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5HKV
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BU of 5hkv by Molmil
The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with lincomycin
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 23s ribosomal RNA, 50S ribosomal protein L13, ...
Authors:Yonath, A, Matzov, D, Eyal, Z, Ben Hamou, R, Zimmerman, E, Rozenberg, H, Bashan, A, Fridman, M.
Deposit date:2016-01-14
Release date:2017-05-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.66 Å)
Cite:Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus.
Nucleic Acids Res., 45, 2017
5NRG
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BU of 5nrg by Molmil
The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with RB02
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 23S ribosomal RNA, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Yonath, A, Matzov, D, Eyal, Z, Ben Hamou, R, Zimmerman, E, Rozenberg, H, Bashan, A, Fridman, M.
Deposit date:2017-04-23
Release date:2017-08-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.442 Å)
Cite:Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus.
Nucleic Acids Res., 45, 2017
5JVH
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BU of 5jvh by Molmil
The crystal structure large ribosomal subunit (50S) of Deinococcus radiodurans in complex with evernimicin
Descriptor: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Yonath, A.
Deposit date:2016-05-11
Release date:2016-11-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.58 Å)
Cite:Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding.
Proc.Natl.Acad.Sci.USA, 113, 2016
4U67
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BU of 4u67 by Molmil
Crystal structure of the large ribosomal subunit (50S) of Deinococcus radiodurans containing a three residue insertion in L22
Descriptor: 23s RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Wekselman, I, Zimmerman, E, Rozenberg, H, Bashan, A, Yonath, A.
Deposit date:2014-07-28
Release date:2015-08-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel.
Structure, 25, 2017
8OVE
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BU of 8ove by Molmil
CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : TB11CS6H1 snoRNA mutant
Descriptor: 40S ribosomal protein L14, putative, 40S ribosomal protein S10, ...
Authors:Rajan, K.S, Yonath, A.
Deposit date:2023-04-25
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Nat Commun, 14, 2023
8OVA
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BU of 8ova by Molmil
CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : PARENTAL STRAIN
Descriptor: 40S ribosomal protein L14, putative, 40S ribosomal protein S10, ...
Authors:Rajan, K.S, Yonath, A.
Deposit date:2023-04-25
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (2.47 Å)
Cite:A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Nat Commun, 14, 2023
5HL7
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BU of 5hl7 by Molmil
The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with lefamulin
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 23S ribosomal RNA, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Eyal, Z, Matzov, D, Krupkin, M, Rozenberg, H, Zimmerman, E, Bashan, A, Yonath, A.
Deposit date:2016-01-14
Release date:2016-12-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism.
Sci Rep, 6, 2016
7PWO
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BU of 7pwo by Molmil
Cryo-EM structure of Giardia lamblia ribosome at 2.75 A resolution
Descriptor: 40S ribosomal protein S21, 40S ribosomal protein S26, 40S ribosomal protein S30, ...
Authors:Hiregange, D.G, Rivalta, A, Bose, T, Breiner-Goldstein, E, Samiya, S, Cimicata, G, Kulakova, L, Zimmerman, E, Bashan, A, Herzberg, O, Yonath, A.
Deposit date:2021-10-07
Release date:2022-04-20
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia.
Nucleic Acids Res., 50, 2022
7PWG
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BU of 7pwg by Molmil
Cryo-EM structure of large subunit of Giardia lamblia ribosome at 2.7 A resolution
Descriptor: 60S ribosomal protein L13, 60S ribosomal protein L18a, 60S ribosomal protein L27, ...
Authors:Hiregange, D.G, Rivalta, A, Bose, T, Breiner-Goldstein, E, Samiya, S, Cimicata, G, Kulakova, L, Zimmerman, E, Bashan, A, Herzberg, O, Yonath, A.
Deposit date:2021-10-06
Release date:2022-04-20
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia.
Nucleic Acids Res., 50, 2022
7PWF
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BU of 7pwf by Molmil
Cryo-EM structure of small subunit of Giardia lamblia ribosome at 2.9 A resolution
Descriptor: 40S ribosomal protein S21, 40S ribosomal protein S25, 40S ribosomal protein S26, ...
Authors:Hiregange, D.G, Rivalta, A, Bose, T, Breiner-Goldstein, E, Samiya, S, Cimicata, G, Kulakova, L, Zimmerman, E, Bashan, A, Herzberg, O, Yonath, A.
Deposit date:2021-10-06
Release date:2022-05-25
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia.
Nucleic Acids Res., 50, 2022
3FWO
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BU of 3fwo by Molmil
The large ribosomal subunit from Deinococcus radiodurans complexed with Methymycin
Descriptor: (3R,4S,5S,7R,9E,11S,12R)-12-ethyl-11-hydroxy-3,5,7,11-tetramethyl-2,8-dioxooxacyclododec-9-en-4-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside, 23S RIBOSOMAL RNA, 5S RIBOSOMAL RNA
Authors:Auerbach, T, Mermershtain, I, Bashan, A, Davidovich, C, Rozenberg, H, Sherman, D.H, Yonath, A.
Deposit date:2009-01-19
Release date:2010-01-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.71 Å)
Cite:Structural basis for the antibacterial activity of the 12-membered-ring mono-sugar macrolide methymycin
Biotechnologia, 1, 2009
4WCE
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BU of 4wce by Molmil
The crystal structure of the large ribosomal subunit of Staphylococcus aureus
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 23S rRNA, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Eyal, Z, Matzov, D, Krupkin, M, Wekselman, I, Zimmerman, E, Rozenberg, H, Bashan, A, Yonath, A.
Deposit date:2014-09-04
Release date:2015-10-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.526 Å)
Cite:Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.
Proc.Natl.Acad.Sci.USA, 112, 2015
4WFN
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BU of 4wfn by Molmil
Crystal structure of the large ribosomal subunit (50S) of Deinococcus radiodurans containing a three residue insertion in L22 in complex with erythromycin
Descriptor: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Wekselman, I, Zimmerman, E, Rozenberg, H, Bashan, A, Yonath, A.
Deposit date:2014-09-16
Release date:2015-12-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.54 Å)
Cite:The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel.
Structure, 25, 2017
6AZ3
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BU of 6az3 by Molmil
Cryo-EM structure of of the large subunit of Leishmania ribosome bound to paromomycin
Descriptor: 60S ribosomal protein L10, putative, 60S ribosomal protein L11 (L5, ...
Authors:Shalev-Benami, M, Zhang, Y, Rozenberg, H, Nobe, Y, Taoka, M, Matzov, D, Zimmerman, E, Bashan, A, Isobe, T, Jaffe, C.L, Yonath, A, Skiniotis, G.
Deposit date:2017-09-09
Release date:2017-12-06
Last modified:2022-04-13
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Nat Commun, 8, 2017
6AZ1
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BU of 6az1 by Molmil
Cryo-EM structure of the small subunit of Leishmania ribosome bound to paromomycin
Descriptor: E-site tRNA, LACK1, MAGNESIUM ION, ...
Authors:Shalev-Benami, M, Zhang, Y, Rozenberg, H, Matzov, D, Zimmerman, E, Bashan, A, Jaffe, C.L, Yonath, A, Skiniotis, G.
Deposit date:2017-09-09
Release date:2017-12-06
Last modified:2019-07-03
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Nat Commun, 8, 2017
3JCS
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BU of 3jcs by Molmil
2.8 Angstrom cryo-EM structure of the large ribosomal subunit from the eukaryotic parasite Leishmania
Descriptor: 26S alpha ribosomal RNA, 26S delta ribosomal RNA, 26S epsilon ribosomal RNA, ...
Authors:Shalev-Benami, M, Zhang, Y, Matzov, D, Halfon, Y, Zackay, A, Rozenberg, H, Zimmerman, E, Bashan, A, Jaffe, C.L, Yonath, A, Skiniotis, G.
Deposit date:2016-01-21
Release date:2016-07-20
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:2.8- angstrom Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.
Cell Rep, 16, 2016
7LYZ
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BU of 7lyz by Molmil
PROTEIN MODEL BUILDING BY THE USE OF A CONSTRAINED-RESTRAINED LEAST-SQUARES PROCEDURE
Descriptor: HEN EGG WHITE LYSOZYME
Authors:Moult, J, Yonath, A, Sussman, J, Herzberg, O, Podjarny, A, Traub, W.
Deposit date:1977-05-06
Release date:1977-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Protein Model Building by the Use of a Constrained-Restrained Least-Squares Procedure
J.Appl.Crystallogr., 16, 1983
5JVG
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BU of 5jvg by Molmil
The large ribosomal subunit from Deinococcus radiodurans in complex with avilamycin
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 23S ribosomal RNA, 50S ribosomal protein L11, ...
Authors:Krupkin, M, Wekselman, I, Matzov, D, Eyal, Z, Diskin Posner, Y, Rozenberg, H, Zimmerman, E, Bashan, A, Yonath, A.
Deposit date:2016-05-11
Release date:2016-11-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.428 Å)
Cite:Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding.
Proc.Natl.Acad.Sci.USA, 113, 2016
3JQ4
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BU of 3jq4 by Molmil
The structure of the complex of the large ribosomal subunit from D. Radiodurans with the antibiotic lankacidin
Descriptor: 23S ribosomal RNA, 5S ribosomal RNA, N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-7,13-dihydroxy-1,4,10,19-tetramethyl-17,18-dioxo-16-oxabicyclo[13.2.2]nonadeca-3,5,9,11-tetraen-2-yl]-2-oxopropanamide
Authors:Auerbach-Nevo, T, Mermershtain, I, Davidovich, C, Bashan, A, Rozenberg, H, Yonath, A.
Deposit date:2009-09-06
Release date:2010-09-08
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.52 Å)
Cite:The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics
Proc.Natl.Acad.Sci.USA, 107, 2010
3PIO
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BU of 3pio by Molmil
Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit
Descriptor: 50S ribosomal protein L11, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Belousoff, M.J, Shapira, T, Bashan, A, Zimmerman, E, Arakawa, K, Kinashi, H, Rozenberg, H, Yonath, A.
Deposit date:2010-11-07
Release date:2011-02-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.2473 Å)
Cite:Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PIP
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BU of 3pip by Molmil
Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit
Descriptor: 50S ribosomal protein L11, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Belousoff, M.J, Shapira, T, Bashan, A, Zimmerman, E, Kinashi, H, Rozenberg, H, Yonath, A.
Deposit date:2010-11-07
Release date:2011-02-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit.
Proc.Natl.Acad.Sci.USA, 108, 2011
6HMA
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BU of 6hma by Molmil
Improved model derived from cryo-EM map of Staphylococcus aureus large ribosomal subunit
Descriptor: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Eyal, Z, Cimicata, G, Matzov, D, Fox, T, de Val, N, Zimmerman, E, Bashan, A, Yonath, A.
Deposit date:2018-09-12
Release date:2018-11-14
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (2.65 Å)
Cite:Improved model derived from cryo-EM map of Staphylococcus aureus large ribosomal subunit
To Be Published
1CN1
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BU of 1cn1 by Molmil
CRYSTAL STRUCTURE OF DEMETALLIZED CONCANAVALIN A. THE METAL-BINDING REGION
Descriptor: CONCANAVALIN A
Authors:Shoham, M, Yonath, A, Sussman, J.L, Moult, J, Traub, W, Gilboa(Kalb), A.J.
Deposit date:1981-12-21
Release date:1982-03-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of demetallized concanavalin A: the metal-binding region.
J.Mol.Biol., 131, 1979
7A0R
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BU of 7a0r by Molmil
50S Deinococcus radiodurans ribosome bounded with mycinamicin I
Descriptor: 50S ribosomal protein L13, 50S ribosomal protein L14, 50S ribosomal protein L15, ...
Authors:Breiner, E, Eyal, Z, Matzov, D, Halfon, Y, Cimicata, G, Rozenberg, H, Zimmerman, E, Bashan, A, Yonath, A.
Deposit date:2020-08-10
Release date:2021-08-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida.
Nucleic Acids Res., 49, 2021
7A0S
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BU of 7a0s by Molmil
50S Deinococcus radiodurans ribosome bounded with mycinamicin I
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Breiner, E, Eyal, Z, Matzov, D, Halfon, Y, Cimicata, G, Rozenberg, H, Zimmerman, E, Bashan, A, Yonath, A.
Deposit date:2020-08-10
Release date:2021-08-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida.
Nucleic Acids Res., 49, 2021

 

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