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4WV1
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BU of 4wv1 by Molmil
Crystal structure of the FGFR2 D2 domain in complex with Fab 2B.1.3
Descriptor: Fab heavy chain, Fab light chain, Fibroblast growth factor receptor 2
Authors:Yin, Y, Carter, P.J.
Deposit date:2014-11-04
Release date:2015-09-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.362 Å)
Cite:Redesigning a Monospecific Anti-FGFR3 Antibody to Add Selectivity for FGFR2 and Expand Antitumor Activity.
Mol.Cancer Ther., 14, 2015
6W6G
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BU of 6w6g by Molmil
The Mycobacterium tuberculosis ClpB disaggregase hexamer structure in conformation I in the presence of DnaK chaperone and a model substrate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Yin, Y, Li, H.
Deposit date:2020-03-16
Release date:2021-03-17
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system.
Cell Rep, 35, 2021
6W6H
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BU of 6w6h by Molmil
The Mycobacterium tuberculosis ClpB disaggregase hexamer structure in conformation II in the presence of DnaK chaperone and a model substrate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Yin, Y, Li, H.
Deposit date:2020-03-16
Release date:2021-05-26
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system.
Cell Rep, 35, 2021
6W6I
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BU of 6w6i by Molmil
The Mycobacterium tuberculosis ClpB disaggregase hexamer structure in conformation T in the presence of DnaK chaperone and a model substrate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Yin, Y, Li, H.
Deposit date:2020-03-17
Release date:2021-05-26
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system.
Cell Rep, 35, 2021
6W6E
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BU of 6w6e by Molmil
The Mycobacterium tuberculosis ClpB disaggregase hexamer structure with a locally refined ClpB middle domain and a DnaK nucleotide binding domain
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, Chaperone protein DnaK, ...
Authors:Yin, Y, Li, H.
Deposit date:2020-03-16
Release date:2021-05-26
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system.
Cell Rep, 35, 2021
6W6J
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BU of 6w6j by Molmil
The Mycobacterium tuberculosis ClpB disaggregase hexamer structure with a locally refined N-terminal domain in the presence of DnaK chaperone and a model substrate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Yin, Y, Li, H.
Deposit date:2020-03-17
Release date:2021-05-26
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system.
Cell Rep, 35, 2021
6PKW
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BU of 6pkw by Molmil
Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C2 symmetry (pseudo C4 symmetry)
Descriptor: Transient receptor potential cation channel subfamily M member 2
Authors:Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y.
Deposit date:2019-06-30
Release date:2019-08-28
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
6PKV
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BU of 6pkv by Molmil
Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C4 symmetry
Descriptor: Transient receptor potential cation channel subfamily M member 2
Authors:Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y.
Deposit date:2019-06-30
Release date:2019-08-28
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
6PKX
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BU of 6pkx by Molmil
Cryo-EM structure of the zebrafish TRPM2 channel in the presence of ADPR and Ca2+
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 2, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y.
Deposit date:2019-06-30
Release date:2019-08-28
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
6D73
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BU of 6d73 by Molmil
Cryo-EM structure of the zebrafish TRPM2 channel in the presence of Ca2+
Descriptor: CALCIUM ION, Transient receptor potential cation channel, subfamily M
Authors:Yin, Y, Wu, M, Borschel, W.F, Lander, G.C, Lee, S.-Y.
Deposit date:2018-04-23
Release date:2019-05-15
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
3O6F
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BU of 3o6f by Molmil
Crystal structure of a human autoimmune TCR MS2-3C8 bound to MHC class II self-ligand MBP/HLA-DR4
Descriptor: HLA class II histocompatibility antigen, DR alpha chain, DRB1-4 beta chain, ...
Authors:Yin, Y, Li, Y, Martin, R, Mariuzza, R.A.
Deposit date:2010-07-29
Release date:2011-03-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection.
Embo J., 30, 2011
7LJF
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BU of 7ljf by Molmil
Cryo-EM structure of the Mpa hexamer in the presence of ATP and the Pup-FabD substrate
Descriptor: AAA ATPase forming ring-shaped complexes, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Yin, Y, Li, H.
Deposit date:2021-01-29
Release date:2021-05-05
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structure of the Mpa hexamer in the presence of ATP and the Pup-FabD substrate
J.Biol.Chem., 2021
2GFP
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BU of 2gfp by Molmil
Structure of the Multidrug Transporter EmrD from Escherichia coli
Descriptor: Multidrug resistance protein D
Authors:Yin, Y, He, X, Szewczyk, P, Nguyen, T, Chang, G.
Deposit date:2006-03-22
Release date:2006-05-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of the multidrug transporter EmrD from Escherichia coli
Science, 312, 2006
5TDP
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BU of 5tdp by Molmil
Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces
Descriptor: GLYCEROL, anti-HER2 Fab Heavy Chain, anti-HER2 Fab Light Chain
Authors:Yin, Y, Carter, P.J.
Deposit date:2016-09-19
Release date:2016-12-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.716 Å)
Cite:Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces
To Be Published
5TDN
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BU of 5tdn by Molmil
Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces
Descriptor: GLYCEROL, anti-HER2 Fab Heavy Chain, anti-HER2 Fab Light Chain
Authors:Yin, Y, Carter, P.J.
Deposit date:2016-09-19
Release date:2016-12-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces
To Be Published
5TDO
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BU of 5tdo by Molmil
Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces
Descriptor: GLYCEROL, anti-HER2 Fab Heavy Chain, anti-HER2 Fab Light Chain
Authors:Yin, Y, Carter, P.J.
Deposit date:2016-09-19
Release date:2016-12-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces
To Be Published
8E4P
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BU of 8e4p by Molmil
Mouse TRPM8 structure determined in the ligand- and PI(4,5)P2-free condition, Class I , C0 state
Descriptor: CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8
Authors:Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
Deposit date:2022-08-18
Release date:2022-10-26
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
8E4O
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BU of 8e4o by Molmil
The closed C1-state mouse TRPM8 structure in complex with putative PI(4,5)P2
Descriptor: Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
Deposit date:2022-08-18
Release date:2022-10-26
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
8E4Q
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BU of 8e4q by Molmil
The closed C0-state flycatcher TRPM8 structure in complex with PI(4,5)P2
Descriptor: Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
Deposit date:2022-08-18
Release date:2022-10-26
Method:ELECTRON MICROSCOPY (3.51 Å)
Cite:Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
8E4M
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BU of 8e4m by Molmil
The intermediate C2-state mouse TRPM8 structure in complex with the cooling agonist C3 and PI(4,5)P2
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ...
Authors:Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
Deposit date:2022-08-18
Release date:2022-10-26
Method:ELECTRON MICROSCOPY (3.44 Å)
Cite:Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
8E4L
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BU of 8e4l by Molmil
The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2
Descriptor: 3-isothiocyanatoprop-1-ene, CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, ...
Authors:Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
Deposit date:2022-08-18
Release date:2022-10-26
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
8E4N
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BU of 8e4n by Molmil
The closed C1-state mouse TRPM8 structure in complex with PI(4,5)P2
Descriptor: Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
Deposit date:2022-08-18
Release date:2022-10-26
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
3T0E
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BU of 3t0e by Molmil
Crystal structure of a complete ternary complex of T cell receptor, peptide-MHC and CD4
Descriptor: HLA class II histocompatibility antigen, DR alpha chain, DRB1-4 beta chain, ...
Authors:Yin, Y, Mariuzza, R.A.
Deposit date:2011-07-20
Release date:2012-03-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (4 Å)
Cite:Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4.
Proc.Natl.Acad.Sci.USA, 109, 2012
6NR3
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BU of 6nr3 by Molmil
Cryo-EM structure of the TRPM8 ion channel in complex with high occupancy icilin, PI(4,5)P2, and calcium
Descriptor: (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, CALCIUM ION, Icilin, ...
Authors:Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y.
Deposit date:2019-01-22
Release date:2019-02-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.
Science, 363, 2019
6NR4
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BU of 6nr4 by Molmil
Cryo-EM structure of the TRPM8 ion channel with low occupancy icilin, PI(4,5)P2, and calcium
Descriptor: Transient receptor potential cation channel subfamily M member 8
Authors:Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y.
Deposit date:2019-01-22
Release date:2019-02-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.
Science, 363, 2019

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