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1WUG
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BU of 1wug by Molmil
complex structure of PCAF bromodomain with small chemical ligand NP1
Descriptor: Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-4-METHYL-2-NITROBENZENAMINE
Authors:Zeng, L, Li, J, Muller, M, Yan, S, Mujtaba, S, Pan, C, Wang, Z, Zhou, M.M.
Deposit date:2004-12-07
Release date:2005-08-16
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Selective small molecules blocking HIV-1 Tat and coactivator PCAF association
J.Am.Chem.Soc., 127, 2005
1WUM
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BU of 1wum by Molmil
Complex structure of PCAF bromodomain with small chemical ligand NP2
Descriptor: Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
Authors:Zeng, L, Li, J, Muller, M, Yan, S, Mujtaba, S, Pan, C, Wang, Z, Zhou, M.M.
Deposit date:2004-12-08
Release date:2005-08-16
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Selective small molecules blocking HIV-1 Tat and coactivator PCAF association
J.Am.Chem.Soc., 127, 2005
1ZS5
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BU of 1zs5 by Molmil
Structure-based evaluation of selective and non-selective small molecules that block HIV-1 TAT and PCAF association
Descriptor: (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE, Histone acetyltransferase PCAF
Authors:Zeng, L, Godbole, S, Muller, M, Yan, S, Sanchez, R, Zhou, M.
Deposit date:2005-05-23
Release date:2006-05-23
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structure-based evaluation of selective nad non-selective small molecules that block hiv-1 tat and pcaf association
TO BE PUBLISHED
2KWJ
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BU of 2kwj by Molmil
Solution structures of the double PHD fingers of human transcriptional protein DPF3 bound to a histone peptide containing acetylation at lysine 14
Descriptor: Histone peptide, ZINC ION, Zinc finger protein DPF3
Authors:Zeng, L, Zhang, Q, Li, S, Plotnikov, A.N, Walsh, M.J, Zhou, M.
Deposit date:2010-04-12
Release date:2010-07-14
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b.
Nature, 466, 2010
2KWO
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BU of 2kwo by Molmil
Solution structure of the double PHD (plant homeodomain) fingers of human transcriptional protein DPF3b bound to a histone H4 peptide containing N-terminal acetylation at Serine 1
Descriptor: Histone peptide, ZINC ION, Zinc finger protein DPF3
Authors:Zeng, L, Zhang, Q, Li, S, Plotnikov, A.N, Walsh, M.J, Zhou, M.
Deposit date:2010-04-14
Release date:2010-07-14
Last modified:2013-06-19
Method:SOLUTION NMR
Cite:Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b.
Nature, 466, 2010
2KWN
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BU of 2kwn by Molmil
Solution structure of the double PHD (plant homeodomain) fingers of human transcriptional protein DPF3b bound to a histone H4 peptide containing acetylation at Lysine 16
Descriptor: Histone peptide, ZINC ION, Zinc finger protein DPF3
Authors:Zeng, L, Zhang, Q, Li, S, Plotnikov, A.N, Walsh, M.J, Zhou, M.
Deposit date:2010-04-13
Release date:2010-07-14
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b.
Nature, 466, 2010
2KWK
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BU of 2kwk by Molmil
Solution structures of the double PHD fingers of human transcriptional protein DPF3b bound to a H3 peptide wild type
Descriptor: Histone peptide, ZINC ION, Zinc finger protein DPF3
Authors:Zeng, L, Zhang, Q, Li, S, Plotnikov, A.N, Walsh, M.J, Zhou, M.
Deposit date:2010-04-12
Release date:2010-07-14
Last modified:2013-06-19
Method:SOLUTION NMR
Cite:Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b.
Nature, 466, 2010
2L5D
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BU of 2l5d by Molmil
Solution Structures of human PIWI-like 1 PAZ domain with ssRNA (5'-pUGACA)
Descriptor: 5'-R(*UP*GP*AP*CP*A)-3', Piwi-like protein 1
Authors:Zeng, L, Zhang, Q, Yan, K, Zhou, M.
Deposit date:2010-10-29
Release date:2011-04-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain.
Proteins, 79, 2011
2L5C
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BU of 2l5c by Molmil
Solution structures of human PIWI-like 1 PAZ domain
Descriptor: Piwi-like protein 1
Authors:Zeng, L, Zhang, Q, Yan, K, Zhou, M.
Deposit date:2010-10-29
Release date:2011-04-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain.
Proteins, 79, 2011
3VJ6
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BU of 3vj6 by Molmil
Structure of the MHC class Ib molecule Qa-1b
Descriptor: Beta-2-microglobulin, H-2 class I histocompatibility antigen, D-37 alpha chain, ...
Authors:Zeng, L, Clements, C.S, Rossjohn, J.
Deposit date:2011-10-12
Release date:2012-03-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A structural basis for antigen presentation by the MHC class Ib molecule, Qa-1b
J.Immunol., 188, 2012
2MFQ
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BU of 2mfq by Molmil
NMR solution structures of FRS2a PTB domain with neurotrophin receptor TrkB
Descriptor: BDNF/NT-3 growth factors receptor, Fibroblast growth factor receptor substrate 2
Authors:Zeng, L, Zhou, M.
Deposit date:2013-10-18
Release date:2014-03-05
Last modified:2014-06-25
Method:SOLUTION NMR
Cite:Structural insights into FRS2 alpha PTB domain recognition by neurotrophin receptor TrkB.
Proteins, 82, 2014
2RO1
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BU of 2ro1 by Molmil
NMR Solution Structures of Human KAP1 PHD finger-bromodomain
Descriptor: Transcription intermediary factor 1-beta, ZINC ION
Authors:Zeng, L, Yap, K.L, Ivanov, A.V, Wang, X, Mujtaba, S, Plotnikova, O, Rauscher, F.J.
Deposit date:2008-03-04
Release date:2008-05-20
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing
Nat.Struct.Mol.Biol., 15, 2008
2RNW
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BU of 2rnw by Molmil
The Structural Basis for Site-Specific Lysine-Acetylated Histone Recognition by the Bromodomains of the Human Transcriptional Co-Activators PCAf and CBP
Descriptor: Histone H3, Histone acetyltransferase PCAF
Authors:Zeng, L, Zhang, Q, Gerona-Navarro, G, Zhou, M.M.
Deposit date:2008-02-03
Release date:2008-05-06
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300
Structure, 16, 2008
2RNX
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BU of 2rnx by Molmil
The Structural Basis for Site-Specific Lysine-Acetylated Histone Recognition by the Bromodomains of the HUman Transcriptional Co-Activators PCAF and CBP
Descriptor: Histone H3, Histone acetyltransferase PCAF
Authors:Zeng, L, Zhang, Q, Gerona-Navarro, G, Zhou, M.M.
Deposit date:2008-02-03
Release date:2008-05-06
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300
Structure, 16, 2008
2RNY
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BU of 2rny by Molmil
Complex Structures of CBP Bromodomain with H4 ack20 Peptide
Descriptor: CREB-binding protein, Histone H4
Authors:Zeng, L, Zhang, Q, Gerona-Navarro, G, Zhou, M.M.
Deposit date:2008-02-03
Release date:2008-05-06
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300
Structure, 16, 2008
2MJV
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BU of 2mjv by Molmil
Solution structures of second bromodomain of Brd4 with di-acetylated Twist peptide
Descriptor: Bromodomain-containing protein 4, Twist-related protein 1
Authors:Zeng, L, Zhou, M.
Deposit date:2014-01-16
Release date:2014-03-19
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer.
Cancer Cell, 25, 2014
5U5S
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BU of 5u5s by Molmil
Solution structures of Brd2 second bromodomain in complex with stat3 peptide
Descriptor: Bromodomain-containing protein 2, Stat3 peptide
Authors:Zeng, L, Zhou, M.-M.
Deposit date:2016-12-07
Release date:2017-03-22
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.
Mol. Cell, 65, 2017
2NDF
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BU of 2ndf by Molmil
Solution NMR structures of AF9 yeats domain in complex with histon H3 acetylation at K18
Descriptor: Histone H3 peptide, Protein AF-9
Authors:Zeng, L, Zhou, M.
Deposit date:2016-05-19
Release date:2016-09-07
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain.
Structure, 24, 2016
2NDG
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BU of 2ndg by Molmil
Solution NMR structures of AF9 yeats domain in complex with histone H3 crotonylation at K18
Descriptor: Histone H3 peptide, Protein AF-9
Authors:Zeng, L, Zhou, M.
Deposit date:2016-05-19
Release date:2016-09-07
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain.
Structure, 24, 2016
2ND0
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BU of 2nd0 by Molmil
Solution NMR structures of BRD4 ET domain with LANA peptide
Descriptor: Bromodomain-containing protein 4, LANA
Authors:Zeng, L, Zhou, M.
Deposit date:2016-04-18
Release date:2016-06-29
Last modified:2016-07-20
Method:SOLUTION NMR
Cite:Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4.
Structure, 24, 2016
2NCZ
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BU of 2ncz by Molmil
Solution NMR structures of BRD4 ET domain in complex with NSD3_1 peptide
Descriptor: Bromodomain-containing protein 4, Histone-lysine N-methyltransferase NSD3
Authors:Zeng, L, Zhou, M.
Deposit date:2016-04-18
Release date:2016-06-29
Last modified:2016-07-20
Method:SOLUTION NMR
Cite:Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4.
Structure, 24, 2016
2ND1
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BU of 2nd1 by Molmil
Solution NMR structures of BRD4 ET domain in complex with NSD3_3 peptide
Descriptor: Bromodomain-containing protein 4, Histone-lysine N-methyltransferase NSD3
Authors:Zeng, L, Zhou, M.
Deposit date:2016-04-19
Release date:2016-06-29
Last modified:2016-07-20
Method:SOLUTION NMR
Cite:Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4.
Structure, 24, 2016
6MNL
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BU of 6mnl by Molmil
NMR solution structures of second bromodomain of BRD4 with FOXO3a peptide
Descriptor: Bromodomain-containing protein 4, FOXO3a peptide
Authors:Zeng, L, Zhou, M.-M.
Deposit date:2018-10-02
Release date:2018-10-31
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.
Nat Commun, 9, 2018
5Z9C
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BU of 5z9c by Molmil
Solution NMR structures of BRD4 first bromodomain with small compound MMQO
Descriptor: 8-methoxy-6-methylquinolin-4(1H)-one, Bromodomain-containing protein 4
Authors:Zeng, L, Zhou, M.-M.
Deposit date:2018-02-02
Release date:2018-02-14
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other "Shock" Drugs.
J. Virol., 92, 2018
7WWZ
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BU of 7wwz by Molmil
BRD4-BD1 complexed with NEO2734
Descriptor: 1,3-dimethyl-5-[2-(oxan-4-yl)-3-[2-(trifluoromethyloxy)ethyl]benzimidazol-5-yl]pyridin-2-one, Isoform C of Bromodomain-containing protein 4
Authors:Zeng, L, Lei, J.D.
Deposit date:2022-02-14
Release date:2022-06-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Targeting CDCP1 gene transcription coactivated by BRD4 and CBP/p300 in castration-resistant prostate cancer.
Oncogene, 41, 2022

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