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2HIM
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CRYSTAL STRUCTURE AND ALLOSTERIC REGULATION OF THE CYTOPLASMIC ESCHERICHIA COLI L-ASPARAGINASE I
Descriptor:L-asparaginase 1, ASPARTIC ACID, ASPARAGINE, ...
Authors:Yun, M.K., Nourse, A., White, S.W., Rock, C.O., Heath, R.J.
Deposit date:2006-06-29
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia coli L-Asparaginase I.
J.Mol.Biol., 369, 2007
3TYU
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CRYSTAL STRUCTURE OF DIHYDROPTEROATE SYNTHETASE WITH PRODUCT1
Descriptor:7,8-dihydropteroate synthase, PTEROIC ACID
Authors:Yun, M.K.
Deposit date:2011-09-26
Release date:2012-03-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Catalysis and sulfa drug resistance in dihydropteroate synthase.
Science, 335, 2012
2F9T
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STRUCTURE OF THE TYPE III COAA FROM PSEUDOMONAS AERUGINOSA
Descriptor:Pantothenate Kinase
Authors:Leonardi, R., Yun, M.K., Chohnan, S., White, S.W., Rock, C.O., Jackowski, S.
Deposit date:2005-12-06
Release date:2006-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Prokaryotic Type II and Type III Pantothenate Kinases: The Same Monomer Fold Creates Dimers with Distinct Catalytic Properties.
Structure, 14, 2006
2F9W
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STRUCTURE OF THE TYPE III COAA FROM PSEUDOMONAS AERUGINOSA
Descriptor:Pantothenate Kinase, PANTOTHENOIC ACID, 1,2-ETHANEDIOL, ...
Authors:Leonardi, R., Yun, M.K., Chohnan, S., White, S.W., Rock, C.O., Jackowski, S.
Deposit date:2005-12-06
Release date:2006-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Prokaryotic Type II and Type III Pantothenate Kinases: The Same Monomer Fold Creates Dimers with Distinct Catalytic Properties.
Structure, 14, 2006
3UPU
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CRYSTAL STRUCTURE OF THE T4 PHAGE SF1B HELICASE DDA
Descriptor:ATP-dependent DNA helicase dda, 5'-D(*TP*TP*TP*TP*TP*TP*TP*T)-3'
Authors:He, X., Yun, M.K., Pemble IV, C.W., Kreuzer, K.N., Raney, K.D., White, S.W.
Deposit date:2011-11-18
Release date:2012-06-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.299 Å)
Cite:The T4 Phage SF1B Helicase Dda Is Structurally Optimized to Perform DNA Strand Separation.
Structure, 20, 2012
4HNJ
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CRYSTALLOGRAPHIC STRUCTURE OF BCL-XL DOMAIN-SWAPPED DIMER IN COMPLEX WITH PUMA BH3 PEPTIDE AT 2.9A RESOLUTION
Descriptor:Bcl-2-like protein 1, Bcl-2-binding component 3
Authors:Fisher, J.C., Yun, M.K., White, S.W.
Deposit date:2012-10-19
Release date:2013-01-23
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
Nat.Chem.Biol., 9, 2013
3TYA
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DIHYDROPTEROATE SYNTHASE IN COMPLEX WITH PRODUCT
Descriptor:Dihydropteroate synthase, 7,8-DIHYDROPTEROATE, SULFATE ION
Authors:White, S.W., Yun, M.-K.
Deposit date:2011-09-24
Release date:2012-03-14
Method:X-RAY DIFFRACTION (2.611 Å)
Cite:Catalysis and sulfa drug resistance in dihydropteroate synthase.
Science, 335, 2012
3TYB
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DIHYDROPTEROATE SYNTHASE IN COMPLEX WITH PHBA AND DHP+
Descriptor:Dihydropteroate synthase, 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, P-HYDROXYBENZOIC ACID, ...
Authors:Yun, M.-K., White, S.W.
Deposit date:2011-09-24
Release date:2012-03-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Catalysis and sulfa drug resistance in dihydropteroate synthase.
Science, 335, 2012
3TYC
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DIHYDROPTEROATE SYNTHASE IN COMPLEX WITH DHP+
Descriptor:Dihydropteroate synthase, 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, SULFATE ION
Authors:Yun, M.-K., White, S.W.
Deposit date:2011-09-24
Release date:2012-03-14
Method:X-RAY DIFFRACTION (2.303 Å)
Cite:Catalysis and sulfa drug resistance in dihydropteroate synthase.
Science, 335, 2012
3TYD
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DIHYDROPTEROATE SYNTHASE IN COMPLEX WITH PPI AND DHP+
Descriptor:Dihydropteroate synthase, PYROPHOSPHATE 2-, 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, ...
Authors:Yun, M.-K., White, S.W.
Deposit date:2011-09-24
Release date:2012-03-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Catalysis and sulfa drug resistance in dihydropteroate synthase.
Science, 335, 2012
3TYE
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DIHYDROPTEROATE SYNTHASE IN COMPLEX WITH DHP-STZ
Descriptor:Dihydropteroate synthase, 4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide, SULFATE ION, ...
Authors:Yun, M.-K., White, S.W.
Deposit date:2011-09-24
Release date:2012-03-14
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Catalysis and sulfa drug resistance in dihydropteroate synthase.
Science, 335, 2012
3V5O
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STRUCTURAL AND MECHANISTIC STUDIES OF CATALYSIS AND SULFA DRUG RESISTANCE IN DIHYDROPTEROATE SYNTHASE
Descriptor:Dihydropteroate synthase, SULFATE ION
Authors:Yun, M., Wu, Y., Li, Z., Zhao, Y., Waddell, M.B., Ferreira, A.M., Lee, R.E., Bashford, D., White, S.W.
Deposit date:2011-12-16
Release date:2012-03-14
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Catalysis and sulfa drug resistance in dihydropteroate synthase.
Science, 335, 2012
4M5G
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, 2-amino-8-[(2-oxo-2-phenylethyl)sulfanyl]-1,9-dihydro-6H-purin-6-one, ...
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5H
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, 4-{[(2-amino-6-oxo-6,9-dihydro-1H-purin-8-yl)sulfanyl]methyl}benzonitrile, ...
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5I
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, CALCIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5J
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, 2-amino-8-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-1,9-dihydro-6H-purin-6-one, ...
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (1.696 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5K
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, CALCIUM ION, ...
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.296 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5L
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, CALCIUM ION, ...
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.094 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5M
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-amino-1,9-dihydro-6H-purine-6-thione, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.118 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5N
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, MAGNESIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2014-06-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
3TYZ
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CRYSTAL STRUCTURE OF THE YERSINIA PESTIS DIHYDROPTEROATE SYNTHETASE WITH SUBSTRATE TRANSITION STATE COMPLEX.
Descriptor:7,8-dihydropteroate synthase, 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, PYROPHOSPHATE 2-, ...
Authors:Wu, Y.
Deposit date:2011-09-26
Release date:2012-03-14
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Catalysis and sulfa drug resistance in dihydropteroate synthase.
Science, 335, 2012
3TZF
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CRYSTAL STRUCTURE OF THE YERSINIA PESTIS DIHYDROPTEROATE SYNTHASE WITH SULFONAMIDE DRUG COMPLEX.
Descriptor:7,8-dihydropteroate synthase, 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Wu, Y.
Deposit date:2011-09-27
Release date:2012-03-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Catalysis and sulfa drug resistance in dihydropteroate synthase.
Science, 335, 2012
3TZN
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CRYSTAL STRUCTURE OF THE YERSINIA PESTIS DIHYDROPTEROATE SYNTHASE.
Descriptor:7,8-dihydropteroate synthase
Authors:Wu, Y.
Deposit date:2011-09-27
Release date:2012-03-14
Method:X-RAY DIFFRACTION (2.083 Å)
Cite:Catalysis and sulfa drug resistance in dihydropteroate synthase.
Science, 335, 2012
3H21
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STRUCTURAL STUDIES OF PTERIN-BASED INHIBITORS OF DIHYDROPTEROATE SYNTHASE
Descriptor:Dihydropteroate synthase, (2R)-2-(7-amino-1-methyl-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)propanoic acid, SULFATE ION
Authors:Yun, M.-K., White, S.W.
Deposit date:2009-04-14
Release date:2009-12-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural studies of pterin-based inhibitors of dihydropteroate synthase.
J.Med.Chem., 53, 2010
3H22
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STRUCTURAL STUDIES OF PTERIN-BASED INHIBITORS OF DIHYDROPTEROATE SYNTHASE
Descriptor:Dihydropteroate synthase, 2,6-diamino-5-nitrosopyrimidin-4(3H)-one, SULFATE ION
Authors:Yun, M.-K., White, S.W.
Deposit date:2009-04-14
Release date:2009-12-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural studies of pterin-based inhibitors of dihydropteroate synthase.
J.Med.Chem., 53, 2010
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