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1O5T
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CRYSTAL STRUCTURE OF THE AMINOACYLATION CATALYTIC FRAGMENT OF HUMAN TRYPTOPHANYL-TRNA SYNTHETASE
分子名称:Tryptophanyl-tRNA synthetase
著者Yu, Y., Liu, Y., Shen, N., Xu, X., Jia, J., Jin, Y., Arnold, E., Ding, J.
登録日2003-10-05
公開日2004-07-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of Human Tryptophanyl-tRNA Synthetase Catalytic Fragment
J.BIOL.CHEM., 279, 2004
3IPM
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CRYSTAL STRUCTURE OF ARCHAEAL 20S PROTEASOME IN COMPLEX WITH THE C-TERMINUS OF PAN
分子名称:Proteasome subunit alpha, Proteasome subunit beta, Proteasome activator PA26, ...
著者Yu, Y., Cheng, Y.
登録日2009-08-17
公開日2009-12-29
最終更新日2017-08-02
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome-ATPase interactions.
Embo J., 29, 2010
4HK4
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CRYSTAL STRUCTURE OF APO TYROSINE-TRNA LIGASE MUTANT PROTEIN
分子名称:Tyrosine--tRNA ligase, DI(HYDROXYETHYL)ETHER
著者Yu, Y., Zhou, Q., Dong, J., Li, J., Xiaoxuan, L., Mukherjee, A., Ouyang, H., Nilges, M., Li, H., Gao, F., Gong, W., Lu, Y., Wang, J.
登録日2012-10-15
公開日2013-04-17
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.298 Å)
主引用文献Crystal structure of apo Tyrosine-tRNA ligase mutant protein
To be Published
4HPW
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CRYSTAL STRUCTURE OF TYROSINE-TRNA LIGASE MUTANT COMPLEXED WITH UNNATURAL AMINO ACID 3-O-METHYL-TYROSINE
分子名称:Tyrosine--tRNA ligase, 3-methoxy-L-tyrosine
著者Yu, Y., Zhou, Q., Dong, J., Li, J., Xiaoxuan, L., Mukherjee, A., Ouyang, H., Nilges, M., Li, H., Gao, F., Gong, W., Lu, Y., Wang, J.
登録日2012-10-24
公開日2013-10-30
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (1.998 Å)
主引用文献Crystal structure of Tyrosine-tRNA ligase mutant complexed with unnatural amino acid 3-o-methyl-Tyrosine
To be Published
1XTQ
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STRUCTURE OF SMALL GTPASE HUMAN RHEB IN COMPLEX WITH GDP
分子名称:GTP-binding protein Rheb, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
著者Yu, Y., Ding, J.
登録日2004-10-24
公開日2005-03-08
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for the Unique Biological Function of Small GTPase RHEB
J.Biol.Chem., 280, 2005
1XTR
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STRUCTURE OF SMALL GTPASE HUMAN RHEB IN COMPLEX WITH GPPNHP
分子名称:GTP-binding protein Rheb, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Yu, Y., Ding, J.
登録日2004-10-24
公開日2005-03-08
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structural Basis for the Unique Biological Function of Small GTPase RHEB
J.Biol.Chem., 280, 2005
1XTS
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STRUCTURE OF SMALL GTPASE HUMAN RHEB IN COMPLEX WITH GTP
分子名称:GTP-binding protein Rheb, MAGNESIUM ION, GUANOSINE-5'-TRIPHOSPHATE
著者Yu, Y., Ding, J.
登録日2004-10-24
公開日2005-03-08
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Basis for the Unique Biological Function of Small GTPase RHEB
J.Biol.Chem., 280, 2005
4M58
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CRYSTAL STRUCTURE OF AN TRANSITION METAL TRANSPORTER
分子名称:Cobalamin biosynthesis protein CbiM, NICKEL (II) ION
著者Yu, Y., Yan, C.Y., Zhang, B., Li, X.L., Gu, J.K.
登録日2013-08-08
公開日2014-03-26
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献Planar substrate-binding site dictates the specificity of ECF-type nickel/cobalt transporters
Cell Res., 24, 2014
4M5B
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CRYSTAL STRUCTURE OF AN TRUNCATED TRANSITION METAL TRANSPORTER
分子名称:Cobalamin biosynthesis protein CbiM, HEXANE-1,6-DIOL, NICKEL (II) ION
著者Yu, Y.
登録日2013-08-08
公開日2014-03-26
実験手法X-RAY DIFFRACTION (1.833 Å)
主引用文献Planar substrate-binding site dictates the specificity of ECF-type nickel/cobalt transporters
Cell Res., 24, 2014
4M5C
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CRYSTAL STRUCTURE OF AN TRUNCATED TRANSITION METAL TRANSPORTER
分子名称:Cobalamin biosynthesis protein CbiM, COBALT (II) ION, HEXANE-1,6-DIOL
著者Yu, Y., Zhou, M.Z., Gu, J.K.
登録日2013-08-08
公開日2014-03-26
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Planar substrate-binding site dictates the specificity of ECF-type nickel/cobalt transporters
Cell Res., 24, 2014
2G3F
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CRYSTAL STRUCTURE OF IMIDAZOLONEPROPIONASE COMPLEXED WITH IMIDAZOLE-4-ACETIC ACID SODIUM SALT, A SUBSTRATE HOMOLOGUE
分子名称:Imidazolonepropionase, ZINC ION, 2H-IMIDAZOL-4-YLACETIC ACID
著者Yu, Y., Liang, Y.H., Su, X.D.
登録日2006-02-19
公開日2006-09-26
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A catalytic mechanism revealed by the crystal structures of the imidazolonepropionase from Bacillus subtilis
J.Biol.Chem., 281, 2006
3HRN
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CRYSTAL STRUCTURE OF A C-TERMINAL COILED COIL DOMAIN OF TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNEL SUBFAMILY P MEMBER 2 (TRPP2, POLYCYSTIC KIDNEY DISEASE 2)
分子名称:Transient receptor potential (TRP) channel subfamily P member 2 (TRPP2)
著者Yu, Y., Ulbrich, M.H., Li, M.-H., Buraei, Z., Chen, X.-Z., Ong, A.C.M., Tong, L., Isacoff, E.Y., Yang, J.
登録日2009-06-09
公開日2009-07-28
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and molecular basis of the assembly of the TRPP2/PKD1 complex.
Proc.Natl.Acad.Sci.USA, 106, 2009
3HRO
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CRYSTAL STRUCTURE OF A C-TERMINAL COILED COIL DOMAIN OF TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNEL SUBFAMILY P MEMBER 2 (TRPP2, POLYCYSTIC KIDNEY DISEASE 2)
分子名称:Transient receptor potential (TRP) channel subfamily P member 2 (TRPP2), also called Polycystin-2 or polycystic kidney disease 2(PKD2)
著者Yu, Y., Ulbrich, M.H., Li, M.-H., Buraei, Z., Chen, X.-Z., Ong, A.C.M., Tong, L., Isacoff, E.Y., Yang, J.
登録日2009-06-09
公開日2009-07-28
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and molecular basis of the assembly of the TRPP2/PKD1 complex.
Proc.Natl.Acad.Sci.USA, 106, 2009
3V4P
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CRYSTAL STRUCTURE OF A4B7 HEADPIECE COMPLEXED WITH FAB ACT-1
分子名称:Integrin alpha-4, Integrin beta-7, MONOCLONAL ANTIBODY Act-1 HEAVY CHAIN, ...
著者Yu, Y., Zhu, J., Springer, T.A.
登録日2011-12-15
公開日2012-01-11
最終更新日2012-03-28
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Structural specializations of a4b7, an Integrin that Mediates Rolling Adhesion
J.Cell Biol., 196, 2012
3V4V
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CRYSTAL STRUCTURE OF A4B7 HEADPIECE COMPLEXED WITH FAB ACT-1 AND RO0505376
分子名称:Integrin alpha-4, Integrin beta-7, MONOCLONAL ANTIBODY Act-1 HEAVY CHAIN, ...
著者Yu, Y., Zhu, J., Springer, T.A.
登録日2011-12-15
公開日2012-01-11
最終更新日2012-03-28
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural specializations of a4b7, an Integrin that Mediates Rolling Adhesion
J.Cell Biol., 196, 2012
4B2H
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COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS
分子名称:DODECIN, SODIUM ION, SULFATE ION, ...
著者Yu, Y., Heidel, B., Parapugna, T.L., Wenderhold-Reeb, S., Song, B., Schoenherr, H., Grininger, M., Noell, G.
登録日2012-07-16
公開日2013-05-29
最終更新日2019-10-16
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The Flavoprotein Dodecin as a Redox Probe for Electron Transfer Through DNA.
Angew.Chem.Int.Ed.Engl., 52, 2013
4GIF
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C-TERMINAL COILED-COIL DOMAIN OF TRANSIENT RECEPTOR POTENTIAL CHANNEL TRPP3 (PKD2L1, POLYCYSTIN-L)
分子名称:Polycystic kidney disease 2-like 1 protein
著者Yu, Y., Ulbrich, M.H., Li, M.-H., Dobbins, S., Zhang, W.K., Tong, L., Isacoff, E.Y., Yang, J.
登録日2012-08-08
公開日2012-12-05
最終更新日2012-12-26
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex.
Nat Commun, 3, 2012
4IRZ
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CRYSTAL STRUCTURE OF A4B7 HEADPIECE COMPLEXED WITH FAB NATALIZUMAB
分子名称:Integrin alpha4 subunit, Fab Natalizumab light chain, Fab Natalizumab heavy chain, ...
著者Yu, Y., Schurpf, T., Springer, T.A.
登録日2013-01-15
公開日2013-09-25
最終更新日2014-12-10
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献How natalizumab binds and antagonizes alpha 4 integrins.
J.Biol.Chem., 288, 2013
5JWA
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THE STRUCTURE OF MALARIA PFNDH2
分子名称:NADH dehydrogenase, putative, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Yu, Y., Yang, Y.Q., Li, X.L., Yu, J., Ge, J.P., Li, J., Rao, Y., Yang, M.J.
登録日2016-05-11
公開日2017-03-22
実験手法X-RAY DIFFRACTION (2.162 Å)
主引用文献Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria
J. Med. Chem., 60, 2017
5JWB
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STRUCTURE OF NDH2 FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH NADH
分子名称:Type II NADH:ubiquinone oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ...
著者Yu, Y., Li, X.L.
登録日2016-05-12
公開日2017-03-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria
J. Med. Chem., 60, 2017
5JWC
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STRUCTURE OF NDH2 FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH RYL-552
分子名称:NADH dehydrogenase, putative, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Yu, Y.
登録日2016-05-12
公開日2017-03-22
実験手法X-RAY DIFFRACTION (2.051 Å)
主引用文献Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria
J. Med. Chem., 60, 2017
5XHS
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CRYSTAL STRUCTURE OF SIRT5 COMPLEXED WITH A FLUOROGENIC SMALL-MOLECULE SUBSTRATE SUBKA
分子名称:NAD-dependent protein deacylase sirtuin-5, mitochondrial, benzyl chlorocarbonate, ...
著者Yu, Y., Li, B., Chen, Q.
登録日2017-04-24
公開日2018-05-02
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Interactions between sirtuins and fluorogenic small-molecule substrates offer insights into inhibitor design
Rsc Adv, 7, 2017
5XLZ
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THE CRYSTAL STRUCTURE OF TUBULIN COMPLEXED WITH A BENZYLIDENE DERIVATIVE OF 9(10H)-ANTHRACENONE
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Yu, Y., Chen, Q.
登録日2017-05-12
公開日2017-11-22
最終更新日2018-01-03
実験手法X-RAY DIFFRACTION (2.298 Å)
主引用文献Structure of a benzylidene derivative of 9(10H)-anthracenone in complex with tubulin provides a rationale for drug design.
Biochem. Biophys. Res. Commun., 495, 2018
5XLT
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THE CRYSTAL STRUCTURE OF TUBULIN IN COMPLEX WITH 4'-DEMETHYLEPIPODOPHYLLOTOXIN
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Yu, Y., Chen, Q.
登録日2017-05-11
公開日2017-09-27
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.813 Å)
主引用文献Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design
Biochem. Biophys. Res. Commun., 493, 2017
6J3B
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CRYSTAL STRUCTURE OF HUMAN DHODH IN COMPLEX WITH INHIBITOR 1289
分子名称:Dihydroorotate dehydrogenase (quinone), mitochondrial, SULFATE ION, ...
著者Yu, Y., Chen, Q.
登録日2019-01-04
公開日2019-08-21
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.
Febs Open Bio, 9, 2019