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5W5F
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BU of 5w5f by Molmil
Cryo-EM structure of the T4 tail tube
Descriptor: Tail tube protein gp19
Authors:Zheng, W, Wang, F, Taylor, N.M, Guerrero-Ferreira, R.C, Leiman, P.G, Egelman, E.H.
Deposit date:2017-06-15
Release date:2017-08-16
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Refined Cryo-EM Structure of the T4 Tail Tube: Exploring the Lowest Dose Limit.
Structure, 25, 2017
6D1W
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BU of 6d1w by Molmil
human PKD2 F604P mutant
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2
Authors:Zheng, W, Yang, X, Bulkley, D, Chen, X.Z, Cao, E.
Deposit date:2018-04-12
Release date:2018-06-27
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels.
Nat Commun, 9, 2018
2ICJ
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BU of 2icj by Molmil
The crystal structure of human isopentenyl diphophate isomerase
Descriptor: Isopentenyl-diphosphate delta isomerase, MAGNESIUM ION, SULFATE ION
Authors:Zheng, W, Bartlam, M, Rao, Z.
Deposit date:2006-09-12
Release date:2007-03-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The crystal structure of human isopentenyl diphosphate isomerase at 1.7 A resolution reveals its catalytic mechanism in isoprenoid biosynthesis
J.Mol.Biol., 366, 2007
2ICK
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BU of 2ick by Molmil
Human isopentenyl diphophate isomerase complexed with substrate analog
Descriptor: DIMETHYLALLYL DIPHOSPHATE, Isopentenyl-diphosphate delta isomerase, MANGANESE (II) ION
Authors:Zheng, W, Bartlam, M, Rao, Z.
Deposit date:2006-09-12
Release date:2007-03-20
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The crystal structure of human isopentenyl diphosphate isomerase at 1.7 A resolution reveals its catalytic mechanism in isoprenoid biosynthesis
J.Mol.Biol., 366, 2007
8EHX
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BU of 8ehx by Molmil
cryo-EM structure of TMEM63B in LMNG
Descriptor: CSC1-like protein 2
Authors:Zheng, W, Fu, T.M, Holt, J.R.
Deposit date:2022-09-14
Release date:2023-08-23
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels.
Neuron, 111, 2023
8EHW
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BU of 8ehw by Molmil
cryo-EM structure of TMEM63A in nanodisc
Descriptor: CSC1-like protein 1
Authors:Zheng, W, Fu, T.M, Holt, J.R.
Deposit date:2022-09-14
Release date:2023-08-23
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels.
Neuron, 111, 2023
4EWC
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BU of 4ewc by Molmil
Crystal Structure of the Infectious Salmon Anemia Virus Nucleoprotein
Descriptor: Putative nucleoprotein
Authors:Zheng, W, Tao, Y.J.
Deposit date:2012-04-26
Release date:2013-05-08
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The crystal structure and RNA-binding of an orthomyxovirus nucleoprotein.
Plos Pathog., 9, 2013
6NRV
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BU of 6nrv by Molmil
Cryo-EM reconstruction of CFA/I pili
Descriptor: CFA/I fimbrial subunit B
Authors:Zheng, W, Andersson, M, Bullitt, E, Egelman, E.H.
Deposit date:2019-01-24
Release date:2019-09-11
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structure of the CFA/I pilus rod.
Iucrj, 6, 2019
7EHW
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BU of 7ehw by Molmil
BRD4-BD1 in complex with LT-642-602
Descriptor: 1-[4-ethyl-2-methyl-5-(6-morpholin-4-yl-1H-benzimidazol-2-yl)-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4
Authors:Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y.
Deposit date:2021-03-30
Release date:2022-03-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:BRD4-BD1 in complex with LT-642-602
To Be Published
7EIK
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BU of 7eik by Molmil
RD4-BD1 in complex with LT-872-297
Descriptor: 1-[2-methyl-5-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-4-(1-methylpyrazol-4-yl)-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4
Authors:Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y.
Deposit date:2021-03-31
Release date:2022-04-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:RD4-BD1 in complex with LT-872-297
To Be Published
7EHY
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BU of 7ehy by Molmil
BRD4-BD1 in complex with LT-448-138
Descriptor: 1-[2,4-dimethyl-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4
Authors:Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y.
Deposit date:2021-03-30
Release date:2022-03-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:BRD4-BD1 in complex with LT-642-602
To Be Published
7EIG
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BU of 7eig by Molmil
BRD4-BD1 in complex with LT-730-903
Descriptor: 1-[5-(5-azanyl-1H-benzimidazol-2-yl)-2-methyl-4-phenyl-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4
Authors:Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y.
Deposit date:2021-03-31
Release date:2022-04-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:BRD4-BD1 in complex with LT-730-903
To Be Published
7DMP
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BU of 7dmp by Molmil
Mouse radial spoke complex
Descriptor: Radial spoke head 1 homolog, Radial spoke head protein 4 homolog A, Radial spoke head protein 9 homolog
Authors:Zheng, W, Cong, Y.
Deposit date:2020-12-05
Release date:2021-07-21
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM
Proc.Natl.Acad.Sci.USA, 118, 2021
7JSV
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BU of 7jsv by Molmil
Cryo-EM structure of conjugative pili from carbapenem-resistant Klebsiella pneumoniae
Descriptor: 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, Pilin
Authors:Zheng, W, Pena, A, Frankel, G, Egelman, E.H.
Deposit date:2020-08-16
Release date:2020-09-02
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryoelectron-Microscopic Structure of the pKpQIL Conjugative Pili from Carbapenem-Resistant Klebsiella pneumoniae.
Structure, 28, 2020
7KHW
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BU of 7khw by Molmil
Cryo-EM structure of enteropathogenic Escherichia coli type III secretion system EspA filament
Descriptor: Translocon EspA
Authors:Zheng, W, Ilangovan, A, Costa, T.R.D, Egelman, E.H.
Deposit date:2020-10-22
Release date:2020-12-23
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryoelectron-microscopy structure of the enteropathogenic Escherichia coli type III secretion system EspA filament.
Proc.Natl.Acad.Sci.USA, 118, 2021
1A6R
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BU of 1a6r by Molmil
GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A
Descriptor: GAL6, SULFATE ION
Authors:Joshua-Tor, L, Zheng, W, Johnston, S.A.
Deposit date:1998-02-27
Release date:1998-10-21
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase.
Cell(Cambridge,Mass.), 93, 1998
8TJ2
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BU of 8tj2 by Molmil
CryoEM structure of Myxococcus xanthus type IV pilus
Descriptor: Type IV major pilin protein PilA
Authors:Zheng, W, Egelman, E.H.
Deposit date:2023-07-20
Release date:2023-08-09
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Large pilin subunits provide distinct structural and mechanical properties for the Myxococcus xanthus type IV pilus.
Biorxiv, 2023
6VEC
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BU of 6vec by Molmil
Cryo-EM structure of F-actin/Plastin2-ABD2 complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Zheng, W, Kudryashov, D.S, Egelman, E.H.
Deposit date:2019-12-31
Release date:2020-12-09
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Osteogenesis imperfecta mutations in plastin 3 lead to impaired calcium regulation of actin bundling.
Bone Res, 8, 2020
5W5E
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BU of 5w5e by Molmil
Re-refinement of the pyocin tube structure
Descriptor: FIIR2 protein
Authors:Wang, F, Zheng, W, Taylor, N.M, Guerrero-Ferreira, R.C, Leiman, P.G, Egelman, E.H.
Deposit date:2017-06-15
Release date:2017-08-16
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Refined Cryo-EM Structure of the T4 Tail Tube: Exploring the Lowest Dose Limit.
Structure, 25, 2017
7K3R
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BU of 7k3r by Molmil
Cryo-EM structure of AIM2-PYD filament
Descriptor: Interferon-inducible protein AIM2
Authors:Zheng, W, Matyszewski, M, Sohn, J, Egelman, E.H.
Deposit date:2020-09-12
Release date:2021-05-26
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome.
Nat Commun, 12, 2021
3GCB
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BU of 3gcb by Molmil
GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A/DELTAK454
Descriptor: GAL6, GLYCEROL, SULFATE ION
Authors:Joshua-Tor, L, Zheng, W, Johnston, S.A.
Deposit date:1998-02-27
Release date:1998-10-21
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase.
Cell(Cambridge,Mass.), 93, 1998
4FMU
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BU of 4fmu by Molmil
Crystal structure of Methyltransferase domain of human SET domain-containing protein 2 Compound: Pr-SNF
Descriptor: (2S,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-(propylamino)hexanoic acid, Histone-lysine N-methyltransferase SETD2, UNKNOWN ATOM OR ION, ...
Authors:Dong, A, Zeng, H, Ibanez, G, Zheng, W, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Min, J, Luo, M, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2012-06-18
Release date:2012-09-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2.
J.Am.Chem.Soc., 134, 2012
6C53
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BU of 6c53 by Molmil
Cryo-EM structure of the Type 1 pilus rod
Descriptor: Type-1 fimbrial protein, A chain
Authors:Zheng, W, Wang, F, Luna-Rico, A, Francetic, O, Hultgren, S.J, Egelman, E.H.
Deposit date:2018-01-13
Release date:2018-01-31
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions.
Elife, 7, 2018
6MKS
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BU of 6mks by Molmil
Cryo-EM structure of NLRC4-CARD filament
Descriptor: Chimera protein of NLR family CARD domain-containing protein 4 and EGFP
Authors:Zheng, W, Matyszewski, M, Sohn, J, Egelman, E.H.
Deposit date:2018-09-26
Release date:2018-11-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure of the NLRC4CARDfilament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly.
J. Biol. Chem., 293, 2018
6OIF
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BU of 6oif by Molmil
Cryo-EM structure of human TorsinA filament
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Torsin-1A
Authors:Zheng, W, Demircioglu, F.E, Schwartz, T.U, Egelman, E.H.
Deposit date:2019-04-09
Release date:2019-07-24
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn.
Nat Commun, 10, 2019

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