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6HHQ
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CRYSTAL STRUCTURE OF COMPOUND C45 BOUND TO THE YEAST 80S RIBOSOME
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Pellegrino, S., Vanderwal, C.D., Yusupov, M.
Deposit date:2018-08-28
Release date:2019-02-20
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome.
Nucleic Acids Res., 2019
6GZQ
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T. THERMOPHILUS HIBERNATING 70S RIBOSOME
Descriptor:50S ribosomal protein L2, 50S ribosomal protein L3, 50S ribosomal protein L4, ...
Authors:Flygaard, R.K., Jenner, L.B.
Deposit date:2018-07-04
Release date:2018-10-24
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism.
Nat Commun, 9, 2018
6GZX
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T. THERMOPHILUS HIBERNATING 100S RIBOSOME (ICE)
Descriptor:50S ribosomal protein L2, 50S ribosomal protein L3, 50S ribosomal protein L4, ...
Authors:Flygaard, R.K., Jenner, L.B.
Deposit date:2018-07-05
Release date:2018-10-24
Method:ELECTRON MICROSCOPY (4.57 Å)
Cite:Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism.
Nat Commun, 9, 2018
6GZZ
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T. THERMOPHILUS HIBERNATING 100S RIBOSOME (AMC)
Descriptor:50S ribosomal protein L2, 50S ribosomal protein L3, 50S ribosomal protein L4, ...
Authors:Flygaard, R.K., Jenner, L.B.
Deposit date:2018-07-05
Release date:2018-10-24
Method:ELECTRON MICROSCOPY (4.13 Å)
Cite:Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism.
Nat Commun, 9, 2018
6GQ1
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CRYO-EM RECONSTRUCTION OF YEAST 80S RIBOSOME IN COMPLEX WITH MRNA, TRNA AND EEF2 (GMPPCP/SORDARIN)
Descriptor:Saccharomyces cerevisiae S288C 35S pre-ribosomal RNA (RDN37-1), miscRNA, 5.8S ribosomal RNA, ...
Authors:Pellegrino, S., Demeshkina, N., Mancera-Martinez, E., Melnikov, S., Simonetti, A., Myasnikov, A., Yusupov, M., Yusupova, G., Hashem, Y.
Deposit date:2018-06-07
Release date:2018-07-11
Last modified:2018-08-08
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
J. Mol. Biol., 430, 2018
6GQB
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CRYO-EM RECONSTRUCTION OF YEAST 80S RIBOSOME IN COMPLEX WITH MRNA, TRNA AND EEF2 (GDP+ALF4/SORDARIN)
Descriptor:Saccharomyces cerevisiae S288C 35S pre-ribosomal RNA (RDN37-1), miscRNA, 5S ribosomal RNA, ...
Authors:Pellegrino, S., Yusupov, M., Yusupova, G., Hashem, Y.
Deposit date:2018-06-07
Release date:2018-07-11
Last modified:2018-11-28
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
J. Mol. Biol., 430, 2018
6GQV
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CRYO-EM RECOSNTRUCTION OF YEAST 80S RIBOSOME IN COMPLEX WITH MRNA, TRNA AND EEF2 (GMPPCP)
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Pellegrino, S., Yusupov, M., Yusupova, G., Hashem, Y.
Deposit date:2018-06-08
Release date:2018-07-11
Last modified:2018-08-08
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
J. Mol. Biol., 430, 2018
6GSJ
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STRUCTURE OF T. THERMOPHILUS 70S RIBOSOME COMPLEX WITH MRNA, TRNAFMET AND COGNATE TRNATHR IN THE A-SITE
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Rozov, A., Yusupov, M., Yusupova, G.
Deposit date:2018-06-14
Release date:2018-07-04
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Tautomeric G•U pairs within the molecular ribosomal grip and fidelity of decoding in bacteria.
Nucleic Acids Res., 46, 2018
6GSK
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STRUCTURE OF T. THERMOPHILUS 70S RIBOSOME COMPLEX WITH MRNA, TRNAFMET AND NEAR-COGNATE TRNATHR IN THE A-SITE
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Rozov, A., Yusupov, M., Yusupova, G.
Deposit date:2018-06-14
Release date:2018-07-04
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.36 Å)
Cite:Tautomeric G•U pairs within the molecular ribosomal grip and fidelity of decoding in bacteria.
Nucleic Acids Res., 46, 2018
6GSL
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STRUCTURE OF T. THERMOPHILUS 70S RIBOSOME COMPLEX WITH MRNA, TRNAFMET AND COGNATE TRNAARG IN THE A-SITE
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Rozov, A., Yusupov, M., Yusupova, G.
Deposit date:2018-06-14
Release date:2018-07-04
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Tautomeric G•U pairs within the molecular ribosomal grip and fidelity of decoding in bacteria.
Nucleic Acids Res., 46, 2018
5NDJ
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE TC007 IN COMPLEX WITH 70S RIBOSOME FROM THERMUS THERMOPHILUS, THREE TRNAS AND MRNA (SOAKING)
Descriptor:16S ribosomal RNA, 50S ribosomal protein L18, 50S ribosomal protein L23, ...
Authors:Prokhorova, I., Djumagulov, M., Urzhumtsev, A., Yusupov, M., Yusupova, G.
Deposit date:2017-03-08
Release date:2018-05-02
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Aminoglycoside interactions and impacts on the eukaryotic ribosome.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5ON6
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CRYSTAL STRUCTURE OF HAEMANTHAMINE BOUND TO THE 80S RIBOSOME
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Pellegrino, S., Meyer, M., Yusupova, G., Yusupov, M.
Deposit date:2017-08-03
Release date:2018-02-28
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (3.100002 Å)
Cite:The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth.
Structure, 26, 2018
5NDG
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CRYSTAL STRUCTURE OF GENETICIN (G418) BOUND TO THE YEAST 80S RIBOSOME
Descriptor:18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ...
Authors:Prokhorova, I., Djumagulov, M., Urzhumtsev, A., Yusupov, M., Yusupova, G.
Deposit date:2017-03-08
Release date:2017-12-13
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Aminoglycoside interactions and impacts on the eukaryotic ribosome.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NDK
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE TC007 CO-CRYSTALLIZED WITH 70S RIBOSOME FROM THERMUS THERMOPHILUS, THREE TRNAS AND MRNA
Descriptor:16S ribosomal RNA, 50S ribosomal protein L18, 50S ribosomal protein L23, ...
Authors:Prokhorova, I., Djumagulov, M., Urzhumtsev, A., Yusupov, M., Yusupova, G.
Deposit date:2017-03-08
Release date:2017-12-13
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Aminoglycoside interactions and impacts on the eukaryotic ribosome.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NDV
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CRYSTAL STRUCTURE OF PAROMOMYCIN BOUND TO THE YEAST 80S RIBOSOME
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Prokhorova, I., Djumagulov, M., Urzhumtsev, A., Yusupov, M., Yusupova, G.
Deposit date:2017-03-09
Release date:2017-12-13
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Aminoglycoside interactions and impacts on the eukaryotic ribosome.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NDW
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE TC007 BOUND TO THE YEAST 80S RIBOSOME
Descriptor:25S ribosomal RNA, 18S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Prokhorova, I., Djumagulov, M., Urzhumtsev, A., Yusupov, M., Yusupova, G.
Deposit date:2017-03-09
Release date:2017-12-13
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Aminoglycoside interactions and impacts on the eukaryotic ribosome.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5OBM
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CRYSTAL STRUCTURE OF GENTAMICIN BOUND TO THE YEAST 80S RIBOSOME
Descriptor:25S ribosomal RNA, 5S Ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Prokhorova, I., Djumagulov, M., Urzhumtsev, A., Yusupov, M., Yusupova, G.
Deposit date:2017-06-28
Release date:2017-12-13
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Aminoglycoside interactions and impacts on the eukaryotic ribosome.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5TBW
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CRYSTAL STRUCTURE OF CHLOROLISSOCLIMIDE BOUND TO THE YEAST 80S RIBOSOME
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Konst, Z.A., Szklarski, A.R., Pellegrino, S., Michalak, S.E., Meyer, M., Zanette, C., Cencic, R., Nam, S., Horne, D.A., Pelletier, J., Mobley, D.L., Yusupova, G., Yusupov, M., Vanderwal, C.D.
Deposit date:2016-09-13
Release date:2017-07-26
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides.
Nat Chem, 9, 2017
5NKO
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SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OF S. AUREUS HIBERNATING PROMOTING FACTOR (CTD-SAHPF)
Descriptor:Ribosome hibernation promotion factor
Authors:Usachev, K.S., Khusainov, I.S., Ayupov, R.K., Validov, S.Z., Kieffer, B., Yusupov, M.M.
Deposit date:2017-03-31
Release date:2017-07-05
Last modified:2017-07-26
Method:SOLUTION NMR
Cite:Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF.
EMBO J., 36, 2017
5MEI
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CRYSTAL STRUCTURE OF AGELASTATIN A BOUND TO THE 80S RIBOSOME
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:McClary, B., Zinshteyn, B., Meyer, M., Jouanneau, M., Pellegrino, S., Yusupova, G., Schuller, A., Reyes, J.C.P., Lu, J., Luo, C., Dang, Y., Romo, D., Yusupov, M., Green, R., Liu, J.O.
Deposit date:2016-11-15
Release date:2017-06-28
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.
Cell Chem Biol, 24, 2017
5ND8
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HIBERNATING RIBOSOME FROM STAPHYLOCOCCUS AUREUS (UNROTATED STATE)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Khusainov, I., Vicens, Q., Ayupov, R., Usachev, K., Myasnikov, A., Simonetti, A., Validov, S., Kieffer, B., Yusupova, G., Yusupov, M., Hashem, Y.
Deposit date:2017-03-07
Release date:2017-06-28
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF.
EMBO J., 36, 2017
5ND9
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HIBERNATING RIBOSOME FROM STAPHYLOCOCCUS AUREUS (ROTATED STATE)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Khusainov, I., Vicens, Q., Ayupov, R., Usachev, K., Myasnikov, A., Simonetti, A., Validov, S., Kieffer, B., Yusupova, G., Yusupov, M., Hashem, Y.
Deposit date:2017-03-07
Release date:2017-06-28
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF.
EMBO J., 36, 2017
5DGE
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COPING WITH PROLINE STALLING: STRUCTURAL BASIS OF HYPUSINE-INDUCED PROTEIN SYNTHESIS BY THE EUKARYOTIC RIBOSOME
Descriptor:18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ...
Authors:Melnikov, S., Mailliot, J., Shin, B.-S., Rigger, L., Yusupova, G., Micura, R., Dever, T.E., Yusupov, M.
Deposit date:2015-08-27
Release date:2017-01-25
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome
To Be Published
5TGM
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CRYSTAL STRUCTURE OF THE S.CEREVISIAE 80S RIBOSOME IN COMPLEX WITH THE A-SITE BOUND AMINOACYL-TRNA ANALOG ACCA-PRO
Descriptor:18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ...
Authors:Melnikov, S., Mailliot, J., Yusupov, M.
Deposit date:2016-09-28
Release date:2017-01-18
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Molecular insights into protein synthesis with proline residues.
EMBO Rep., 17, 2016
5LI0
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70S RIBOSOME FROM STAPHYLOCOCCUS AUREUS
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Khusainov, I., Vicens, Q., Bochler, A., Grosse, F., Myasnikov, A., Menetret, J.F., Chicher, J., Marzi, S., Romby, P., Yusupova, G., Yusupov, M., Hashem, Y.
Deposit date:2016-07-13
Release date:2016-12-28
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of the 70S ribosome from human pathogen Staphylococcus aureus.
Nucleic Acids Res., 44, 2016