synthase, 1-DEOXY-D-XYLULOSE-5-PHOSPHATE
Authors:Zhang, J., Zhang, B., Zhao, Y., Yang, X., Huang, M., Cui, P., Zhang, W., Li, J., Zhang, Y.
Deposit date:2018-02-05
Release date:2018-04-11
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Snapshots of catalysis: Structure of covalently bound substrate trapped in Mycobacterium tuberculosis thiazole synthase (ThiG).
Biochem. Biophys. Res. Commun., 497, 2018
4H5S
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COMPLEX STRUCTURE OF NECL-2 AND CRTAM
Descriptor:Cytotoxic and regulatory T-cell molecule, Cell adhesion molecule 1
Authors:Zhang, S., Lu, G., Qi, J., Li, Y., Zhang, Z., Zhang, B., Yan, J., Gao, G.F.
Deposit date:2012-09-18
Release date:2013-08-07
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Competition of Cell Adhesion and Immune Recognition: Insights into the Interaction between CRTAM and Nectin-like 2
Structure, 21, 2013