Author results

6BV7
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NMR STRUCTURE OF SODIUM/CALCIUM EXCHANGER 1 (NCX1) TWO-HELIX BUNDLE (THB) DOMAIN
Descriptor:Sodium/calcium exchanger 1
Authors:Yuan, J., Yuan, C., Bruschweiler, R.
Deposit date:2017-12-12
Release date:2018-06-20
Last modified:2019-02-20
Method:SOLUTION NMR
Cite:The Intracellular Loop of the Na+/Ca2+Exchanger Contains an "Awareness Ribbon"-Shaped Two-Helix Bundle Domain.
Biochemistry, 57, 2018
1C15
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SOLUTION STRUCTURE OF APAF-1 CARD
Descriptor:APOPTOTIC PROTEASE ACTIVATING FACTOR 1
Authors:Zhou, P., Chou, J., Olea, R.S., Yuan, J., Wagner, G.
Deposit date:1999-07-20
Release date:1999-09-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction.
Proc.Natl.Acad.Sci.USA, 96, 1999
1GH2
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF A NEW HUMAN THIOREDOXIN-LIKE PROTEIN
Descriptor:THIOREDOXIN-LIKE PROTEIN
Authors:Jin, J., Chen, X., Guo, Q., Yuan, J., Qiang, B., Rao, Z.
Deposit date:2000-11-01
Release date:2001-05-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Crystal structure of the catalytic domain of a human thioredoxin-like protein.
Eur.J.Biochem., 269, 2002
1Z9M
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CRYSTAL STRUCTURE OF NECTIN-LIKE MOLECULE-1 PROTEIN DOMAIN 1
Descriptor:GAPA225
Authors:Dong, X., Xu, F., Gong, Y., Gao, J., Lin, P., Chen, T., Peng, Y., Qiang, B., Yuan, J., Peng, X., Rao, Z.
Deposit date:2005-04-03
Release date:2006-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the V Domain of Human Nectin-like Molecule-1/Syncam3/Tsll1/Igsf4b, a Neural Tissue-specific Immunoglobulin-like Cell-Cell Adhesion Molecule
J.Biol.Chem., 281, 2006
5ZO1
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CRYSTAL STRUCTURE OF MOUSE NECTIN-LIKE MOLECULE 4 (MNECL-4) FULL ECTODOMAIN (IG1-IG3), 2.2A
Descriptor:Cell adhesion molecule 4, ALPHA-L-FUCOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Liu, X., An, T., Li, D., Fan, Z., Xiang, P., Li, C., Ju, W., Li, J., Hu, G., Qin, B., Yin, B., Wojdyla, J.A., Wang, M., Yuan, J., Qiang, B., Shu, P., Cui, S., Peng, X.
Deposit date:2018-04-12
Release date:2019-01-30
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:Structure of the heterophilic interaction between the nectin-like 4 and nectin-like 1 molecules.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
5ZO2
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CRYSTAL STRUCTURE OF MOUSE NECTIN-LIKE MOLECULE 4 (MNECL-4) FULL ECTODOMAIN IN COMPLEX WITH MOUSE NECTIN-LIKE MOLECULE 1 (MNECL-1) IG1 DOMAIN, 3.3A
Descriptor:Cell adhesion molecule 4, Cell adhesion molecule 3, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Liu, X., An, T., Li, D., Fan, Z., Xiang, P., Li, C., Ju, W., Li, J., Hu, G., Qin, B., Yin, B., Wojdyla, J.A., Wang, M., Yuan, J., Qiang, B., Shu, P., Cui, S., Peng, X.
Deposit date:2018-04-12
Release date:2019-01-30
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.29 Å)
Cite:Structure of the heterophilic interaction between the nectin-like 4 and nectin-like 1 molecules.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
1P5T
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CRYSTAL STRUCTURE OF DOK1 PTB DOMAIN
Descriptor:Docking protein 1
Authors:Shi, N., Ye, S., Liu, Y., Zhou, W., Ding, Y., Lou, Z., Qiang, B., Yuan, J., Rao, Z.
Deposit date:2003-04-28
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Basis for the Specific Recognition of RET by the Dok1 Phosphotyrosine Binding Domain
J.BIOL.CHEM., 279, 2004
2BID
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HUMAN PRO-APOPTOTIC PROTEIN BID
Descriptor:PROTEIN (BID)
Authors:Chou, J.J., Li, H., Salvesen, G.S., Yuan, J., Wagner, G.
Deposit date:1999-01-27
Release date:2000-02-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of BID, an intracellular amplifier of apoptotic signaling.
Cell(Cambridge,Mass.), 96, 1999
2K0J
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SOLUTION STRUCTURE OF CAM COMPLEXED TO DRP1P
Descriptor:calmodulin, CALCIUM ION, LANTHANUM (III) ION
Authors:Bertini, I., Luchinat, C., Parigi, G., Yuan, J., Structural Proteomics in Europe (SPINE)
Deposit date:2008-02-04
Release date:2009-03-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Accurate solution structures of proteins from X-ray data and a minimal set of NMR data: calmodulin-peptide complexes as examples.
J.Am.Chem.Soc., 131, 2009
2K1I
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SYNTHESIS, STRUCTURE AND ACTIVITIES OF AN ORAL MUCOSAL ALPHA-DEFENSIN FROM RHESUS MACAQUE
Descriptor:Mucosal Alpha-Defensin
Authors:Vasudevan, S.V., Yuan, J., Osapay, G., Tran, P., Tai, K., Selsted, M., Cocco, M.J.
Deposit date:2008-03-05
Release date:2008-10-28
Last modified:2018-01-24
Method:SOLUTION NMR
Cite:Synthesis, structure, and activities of an oral mucosal alpha-defensin from rhesus macaque.
J.Biol.Chem., 283, 2008
2K61
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SOLUTION STRUCTURE OF CAM COMPLEXED TO DAPK PEPTIDE
Descriptor:Calmodulin, CALCIUM ION, TERBIUM(III) ION
Authors:Bertini, I., Luchinat, C., Parigi, G., Yuan, J.
Deposit date:2008-07-02
Release date:2009-05-05
Last modified:2016-06-08
Method:SOLUTION NMR
Cite:Accurate solution structures of proteins from X-ray data and a minimal set of NMR data: calmodulin-peptide complexes as examples.
J.Am.Chem.Soc., 131, 2009
2KAX
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SOLUTION STRUCTURE AND DYNAMICS OF S100A5 IN THE APO AND CA2+ -BOUND STATES
Descriptor:Protein S100-A5
Authors:Bertini, I., Das Gupta, S., Hu, X., Karavelas, T., Luchinat, C., Parigi, G., Yuan, J., Structural Proteomics in Europe (SPINE)
Deposit date:2008-11-17
Release date:2009-06-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states
J.Biol.Inorg.Chem., 14, 2009
2KAY
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SOLUTION STRUCTURE AND DYNAMICS OF S100A5 IN THE CA2+ -BOUND STATES
Descriptor:Protein S100-A5, CALCIUM ION
Authors:Bertini, I., Das Gupta, S., Hu, X., Karavelas, T., Luchinat, C., Parigi, G., Yuan, J., Structural Proteomics in Europe (SPINE)
Deposit date:2008-11-17
Release date:2009-06-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states
J.Biol.Inorg.Chem., 14, 2009
3Q3T
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ALKYL AMINE RENIN INHIBITORS: FILLING S1 FROM S3
Descriptor:Renin, [(1S,3R,4S)-3-amino-4-hydroxycyclopentyl]{(3R)-3-[(1S)-1-(biphenyl-2-yl)-1-hydroxy-5-methoxypentyl]piperidin-1-yl}methanone, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wu, Z., McKeever, B.
Deposit date:2010-12-22
Release date:2011-08-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket.
Bioorg.Med.Chem.Lett., 21, 2011
4M5E
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TSE3 STRUCTURE
Descriptor:Uncharacterized protein, GLYCEROL, CADMIUM ION, ...
Authors:Qian, Y.
Deposit date:2013-08-08
Release date:2014-04-23
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism
Mol.Microbiol., 92, 2014
4M5F
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COMPLEX STRUCTURE OF TSE3-TSI3
Descriptor:Uncharacterized protein, CALCIUM ION, PHOSPHATE ION
Authors:Gu, L.C.
Deposit date:2013-08-08
Release date:2014-04-23
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism
Mol.Microbiol., 92, 2014
4N7S
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CRYSTAL STRUCTURE OF TSE3-TSI3 COMPLEX WITH ZINC ION
Descriptor:Uncharacterized protein, inhibitor, ZINC ION, ...
Authors:Shang, G.J.
Deposit date:2013-10-16
Release date:2014-04-23
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism
Mol.Microbiol., 92, 2014
4N80
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CRYSTAL STRUCTURE OF TSE3-TSI3 COMPLEX
Descriptor:Uncharacterized protein, ZINC ION, CALCIUM ION
Authors:Shang, G.J.
Deposit date:2013-10-16
Release date:2014-04-23
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism
Mol.Microbiol., 92, 2014
4N88
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CRYSTAL STRUCTURE OF TSE3-TSI3 COMPLEX WITH CALCIUM ION
Descriptor:Uncharacterized protein, CALCIUM ION
Authors:Shang, G.J.
Deposit date:2013-10-17
Release date:2014-04-23
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism
Mol.Microbiol., 92, 2014
1UEF
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CRYSTAL STRUCTURE OF DOK1 PTB DOMAIN COMPLEX
Descriptor:Docking protein 1, 13-mer peptide from Proto-oncogene tyrosine-protein kinase receptor ret
Authors:Shi, N., Ye, S., Liu, Y., Zhou, W., Ding, Y., Lou, Z., Qiang, B., Yan, J., Rao, Z.
Deposit date:2003-05-14
Release date:2004-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for the Specific Recognition of RET by the Dok1 Phosphotyrosine Binding Domain
J.Biol.Chem., 279, 2004
3GW5
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CRYSTAL STRUCTURE OF HUMAN RENIN COMPLEXED WITH A NOVEL INHIBITOR
Descriptor:Renin, (3R)-3-[(1S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxypentyl]-N-{(1S)-2-cyclohexyl-1-[(methylamino)methyl]ethyl}piperidine-1-carboxamide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wu, Z., McKeever, B.M.
Deposit date:2009-03-31
Release date:2009-06-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and optimization of renin inhibitors: Orally bioavailable alkyl amines.
Bioorg.Med.Chem.Lett., 19, 2009
3KM4
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OPTIMIZATION OF ORALLY BIOAVAILABLE ALKYL AMINE RENIN INHIBITORS
Descriptor:Renin, N-ACETYL-D-GLUCOSAMINE, (3R)-3-[(1S)-4-(acetylamino)-1-(3-chlorophenyl)-1-hydroxybutyl]-N-{(1S)-2-cyclohexyl-1-[(methylamino)methyl]ethyl}piperidine-1-carboxamide
Authors:Wu, Z., McKeever, B.M.
Deposit date:2009-11-09
Release date:2010-01-12
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Optimization of orally bioavailable alkyl amine renin inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
5EHR
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NON-RECEPTOR PROTEIN TYROSINE PHOSPHATASE SHP2 IN COMPLEX WITH ALLOSTERIC INHIBITOR SHP099
Descriptor:Tyrosine-protein phosphatase non-receptor type 11, 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, PHOSPHATE ION
Authors:Stams, T., Fodor, M.
Deposit date:2015-10-28
Release date:2016-06-29
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Nature, 535, 2016
5GP7
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STRUCTURAL BASIS FOR THE BINDING BETWEEN TANKYRASE-1 AND USP25
Descriptor:Tankyrase-1, Ubiquitin carboxyl-terminal hydrolase 25, GLYCEROL
Authors:Liu, J., Xu, D., Fu, T., Pan, L.
Deposit date:2016-08-01
Release date:2017-07-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.502 Å)
Cite:USP25 regulates Wnt signaling by controlling the stability of tankyrases
Genes Dev., 31, 2017
5WDY
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CRYSTAL STRUCTURE OF WNK1 IN COMPLEX WITH 1-CYCLOHEXYL-N-({6-FLUORO-1-[2-(3-METHOXYPHENYL)PYRIDIN-4-YL]-1H-INDOL-3-YL}METHYL)METHANAMINE (COMPOUND 6)
Descriptor:Serine/threonine-protein kinase WNK1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 1-cyclohexyl-N-({6-fluoro-1-[2-(3-methoxyphenyl)pyridin-4-yl]-1H-indol-3-yl}methyl)methanamine, ...
Authors:Xie, X., Kohls, D.
Deposit date:2017-07-06
Release date:2017-08-16
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.458 Å)
Cite:Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models.
J. Med. Chem., 60, 2017
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