Author results

4XNV
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THE HUMAN P2Y1 RECEPTOR IN COMPLEX WITH BPTU
Descriptor:P2Y purinoceptor 1, Rubredoxin, 1-[2-(2-tert-butylphenoxy)pyridin-3-yl]-3-[4-(trifluoromethoxy)phenyl]urea, ...
Authors:Zhang, D., Gao, Z., Jacobson, K., Han, G.W., Stevens, R., Zhao, Q., Wu, B., GPCR Network (GPCR)
Deposit date:2015-01-16
Release date:2015-04-01
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Two disparate ligand-binding sites in the human P2Y1 receptor
Nature, 520, 2015
4XNW
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THE HUMAN P2Y1 RECEPTOR IN COMPLEX WITH MRS2500
Descriptor:P2Y purinoceptor 1,Rubredoxin,P2Y purinoceptor 1, [(1R,2S,4S,5S)-4-[2-iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hex-1-yl]methyl dihydrogen phosphate, ZINC ION
Authors:Zhang, D., Gao, Z., Jacobson, K., Han, G.W., Stevens, R., Zhao, Q., Wu, B., GPCR Network (GPCR)
Deposit date:2015-01-16
Release date:2015-04-01
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Two disparate ligand-binding sites in the human P2Y1 receptor
Nature, 520, 2015
2JY5
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NMR STRUCTURE OF UBIQUILIN 1 UBA DOMAIN
Descriptor:Ubiquilin-1
Authors:Zhang, D., Raasi, S., Fushman, D.
Deposit date:2007-12-06
Release date:2008-03-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Affinity makes the difference: nonselective interaction of the UBA domain of Ubiquilin-1 with monomeric ubiquitin and polyubiquitin chains
J.Mol.Biol., 377, 2008
2JY6
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SOLUTION STRUCTURE OF THE COMPLEX OF UBIQUITIN AND UBIQUILIN 1 UBA DOMAIN
Descriptor:Ubiquitin protein, Ubiquilin-1
Authors:Zhang, D., Raasi, S., Fushman, D.
Deposit date:2007-12-06
Release date:2008-03-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Affinity makes the difference: nonselective interaction of the UBA domain of Ubiquilin-1 with monomeric ubiquitin and polyubiquitin chains
J.Mol.Biol., 377, 2008
1ATL
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STRUCTURAL INTERACTION OF NATURAL AND SYNTHETIC INHIBITORS WITH THE VENOM METALLOPROTEINASE, ATROLYSIN C (FORM-D)
Descriptor:ATROLYSIN C, ZINC ION, CALCIUM ION, ...
Authors:Zhang, D., Botos, I., Gomis-Rueth, F.-X., Doll, R., Blood, C., Njoroge, F.G., Fox, J.W., Bode, W., Meyer, E.F.
Deposit date:1995-05-26
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d).
Proc.Natl.Acad.Sci.USA, 91, 1994
1HTD
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STRUCTURAL INTERACTION OF NATURAL AND SYNTHETIC INHIBITORS WITH THE VENOM METALLOPROTEINASE, ATROLYSIN C (HT-D)
Descriptor:ATROLYSIN C, ZINC ION, CALCIUM ION
Authors:Zhang, D., Botos, I., Gomis-Rueth, F.-X., Doll, R., Blood, C., Njoroge, F.G., Fox, J.W., Bode, W., Meyer, E.F.
Deposit date:1994-01-20
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d).
Proc.Natl.Acad.Sci.USA, 91, 1994
1HYN
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CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF HUMAN ERYTHROCYTE BAND-3 PROTEIN
Descriptor:BAND 3 ANION TRANSPORT PROTEIN
Authors:Zhang, D., Kiyatkin, A., Bolin, J.T., Low, P.S.
Deposit date:2001-01-20
Release date:2001-05-16
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystallographic structure and functional interpretation of the cytoplasmic domain of erythrocyte membrane band 3.
Blood, 96, 2000
3JCD
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STRUCTURE OF ESCHERICHIA COLI EF4 IN POSTTRANSLOCATIONAL RIBOSOMES (POST EF4)
Descriptor:30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhang, D., Yan, K., Liu, G., Song, G., Luo, J., Shi, Y., Cheng, E., Wu, S., Jiang, T., Low, J., Gao, N., Qin, Y.
Deposit date:2015-12-01
Release date:2016-01-13
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome
Nat. Struct. Mol. Biol., 23, 2016
3JCE
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STRUCTURE OF ESCHERICHIA COLI EF4 IN PRETRANSLOCATIONAL RIBOSOMES (PRE EF4)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhang, D., Yan, K., Liu, G., Song, G., Luo, J., Shi, Y., Cheng, E., Wu, S., Jiang, T., Low, J., Gao, N., Qin, Y.
Deposit date:2015-12-01
Release date:2016-01-13
Last modified:2017-02-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome
Nat. Struct. Mol. Biol., 23, 2016
5ISY
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CRYSTAL STRUCTURE OF NUDIX FAMILY PROTEIN WITH NAD
Descriptor:NADH pyrophosphatase, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Zhang, D., Guan, Z., Zou, T., Yin, P.
Deposit date:2016-03-15
Release date:2016-09-14
Method:X-RAY DIFFRACTION (2.354 Å)
Cite:Structural basis of prokaryotic NAD-RNA decapping by NudC
Cell Res., 26, 2016
2MR9
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NMR STRUCTURE OF UBA DOMAIN OF DNA-DAMAGE-INDUCIBLE 1 PROTEIN (DDI1)
Descriptor:DNA damage-inducible protein 1
Authors:Zhang, D., Fushman, D.
Deposit date:2014-07-02
Release date:2015-02-04
Last modified:2015-03-18
Method:SOLUTION NMR
Cite:DNA-Damage-Inducible 1 Protein (Ddi1) Contains an Uncharacteristic Ubiquitin-like Domain that Binds Ubiquitin.
Structure, 23, 2015
2MRO
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STRUCTURE OF THE COMPLEX OF UBIQUITIN AND THE UBA DOMAIN FROM DNA-DAMAGE-INDUCIBLE 1 PROTEIN (DDI1)
Descriptor:Polyubiquitin-B, DNA damage-inducible protein 1
Authors:Zhang, D., Fushman, D.
Deposit date:2014-07-14
Release date:2015-02-04
Last modified:2015-03-18
Method:SOLUTION NMR
Cite:DNA-Damage-Inducible 1 Protein (Ddi1) Contains an Uncharacteristic Ubiquitin-like Domain that Binds Ubiquitin.
Structure, 23, 2015
3NS8
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CRYSTAL STRUCTURE OF AN OPEN CONFORMATION OF LYS48-LINKED DIUBIQUITIN AT PH 7.5
Descriptor:Ubiquitin, GLYCEROL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Zhang, D., LaRonde-LeBlanc, N., Fushman, D.
Deposit date:2010-07-01
Release date:2011-07-20
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (1.707 Å)
Cite:Structural and biochemical studies of the open state of Lys48-linked diubiquitin.
Biochim.Biophys.Acta, 1823, 2012
5JMX
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CRYSTAL STRUCTURE OF BCII METALLO-BETA-LACTAMASE IN COMPLEX WITH DZ-305
Descriptor:Metallo-beta-lactamase type 2, ZINC ION, SULFATE ION, ...
Authors:Stepanovs, D., McDonough, M.A., Schofield, C.J., Zhang, D., Brem, J.
Deposit date:2016-04-29
Release date:2017-05-24
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-beta-lactamases.
Bioorg. Med. Chem., 26, 2018
6EUM
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CRYSTAL STRUCTURE OF BCII METALLO-BETA-LACTAMASE IN COMPLEX WITH DZ-307
Descriptor:Metallo-beta-lactamase type 2, ZINC ION, SULFATE ION, ...
Authors:Stepanovs, D., McDonough, M.A., Schofield, C.J., Zhang, D., El-Husseiny, A., Brem, J.
Deposit date:2017-10-30
Release date:2018-10-03
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-beta-lactamases.
Bioorg. Med. Chem., 26, 2018
6EWE
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CRYSTAL STRUCTURE OF BCII METALLO-BETA-LACTAMASE IN COMPLEX WITH DZ-308
Descriptor:Metallo-beta-lactamase type 2, ZINC ION, SULFATE ION, ...
Authors:Stepanovs, D., McDonough, M.A., Schofield, C.J., Zhang, D., El-Husseiny, A., Brem, J.
Deposit date:2017-11-03
Release date:2018-10-03
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-beta-lactamases.
Bioorg. Med. Chem., 26, 2018
6F2N
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CRYSTAL STRUCTURE OF BCII METALLO-BETA-LACTAMASE IN COMPLEX WITH KDU197
Descriptor:Metallo-beta-lactamase type 2, ZINC ION, SULFATE ION, ...
Authors:McDonough, M.A., El-Hussein, A., Schofield, C.J., Zhang, D., Brem, J.
Deposit date:2017-11-24
Release date:2018-10-03
Method:X-RAY DIFFRACTION (1.149 Å)
Cite:Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-beta-lactamases.
Bioorg. Med. Chem., 26, 2018
4U92
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CRYSTAL STRUCTURE OF A DNA/BA2+ G-QUADRUPLEX CONTAINING A WATER-MEDIATED C-TETRAD
Descriptor:DNA (5'-D(*CP*CP*AP*KP*GP*CP*GP*TP*GP*G)-3'), BARIUM ION, MAGNESIUM ION
Authors:Paukstelis, P.J., Zhang, D., Huang, T., Lukeman, P.
Deposit date:2014-08-05
Release date:2014-11-26
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of a DNA/Ba2+ G-quadruplex containing a water-mediated C-tetrad.
Nucleic Acids Res., 42, 2014
5L04
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STRUCTURE OF INTERFERON LAMBDA 1 RECEPTOR WITH HUMAN KINASE JAK1
Descriptor:Tyrosine-protein kinase JAK1, Interferon lambda receptor 1
Authors:Lubkowski, J., Wlodawer, A., Zhang, D.
Deposit date:2016-07-26
Release date:2016-10-12
Last modified:2017-04-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of a Complex of the Intracellular Domain of Interferon lambda Receptor 1 (IFNLR1) and the FERM/SH2 Domains of Human JAK1.
J. Mol. Biol., 428, 2016
4M3Q
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1917
Descriptor:Tyrosine-protein kinase Mer, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Zhang, W., Zhang, D., Stashko, M.A., DeRyckere, D., Hunter, D., Kireev, D.B., Miley, M., Cummings, C., Lee, M., Norris-Drouin, J., Stewart, W.M., Sather, S., Zhou, Y., Kirkpatrick, G., Machius, M., Janzen, W.P., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
Deposit date:2013-08-06
Release date:2013-11-27
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.718 Å)
Cite:Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors.
J.Med.Chem., 56, 2013
4NTJ
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STRUCTURE OF THE HUMAN P2Y12 RECEPTOR IN COMPLEX WITH AN ANTITHROMBOTIC DRUG
Descriptor:P2Y purinoceptor 12,Soluble cytochrome b562,P2Y purinoceptor 12, ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-5-cyano-2-methylpyridine-3-carboxylate, CHOLESTEROL, ...
Authors:Zhang, K., Zhang, J., Gao, Z.-G., Zhang, D., Zhu, L., Han, G.W., Moss, S.M., Paoletta, S., Kiselev, E., Lu, W., Fenalti, G., Zhang, W., Muller, C.E., Yang, H., Jiang, H., Cherezov, V., Katritch, V., Jacobson, K.A., Stevens, R.C., Wu, B., Zhao, Q., GPCR Network (GPCR)
Deposit date:2013-12-02
Release date:2014-03-26
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structure of the human P2Y12 receptor in complex with an antithrombotic drug
Nature, 509, 2014
4PXZ
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CRYSTAL STRUCTURE OF P2Y12 RECEPTOR IN COMPLEX WITH 2MESADP
Descriptor:P2Y purinoceptor 12, Soluble cytochrome b562, 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), ...
Authors:Zhang, J., Zhang, K., Gao, Z.G., Paoletta, S., Zhang, D., Han, G.W., Li, T., Ma, L., Zhang, W., Muller, C.E., Yang, H., Jiang, H., Cherezov, V., Katritch, V., Jacobson, K.A., Stevens, R.C., Wu, B., Zhao, Q., GPCR Network (GPCR)
Deposit date:2014-03-25
Release date:2014-04-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Agonist-bound structure of the human P2Y12 receptor
Nature, 509, 2014
4PY0
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CRYSTAL STRUCTURE OF P2Y12 RECEPTOR IN COMPLEX WITH 2MESATP
Descriptor:P2Y purinoceptor 12, Soluble cytochrome b562, 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate), ...
Authors:Zhang, J., Zhang, K., Gao, Z.G., Paoletta, S., Zhang, D., Han, G.W., Li, T., Ma, L., Zhang, W., Muller, C.E., Yang, H., Jiang, H., Cherezov, V., Katritch, V., Jacobson, K.A., Stevens, R.C., Wu, B., Zhao, Q., GPCR Network (GPCR)
Deposit date:2014-03-25
Release date:2014-04-30
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Agonist-bound structure of the human P2Y12 receptor
Nature, 509, 2014
5ADY
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CRYO-EM STRUCTURES OF THE 50S RIBOSOME SUBUNIT BOUND WITH HFLX
Descriptor:50S RIBOSOMAL PROTEIN L32, 50S RIBOSOMAL PROTEIN L33, 50S RIBOSOMAL PROTEIN L34, ...
Authors:Zhang, Y., Mandava, C.S., Cao, W., Li, X., Zhang, D., Li, N., Zhang, Y., Zhang, X., Qin, Y., Mi, K., Lei, J., Sanyal, S., Gao, N.
Deposit date:2015-08-25
Release date:2015-10-14
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Hflx is a Ribosome Splitting Factor Rescuing Stalled Ribosomes Under Stress Conditions
Nat.Struct.Mol.Biol., 22, 2015
3P2M
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CRYSTAL STRUCTURE OF A NOVEL ESTERASE RV0045C FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:POSSIBLE HYDROLASE
Authors:Zheng, X.D., Guo, J., Xu, L., Li, H., Zhang, D., Zhang, K., Sun, F., Wen, T., Liu, S., Pang, H.
Deposit date:2010-10-03
Release date:2011-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of a Novel Esterase Rv0045c from Mycobacterium tuberculosis
Plos One, 6, 2011