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4KYH
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CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I COMPLEXED WITH ZOPOLRESTAT
Descriptor:Lactoylglutathione lyase, ZINC ION, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID
Authors:Zhai, J., Yuan, M., Zhang, L., Chen, Y., Zhang, H., Chen, S., Zhao, Y.
Deposit date:2013-05-29
Release date:2013-08-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis
Chemmedchem, 2013
4KYK
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CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I COMPLEXED WITH INDOMETHACIN
Descriptor:Lactoylglutathione lyase, ZINC ION, INDOMETHACIN
Authors:Zhai, J., Yuan, M., Zhang, L., Chen, Y., Zhang, H., Chen, S., Zhao, Y.
Deposit date:2013-05-29
Release date:2013-08-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis
Chemmedchem, 2013
4OPN
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CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I COMPLEXED WITH MAH
Descriptor:Lactoylglutathione lyase, ZINC ION, L-gamma-glutamyl-N-(3-ethynylphenyl)-N-hydroxy-L-glutaminylglycine
Authors:Zhai, J., Zhang, L., Yuan, M., Zhang, H.
Deposit date:2014-02-06
Release date:2015-02-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Reversible Inhibition of Glyoxalase I: Synthesis and Activity Evaluation
To be Published
4GQG
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CRYSTAL STRUCTURE OF AKR1B10 COMPLEXED WITH NADP+
Descriptor:Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zhang, L., Zheng, X., Chen, S., Zhai, J., Hu, X.
Deposit date:2012-08-23
Release date:2013-08-28
Last modified:2013-12-11
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111)
Febs Lett., 587, 2013
4I5X
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CRYSTAL STRUCTURE OF AKR1B10 COMPLEXED WITH NADP+ AND FLUFENAMIC ACID
Descriptor:Aldo-keto reductase family 1 member B10, 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zhang, L., Zheng, X., Chen, S., Zhai, J., Zhang, H., Zhao, Y.
Deposit date:2012-11-29
Release date:2013-10-23
Last modified:2013-12-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111)
Febs Lett., 587, 2013
4JIH
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CRYSTAL STRUCTURE OF AKR1B10 COMPLEXED WITH NADP+ AND EPALRESTAT
Descriptor:Aldo-keto reductase family 1 member B10, {5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zhang, L., Zheng, X., Zhang, H., Zhao, Y., Chen, K., Zhai, J., Hu, X., Structural Genomics Consortium (SGC)
Deposit date:2013-03-06
Release date:2013-10-23
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111).
Febs Lett., 587, 2013
4JII
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CRYSTAL STRUCTURE OF AKR1B10 COMPLEXED WITH NADP+ AND ZOPOLRESTAT
Descriptor:Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, ...
Authors:Zhang, L., Zheng, X., Zhang, H., Zhao, Y., Chen, K., Zhai, J., Hu, X., Structural Genomics Consortium (SGC)
Deposit date:2013-03-06
Release date:2013-10-23
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111).
Febs Lett., 587, 2013
4JIR
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CRYSTAL STRUCTURE OF ALDOSE REDUCTASE (AKR1B1) COMPLEXED WITH NADP+ AND EPALRESTAT
Descriptor:Aldose reductase, {5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid, SULFATE ION, ...
Authors:Zhang, L., Zheng, X., Zhang, H., Zhao, Y., Chen, K., Zhai, J., Hu, X.
Deposit date:2013-03-06
Release date:2013-10-23
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111).
Febs Lett., 587, 2013
4PV5
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CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I IN COMPLEXED WITH 18-BETA-GLYCYRRHETINIC ACID
Descriptor:Lactoylglutathione lyase, ZINC ION, (3BETA,5BETA,14BETA)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OIC ACID
Authors:Zhang, H., Zhai, J., Zhang, L.P., Zhao, Y.N., Li, C., Hu, X.P.
Deposit date:2014-03-15
Release date:2015-03-18
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for 18-beta-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor
Acta Pharmacol.Sin., 36, 2015
4RVP
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CRYSTAL STRUCTURE OF SUPEROXIDE DISMUTASE FROM SEDUM ALFREDII
Descriptor:superoxide dismutase, ZINC ION
Authors:Qiu, R., Li, C., Zhai, J., Tang, L., Zhang, H., Yuan, M., Hu, X.
Deposit date:2014-11-27
Release date:2015-12-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The positive effects of Cd and Cd-Zn relationship in the Zn-related physiological processes involved in growth in the Zn/Cd hyperaccumulator Sedum alfredii
To be Published
4X2A
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CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I COMPLEXED WITH BAICALEIN
Descriptor:Lactoylglutathione lyase, ZINC ION, 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one
Authors:Zhang, H., Zhai, J., Zhang, L., Li, C., Zhao, Y., Hu, X.
Deposit date:2014-11-26
Release date:2015-09-16
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:In Vitro Inhibition of Glyoxalase by Flavonoids: New Insights from Crystallographic Analysis
Curr Top Med Chem, 16, 2016
3RX2
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CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH SULINDAC SULFONE
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[(3Z)-6-fluoranyl-2-methyl-3-[(4-methylsulfonylphenyl)methylidene]inden-1-yl]ethanoic acid
Authors:Zheng, X., Chen, J., Luo, H., Hu, X.
Deposit date:2011-05-10
Release date:2011-11-30
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase
Febs Lett., 586, 2012
3RX3
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CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH SULINDAC
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid
Authors:Zheng, X., Chen, J., Luo, H., Hu, X.
Deposit date:2011-05-10
Release date:2011-11-30
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase.
Febs Lett., 586, 2012
3RX4
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CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH SULINDAC SULFIDE
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[(3Z)-6-fluoranyl-2-methyl-3-[(4-methylsulfanylphenyl)methylidene]inden-1-yl]ethanoic acid
Authors:Zheng, X., Chen, J., Luo, H., Hu, X.
Deposit date:2011-05-10
Release date:2011-11-30
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase.
Febs Lett., 586, 2012
3S3G
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CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH TOLMETIN
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Tolmetin
Authors:Zheng, X., Chen, J., Luo, H., Hu, X.
Deposit date:2011-05-18
Release date:2012-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase.
Febs Lett., 586, 2012
4YVP
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CRYSTAL STRUCTURE OF AKR1C1 COMPLEXED WITH GLIBENCLAMIDE
Descriptor:Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide
Authors:Zhao, Y., Zheng, X., Zhang, H., Hu, X.
Deposit date:2015-03-20
Release date:2015-11-25
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis
Chem.Biol.Interact., 240, 2015
4YVV
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CRYSTAL STRUCTURE OF AKR1C3 COMPLEXED WITH GLIBENCLAMIDE
Descriptor:Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide
Authors:Zhao, Y., Zheng, X., Zhang, H., Hu, X.
Deposit date:2015-03-20
Release date:2015-11-25
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis
Chem.Biol.Interact., 240, 2015
4YVX
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CRYSTAL STRUCTURE OF AKR1C3 COMPLEXED WITH GLIMEPIRIDE
Descriptor:Aldo-keto reductase family 1 member C3, 3-ethyl-4-methyl-N-[2-(4-{[(cis-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zhao, Y., Zheng, X., Zhang, H., Hu, X.
Deposit date:2015-03-20
Release date:2015-11-25
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis
Chem.Biol.Interact., 240, 2015
4ZFC
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CRYSTAL STRUCTURE OF AKR1C3 COMPLEXED WITH GLICAZIDE
Descriptor:Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[(3aR,6aS)-hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl]-4-methylbenzenesulfonamide
Authors:Zhao, Y., Zhrng, X., Hu, X.
Deposit date:2015-04-21
Release date:2015-11-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis
Chem.Biol.Interact., 240, 2015