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Thermolysin with bicyclic inhibitor
Descriptor:	2-(4-METHYLPHENOXY)ETHYLPHOSPHINATE, 3-METHYLBUTAN-1-AMINE, CALCIUM ION, ...
Authors:	Juers, D, Yusuff, N, Bartlett, P.A, Matthews, B.W.
Deposit date:	2003-05-21
Release date:	2004-06-08
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.82 Å)
Cite:	Conformational Constraint and Structural Complementarity in Thermolysin Inhibitors: Structures of Enzyme Complexes and Conclusions To be Published

Thermolysin with tricyclic inhibitor
Descriptor:	(6-METHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL)METHYLPHOSPHINATE, 3-METHYLBUTAN-1-AMINE, CALCIUM ION, ...
Authors:	Juers, D, Holland, D, Morgan, B.P, Bartlett, P.A, Matthews, B.W.
Deposit date:	2003-05-21
Release date:	2004-06-08
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Conformational Constraint and Structural Complementarity in Thermolysin Inhibitors: Structures of Enzyme Complexes and Conclusions To be Published

Thermolysin with monocyclic inhibitor
Descriptor:	2-ETHOXYETHYLPHOSPHINATE, 3-METHYLBUTAN-1-AMINE, CALCIUM ION, ...
Authors:	Juers, D, Pyun, H.-J, Bartlett, P.A, Matthews, B.W.
Deposit date:	2003-05-21
Release date:	2004-06-08
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Conformational Constraint and Structural Complementarity in Thermolysin Inhibitors: Structures of Enzyme Complexes and Conclusions To be Published

Crystal Structure of human Bcl-2 in complex with a small molecule inhibitor targeting Bcl-2 BH3 domain interactions
Descriptor:	Apoptosis regulator Bcl-2, Bcl-2-like protein 1 chimera, N-(6-{4-[(4'-chlorobiphenyl-2-yl)methyl]piperazin-1-yl}-1,1-dioxido-1,2-benzothiazol-3-yl)-4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzenesulfonamide
Authors:	Xie, X, Kulathila, R.
Deposit date:	2012-12-13
Release date:	2013-07-10
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	The role of the acidity of N-heteroaryl sulfonamides as inhibitors of bcl-2 family protein-protein interactions. ACS Med Chem Lett, 4, 2013