Author results

3QPF
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ANALYSIS OF A NEW FAMILY OF WIDELY DISTRIBUTED METAL-INDEPENDENT ALPHA-MANNOSIDASES PROVIDES UNIQUE INSIGHT INTO THE PROCESSING OF N-LINKED GLYCANS, STREPTOCOCCUS PNEUMONIAE SP_2144 APO-STRUCTURE
Descriptor:Putative uncharacterized protein, 1,2-ETHANEDIOL
Authors:Gregg, K.J., Zandberg, W.F., Hehemann, J.-H., Whitworth, G.E., Deng, L.E., Vocadlo, D.J.
Deposit date:2011-02-12
Release date:2011-03-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Analysis of a New Family of Widely Distributed Metal-independent {alpha}-Mannosidases Provides Unique Insight into the Processing of N-Linked Glycans.
J.Biol.Chem., 286, 2011
3QRY
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ANALYSIS OF A NEW FAMILY OF WIDELY DISTRIBUTED METAL-INDEPENDENT ALPHA MANNOSIDASES PROVIDES UNIQUE INSIGHT INTO THE PROCESSING OF N-LINKED GLYCANS, STREPTOCOCCUS PNEUMONIAE SP_2144 1-DEOXYMANNOJIRIMYCIN COMPLEX
Descriptor:Putative uncharacterized protein, 1-DEOXYMANNOJIRIMYCIN, 1,2-ETHANEDIOL
Authors:Gregg, K.J., Zandberg, W.F., Hehemann, J.-H., Whitworth, G.E., Deng, L.E., Vocadlo, D.J., Boraston, A.B.
Deposit date:2011-02-18
Release date:2011-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Analysis of a New Family of Widely Distributed Metal-independent {alpha}-Mannosidases Provides Unique Insight into the Processing of N-Linked Glycans.
J.Biol.Chem., 286, 2011
3QSP
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ANALYSIS OF A NEW FAMILY OF WIDELY DISTRIBUTED METAL-INDEPENDENT ALPHA MANNOSIDASES PROVIDES UNIQUE INSIGHT INTO THE PROCESSING OF N-LINKED GLYCANS, STREPTOCOCCUS PNEUMONIAE SP_2144 NON-PRODUCTIVE SUBSTRATE COMPLEX WITH ALPHA-1,6-MANNOBIOSE
Descriptor:Putative uncharacterized protein, BETA-D-MANNOSE, ALPHA-D-MANNOSE, ...
Authors:Gregg, K.J., Zandberg, W.F., Hehemann, J.-H., Whitworth, G.E., Deng, L.E., Vocadlo, D.J., Boraston, A.B.
Deposit date:2011-02-21
Release date:2011-03-09
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Analysis of a New Family of Widely Distributed Metal-independent {alpha}-Mannosidases Provides Unique Insight into the Processing of N-Linked Glycans.
J.Biol.Chem., 286, 2011
3QT3
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ANALYSIS OF A NEW FAMILY OF WIDELY DISTRIBUTED METAL-INDEPENDENT ALPHA-MANNOSIDASES PROVIDES UNIQUE INSIGHT INTO THE PROCESSING OF N-LINKED GLYCANS, CLOSTRIDIUM PERFRINGENS CPE0426 APO-STRUCTURE
Descriptor:Putative uncharacterized protein CPE0426, 1,2-ETHANEDIOL
Authors:Gregg, K.J., Zandberg, W.F., Hehemann, J.-H., Whitworth, G.E., Deng, L.E., Vocadlo, D.J., Boraston, A.B.
Deposit date:2011-02-22
Release date:2011-03-09
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Analysis of a New Family of Widely Distributed Metal-independent {alpha}-Mannosidases Provides Unique Insight into the Processing of N-Linked Glycans.
J.Biol.Chem., 286, 2011
3QT9
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ANALYSIS OF A NEW FAMILY OF WIDELY DISTRIBUTED METAL-INDEPENDENT ALPHA MANNOSIDASES PROVIDES UNIQUE INSIGHT INTO THE PROCESSING OF N-LINKED GLYCANS, CLOSTRIDIUM PERFRINGENS CPE0426 COMPLEXED WITH ALPHA-1,6-LINKED 1-THIO-ALPHA-MANNOBIOSE
Descriptor:Putative uncharacterized protein CPE0426, 1,2-ETHANEDIOL, 6-S-alpha-D-mannopyranosyl-6-thio-alpha-D-mannopyranose
Authors:Gregg, K.J., Zandberg, W.F., Hehemann, J.-H., Whitworth, G.E., Deng, L.E., Vocadlo, D.J., Boraston, A.B.
Deposit date:2011-02-22
Release date:2011-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Analysis of a New Family of Widely Distributed Metal-independent {alpha}-Mannosidases Provides Unique Insight into the Processing of N-Linked Glycans.
J.Biol.Chem., 286, 2011
4D0T
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GALNAC-T2 CRYSTAL SOAKED WITH UDP-GALNAC, EA2 PEPTIDE AND MANGANESE
Descriptor:POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2, PEPTIDE, MANGANESE (II) ION, ...
Authors:Lira-Navarrete, E., Iglesias-Fernandez, J., Zandberg, W.F., Companon, I., Kong, Y., Corzana, F., Pinto, B.M., Clausen, H., Peregrina, J.M., Vocadlo, D., Rovira, C., Hurtado-Guerrero, R.
Deposit date:2014-04-30
Release date:2014-05-28
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N-Acetylgalactosaminyltransferase 2.
Angew.Chem.Int.Ed.Engl., 53, 2014
4D0Z
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GALNAC-T2 CRYSTAL SOAKED WITH UDP-5SGALNAC, MEA2 AND MANGANESE (HIGHER RESOLUTION DATASET)
Descriptor:POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2, PEPTIDE, MANGANESE (II) ION, ...
Authors:Lira-Navarrete, E., Iglesias-Fernandez, J., Zandberg, W.F., Companon, I., Kong, Y., Corzana, F., Pinto, B.M., Clausen, H., Peregrina, J.M., Vocadlo, D., Rovira, C., Hurtado-Guerrero, R.
Deposit date:2014-04-30
Release date:2014-05-28
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N- Acetylgalactosaminyltransferase 2.
Angew.Chem.Int.Ed.Engl., 53, 2014
4D11
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GALNAC-T2 CRYSTAL SOAKED WITH UDP-5SGALNAC, MEA2 PEPTIDE AND MANGANESE (LOWER RESOLUTION DATASET)
Descriptor:POLYPEPTIDE GALNAC-TRANSFERASE T2, PEPTIDE, MANGANESE (II) ION, ...
Authors:Lira-Navarrete, E., Iglesias-Fernandez, J., Zandberg, W.F., Companon, I., Kong, Y., Corzana, F., Pinto, B.M., Clausen, H., Peregrina, J.M., Vocadlo, D., Rovira, C., Hurtado-Guerrero, R.
Deposit date:2014-05-01
Release date:2014-05-28
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N- Acetylgalactosaminyltransferase 2.
Angew.Chem.Int.Ed.Engl., 53, 2014
4GYW
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE IN COMPLEX WITH UDP AND A GLYCOPEPTIDE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, URIDINE-5'-DIPHOSPHATE, ...
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-05
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4GYY
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE WITH UDP-5SGLCNAC AND A PEPTIDE SUBSTRATE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, ...
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-05
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4GZ3
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE WITH UDP AND A THIOGLYCOPEPTIDE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, URIDINE-5'-DIPHOSPHATE, ...
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-05
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4GZ5
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE WITH UDP-GLCNAC
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, SULFATE ION
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-06
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (3.075 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4GZ6
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE WITH UDP-5SGLCNAC
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, SULFATE ION
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-06
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
5ABE
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STRUCTURE OF GH84 WITH LIGAND
Descriptor:O-GLCNACASE BT_4395, 2-[(2S,3S,4R,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)-1-pentyl-pyrrolidin-2-yl]-N-methyl-ethanamide, CALCIUM ION
Authors:Bergeron-Brlek, M., Goodwin-Tindall, J., Cekic, N., Varghese, V., Zandberg, W.F., Shan, X., Roth, C., Chan, S., Davies, G.J., Vocadlo, D.J., Britton, R.
Deposit date:2015-08-05
Release date:2015-11-18
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable Oga Inhibitors.
Angew.Chem.Int.Ed.Engl., 54, 2015
5ABF
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STRUCTURE OF GH84 WITH LIGAND
Descriptor:O-GLCNACASE BT_4395, 1,2-ETHANEDIOL, 2-[(2S,3R,4R,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)-1-pentyl-pyrrolidin-2-yl]-N-methyl-ethanamide, ...
Authors:Bergeron-Brlek, M., Goodwin-Tindall, J., Cekic, N., Varghese, V., Zandberg, W.F., Shan, X., Roth, C., Chan, S., Davies, G.J., Vocadlo, D.J., Britton, R.
Deposit date:2015-08-05
Release date:2015-11-18
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable Oga Inhibitors.
Angew.Chem.Int.Ed.Engl., 54, 2015
5ABG
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STRUCTURE OF GH84 WITH LIGAND
Descriptor:O-GLCNACASE BT_4395, 1,2-ETHANEDIOL, 2-[(2R,3S,4R,5R)-1-[3-(4-fluorophenyl)propyl]-5-(hydroxymethyl)-3,4-bis(oxidanyl)pyrrolidin-2-yl]-N-methyl-ethanamide, ...
Authors:Bergeron-Brlek, M., Goodwin-Tindall, J., Cekic, N., Varghese, V., Zandberg, W.F., Shan, X., Roth, C., Chan, S., Davies, G.J., Vocadlo, D.J., Britton, R.
Deposit date:2015-08-05
Release date:2015-11-18
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable Oga Inhibitors.
Angew.Chem.Int.Ed.Engl., 54, 2015
5ABH
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STRUCTURE OF GH84 WITH LIGAND
Descriptor:O-GLCNACASE BT_4395, CHLORIDE ION, 2-[(2R,3S,4R,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)-1-pentyl-pyrrolidin-2-yl]-N-methyl-ethanamide, ...
Authors:Bergeron-Brlek, M., Goodwin-Tindall, J., Cekic, N., Varghese, V., Zandberg, W.F., Shan, X., Roth, C., Chan, S., Davies, G.J., Vocadlo, D.J., Britton, R.
Deposit date:2015-08-05
Release date:2015-11-18
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable Oga Inhibitors.
Angew.Chem.Int.Ed.Engl., 54, 2015
4AIS
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A COMPLEX STRUCTURE OF BTGH84
Descriptor:O-GLCNACASE BT_4395, GLYCOLIC ACID, GLYCEROL
Authors:He, Y., Davies, G.J.
Deposit date:2012-02-13
Release date:2012-06-20
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: Intracellular Beta-O-Linked N-Glycolylglucosamine (Glcngc), Udp-Glcngc, and the Biochemical and Structural Rationale for the Substrate Tolerance of Beta-O-Linked Beta-N-Acetylglucosaminidase.
J.Biol.Chem., 287, 2012
4AIU
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A COMPLEX STRUCTURE OF BTGH84
Descriptor:O-GLCNACASE BT_4395, (3AR,5R,6S,7R,7AR)-2,5-BIS(HYDROXYMETHYL)-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]OXAZOLE-6,7-DIOL, CALCIUM ION
Authors:He, Y., Davies, G.J.
Deposit date:2012-02-13
Release date:2012-06-20
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: Intracellular Beta-O-Linked N-Glycolylglucosamine (Glcngc), Udp-Glcngc, and the Biochemical and Structural Rationale for the Substrate Tolerance of Beta-O-Linked Beta-N-Acetylglucosaminidase.
J.Biol.Chem., 287, 2012
4N39
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE BOUND TO A PEPTIDE FROM HCF-1 PRO-REPEAT 2 (11-26)
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Host cell factor 1, URIDINE-5'-DIPHOSPHATE
Authors:Lazarus, M.B., Herr, W., Walker, S.
Deposit date:2013-10-06
Release date:2014-01-01
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Science, 342, 2013
4N3A
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE BOUND TO A PEPTIDE FROM HCF-1 PRO-REPEAT 2 (1-26)E10A
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Host cell factor 1, URIDINE-5'-DIPHOSPHATE
Authors:Lazarus, M.B., Herr, W., Walker, S.
Deposit date:2013-10-06
Release date:2014-01-01
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Science, 342, 2013
4N3B
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE BOUND TO A PEPTIDE FROM HCF-1 PRO-REPEAT2(1-26)E10Q AND UDP-5SGLCNAC
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Host cell factor 1, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Lazarus, M.B., Herr, W., Walker, S.
Deposit date:2013-10-06
Release date:2014-01-01
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Science, 342, 2013
4N3C
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE BOUND TO A PEPTIDE FROM HCF-1 PRO-REPEAT2(1-26) AND UDP-GLCNAC
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Host cell factor 1, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE
Authors:Lazarus, M.B., Herr, W., Walker, S.
Deposit date:2013-10-06
Release date:2014-01-01
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Science, 342, 2013