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1BDF
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BU of 1bdf by Molmil
STRUCTURE OF ESCHERICHIA COLI RNA POLYMERASE ALPHA SUBUNIT N-TERMINAL DOMAIN
Descriptor: RNA POLYMERASE ALPHA SUBUNIT
Authors:Zhang, G, Darst, S.A.
Deposit date:1998-05-08
Release date:1999-05-11
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Escherichia coli RNA polymerase alpha subunit amino-terminal domain.
Science, 281, 1998
1AB8
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BU of 1ab8 by Molmil
RAT TYPE II ADENYLYL CYCLASE C2 DOMAIN/FORSKOLIN COMPLEX
Descriptor: ADENYLYL CYCLASE, FORSKOLIN
Authors:Zhang, G, Hurley, J.H.
Deposit date:1997-02-04
Release date:1997-05-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the adenylyl cyclase catalytic core.
Nature, 386, 1997
2LSP
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BU of 2lsp by Molmil
solution structures of BRD4 second bromodomain with NF-kB-K310ac peptide
Descriptor: Bromodomain-containing protein 4, NF-kB-K310ac peptide
Authors:Zhang, G, Liu, R, Zhong, Y, Plotnikov, A.N, Zhang, W, Rusinova, E, Gerona-Nevarro, G, Moshkina, N, Joshua, J, Chuang, P.Y, Ohlmeyer, M, He, J, Zhou, M.-M.
Deposit date:2012-05-03
Release date:2012-07-18
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Down-regulation of NF-kappa B transcriptional activity in HIV-associated kidney disease by BRD4 inhibition.
J.Biol.Chem., 287, 2012
1SWV
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BU of 1swv by Molmil
Crystal structure of the D12A mutant of phosphonoacetaldehyde hydrolase complexed with magnesium
Descriptor: MAGNESIUM ION, phosphonoacetaldehyde hydrolase
Authors:Zhang, G, Morais, M.C, Dai, J, Zhang, W, Dunaway-Mariano, D, Allen, K.N.
Deposit date:2004-03-30
Release date:2004-10-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Investigation of metal ion binding in phosphonoacetaldehyde hydrolase identifies sequence markers for metal-activated enzymes of the HAD enzyme superfamily
Biochemistry, 43, 2004
1SWW
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BU of 1sww by Molmil
Crystal structure of the phosphonoacetaldehyde hydrolase D12A mutant complexed with magnesium and substrate phosphonoacetaldehyde
Descriptor: MAGNESIUM ION, PHOSPHONOACETALDEHYDE, phosphonoacetaldehyde hydrolase
Authors:Zhang, G, Morais, M.C, Dai, J, Zhang, W, Dunaway-Mariano, D, Allen, K.N.
Deposit date:2004-03-30
Release date:2004-10-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Investigation of metal ion binding in phosphonoacetaldehyde hydrolase identifies sequence markers for metal-activated enzymes of the HAD enzyme superfamily
Biochemistry, 43, 2004
1ZOL
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BU of 1zol by Molmil
native beta-PGM
Descriptor: MAGNESIUM ION, beta-phosphoglucomutase
Authors:Zhang, G, Tremblay, L.W, Dai, J, Wang, L, Dunaway-Mariano, D, Allen, K.N.
Deposit date:2005-05-13
Release date:2005-08-30
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Catalytic cycling in beta-phosphoglucomutase: a kinetic and structural analysis
Biochemistry, 44, 2005
1PTR
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BU of 1ptr by Molmil
PROTEIN KINASE C DELTA CYS2 DOMAIN COMPLEXED WITH PHORBOL-13-ACETATE
Descriptor: 13-ACETYLPHORBOL, PROTEIN KINASE C DELTA TYPE, ZINC ION
Authors:Zhang, G, Hurley, J.H.
Deposit date:1995-05-11
Release date:1995-07-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester.
Cell(Cambridge,Mass.), 81, 1995
1PTQ
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BU of 1ptq by Molmil
PROTEIN KINASE C DELTA CYS2 DOMAIN
Descriptor: PROTEIN KINASE C DELTA TYPE, ZINC ION
Authors:Zhang, G, Hurley, J.H.
Deposit date:1995-05-11
Release date:1995-07-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester.
Cell(Cambridge,Mass.), 81, 1995
7F12
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BU of 7f12 by Molmil
A SARS-CoV-2 neutralizing antibody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody, Spike protein S1
Authors:Zhang, G, Li, X, Guo, Y, Wang, Y, Yuan, S.
Deposit date:2021-06-07
Release date:2022-06-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:A SARS-CoV-2 neutralizing antibody
To Be Published
7F0X
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BU of 7f0x by Molmil
A SARS-CoV-2 neutralizing antibody
Descriptor: Antibody, Spike protein S1
Authors:Zhang, G, Li, X, Guo, Y, Wang, Y, Yuan, S.
Deposit date:2021-06-07
Release date:2022-06-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A SARS-CoV-2 neutralizing antibody
To Be Published
7F15
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BU of 7f15 by Molmil
A SARS-CoV-2 neutralizing antibody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody, Spike protein S1
Authors:Zhang, G, Li, X, Guo, Y, Wang, Y, Yuan, S.
Deposit date:2021-06-07
Release date:2022-06-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A SARS-CoV-2 neutralizing antibody
To Be Published
1OQD
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BU of 1oqd by Molmil
Crystal structure of sTALL-1 and BCMA
Descriptor: Tumor necrosis factor ligand superfamily member 13B, soluble form, Tumor necrosis factor receptor superfamily member 17
Authors:Zhang, G.
Deposit date:2003-03-07
Release date:2003-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Ligand-receptor binding revealed by the TNF family member TALL-1.
Nature, 423, 2003
1OQE
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BU of 1oqe by Molmil
Crystal structure of sTALL-1 with BAFF-R
Descriptor: Tumor necrosis factor ligand superfamily member 13B, soluble form, Tumor necrosis factor receptor superfamily member 13C
Authors:Zhang, G.
Deposit date:2003-03-07
Release date:2003-05-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ligand-receptor binding revealed by the TNF family member TALL-1.
Nature, 423, 2003
8IL3
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BU of 8il3 by Molmil
Cryo-EM structure of CD38 in complex with FTL004
Descriptor: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, Heavy chain, Light chain
Authors:Yang, J, Wang, Y, Zhang, G.
Deposit date:2023-03-01
Release date:2023-03-29
Method:ELECTRON MICROSCOPY (3.86 Å)
Cite:FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma.
J Hematol Oncol, 15, 2022
1HSJ
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BU of 1hsj by Molmil
SARR MBP FUSION STRUCTURE
Descriptor: FUSION PROTEIN CONSISTING OF STAPHYLOCOCCUS ACCESSORY REGULATOR PROTEIN R AND MALTOSE BINDING PROTEIN, alpha-D-glucopyranose
Authors:Zhang, G.
Deposit date:2000-12-26
Release date:2001-06-06
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the SarR protein from Staphylococcus aureus.
Proc.Natl.Acad.Sci.USA, 98, 2001
2P5B
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BU of 2p5b by Molmil
The complex structure of JMJD2A and trimethylated H3K36 peptide
Descriptor: FE (II) ION, Histone H3, JmjC domain-containing histone demethylation protein 3A, ...
Authors:Zhang, G, Chen, Z, Zang, J, Hong, X, Shi, Y.
Deposit date:2007-03-14
Release date:2007-06-12
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural basis of the recognition of a methylated histone tail by JMJD2A.
Proc.Natl.Acad.Sci.USA, 104, 2007
7CJF
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BU of 7cjf by Molmil
Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody heavy chain, ...
Authors:Guo, Y, Li, X, Zhang, G, Fu, D, Schweizer, L, Zhang, H, Rao, Z.
Deposit date:2020-07-10
Release date:2020-11-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.108 Å)
Cite:A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes.
Nat Commun, 12, 2021
2W7X
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BU of 2w7x by Molmil
Cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel Chk2 inhibitor PV1019
Descriptor: 1,2-ETHANEDIOL, MAGNESIUM ION, N-[4-[(E)-N-carbamimidamido-C-methyl-carbonimidoyl]phenyl]-7-nitro-1H-indole-2-carboxamide, ...
Authors:Jobson, A.G, Lountos, G.T, Lorenzi, P.L, Llamas, J, Connelly, J, Tropea, J.E, Onda, A, Kondapaka, S, Zhang, G, Caplen, N.J, Caredellina, J.H, Monks, A, Self, C, Waugh, D.S, Shoemaker, R.H, Pommier, Y.
Deposit date:2009-01-06
Release date:2009-09-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Cellular Inhibition of Chk2 Kinase and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor Pv1019.
J.Pharmacol.Exp.Ther., 331, 2009
2YIQ
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BU of 2yiq by Molmil
Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1322
Descriptor: (E)-5-(1-(2-CARBAMIMIDOYLHYDRAZONO)ETHYL)-N-(1H-INDOL-6-YL)-1H-INDOLE-2-CARBOXAMIDE, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2
Authors:Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C, Zhang, G, Pommier, Y, Shoemaker, R.H, Waugh, D.S.
Deposit date:2011-05-16
Release date:2011-09-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:X-Ray Structures of Checkpoint Kinase 2 in Complex with Inhibitors that Target its Gatekeeper-Dependent Hydrophobic Pocket.
FEBS Lett., 585, 2011
2YIR
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BU of 2yir by Molmil
Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1352
Descriptor: (E)-N-(5-(2-CARBAMIMIDOYLHYDRAZONO)-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)-7-NITRO-1H-INDOLE-2-CARBOXAMIDE, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2
Authors:Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C, Zhang, G, Pommier, Y, Shoemaker, R.H, Waugh, D.S.
Deposit date:2011-05-16
Release date:2011-09-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-Ray Structures of Checkpoint Kinase 2 in Complex with Inhibitors that Target its Gatekeeper-Dependent Hydrophobic Pocket.
FEBS Lett., 585, 2011
2YIT
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BU of 2yit by Molmil
Structural analysis of checkpoint kinase 2 in complex with PV1162, a novel inhibitor
Descriptor: N-{4-[(1E)-N-carbamimidoylbutanehydrazonoyl]phenyl}-5-methoxy-1H-indole-2-carboxamide, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2
Authors:Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C, Zhang, G, Pommier, Y, Shoemaker, R.H, Waugh, D.S.
Deposit date:2011-05-16
Release date:2011-09-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-Ray Structures of Checkpoint Kinase 2 in Complex with Inhibitors that Target its Gatekeeper-Dependent Hydrophobic Pocket.
FEBS Lett., 585, 2011
6R8I
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BU of 6r8i by Molmil
PP4R3A EVH1 domain bound to FxxP motif
Descriptor: SER-LEU-PRO-PHE-THR-PHE-LYS-VAL-PRO-ALA-PRO-PRO-PRO-SER-LEU-PRO-PRO-SER, Serine/threonine-protein phosphatase 4 regulatory subunit 3A
Authors:Ueki, Y, Kruse, T, Weisser, M.B, Sundell, G.N, Yoo Larsen, M.S, Lopez Mendez, B, Jenkins, N.P, Garvanska, D.H, Cressey, L, Zhang, G, Davey, N, Montoya, G, Ivarsson, Y, Kettenbach, A, Nilsson, J.
Deposit date:2019-04-02
Release date:2019-10-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.517 Å)
Cite:A Consensus Binding Motif for the PP4 Protein Phosphatase.
Mol.Cell, 76, 2019
1FEZ
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BU of 1fez by Molmil
THE CRYSTAL STRUCTURE OF BACILLUS CEREUS PHOSPHONOACETALDEHYDE HYDROLASE COMPLEXED WITH TUNGSTATE, A PRODUCT ANALOG
Descriptor: MAGNESIUM ION, PHOSPHONOACETALDEHYDE HYDROLASE, TUNGSTATE(VI)ION
Authors:Morais, M.C, Zhang, W, Baker, A.S, Zhang, G, Dunaway-Mariano, D, Allen, K.N.
Deposit date:2000-07-24
Release date:2000-10-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:The crystal structure of bacillus cereus phosphonoacetaldehyde hydrolase: insight into catalysis of phosphorus bond cleavage and catalytic diversification within the HAD enzyme superfamily.
Biochemistry, 39, 2000
8GOU
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BU of 8gou by Molmil
Omicron BA.4/5 SARS-CoV-2 S in complex with TH003 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, TH003 Fab heavy chain, ...
Authors:Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z.
Deposit date:2022-08-25
Release date:2023-06-28
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection.
Nat Commun, 14, 2023
2YCR
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BU of 2ycr by Molmil
Crystal structure of checkpoint kinase 2 in complex with inhibitor PV976
Descriptor: 1,3-BIS{4-[(1E)-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)ETHANEHYDRAZONOYL]PHENYL}UREA, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2
Authors:Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C.R, Pommier, Y, Shoemaker, R.H, Zhang, G, Waugh, D.S.
Deposit date:2011-03-16
Release date:2011-11-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy.
J.Struct.Biol., 176, 2011

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