Author results

2GKS
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CRYSTAL STRUCTURE OF THE BI-FUNCTIONAL ATP SULFURYLASE-APS KINASE FROM AQUIFEX AEOLICUS, A CHEMOLITHOTROPHIC THERMOPHILE
分子名称:Bifunctional SAT/APS kinase, ADENOSINE-5'-DIPHOSPHATE
著者Yu, Z., MacRea, I.J., Lansdon, E.B., Segel, I.H., Fisher, A.J.
登録日2006-04-03
公開日2007-03-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Crystal structure of the bifunctional ATP sulfurylase-APS kinase from the chemolithotrophic thermophile Aquifex aeolicus.
J.Mol.Biol., 365, 2007
2OQ2
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CRYSTAL STRUCTURE OF YEAST PAPS REDUCTASE WITH PAP, A PRODUCT COMPLEX
分子名称:Phosphoadenosine phosphosulfate reductase, ADENOSINE-3'-5'-DIPHOSPHATE
著者Yu, Z., Fisher, A.J.
登録日2007-01-31
公開日2008-01-15
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of Saccharomyces cerevisiae 3'-phosphoadenosine-5'-phosphosulfate reductase complexed with adenosine 3',5'-bisphosphate.
Biochemistry, 47, 2008
4B10
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PLASMODIUM VIVAX N-MYRISTOYLTRANSFERASE WITH A NON-HYDROLYSABLE CO- FACTOR
分子名称:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 2-oxopentadecyl-CoA, DIMETHYL SULFOXIDE, ...
著者Yu, Z., Brannigan, J.A., Moss, D.K., Brzozowski, A.M., Wilkinson, A.J., Holder, A.A., Tate, E.W., Leatherbarrow, R.J.
登録日2012-07-06
公開日2012-10-17
最終更新日2012-11-07
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery.
J.Med.Chem., 55, 2012
4B11
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PLASMODIUM VIVAX N-MYRISTOYLTRANSFERASE WITH A BOUND BENZOFURAN INHIBITOR (COMPOUND 13)
分子名称:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 3-methyl-N-(naphthalen-1-ylmethyl)-4-piperidin-4-yloxy-1-benzofuran-2-carboxamide, 2-oxopentadecyl-CoA, ...
著者Yu, Z., Brannigan, J.A., Moss, D.K., Brzozowski, A.M., Wilkinson, A.J., Holder, A.A., Tate, E.W., Leatherbarrow, R.J.
登録日2012-07-06
公開日2012-10-17
最終更新日2012-11-07
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery.
J.Med.Chem., 55, 2012
4B12
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PLASMODIUM VIVAX N-MYRISTOYLTRANSFERASE WITH A BOUND BENZOFURAN INHIBITOR (COMPOUND 23)
分子名称:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 1-[3-methyl-4-(piperidin-4-yloxy)-1-benzofuran-2-yl]-3-phenylpropan-1-one, 2-oxopentadecyl-CoA, ...
著者Yu, Z., Brannigan, J.A., Moss, D.K., Brzozowski, A.M., Wilkinson, A.J., Holder, A.A., Tate, E.W., Leatherbarrow, R.J.
登録日2012-07-06
公開日2012-10-17
最終更新日2012-11-07
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery.
J.Med.Chem., 55, 2012
4B13
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PLASMODIUM VIVAX N-MYRISTOYLTRANSFERASE WITH A BOUND BENZOFURAN INHIBITOR (COMPOUND 25)
分子名称:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 4-{[2-(3-benzyl-1,2,4-oxadiazol-5-yl)-3-methyl-1-benzofuran-4-yl]oxy}piperidine, 2-oxopentadecyl-CoA, ...
著者Yu, Z., Brannigan, J.A., Moss, D.K., Brzozowski, A.M., Wilkinson, A.J., Holder, A.A., Tate, E.W., Leatherbarrow, R.J.
登録日2012-07-06
公開日2012-10-17
最終更新日2012-11-07
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Antimalarial Drug Discovery.
J.Med.Chem., 55, 2012
4B14
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PLASMODIUM VIVAX N-MYRISTOYLTRANSFERASE WITH A BOUND BENZOFURAN INHIBITOR (COMPOUND 26)
分子名称:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, DIMETHYL SULFOXIDE, 3-methoxybenzyl 3-methyl-4-(piperidin-4-yloxy)-1-benzofuran-2-carboxylate, ...
著者Yu, Z., Brannigan, J.A., Moss, D.K., Brzozowski, A.M., Wilkinson, A.J., Holder, A.A., Tate, E.W., Leatherbarrow, R.J.
登録日2012-07-06
公開日2012-10-17
最終更新日2012-11-07
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery.
J.Med.Chem., 55, 2012
4OWP
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CRYSTAL STRUCTURE OF RPN11 IN A HETERODIMER COMPLEX WITH RPN8, REPRESENTING THE ACTIVE PORTION OF THE PROTEOSOME LID.
分子名称:26S proteasome regulatory subunit RPN8, 26S proteasome regulatory subunit RPN11, ZINC ION
著者Yu, Z., Mansour, W., Nakasone, M.A., Glickman, M.H., Dvir, H.
登録日2014-02-03
公開日2015-08-05
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteosome lid. In preparation.
To Be Published
4UFV
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PLASMODIUM VIVAX N-MYRISTOYLTRANSFERASE IN COMPLEX WITH A PYRIDYL INHIBITOR (COMPOUND 18)
分子名称:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 2-oxopentadecyl-CoA, N-[2-(3-methoxyphenyl)ethanimidoyl]-2-piperidin-4-yloxy-benzamide, ...
著者Yu, Z., Brannigan, J.A., Rangachari, K., Heal, W.P., Wilkinson, A.J., Holder, A.A., Tate, E.W., Leatherbarrow, R.J.
登録日2015-03-19
公開日2016-02-03
最終更新日2016-04-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase
Medchemcomm, 6, 2015
4UFW
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PLASMODIUM VIVAX N-MYRISTOYLTRANSFERASE IN COMPLEX WITH A PYRIDYL INHIBITOR (COMPOUND 22)
分子名称:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 2-oxopentadecyl-CoA, 4-chloranyl-N-[2-(3-methoxyphenyl)ethanimidoyl]-2-piperidin-4-yloxy-benzamide, ...
著者Yu, Z., Brannigan, J.A., Rangachari, K., Heal, W.P., Wilkinson, A.J., Holder, A.A., Tate, E.W., Leatherbarrow, R.J.
登録日2015-03-19
公開日2016-02-03
最終更新日2016-04-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase
Medchemcomm, 6, 2015
4UFX
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PLASMODIUM VIVAX N-MYRISTOYLTRANSFERASE IN COMPLEX WITH A PYRIDYL INHIBITOR (COMPOUND 19)
分子名称:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, N-[2-(3-methoxyphenyl)ethanimidoyl]-2-piperidin-4-yloxy-pyridine-3-carboxamide, 2-oxopentadecyl-CoA, ...
著者Yu, Z., Brannigan, J.A., Rangachari, K., Heal, W.P., Wilkinson, A.J., Holder, A.A., Tate, E.W., Leatherbarrow, R.J.
登録日2015-03-19
公開日2016-02-03
最終更新日2016-04-20
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase
Medchemcomm, 6, 2015
3MOW
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CRYSTAL STRUCTURE OF SHP2 IN COMPLEX WITH A TAUTOMYCETIN ANALOG TTN D-1
分子名称:Tyrosine-protein phosphatase non-receptor type 11, (2Z)-2-[(1R)-3-{[(1R,2S,3R,6S,7S,10S,12S,15E,17E)-18-carboxy-16-ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5-oxooctadeca-15,17-dien-1-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid
著者Zhang, Z.-Y., Liu, S., Yu, Z., Yu, X.
登録日2010-04-23
公開日2011-05-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of SHP2 in complex with a tautomycetin analog TTN D-1
To be Published
3O5X
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CRYSTAL STRUCTURE OF THE ONCOGENIC TYROSINE PHOSPHATASE SHP2 COMPLEXED WITH A SALICYLIC ACID-BASED SMALL MOLECULE INHIBITOR
分子名称:Tyrosine-protein phosphatase non-receptor type 11, 3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
著者Zhang, Z.-Y., Zhang, X., He, Y., Liu, S., Yu, Z., Jiang, Z., Yang, Z., Dong, Y., Nabinger, S.C., Wu, L., Gunawan, A.M., Wang, L., Chan, R.J.
登録日2010-07-28
公開日2010-08-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).
J.Med.Chem., 53, 2010
4QQN
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PROTEIN ARGININE METHYLTRANSFERASE 3 IN COMPLEX WITH COMPOUND MTV044246
分子名称:PRMT3 protein, 1-{2-[1-(aminomethyl)cyclohexyl]ethyl}-3-isoquinolin-6-ylurea, GLYCEROL, ...
著者Dong, A., Dobrovetsky, E., Tempel, W., He, H., Zhao, K., Smil, D., Landon, M., Luo, X., Chen, Z., Dai, M., Yu, Z., Lin, Y., Zhang, H., Zhao, K., Schapira, M., Brown, P.J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Vedadi, M., Structural Genomics Consortium (SGC)
登録日2014-06-27
公開日2014-09-17
最終更新日2018-05-16
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).
J. Med. Chem., 61, 2018
2WUU
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STRUCTURE OF N-MYRISTOYLTRANSFERASE FROM L. DONOVANI
分子名称:N-MYRISTOYLTRANSFERASE, 2-oxopentadecyl-CoA
著者Brannigan, J.A., Smith, B.A., Yu, Z., Hodgkinson, M.R., Leatherbarrow, R.J., Tate, E.W., Brzozowski, A.M., Smith, D.F., Wilkinson, A.J.
登録日2009-10-09
公開日2009-12-01
最終更新日2012-07-18
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献N-Myristoyltransferase from Leishmania Donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis.
J.Mol.Biol., 396, 2010
3J6C
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CRYO-EM STRUCTURE OF MAVS CARD FILAMENT
分子名称:Mitochondrial antiviral-signaling protein
著者Xu, H., He, X., Zheng, H., Huang, L.J., Hou, F., Yu, Z., de la Cruz, M.J., Borkowski, B., Zhang, X., Chen, Z.J., Jiang, Q.-X.
登録日2014-02-04
公開日2014-03-05
最終更新日2018-07-18
実験手法ELECTRON MICROSCOPY (9.6 Å)
主引用文献Structural basis for the prion-like MAVS filaments in antiviral innate immunity.
Elife, 3, 2014
4BBH
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PLASMODIUM VIVAX N-MYRISTOYLTRANSFERASE WITH A BOUND BENZOTHIOPHENE INHIBITOR
分子名称:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, DIMETHYL SULFOXIDE, 2-oxopentadecyl-CoA, ...
著者Rackham, M.D., Brannigan, J.A., Moss, D.K., Yu, Z., Wilkinson, A.J., Holder, A.A., Tate, E.W., Leatherbarrow, R.J.
登録日2012-09-23
公開日2012-12-05
最終更新日2013-01-23
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium Falciparum and Plasmodium Vivax N-Myristoyltransferase.
J.Med.Chem., 56, 2013
4JS9
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STRUCTURAL CHARACTERIZATION OF INDUCIBLE NITRIC OXIDE SYNTHASE SUBSTITUTED WITH MESOHEME
分子名称:Nitric oxide synthase, inducible, Mesoheme, ...
著者Hannibal, L., Page, R.C., Bolisetty, K., Yu, Z., Misra, S., Stuehr, D.J.
登録日2013-03-22
公開日2014-04-23
実験手法X-RAY DIFFRACTION (2.784 Å)
主引用文献Kinetic and Structural Characterization of Inducible Nitric Oxide Synthase Substituted With Mesoheme
To be Published
4PKM
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CRYSTAL STRUCTURE OF BACILLUS THURINGIENSIS CRY51AA1 PROTOXIN AT 1.65 ANGSTROMS RESOLUTION
分子名称:Cry51Aa1, GLYCEROL, SULFATE ION, ...
著者Xu, C., Chinte, U., Chen, L., Yao, Q., Zhou, D., Meng, Y., Li, L., Rose, J., Bi, L.J., Yu, Z., Sun, M., Wang, B.C.
登録日2014-05-15
公開日2015-06-03
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of Cry51Aa1: A potential novel insecticidal aerolysin-type beta-pore-forming toxin from Bacillus thuringiensis.
Biochem.Biophys.Res.Commun., 462, 2015
4PVG
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE SHP2 CATALYTIC DOMAIN COMPLEX WITH SMALL MOLECULAR COMPOUND L88N79
分子名称:Tyrosine-protein phosphatase non-receptor type 11, 2-[3-({4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutanoyl}amino)phenyl]-6-hydroxy-3-iodo-1-methyl-1H-indole-5-carboxylic acid
著者Zhang, Z.-Y., Zeng, L., Liu, D., Yu, Z.
登録日2014-03-17
公開日2015-04-15
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of protein tyrosine Shp2 catalytic domain complex with compound L88N79
To be Published
4RYL
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HUMAN PROTEIN ARGININE METHYLTRANSFERASE 3 IN COMPLEX WITH 1-ISOQUINOLIN-6-YL-3-[2-OXO-2-(PYRROLIDIN-1-YL)ETHYL]UREA
分子名称:PRMT3 protein, 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea, UNKNOWN ATOM OR ION
著者Dong, A., Dobrovetsky, E., Kaniskan, H.U., Szewczyk, M., Yu, Z., Eram, M.S., Yang, X., Schmidt, K., Luo, X., Dai, M., He, F., Zang, I., Lin, Y., Kennedy, S., Li, F., Tempel, W., Smil, D., Min, S.J., Landon, M., Lin-Jones, J., Huang, X.P., Roth, B.L., Schapira, M., Atadja, P., Barsyte-Lovejoy, D., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Brown, P.J., Zhao, K., Jin, J., Vedadi, M., Structural Genomics Consortium (SGC)
登録日2014-12-15
公開日2015-02-25
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3).
Angew.Chem.Int.Ed.Engl., 54, 2015
5A27
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LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE IN COMPLEX WITH A CHLOROPHENYL 1,2,4-OXADIAZOLE INHIBITOR.
分子名称:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA, 5-chloranyl-N-[2-(3-methoxyphenyl)ethanimidoyl]-2-piperidin-4-yloxy-benzamide, ...
著者Rackham, M.D., Yu, Z., Brannigan, J.A., Heal, W.P., Paape, D., Barker, K.V., Wilkinson, A.J., Smith, D.F., Tate, E.W., Leatherbarrow, R.J.
登録日2015-05-15
公開日2016-03-23
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献Discovery of High Affinity Inhibitors of Leishmania Donovani N-Myristoyltransferase.
Medchemcomm, 6, 2015
5A28
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LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE IN COMPLEX WITH A CHLOROPHENYL 1,3,4-OXADIAZOLE INHIBITOR.
分子名称:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA, 4-(4-chloro-2-{5-[(trimethyl-1H-pyrazol-4-yl)methyl]-1,3,4-oxadiazol-2-yl}phenoxy)piperidine, ...
著者Rackham, M.D., Yu, Z., Brannigan, J.A., Heal, W.P., Paape, D., Barker, K.V., Wilkinson, A.J., Smith, D.F., Tate, E.W., Leatherbarrow, R.J.
登録日2015-05-15
公開日2016-03-23
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Discovery of High Affinity Inhibitors of Leishmania Donovani N-Myristoyltransferase.
Medchemcomm, 6, 2015
5CD7
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CRYSTAL STRUCTURE OF THE NTD L199M OF DROSOPHILA OSKAR PROTEIN
分子名称:Maternal effect protein oskar, GLYCEROL
著者Yang, N., Hu, M., Yu, Z., Wang, M., Lehmann, R., Xu, R.M.
登録日2015-07-03
公開日2015-09-02
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.502 Å)
主引用文献Structure of Drosophila Oskar reveals a novel RNA binding protein
Proc.Natl.Acad.Sci.USA, 112, 2015
5CD8
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CRYSTAL STRUCTURE OF THE NTD OF DROSOPHILA OSKAR PROTEIN
分子名称:Maternal effect protein oskar, GLYCEROL
著者Yang, N., Hu, M., Yu, Z., Wang, M., Lehmann, R., Xu, R.M.
登録日2015-07-03
公開日2015-09-02
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (3.001 Å)
主引用文献Structure of Drosophila Oskar reveals a novel RNA binding protein
Proc.Natl.Acad.Sci.USA, 112, 2015