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4L5E
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BU of 4l5e by Molmil
Crystal structure of A. aeolicus NtrC1 DNA binding domain
Descriptor: SULFATE ION, Transcriptional regulator (NtrC family)
Authors:Young, A, Maris, A.E, Vidangos, N.K, Hong, E, Pelton, J.G, Batchelor, J.D, Wemmer, D.E.
Deposit date:2013-06-10
Release date:2013-08-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Structure, function, and tethering of DNA-binding domains in sigma (54) transcriptional activators.
Biopolymers, 99, 2013
8FCH
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BU of 8fch by Molmil
Apo Structure of (N1G37) Methyltransferase from Mycobacterium avium
Descriptor: tRNA (guanine-N(1)-)-methyltransferase
Authors:Isaacson, B, Brylewski, J, Schlegel, F, Cortes, J, Lavallee, T, Mehta, K, Young, A, Doti, L, Battaile, K.P, Stojanoff, V, Perez, A, Bolen, R.
Deposit date:2022-12-01
Release date:2023-12-13
Method:X-RAY DIFFRACTION (1.956 Å)
Cite:Apo structure of (N1G37) Methyltransferase from Mycobacterium avium.
To Be Published
8FCI
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BU of 8fci by Molmil
tRNA (N1G37) Methyltransferase (TrmD) of Mycobacterium avium complexed with S-Adenosyl homocysteine
Descriptor: S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine-N(1)-)-methyltransferase
Authors:Lavallee, T, Mehta, K, Young, A, Cortes, J, Isaacson, B, Brylewski, J, Schlegel, F, Doti, L, Battaile, K, Stojanoff, V, Perez, A, Bolen, R.
Deposit date:2022-12-01
Release date:2023-12-13
Method:X-RAY DIFFRACTION (1.752 Å)
Cite:tRNA (N1G37) Methyltransferase (TrmD) of Mycobacterium avium complexed with S-Adenosyl homocysteine
To Be Published
4L4U
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BU of 4l4u by Molmil
Crystal structure of construct containing A. aeolicus NtrC1 receiver, central and DNA binding domains
Descriptor: Transcriptional regulator (NtrC family)
Authors:Vidangos, N.K, Maris, A.E, Young, A, Hong, E, Pelton, J.G, Batchelor, J.D, Wemmer, D.E.
Deposit date:2013-06-09
Release date:2013-08-28
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure, function, and tethering of DNA-binding domains in sigma (54) transcriptional activators.
Biopolymers, 99, 2013
7SA1
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BU of 7sa1 by Molmil
LRR-F-Box plant ubiquitin ligase
Descriptor: CITRIC ACID, DI(HYDROXYETHYL)ETHER, F-box/LRR-repeat MAX2 homolog, ...
Authors:Palayam, M, Shabek, N.
Deposit date:2021-09-21
Release date:2022-04-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:A conformational switch in the SCF-D3/MAX2 ubiquitin ligase facilitates strigolactone signalling.
Nat.Plants, 8, 2022
8EXL
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BU of 8exl by Molmil
Crystal structure of PI3K-alpha in complex with taselisib
Descriptor: 2-methyl-2-(4-{2-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-1H-pyrazol-1-yl)propanamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Authors:Kiefer, J.R, Eigenbrot, C, Staben, S.T, Hanan, E.J, Wallweber, H.J.A, Ultsch, M, Braun, M.G, Friedman, L.S, Purkey, H.E.
Deposit date:2022-10-25
Release date:2022-11-30
Last modified:2023-01-04
Method:X-RAY DIFFRACTION (1.989 Å)
Cite:Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3K alpha.
J.Med.Chem., 65, 2022
8EXO
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BU of 8exo by Molmil
Crystal structure of PI3K-alpha in complex with compound 19
Descriptor: 1-{(4S,11aM)-2-[(4R)-2-oxo-4-(propan-2-yl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-L-prolinamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Authors:Kiefer, J.R, Eigenbrot, C, Staben, S.T, Hanan, E.J, Wallweber, H.J.A, Ultsch, M, Braun, M.G, Friedman, L.S, Purkey, H.E.
Deposit date:2022-10-25
Release date:2022-11-30
Last modified:2023-01-04
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3K alpha.
J.Med.Chem., 65, 2022
8EXU
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BU of 8exu by Molmil
Crystal structure of PI3K-alpha in complex with compound 30
Descriptor: (2S)-2-cyclopropyl-2-({(4S,11aM)-2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}amino)acetamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Authors:Kiefer, J.R, Eigenbrot, C, Staben, S.T, Hanan, E.J, Wallweber, H.J.A, Ultsch, M, Braun, M.G, Friedman, L.S, Purkey, H.E.
Deposit date:2022-10-25
Release date:2022-11-30
Last modified:2023-01-04
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3K alpha.
J.Med.Chem., 65, 2022
8EXV
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BU of 8exv by Molmil
Crystal structure of PI3K-alpha in complex with compound 32
Descriptor: N~2~-{(4S,11aP)-2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-L-alaninamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Authors:Kiefer, J.R, Eigenbrot, C, Staben, S.T, Hanan, E.J, Wallweber, H.J.A, Ultsch, M, Braun, M.G, Friedman, L.S, Purkey, H.E.
Deposit date:2022-10-25
Release date:2022-11-30
Last modified:2023-01-04
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3K alpha.
J.Med.Chem., 65, 2022
6WOK
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BU of 6wok by Molmil
Crystal structure of estrogen receptor alpha in complex with receptor degrader 6
Descriptor: (1R,3R)-1-(2,6-difluoro-4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-beta-carboline, (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, Estrogen receptor
Authors:Kiefer, J.R, Vinogradova, M, Liang, J, Zhang, B, Wang, X, Labadie, S.
Deposit date:2020-04-24
Release date:2020-07-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.309 Å)
Cite:Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer.
Acs Med.Chem.Lett., 11, 2020
4O0T
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BU of 4o0t by Molmil
Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
Descriptor: 1-({1-(2-aminopyrimidin-4-yl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl}ethynyl)cyclohexanol, Serine/threonine-protein kinase PAK 1
Authors:Oh, A, Tam, C, Wang, W.
Deposit date:2013-12-14
Release date:2014-02-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors.
J.Med.Chem., 57, 2014
4O0R
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BU of 4o0r by Molmil
Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
Descriptor: PF-3758309, Serine/threonine-protein kinase PAK 1
Authors:Rouge, L, Tam, C, Wang, W.
Deposit date:2013-12-14
Release date:2014-02-12
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors.
J.Med.Chem., 57, 2014
4O0Y
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BU of 4o0y by Molmil
Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
Descriptor: 4-[1-(4-amino-1,3,5-triazin-2-yl)-2-(ethylamino)-1H-benzimidazol-6-yl]-2-methylbut-3-yn-2-ol, Serine/threonine-protein kinase PAK 4
Authors:Rouge, L, Tam, C, Wang, W.
Deposit date:2013-12-14
Release date:2014-02-12
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors.
J.Med.Chem., 57, 2014
4O0V
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BU of 4o0v by Molmil
Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
Descriptor: 1-({1-(2-aminopyrimidin-4-yl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl}ethynyl)cyclohexanol, Serine/threonine-protein kinase PAK 4
Authors:Rouge, L, Tam, C, Wang, W.
Deposit date:2013-12-14
Release date:2014-02-12
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors.
J.Med.Chem., 57, 2014
4O0X
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BU of 4o0x by Molmil
Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
Descriptor: 1-{[1-(4-amino-1,3,5-triazin-2-yl)-2-methyl-1H-benzimidazol-6-yl]ethynyl}cyclohexanol, Serine/threonine-protein kinase PAK 4
Authors:Rouge, L, Tam, C, Wang, W.
Deposit date:2013-12-14
Release date:2014-02-12
Last modified:2014-11-05
Method:X-RAY DIFFRACTION (2.483 Å)
Cite:Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors.
J.Med.Chem., 57, 2014
7MSA
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BU of 7msa by Molmil
GDC-9545 in complex with estrogen receptor alpha
Descriptor: (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, 3-[(1R,3R)-1-(2,6-difluoro-4-{[1-(3-fluoropropyl)azetidin-3-yl]amino}phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl]-2,2-difluoropropan-1-ol, Estrogen receptor
Authors:Kiefer, J.R, Vinogradova, M, Liang, J, Zbieg, J.R, Wang, X, Ortwine, D.F.
Deposit date:2021-05-10
Release date:2021-06-02
Last modified:2021-09-08
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.
J.Med.Chem., 64, 2021
3OUH
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BU of 3ouh by Molmil
PHD2-R127 with JNJ41536014
Descriptor: 1-(5-chloro-6-fluoro-1H-benzimidazol-2-yl)-1H-pyrazole-4-carboxylic acid, Egl nine homolog 1, FE (II) ION, ...
Authors:Kim, H, Clark, R.
Deposit date:2010-09-14
Release date:2010-12-01
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues.
ACS Med Chem Lett, 1, 2010
3OUI
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BU of 3oui by Molmil
PHD2-R717 with 40787422
Descriptor: ACETATE ION, DI(HYDROXYETHYL)ETHER, Egl nine homolog 1, ...
Authors:Arakaki, T.L, Kim, H.
Deposit date:2010-09-14
Release date:2010-12-01
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues.
ACS Med Chem Lett, 1, 2010
3OUJ
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BU of 3ouj by Molmil
PHD2 with 2-Oxoglutarate
Descriptor: 2-OXOGLUTARIC ACID, Egl nine homolog 1, FE (II) ION, ...
Authors:Staker, B.L, Arakaki, T.L.
Deposit date:2010-09-14
Release date:2010-12-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues.
ACS Med Chem Lett, 1, 2010
2M8G
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BU of 2m8g by Molmil
Structure, function, and tethering of DNA-binding domains in 54 transcriptional activators
Descriptor: Transcriptional regulator
Authors:Hong, E, Wemmer, D.
Deposit date:2013-05-19
Release date:2013-08-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure, function, and tethering of DNA-binding domains in sigma (54) transcriptional activators.
Biopolymers, 99, 2013

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