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2F4J
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BU of 2f4j by Molmil
Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680
Descriptor: CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, Proto-oncogene tyrosine-protein kinase ABL1
Authors:Young, M.A, Shah, N.P, Chao, L.H, Zarrinkar, P, Sawyers, P, Kuriyan, J.
Deposit date:2005-11-23
Release date:2006-01-24
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.
Cancer Res., 66, 2006
3QHR
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BU of 3qhr by Molmil
Structure of a pCDK2/CyclinA transition-state mimic
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CDK2 substrate peptide: PKTPKKAKKL, CHLORIDE ION, ...
Authors:Young, M.A, Jacobsen, D.M, Bao, Z.Q.
Deposit date:2011-01-26
Release date:2011-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis.
Structure, 19, 2011
3QHW
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BU of 3qhw by Molmil
Structure of a pCDK2/CyclinA transition-state mimic
Descriptor: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, CDK2 substrate peptide: PKTPKKAKKL, ...
Authors:Young, M.A, Jacobsen, D.M, Bao, Z.Q.
Deposit date:2011-01-26
Release date:2011-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis.
Structure, 19, 2011
4I3Z
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BU of 4i3z by Molmil
Structure of pCDK2/CyclinA bound to ADP and 2 Magnesium ions
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Cyclin-A2, ...
Authors:Jacobsen, D.M, Bao, Z.-Q, O'Brien, P.J, Brooks, C.L, Young, M.A.
Deposit date:2012-11-27
Release date:2012-12-26
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Price To Be Paid for Two-Metal Catalysis: Magnesium Ions That Accelerate Chemistry Unavoidably Limit Product Release from a Protein Kinase
J.Am.Chem.Soc., 134, 2012
4II5
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BU of 4ii5 by Molmil
Structure of PCDK2/CYCLINA bound to ADP and 1 MAGNESIUM ION
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ...
Authors:Jacobsen, D.M, Bao, Z.-Q, O'Brien, P.J, Brooks III, C.L, Young, M.A.
Deposit date:2012-12-19
Release date:2013-01-23
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Price to be paid for two-metal catalysis: Magnesium ions that accelerate chemistry unavoidably limit product release from a PROTEIN KINASE
J.Am.Chem.Soc., 134, 2012
1OPK
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BU of 1opk by Molmil
Structural basis for the auto-inhibition of c-Abl tyrosine kinase
Descriptor: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, GLYCEROL, MYRISTIC ACID, ...
Authors:Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J.
Deposit date:2003-03-06
Release date:2003-04-08
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
1OPJ
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BU of 1opj by Molmil
Structural basis for the auto-inhibition of c-Abl tyrosine kinase
Descriptor: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, CHLORIDE ION, MYRISTIC ACID, ...
Authors:Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J.
Deposit date:2003-03-06
Release date:2003-04-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
1OPL
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BU of 1opl by Molmil
Structural basis for the auto-inhibition of c-Abl tyrosine kinase
Descriptor: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, MYRISTIC ACID, proto-oncogene tyrosine-protein kinase
Authors:Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J.
Deposit date:2003-03-06
Release date:2003-04-08
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
3M9E
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BU of 3m9e by Molmil
Thyroid hormone beta DNA binding domain homodimer with inverted palindrome TRE
Descriptor: DNA (5'-D(*AP*TP*TP*GP*AP*CP*CP*TP*CP*AP*GP*CP*TP*GP*AP*GP*GP*TP*CP*AP*AP*T)-3'), Thyroid hormone receptor beta, ZINC ION
Authors:Chen, Y.
Deposit date:2010-03-22
Release date:2010-08-18
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.406 Å)
Cite:Structure of a thyroid hormone receptor DNA-binding domain homodimer bound to an inverted palindrome DNA response element.
Mol.Endocrinol., 24, 2010
2G2H
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BU of 2g2h by Molmil
A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain
Descriptor: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, Abl Tyrosine
Authors:Levinson, N.M, Kuchment, O.
Deposit date:2006-02-16
Release date:2006-05-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:A SRC-like inactive conformation in the abl tyrosine kinase domain.
Plos Biol., 4, 2006
2G2F
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BU of 2g2f by Molmil
A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain
Descriptor: ATP-Peptide Conjugate, Abl Kinase, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Levinson, N.M, Kuchment, O.
Deposit date:2006-02-15
Release date:2006-05-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A SRC-like inactive conformation in the abl tyrosine kinase domain.
Plos Biol., 4, 2006
2G1T
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BU of 2g1t by Molmil
A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain
Descriptor: ATP-Peptide Conjugate, MAGNESIUM ION, Proto-oncogene tyrosine-protein kinase ABL1, ...
Authors:Levinson, N.M, Kuchment, O.
Deposit date:2006-02-14
Release date:2006-05-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A SRC-like inactive conformation in the abl tyrosine kinase domain.
Plos Biol., 4, 2006
2G2I
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BU of 2g2i by Molmil
A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-Peptide Conjugate, Abl Tyrosine Kinase
Authors:Levinson, N.M, Kuchment, O.
Deposit date:2006-02-16
Release date:2006-05-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:A SRC-like inactive conformation in the abl tyrosine kinase domain.
Plos Biol., 4, 2006

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