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5ZG0
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CRYSTAL STRUCTURE OF THE GLUA2O LBD IN COMPLEX WITH GLUTAMATE AND COMPOUND-1
Descriptor:Glutamate receptor 2, GLUTAMIC ACID, ZINC ION, ...
Authors:Sogabe, S., Igaki, S., Hirokawa, A., Zama, Y., Lane, W., Snell, G.
Deposit date:2018-03-07
Release date:2019-01-16
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.
Neuropsychopharmacology, 44, 2019
5ZG1
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CRYSTAL STRUCTURE OF THE GLUA2O LBD IN COMPLEX WITH GLUTAMATE AND COMPOUND-2
Descriptor:Glutamate receptor 2, GLUTAMIC ACID, 9-(4-~{tert}-butylphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide, ...
Authors:Sogabe, S., Igaki, S., Hirokawa, A., Zama, Y., Lane, W., Snell, G.
Deposit date:2018-03-07
Release date:2019-01-16
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.
Neuropsychopharmacology, 44, 2019
5ZG2
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CRYSTAL STRUCTURE OF THE GLUA2O LBD IN COMPLEX WITH ZK200775 AND COMPOUND-2
Descriptor:Glutamate receptor 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid, 9-(4-~{tert}-butylphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide, ...
Authors:Sogabe, S., Igaki, S., Hirokawa, A., Zama, Y., Lane, W., Snell, G.
Deposit date:2018-03-07
Release date:2019-01-16
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.
Neuropsychopharmacology, 44, 2019
5ZG3
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CRYSTAL STRUCTURE OF THE GLUA2O LBD IN COMPLEX WITH GLUTAMATE AND TAK-137
Descriptor:Glutamate receptor 2, 9-(4-phenoxyphenyl)-3,4-dihydro-2H-2lambda~6~-pyrido[2,1-c][1,2,4]thiadiazine-2,2-dione, GLUTAMIC ACID, ...
Authors:Sogabe, S., Igaki, S., Hirokawa, A., Zama, Y., Lane, W., Snell, G.
Deposit date:2018-03-07
Release date:2019-01-16
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.
Neuropsychopharmacology, 44, 2019
5V7T
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CRYSTAL STRUCTURE OF PARP14 BOUND TO N-{4-[4-(DIPHENYLMETHOXY)PIPERIDIN-1-YL]BUTYL}[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-AMINE INHIBITOR
Descriptor:Poly [ADP-ribose] polymerase 14, N-{4-[4-(diphenylmethoxy)piperidin-1-yl]butyl}[1,2,4]triazolo[4,3-b]pyridazin-6-amine
Authors:saikatendu, k.s., Hirozane, M.
Deposit date:2017-03-20
Release date:2017-05-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation.
Biochem. Biophys. Res. Commun., 486, 2017
5V7W
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CRYSTAL STRUCTURE OF HUMAN PARP14 BOUND TO 2-{[(1-METHYLPIPERIDIN-4-YL)METHYL]AMINO}-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE INHIBITOR
Descriptor:Poly [ADP-ribose] polymerase 14, 2-{[(1-methylpiperidin-4-yl)methyl]amino}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
Authors:saikatendu, k.s., Hirozane, M.
Deposit date:2017-03-20
Release date:2017-05-10
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation.
Biochem. Biophys. Res. Commun., 486, 2017
5YBF
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CRYSTAL STRUCTURE OF THE GLUA2O LBD IN COMPLEX WITH GLUTAMATE AND HBT1
Descriptor:Glutamate receptor 2,Glutamate receptor 2, GLUTAMIC ACID, 2-[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanoylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, ...
Authors:Sogabe, S., Igaki, S., Hirokawa, A., Zama, Y., Lane, W., Snell, G.
Deposit date:2017-09-04
Release date:2018-01-17
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production.
J. Pharmacol. Exp. Ther., 364, 2018
5YBG
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CRYSTAL STRUCTURE OF THE GLUA2O LBD IN COMPLEX WITH GLUTAMATE AND LY451395
Descriptor:Glutamate receptor 2,Glutamate receptor 2, GLUTAMIC ACID, N-[(2R)-2-[4-[4-[2-(methylsulfonylamino)ethyl]phenyl]phenyl]propyl]propane-2-sulfonamide, ...
Authors:Sogabe, S., Igaki, S., Hirokawa, A., Zama, Y., Lane, W., Snell, G.
Deposit date:2017-09-04
Release date:2018-01-17
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production.
J. Pharmacol. Exp. Ther., 364, 2018
5AXP
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE10A COMPLEXED WITH 1-(2-FLUORO-4-(2-OXO-1,3-OXAZOLIDIN-3-YL)PHENYL)-5-METHOXY-3-(1-PHENYL-1H-PYRAZOL-5-YL)PYRIDAZIN-4(1H)-ONE
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, MAGNESIUM ION, ZINC ION, ...
Authors:Oki, H., Zama, Y.
Deposit date:2015-07-31
Release date:2015-11-11
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor
Bioorg.Med.Chem., 23, 2015
5AXQ
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE10A COMPLEXED WITH HIGHLY POTENT AND BRAIN-PENETRANT PDE10A INHIBITOR WITH 2-OXINDOLE SCAFFOLD
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, MAGNESIUM ION, ZINC ION, ...
Authors:Oki, H., Zama, Y.
Deposit date:2015-07-31
Release date:2015-11-11
Last modified:2015-12-02
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor
Bioorg.Med.Chem., 23, 2015
5B4K
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PDE10A COMPLEXED WITH N-(4-((5-METHYL-5H-PYRROLO[3,2-D]PYRIMIDIN-4-YL)OXY)PHENYL)-1H-BENZIMIDAZOL-2-AMINE
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, MAGNESIUM ION, ZINC ION, ...
Authors:Oki, H., Zama, Y.
Deposit date:2016-04-05
Release date:2016-06-29
Last modified:2016-08-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket
Bioorg.Med.Chem., 24, 2016
5B4L
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PDE10A COMPLEXED WITH 1-(CYCLOPROPYLMETHYL)-5-(2-(2,3-DIHYDRO-1H-IMIDAZO[1,2-A]BENZIMIDAZOL-1-YL)ETHOXY)-3-(1-PHENYL-1H-PYRAZOL-5-YL)PYRIDAZIN-4(1H)-ONE
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, MAGNESIUM ION, ZINC ION, ...
Authors:Oki, H., Zama, Y.
Deposit date:2016-04-05
Release date:2016-06-29
Last modified:2016-08-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket
Bioorg.Med.Chem., 24, 2016
5ZUN
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CRYSTAL STRUCTURE OF HUMAN MONOACYLGLYCEROL LIPASE IN COMPLEX WITH COMPOUND 3L
Descriptor:Monoglyceride lipase, (4R)-1-(2'-chloro[1,1'-biphenyl]-3-yl)-4-[4-(1,3-thiazole-2-carbonyl)piperazin-1-yl]pyrrolidin-2-one, TETRAETHYLENE GLYCOL, ...
Authors:Sogabe, S., Zama, Y., Lane, W., Snell, G.
Deposit date:2018-05-08
Release date:2018-10-17
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin-2-ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors
J. Med. Chem., 61, 2018