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5YLJ
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CRYSTAL STRUCTURE OF T2R-TTL-MILLEPACHINE COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta chain, Stathmin-4, ...
著者Yang, J.H., Chen, L.J.
登録日2017-10-17
公開日2018-04-11
最終更新日2018-07-11
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
J. Biol. Chem., 293, 2018
5YLS
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CRYSTAL STRUCTURE OF T2R-TTL-Y50 COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta chain, Stathmin-4, ...
著者Yang, J.H., Chen, L.J.
登録日2017-10-18
公開日2018-04-11
最終更新日2018-07-11
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
J. Biol. Chem., 293, 2018
6J3O
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CRYSTAL STRUCTURE OF THE HUMAN PCAF BROMODOMAIN IN COMPLEX WITH COMPOUND 12
分子名称:Histone acetyltransferase KAT2B, 3-methyl-2-[[(3~{R})-1-methylpiperidin-3-yl]amino]-5~{H}-pyrrolo[3,2-d]pyrimidin-4-one
著者Huang, L.Y., Li, H., Li, L.L., Niu, L., Seupel, R., Wu, C.Y., Li, G.B., Yu, Y.M., Brennan, P.E., Yang, S.Y.
登録日2019-01-05
公開日2019-05-01
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.
J.Med.Chem., 62, 2019
6J3P
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CRYSTAL STRUCTURE OF THE HUMAN GCN5 BROMODOMAIN IN COMPLEX WITH COMPOUND (R,R)-36N
分子名称:Histone acetyltransferase KAT2A, 2-{[(3R,5R)-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methylpiperidin-3-yl]amino}-3-methyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
著者Huang, L.Y., Li, H., Niu, L., Wu, C.Y., Yu, Y.M., Li, L.L., Yang, S.Y.
登録日2019-01-05
公開日2019-05-01
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (1.598 Å)
主引用文献Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.
J.Med.Chem., 62, 2019