Author results

3J2T
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AN IMPROVED MODEL OF THE HUMAN APOPTOSOME
Descriptor:Apoptotic protease-activating factor 1, Cytochrome c, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Yuan, S., Topf, M., Akey, C.W.
Deposit date:2012-12-23
Release date:2013-04-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (9.5 Å)
Cite:Changes in apaf-1 conformation that drive apoptosome assembly.
Biochemistry, 52, 2013
4V4L
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STRUCTURE OF THE DROSOPHILA APOPTOSOME
Descriptor:Apaf-1 related killer DARK, MAGNESIUM ION, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
Authors:Yuan, S., Topf, M., Akey, C.W., Ludtke, S.J.
Deposit date:2010-10-04
Release date:2014-07-09
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (6.9 Å)
Cite:Structure of the Drosophila apoptosome at 6.9 angstrom resolution
Structure, 19, 2011
5DZN
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HUMAN T-CELL IMMUNOGLOBULIN AND MUCIN DOMAIN PROTEIN 4
Descriptor:T-cell immunoglobulin and mucin domain-containing protein 4
Authors:Yuan, S., Rao, Z., Wang, X.
Deposit date:2015-09-25
Release date:2015-11-25
Last modified:2016-02-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope.
Protein Cell, 6, 2015
5DZO
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CRYSTAL STRUCTURE OF HUMAN T-CELL IMMUNOGLOBULIN AND MUCIN DOMAIN PROTEIN 1
Descriptor:Hepatitis A virus cellular receptor 1, NITRATE ION, SODIUM ION
Authors:Yuan, S., Rao, Z., Wang, X.
Deposit date:2015-09-25
Release date:2015-11-25
Last modified:2016-02-10
Method:X-RAY DIFFRACTION (1.301 Å)
Cite:TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope.
Protein Cell, 6, 2015
5ZAP
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ATOMIC STRUCTURE OF THE HERPES SIMPLEX VIRUS TYPE 2 B-CAPSID
Descriptor:Major capsid protein, Triplex capsid protein 2, Triplex capsid protein 1, ...
Authors:Yuan, S., Wang, J.L., Zhu, D.J., Wang, N., Gao, Q., Chen, W.Y., Tang, H., Wang, J.Z., Zhang, X.Z., Liu, H.R., Rao, Z.H., Wang, X.X.
Deposit date:2018-02-08
Release date:2018-04-18
Last modified:2018-09-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structure of a herpesvirus capsid at 3.1 angstrom.
Science, 360, 2018
1Z5R
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CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B
Descriptor:procarboxypeptidase B, ZINC ION
Authors:Adler, M., Bryant, J., Buckman, B., Islam, I., Larsen, B., Finster, S., Kent, L., May, K., Mohan, R., Yuan, S., Whitlow, M.
Deposit date:2005-03-18
Release date:2005-07-12
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structures of potent thiol-based inhibitors bound to carboxypeptidase b.
Biochemistry, 44, 2005
1ZG7
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CRYSTAL STRUCTURE OF 2-(5-{[AMINO(IMINO)METHYL]AMINO}-2-CHLOROPHENYL)-3-SULFANYLPROPANOIC ACID BOUND TO ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B
Descriptor:procarboxypeptidase B, ZINC ION, 2-(5-{[AMINO(IMINO)METHYL]AMINO}-2-CHLOROPHENYL)-3-SULFANYLPROPANOIC ACID
Authors:Adler, M., Bryant, J., Buckman, B., Islam, I., Larsen, B., Finster, S., Kent, L., May, K., Mohan, R., Yuan, S., Whitlow, M.
Deposit date:2005-04-20
Release date:2005-07-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structures of potent thiol-based inhibitors bound to carboxypeptidase b.
Biochemistry, 44, 2005
1ZG8
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CRYSTAL STRUCTURE OF (R)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-SULFANYLPROPANOIC ACID BOUND TO ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B
Descriptor:procarboxypeptidase B, ZINC ION, (2R)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-SULFANYLPROPANOIC ACID
Authors:Adler, M., Bryant, J., Buckman, B., Islam, I., Larsen, B., Finster, S., Kent, L., May, K., Mohan, R., Yuan, S., Whitlow, M.
Deposit date:2005-04-20
Release date:2005-07-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of potent thiol-based inhibitors bound to carboxypeptidase b.
Biochemistry, 44, 2005
1ZG9
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CRYSTAL STRUCTURE OF 5-{[AMINO(IMINO)METHYL]AMINO}-2-(SULFANYLMETHYL)PENTANOIC ACID BOUND TO ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B
Descriptor:procarboxypeptidase B, ZINC ION, 5-{[AMINO(IMINO)METHYL]AMINO}-2-(SULFANYLMETHYL)PENTANOIC ACID
Authors:Adler, M., Bryant, J., Buckman, B., Islam, I., Larsen, B., Finster, S., Kent, L., May, K., Mohan, R., Yuan, S., Whitlow, M.
Deposit date:2005-04-20
Release date:2005-07-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of potent thiol-based inhibitors bound to carboxypeptidase b.
Biochemistry, 44, 2005
4I11
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STRUCTURE-BASED DESIGN OF NOVEL DIHYDROISOQUINOLINE BACE-1 INHIBITORS THAT DO NOT ENGAGE THE CATALYTIC ASPARTATES.
Descriptor:Beta-secretase 1, ZINC ION, N-(3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)-L-phenylalanine
Authors:Bowers, B., Xu, Y., Yuan, S., Probst, G.D., Hom, R.K., Chan, W., Konradi, A.W., Sham, H.L., Zhu, Y.L., Beroza, P., Pan, H., Brecht, E., Yao, N., Lougheed, J., Artis, D.R., Tam, D., Bova, M.
Deposit date:2012-11-19
Release date:2013-03-06
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Bioorg.Med.Chem.Lett., 23, 2013
5WSN
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STRUCTURE OF JAPANESE ENCEPHALITIS VIRUS
Descriptor:E protein, M protein
Authors:Wang, X., Zhu, L., Li, S., Yuan, S., Qin, C., Fry, E.E., Stuart, I.D., Rao, Z.
Deposit date:2016-12-07
Release date:2017-05-17
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability
Nat Commun, 8, 2017
6BQG
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CRYSTAL STRUCTURE OF 5-HT2C IN COMPLEX WITH ERGOTAMINE
Descriptor:5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, Ergotamine, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Peng, Y., McCorvy, J.D., Harpsoe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajse, L.F., Huang, X.P., Wu, Y., Shen, L., Bjorn-Yoshimoto, W.E., Ding, K., Wacker, D., Han, G.W., Cheng, J., Katritch, V., Jensen, A.A., Hanson, M.A., Zhao, S., Gloriam, D.E., Roth, B.L., Stevens, R.C., Liu, Z.
Deposit date:2017-11-27
Release date:2018-02-14
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Cell, 172, 2018
6BQH
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CRYSTAL STRUCTURE OF 5-HT2C IN COMPLEX WITH RITANSERIN
Descriptor:5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Peng, Y., McCorvy, J.D., Harpsoe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajse, L.F., Huang, X.P., Wu, Y., Shen, L., Bjorn-Yoshimoto, W.E., Ding, K., Wacker, D., Han, G.W., Cheng, J., Katritch, V., Jensen, A.A., Hanson, M.A., Zhao, S., Gloriam, D.E., Roth, B.L., Stevens, R.C., Liu, Z.
Deposit date:2017-11-27
Release date:2018-02-14
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Cell, 172, 2018
4MG3
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CRYSTAL STRUCTURAL ANALYSIS OF 2A PROTEASE FROM COXSACKIEVIRUS A16
Descriptor:Protease 2A, ZINC ION, PENTAETHYLENE GLYCOL, ...
Authors:Sun, Y., Wang, X., Dang, M., Yuan, S.
Deposit date:2013-08-28
Release date:2014-03-26
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:An open conformation determined by a structural switch for 2A protease from coxsackievirus A16.
Protein Cell, 4, 2013
5JUL
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NEAR ATOMIC STRUCTURE OF THE DARK APOPTOSOME
Descriptor:Apaf-1 related killer DARK, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
Authors:Cheng, T.C., Akey, I.V., Yuan, S., Yu, Z., Ludtke, S.J., Akey, C.W.
Deposit date:2016-05-10
Release date:2017-02-22
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:A Near-Atomic Structure of the Dark Apoptosome Provides Insight into Assembly and Activation.
Structure, 25, 2017
5JUY
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ACTIVE HUMAN APOPTOSOME WITH PROCASPASE-9
Descriptor:Apoptotic protease-activating factor 1, Cytochrome c, Caspase-9, ...
Authors:Cheng, T.C., Hong, C., Akey, I.V., Yuan, S., Akey, C.W.
Deposit date:2016-05-10
Release date:2016-10-19
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:A near atomic structure of the active human apoptosome.
Elife, 5, 2016
5WTE
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CRYO-EM STRUCTURE FOR HEPATITIS A VIRUS FULL PARTICLE
Descriptor:VP1, VP2, VP3
Authors:Wang, X., Zhu, L., Dang, M., Hu, Z., Gao, Q., Yuan, S., Sun, Y., Zhang, B., Ren, J., Walter, T.S., Wang, J., Fry, E.E., Stuart, D.I., Rao, Z.
Deposit date:2016-12-11
Release date:2017-01-25
Last modified:2017-02-08
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WTF
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CRYO-EM STRUCTURE FOR HEPATITIS A VIRUS EMPTY PARTICLE
Descriptor:VP1, VP0, VP3
Authors:Wang, X., Zhu, L., Dang, M., Hu, Z., Gao, Q., Yuan, S., Sun, Y., Zhang, B., Ren, J., Walter, T.S., Wang, J., Fry, E.E., Stuart, D.I., Rao, Z.
Deposit date:2016-12-11
Release date:2017-01-25
Last modified:2017-02-08
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WTG
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ANTI-HAV ANTIBODY R10
Descriptor:FAB Light chain, FAB Heavy chain
Authors:Wang, X., Zhu, L., Dang, M., Hu, Z., Gao, Q., Yuan, S., Sun, Y., Zhang, B., Ren, J., Walter, T.S., Wang, J., Fry, E.E., Stuart, D.I., Rao, Z.
Deposit date:2016-12-11
Release date:2017-01-25
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.907 Å)
Cite:Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WTH
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CRYO-EM STRUCTURE FOR HEPATITIS A VIRUS COMPLEXED WITH FAB
Descriptor:Polyprotein, VP2, VP3, ...
Authors:Wang, X., Zhu, L., Dang, M., Hu, Z., Gao, Q., Yuan, S., Sun, Y., Zhang, B., Ren, J., Walter, T.S., Wang, J., Fry, E.E., Stuart, D.I., Rao, Z.
Deposit date:2016-12-12
Release date:2017-01-25
Last modified:2017-02-08
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5YWO
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STRUCTURE OF JEV-2F2 FAB COMPLEX
Descriptor:JEV E protein, JEV M protein, 2F2 light chain, ...
Authors:Qiu, X., Lei, Y.F., Yang, P., Gao, Q., Wang, N., Cao, L., Yuan, S., Wang, X., Xu, Z.K., Rao, Z.
Deposit date:2017-11-29
Release date:2018-03-21
Last modified:2018-09-12
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies
Nat Microbiol, 3, 2018
5YWP
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JEV-2H4 FAB COMPLEX
Descriptor:JEV E protein, JEV M protein, 2H4 light chain, ...
Authors:Qiu, X.D., Lei, Y.F., Yang, P., Gao, Q., WANG, N., Cao, L., Yuan, S., Wang, X.X., Xu, Z.K., Rao, Z.H.
Deposit date:2017-11-29
Release date:2018-05-02
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies
Nat Microbiol, 3, 2018
5ZZ8
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STRUCTURE OF THE HERPES SIMPLEX VIRUS TYPE 2 C-CAPSID WITH CAPSID-VERTEX-SPECIFIC COMPONENT
Descriptor:VP19C, VP23, Major capsid protein, ...
Authors:Wang, J.L., Yuan, S., Zhu, D.J., Tang, H., Wang, N., Chen, W.Y., Gao, Q., Li, Y.H., Wang, J.Z., Liu, H.R., Zhang, X.Z., Rao, Z.H., Wang, X.X.
Deposit date:2018-05-31
Release date:2018-10-10
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component.
Nat Commun, 9, 2018
2PIY
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CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B (S)-2-(3-AMINOMETHYL-PHENYL)-3-{HYDROXY-[(R)-2-METHYL-1-(3-PHENYL-PROPANE-1-SULFONYLAMINO)-PROPYL]-PHOSPHINOYL}-PROPIONIC ACID {ZK 528} COMPLEX
Descriptor:Carboxypeptidase B, ZINC ION, (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-{(R)-HYDROXY[(1R)-2-METHYL-1-{[(3-PHENYLPROPYL)SULFONYL]AMINO}PROPYL]PHOSPHORYL}PROPANOIC ACID
Authors:Adler, M., Whitlow, M.
Deposit date:2007-04-15
Release date:2008-01-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Structures of potent selective peptide mimetics bound to carboxypeptidase B.
Acta Crystallogr.,Sect.D, 64, 2008
2PIZ
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CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B 2-(3-GUANIDINO-PHENYL)-3-[HYDROXY-(3-PHENYL-PROPYL)-PHOSPHINOYL]-PROPIONIC ACID COMPLEX
Descriptor:Carboxypeptidase B, ZINC ION, (2S)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-[(S)-HYDROXY(3-PHENYLPROPYL)PHOSPHORYL]PROPANOIC ACID
Authors:Adler, M., Whitlow, M.
Deposit date:2007-04-15
Release date:2008-01-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of potent selective peptide mimetics bound to carboxypeptidase B.
Acta Crystallogr.,Sect.D, 64, 2008
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