Author results

5XV7
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SRPK1 IN COMPLEX WITH ALECTINIB
Descriptor:serine-arginine (SR) protein kinase 1, 1,2-ETHANEDIOL, 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
Authors:Zeng, C., Ngo, J.C.K.
Deposit date:2017-06-26
Release date:2018-03-14
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform
Cell Chem Biol, 25, 2018
1HKB
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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN BRAIN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND GLUCOSE-6-PHOSPHATE
Descriptor:D-GLUCOSE 6-PHOSPHOTRANSFERASE, BETA-D-GLUCOSE, ALPHA-D-GLUCOSE-6-PHOSPHATE, ...
Authors:Aleshin, A.E., Zeng, C., Burenkov, G.P., Bartunik, H.D., Fromm, H.J., Honzatko, R.B.
Deposit date:1997-12-01
Release date:1998-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate.
Structure, 6, 1998
2KI0
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NMR STRUCTURE OF A DE NOVO DESIGNED BETA ALPHA BETA
Descriptor:DS119
Authors:Liang, H., Chen, H., Fan, K., Wei, P., Guo, X., Jin, C., Zeng, C., Tang, C., Lai, L.
Deposit date:2009-04-18
Release date:2009-10-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:De novo design of a beta alpha beta motif.
Angew.Chem.Int.Ed.Engl., 48, 2009
5ZJV
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MCR-1 (CMCR-1) IN COMPLEX WITH XYLOSE
Descriptor:Probable phosphatidylethanolamine transferase Mcr-1, BETA-L-XYLOPYRANOSE, ZINC ION
Authors:Liu, Z.X., Han, Z., Yu, X.L., Wen, G., Zeng, C.
Deposit date:2018-03-22
Release date:2018-04-25
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal Structure of the Catalytic Domain of MCR-1 (cMCR-1) in Complex with d-Xylose
Crystals, 8, 2018
5GSA
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EED IN COMPLEX WITH AN ALLOSTERIC PRC2 INHIBITOR
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-08-15
Release date:2017-02-01
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of
Nat. Chem. Biol., 13, 2017
1HKC
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RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND PHOSPHATE
Descriptor:D-GLUCOSE 6-PHOSPHOTRANSFERASE, BETA-D-GLUCOSE, PHOSPHATE ION, ...
Authors:Aleshin, A.E., Honzatko, R.B.
Deposit date:1998-07-01
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate.
J.Mol.Biol., 282, 1998
1CZA
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MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE, GLUCOSE-6-PHOSPHATE, AND ADP
Descriptor:HEXOKINASE TYPE I, ALPHA-D-GLUCOSE, ALPHA-D-GLUCOSE-6-PHOSPHATE, ...
Authors:Aleshin, A.E., Liu, X., Kirby, C., Bourenkov, G.P., Bartunik, H.D., Fromm, H.J., Honzatko, R.B.
Deposit date:1999-09-01
Release date:2000-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.
J.Mol.Biol., 296, 2000
1DGK
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MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I WITH GLUCOSE AND ADP IN THE ACTIVE SITE
Descriptor:HEXOKINASE TYPE I, ALPHA-D-GLUCOSE, PHOSPHATE ION, ...
Authors:Aleshin, A.E., Liu, X., Kirby, C., Bourenkov, G.P., Bartunik, H.D., Fromm, H.J., Honzatko, R.B.
Deposit date:1999-11-24
Release date:2000-03-08
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.
J.Mol.Biol., 296, 2000
1JK4
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DES 1-6 BOVINE NEUROPHYSIN II COMPLEX WITH VASOPRESSIN
Descriptor:NEUROPHYSIN 2, Lys Vasopressin, CADMIUM ION
Authors:Rose, J.P., Wang, B.-C.
Deposit date:2001-07-11
Release date:2003-02-04
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of an Unliganded Neurophysin and its Vasopressin Complex: Implications for Binding and Allosteric Mechanisms
Protein Sci., 10, 2001
1JK6
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UNCOMPLEXED DES 1-6 BOVINE NEUROPHYSIN
Descriptor:NEUROPHYSIN 2
Authors:Rose, J.P., Wang, B.-C.
Deposit date:2001-07-11
Release date:2003-04-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of an Unliganded Neurophysin and its Vasopressin Complex: Implications for Binding and Allosteric Mechanisms
Protein Sci., 10, 2003