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Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model
Descriptor:	(5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-one, 11-beta-Hydroxysteroid Dehydrogenase 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:	Zhang, J.D, Jordan, S.R, Li, V.
Deposit date:	2008-10-17
Release date:	2008-11-11
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model To be Published, 2008

THREE-DIMENSIONAL STRUCTURE OF HUMAN BASIC FIBROBLAST GROWTH FACTOR, A STRUCTURAL HOMOLOG OF INTERLEUKIN 1BETA
Descriptor:	HEPARIN-BINDING GROWTH FACTOR 2 PRECURSOR, SULFATE ION
Authors:	Zhang, J, Sprang, S.R.
Deposit date:	1991-02-19
Release date:	1992-01-15
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.77 Å)
Cite:	Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta. Proc.Natl.Acad.Sci.USA, 88, 1991

Crystal structure of human Pim-1 kinase in complex with an imidazopyridazine inhibitor.
Descriptor:	Serine/threonine-protein kinase pim-1, ~{N}-[4-[(3~{S})-3-azanylpiperidin-1-yl]pyridin-3-yl]-2-[2,6-bis(fluoranyl)phenyl]imidazo[1,5-b]pyridazin-7-amine
Authors:	Mohr, C.
Deposit date:	2016-07-25
Release date:	2016-11-09
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors. Bioorg. Med. Chem. Lett., 26, 2016