Author results

5TTE
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CRYSTAL STRUCTURE OF AN RBR E3 UBIQUITIN LIGASE IN COMPLEX WITH AN E2-UB THIOESTER INTERMEDIATE MIMIC
Descriptor:E3 ubiquitin-protein ligase ARIH1, Ubiquitin-conjugating enzyme E2 L3, ubiquitin, ...
Authors:Yuan, L., Lv, Z., Olsen, S.K.
Deposit date:2016-11-03
Release date:2017-08-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.501 Å)
Cite:Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI.
Nat Commun, 8, 2017
4J0U
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CRYSTAL STRUCTURE OF IFIT5/ISG58
Descriptor:Interferon-induced protein with tetratricopeptide repeats 5
Authors:Liu, Y., Liang, H., Feng, F., Yuan, L., Wang, Y.E., Crowley, C., Lv, Z., Li, J., Zeng, S., Cheng, G.
Deposit date:2013-01-31
Release date:2013-02-13
Method:X-RAY DIFFRACTION (1.969 Å)
Cite:Crystal Structure of IFIT5
To be Published
5KNL
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CRYSTAL STRUCTURE OF S. POMBE UBIQUITIN E1 (UBA1) IN COMPLEX WITH UBC15 AND UBIQUITIN
Descriptor:Ubiquitin-activating enzyme E1 1, Ubiquitin, Ubiquitin-conjugating enzyme E2 15, ...
Authors:Olsen, S.K., Lv, Z., Yuan, L., Williams, K.
Deposit date:2016-06-28
Release date:2017-02-15
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity.
Mol. Cell, 65, 2017
5UM6
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CRYSTAL STRUCTURE OF S. POMBE UBA1 IN A CLOSED CONFORMATION
Descriptor:Ubiquitin-activating enzyme E1 1, SULFATE ION, N-(2-{[(4-chlorophenyl)methyl]disulfanyl}ethyl)decan-1-amine, ...
Authors:Lv, Z., Yuan, L., Aldana-Masangkay, G., Atkison, J.H., Chen, Y., Olsen, S.K.
Deposit date:2017-01-26
Release date:2017-06-14
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.794 Å)
Cite:Domain alternation and active site remodeling are conserved structural features of ubiquitin E1.
J. Biol. Chem., 292, 2017
6CWY
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CRYSTAL STRUCTURE OF SUMO E1 IN COMPLEX WITH AN ALLOSTERIC INHIBITOR
Descriptor:SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, GLYCEROL, ...
Authors:Lv, Z., Yuan, L., Atkison, J.H., Williams, K.M., Olsen, S.K.
Deposit date:2018-04-01
Release date:2019-01-16
Method:X-RAY DIFFRACTION (2.462 Å)
Cite:Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme.
Nat Commun, 9, 2018
6CWZ
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CRYSTAL STRUCTURE OF APO SUMO E1
Descriptor:SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ZINC ION
Authors:Lv, Z., Yuan, L., Atkison, J.H., Williams, K.M., Olsen, S.K.
Deposit date:2018-04-01
Release date:2019-01-16
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme.
Nat Commun, 9, 2018
6DC6
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CRYSTAL STRUCTURE OF HUMAN UBIQUITIN ACTIVATING ENZYME E1 (UBA1) IN COMPLEX WITH UBIQUITIN
Descriptor:Ubiquitin-like modifier-activating enzyme 1, Ubiquitin, MAGNESIUM ION, ...
Authors:Lv, Z., Yuan, L., Williams, K.M., Atkison, J.H., Olsen, S.K.
Deposit date:2018-05-04
Release date:2018-10-10
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity.
J. Biol. Chem., 293, 2018
3J9B
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ELECTRON CRYO-MICROSCOPY OF AN RNA POLYMERASE
Descriptor:Polymerase, RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 2, ...
Authors:Chang, S.H., Sun, D.P., Liang, H.H., Wang, J., Li, J., Guo, L., Wang, X.L., Guan, C.C., Boruah, B.M., Yuan, L.M., Feng, F., Yang, M.R., Wojdyla, J., Wang, J.W., Wang, M.T., Wang, H.W., Liu, Y.F.
Deposit date:2014-12-16
Release date:2015-02-18
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 angstrom Resolution.
Mol.Cell, 2015
5DH3
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CRYSTAL STRUCTURE OF MST2 IN COMPLEX WITH XMU-MP-1
Descriptor:Serine/threonine-protein kinase 3, 4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide, CHLORIDE ION, ...
Authors:Kong, L.L., Yun, C.H.
Deposit date:2015-08-29
Release date:2016-08-31
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.468 Å)
Cite:Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration
Sci Transl Med, 8, 2016
5YZV
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BIOPHYSICAL AND STRUCTURAL CHARACTERIZATION OF THE THERMOSTABLE WD40 DOMAIN OF A PROKARYOTIC PROTEIN, THERMOMONOSPORA CURVATA PKWA
Descriptor:Probable serine/threonine-protein kinase PkwA
Authors:Li, D.Y., Shen, C., Du, Y., Qiao, F.F., Kong, T., Yuan, L.R., Zhang, D.L., Wu, X.H., Wu, Y.D.
Deposit date:2017-12-15
Release date:2018-10-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Biophysical and structural characterization of the thermostable WD40 domain of a prokaryotic protein, Thermomonospora curvata PkwA
Sci Rep, 8, 2018
4RZE
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CRYSTAL STRUCTURE ANALYSIS OF THE NUR77 LIGAND BINDING DOMAIN, L437W,D594E MUTANT
Descriptor:Nuclear receptor subfamily 4 group A member 1, GLYCEROL
Authors:Fengwei, L., Xuyang, T., Anzhong, L., Li, L., Yuan, L., Hangzi, C., Qiao, W., Tianwei, L.
Deposit date:2014-12-21
Release date:2015-03-18
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation.
Nat.Chem.Biol., 11, 2015
3SSW
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E. COLI TRP APOREPRESSOR
Descriptor:Trp operon repressor
Authors:Benoff, B., Carey, J., Berman, H.M., Lawson, C.L.
Deposit date:2011-07-08
Release date:2011-07-20
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (1.6693 Å)
Cite:Environment-dependent long-range structural distortion in a temperature-sensitive point mutant.
Protein Sci., 21, 2012
3SSX
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E. COLI TRP APOREPORESSOR L75F MUTANT
Descriptor:Trp operon repressor, TRIS(HYDROXYETHYL)AMINOMETHANE
Authors:Benoff, B., Carey, J., Berman, H.M., Lawson, C.L.
Deposit date:2011-07-08
Release date:2011-07-20
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (1.5801 Å)
Cite:Environment-dependent long-range structural distortion in a temperature-sensitive point mutant.
Protein Sci., 21, 2012