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1DC3
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STRUCTURAL ANALYSIS OF GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE FROM ESCHERICHIA COLI: DIRECT EVIDENCE FOR SUBSTRATE BINDING AND COFACTOR-INDUCED CONFORMATIONAL CHANGES
Descriptor:GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE
Authors:Yun, M., Park, C.G., Kim, J.Y., Park, H.W.
Deposit date:1999-11-04
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of glyceraldehyde 3-phosphate dehydrogenase from Escherichia coli: direct evidence of substrate binding and cofactor-induced conformational changes.
Biochemistry, 39, 2000
1DC4
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STRUCTURAL ANALYSIS OF GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE FROM ESCHERICHIA COLI: DIRECT EVIDENCE FOR SUBSTRATE BINDING AND COFACTOR-INDUCED CONFORMATIONAL CHANGES
Descriptor:GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE, SN-GLYCEROL-3-PHOSPHATE
Authors:Yun, M., Park, C.-G., Kim, J.-Y., Park, H.-W.
Deposit date:1999-11-04
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of glyceraldehyde 3-phosphate dehydrogenase from Escherichia coli: direct evidence of substrate binding and cofactor-induced conformational changes.
Biochemistry, 39, 2000
1DC5
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STRUCTURAL ANALYSIS OF GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE FROM ESCHERICHIA COLI: DIRECT EVIDENCE FOR SUBSTRATE BINDING AND COFACTOR-INDUCED CONFORMATIONAL CHANGES
Descriptor:GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
Authors:Yun, M., Park, C.-G., Kim, J.-Y., Park, H.-W.
Deposit date:1999-11-04
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of glyceraldehyde 3-phosphate dehydrogenase from Escherichia coli: direct evidence of substrate binding and cofactor-induced conformational changes.
Biochemistry, 39, 2000
1DC6
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STRUCTURAL ANALYSIS OF GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE FROM ESCHERICHIA COLI: DIRECT EVIDENCE FOR SUBSTRATE BINDING AND COFACTOR-INDUCED CONFORMATIONAL CHANGES.
Descriptor:GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Yun, M., Park, C.-G., Kim, J.-Y., Park, H.-W.
Deposit date:1999-11-04
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of glyceraldehyde 3-phosphate dehydrogenase from Escherichia coli: direct evidence of substrate binding and cofactor-induced conformational changes.
Biochemistry, 39, 2000
1ESM
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STRUCTURAL BASIS FOR THE FEEDBACK REGULATION OF ESCHERICHIA COLI PANTOTHENATE KINASE BY COENZYME A
Descriptor:PANTOTHENATE KINASE, COENZYME A
Authors:Yun, M., Park, C.G., Kim, J.Y., Rock, C.O., Jackowski, S., Park, H.W.
Deposit date:2000-04-10
Release date:2000-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A.
J.Biol.Chem., 275, 2000
1ESN
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STRUCTURAL BASIS FOR THE FEEDBACK REGULATION OF ESCHERICHIA COLI PANTOTHENATE KINASE BY COENZYME A
Descriptor:PANTOTHENATE KINASE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Yun, M., Park, C.G., Kim, J.Y., Rock, C.O., Jackowski, S., Park, H.W.
Deposit date:2000-04-10
Release date:2000-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A.
J.Biol.Chem., 275, 2000
1F9T
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CRYSTAL STRUCTURES OF KINESIN MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE MOTOR ATPASE
Descriptor:KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Yun, M., Zhang, X., Park, C.-G., Park, H.-W., Endow, S.A.
Deposit date:2000-07-11
Release date:2001-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A structural pathway for activation of the kinesin motor ATPase.
EMBO J., 20, 2001
1F9U
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CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE
Descriptor:KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Yun, M., Zhang, X., Park, C.G., Park, H.W., Endow, S.A.
Deposit date:2000-07-11
Release date:2001-06-13
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A structural pathway for activation of the kinesin motor ATPase.
EMBO J., 20, 2001
1F9V
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CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE
Descriptor:KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Yun, M., Zhang, X., Park, C.G., Park, H.W., Endow, S.A.
Deposit date:2000-07-11
Release date:2001-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A structural pathway for activation of the kinesin motor ATPase.
EMBO J., 20, 2001
1F9W
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CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE
Descriptor:KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Yun, M., Zhang, X., Park, C.G., Park, H.W., Endow, S.A.
Deposit date:2000-07-11
Release date:2001-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A structural pathway for activation of the kinesin motor ATPase.
EMBO J., 20, 2001
1M7E
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CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE BINDING DOMAIN(PTB) OF MOUSE DISABLED 2(DAB2):IMPLICATIONS FOR REELING SIGNALING
Descriptor:Disabled homolog 2, NGYENPTYK peptide
Authors:Yun, M., Keshvara, L., Park, C.-G., Zhang, Y.-M., Dickerson, J.B., Zheng, J., Rock, C.O., Curran, T., Park, H.-W.
Deposit date:2002-07-19
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structures of the Dab homology domains of mouse disabled 1 and 2
J.Biol.Chem., 278, 2003
1N6M
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ROTATION OF THE STALK/NECK AND ONE HEAD IN A NEW CRYSTAL STRUCTURE OF THE KINESIN MOTOR PROTEIN, NCD
Descriptor:Claret segregational protein, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Yun, M., Bronner, C.E., Park, C.-G., Cha, S.-S., Park, H.-W., Endow, S.A.
Deposit date:2002-11-11
Release date:2003-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd
EMBO J., 22, 2003
1OQN
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CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE BINDING DOMAIN (PTB) OF MOUSE DISABLED 1 (DAB1)
Descriptor:Disabled homolog 1, Alzheimer's disease amyloid A4 protein homolog, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE
Authors:Yun, M., Keshvara, L., Park, C.-G., Zhang, Y.-M., Dickerson, J.B., Zheng, J., Rock, C.O., Curran, T., Park, H.-W.
Deposit date:2003-03-10
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of the Dab homology domains of mouse disabled 1 and 2
J.Biol.Chem., 278, 2003
1P3R
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CRYSTAL STRUCTURE OF THE PHOSPHOTYROSIN BINDING DOMAIN(PTB) OF MOUSE DISABLED 1(DAB1)
Descriptor:Disabled homolog 2
Authors:Yun, M., Keshvara, L., Park, C.G., Zhang, Y.M., Dickerson, J.B., Zheng, J., Rock, C.O., Curran, T., Park, H.W.
Deposit date:2003-04-18
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of the Dab homology domains of mouse disabled 1 and 2.
J.Biol.Chem., 278, 2003
1JYK
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CATALYTIC MECHANISM OF CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE FROM STREPTOCOCCUS PNEUMONIAE (LICC)
Descriptor:CTP:phosphocholine Cytidylyltransferase
Authors:Kwak, B.-Y., Yun, M., Park, H.-w.
Deposit date:2001-09-12
Release date:2002-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure and mechanism of CTP:phosphocholine cytidylyltransferase (LicC) from Streptococcus pneumoniae.
J.Biol.Chem., 277, 2002
1JYL
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CATALYTIC MECHANISM OF CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE FROM STREPTOCOCCUS PNEUMONIAE (LICC)
Descriptor:CTP:phosphocholine Cytidylyltransferase, MAGNESIUM ION, [2-CYTIDYLATE-O'-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM
Authors:Kwak, B.-Y., Yun, M., Park, H.-w.
Deposit date:2001-09-12
Release date:2002-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and mechanism of CTP:phosphocholine cytidylyltransferase (LicC) from Streptococcus pneumoniae.
J.Biol.Chem., 277, 2002
3V5O
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STRUCTURAL AND MECHANISTIC STUDIES OF CATALYSIS AND SULFA DRUG RESISTANCE IN DIHYDROPTEROATE SYNTHASE
Descriptor:Dihydropteroate synthase, SULFATE ION
Authors:Yun, M., Wu, Y., Li, Z., Zhao, Y., Waddell, M.B., Ferreira, A.M., Lee, R.E., Bashford, D., White, S.W.
Deposit date:2011-12-16
Release date:2012-03-14
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Catalysis and sulfa drug resistance in dihydropteroate synthase.
Science, 335, 2012
4M5G
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, 2-amino-8-[(2-oxo-2-phenylethyl)sulfanyl]-1,9-dihydro-6H-purin-6-one, ...
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5H
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, 4-{[(2-amino-6-oxo-6,9-dihydro-1H-purin-8-yl)sulfanyl]methyl}benzonitrile, ...
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5I
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, CALCIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5J
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, 2-amino-8-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-1,9-dihydro-6H-purin-6-one, ...
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (1.696 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5K
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, CALCIUM ION, ...
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.296 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5L
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, CALCIUM ION, ...
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.094 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5M
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-amino-1,9-dihydro-6H-purine-6-thione, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.118 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5N
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, MAGNESIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2014-06-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
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