Author results

6PWC
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A COMPLEX STRUCTURE OF ARRESTIN-2 BOUND TO NEUROTENSIN RECEPTOR 1
Descriptor:Neurotensin receptor type 1, Neurotensin peptide, Beta-arrestin-1, ...
Authors:Yin, W., Li, Z., Jin, M., Yin, Y.-L., de Waal, P.W., Pal, K., Gao, X., He, Y., Gao, J., Wang, X., Zhang, Y., Zhou, H., Melcher, K., Jiang, Y., Cong, Y., Zhou, X.E., Yu, X., Xu, H.E.
Deposit date:2019-07-22
Release date:2019-12-04
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:A complex structure of arrestin-2 bound to a G protein-coupled receptor.
Cell Res., 29, 2019
7BV1
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CRYO-EM STRUCTURE OF THE APO NSP12-NSP7-NSP8 COMPLEX
Descriptor:nsp12, nsp8, nsp7, ...
Authors:Yin, W., Mao, C., Luan, X., Shen, D., Shen, Q., Su, H., Wang, X., Zhou, F., Zhao, W., Gao, M., Chang, S., Xie, Y.C., Tian, G., Jiang, H.W., Tao, S.C., Shen, J., Jiang, Y., Jiang, H., Xu, Y., Zhang, S., Zhang, Y., Xu, H.E.
Deposit date:2020-04-09
Release date:2020-04-22
Last modified:2020-07-15
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.
Science, 368, 2020
7BV2
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THE NSP12-NSP7-NSP8 COMPLEX BOUND TO THE TEMPLATE-PRIMER RNA AND TRIPHOSPHATE FORM OF REMDESIVIR(RTP)
Descriptor:nsp12, nsp8, nsp7, ...
Authors:Yin, W., Mao, C., Luan, X., Shen, D., Shen, Q., Su, H., Wang, X., Zhou, F., Zhao, W., Gao, M., Chang, S., Xie, Y.C., Tian, G., Jiang, H.W., Tao, S.C., Shen, J., Jiang, Y., Jiang, H., Xu, Y., Zhang, S., Zhang, Y., Xu, H.E.
Deposit date:2020-04-09
Release date:2020-04-22
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.
Science, 368, 2020
7D4F
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STRUCTURE OF COVID-19 RNA-DEPENDENT RNA POLYMERASE BOUND TO SURAMIN
Descriptor:Non-structural protein 8, Non-structural protein 7, Non-structural protein 12, ...
Authors:Li, Z., Yin, W., Zhou, Z., Yu, X., Xu, H.
Deposit date:2020-09-23
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (2.57 Å)
Cite:Structural basis for repurposing a 100-years-old drug suramin for treating COVID-19
To Be Published
3VBF
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CRYSTAL STRUCTURE OF FORMALDEHYDE TREATED HUMAN ENTEROVIRUS 71 (SPACE GROUP I23)
Descriptor:Genome Polyprotein, capsid protein VP1, capsid protein VP2, ...
Authors:Wang, X., Peng, W., Ren, J., Hu, Z., Xu, J., Lou, Z., Li, X., Yin, W., Shen, X., Porta, C., Walter, T.S., Evans, G., Axford, D., Owen, R., Rowlands, D.J., Wang, J., Stuart, D.I., Fry, E.E., Rao, Z.
Deposit date:2012-01-02
Release date:2012-02-29
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71.
Nat.Struct.Mol.Biol., 19, 2012
3VBH
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CRYSTAL STRUCTURE OF FORMALDEHYDE TREATED HUMAN ENTEROVIRUS 71 (SPACE GROUP R32)
Descriptor:Genome Polyprotein, capsid protein VP1, Genome polyprotein, ...
Authors:Wang, X., Peng, W., Ren, J., Hu, Z., Xu, J., Lou, Z., Li, X., Yin, W., Shen, X., Porta, C., Walter, T.S., Evans, G., Axford, D., Owen, R., Rowlands, D.J., Wang, J., Stuart, D.I., Fry, E.E., Rao, Z.
Deposit date:2012-01-02
Release date:2012-02-29
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71.
Nat.Struct.Mol.Biol., 19, 2012
3VBO
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CRYSTAL STRUCTURE OF FORMALDEHYDE TREATED EMPTY HUMAN ENTEROVIRUS 71 PARTICLE (CRYO AT 100K)
Descriptor:Genome Polyprotein, capsid protein VP1, capsid protein VP2, ...
Authors:Wang, X., Peng, W., Ren, J., Hu, Z., Xu, J., Lou, Z., Li, X., Yin, W., Shen, X., Porta, C., Walter, T.S., Evans, G., Axford, D., Owen, R., Rowlands, D.J., Wang, J., Stuart, D.I., Fry, E.E., Rao, Z.
Deposit date:2012-01-02
Release date:2012-02-29
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71.
Nat.Struct.Mol.Biol., 19, 2012
3VBR
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CRYSTAL STRUCTURE OF FORMALDEHYDE TREATED EMPTY HUMAN ENTEROVIRUS 71 PARTICLE (ROOM TEMPERATURE)
Descriptor:Genome Polyprotein, capsid protein VP1, capsid protein VP0, ...
Authors:Wang, X., Peng, W., Ren, J., Hu, Z., Xu, J., Lou, Z., Li, X., Yin, W., Shen, X., Porta, C., Walter, T.S., Evans, G., Axford, D., Owen, R., Rowlands, D.J., Wang, J., Stuart, D.I., Fry, E.E., Rao, Z.
Deposit date:2012-01-02
Release date:2012-02-29
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71.
Nat.Struct.Mol.Biol., 19, 2012
3VBS
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CRYSTAL STRUCTURE OF HUMAN ENTEROVIRUS 71
Descriptor:Genome Polyprotein, capsid protein VP1, capsid protein VP2, ...
Authors:Wang, X., Peng, W., Ren, J., Hu, Z., Xu, J., Lou, Z., Li, X., Yin, W., Shen, X., Porta, C., Walter, T.S., Evans, G., Axford, D., Owen, R., Rowlands, D.J., Wang, J., Stuart, D.I., Fry, E.E., Rao, Z.
Deposit date:2012-01-02
Release date:2012-02-29
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (3 Å)
Cite:A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71.
Nat.Struct.Mol.Biol., 19, 2012
3VBU
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CRYSTAL STRUCTURE OF EMPTY HUMAN ENTEROVIRUS 71 PARTICLE
Descriptor:Genome Polyprotein, capsid protein VP1, capsid protein VP0, ...
Authors:Wang, X., Peng, W., Ren, J., Hu, Z., Xu, J., Lou, Z., Li, X., Yin, W., Shen, X., Porta, C., Walter, T.S., Evans, G., Axford, D., Owen, R., Rowlands, D.J., Wang, J., Stuart, D.I., Fry, E.E., Rao, Z.
Deposit date:2012-01-02
Release date:2012-02-29
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (4 Å)
Cite:A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71.
Nat.Struct.Mol.Biol., 19, 2012
4JGY
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CRYSTAL STRUCTURE OF HUMAN COXSACKIEVIRUS A16 UNCOATING INTERMEDIATE (SPACE GROUP P4232)
Descriptor:Polyprotein, capsid protein VP1, capsid protein VP2, ...
Authors:Ren, J., Wang, X., Hu, Z., Gao, Q., Sun, Y., Li, X., Porta, C., Walter, T.S., Gilbert, R.J., Zhao, Y., Axford, D., Williams, M., Mcauley, K., Rowlands, D.J., Yin, W., Wang, J., Stuart, D.I., Rao, Z., Fry, E.E.
Deposit date:2013-03-04
Release date:2013-06-05
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (3 Å)
Cite:Picornavirus uncoating intermediate captured in atomic detail.
Nat Commun, 4, 2013
4JGZ
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CRYSTAL STRUCTURE OF HUMAN COXSACKIEVIRUS A16 UNCOATING INTERMEDIATE (SPACE GROUP I222)
Descriptor:Polyprotein, capsid protein VP1, capsid protein VP2, ...
Authors:Ren, J., Wang, X., Hu, Z., Gao, Q., Sun, Y., Li, X., Porta, C., Walter, T.S., Gilbert, R.J., Zhao, Y., Axford, D., Williams, M., McAuley, K., Rowlands, D.J., Yin, W., Wang, J., Stuart, D.I., Rao, Z., Fry, E.E.
Deposit date:2013-03-04
Release date:2013-06-05
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (3 Å)
Cite:Picornavirus uncoating intermediate captured in atomic detail.
Nat Commun, 4, 2013
4QPG
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CRYSTAL STRUCTURE OF EMPTY HEPATITIS A VIRUS
Descriptor:Capsid protein VP1, Capsid protein VP0, Capsid protein VP3, ...
Authors:Wang, X., Ren, J., Gao, Q., Hu, Z., Sun, Y., Li, X., Rowlands, D.J., Yin, W., Wang, J., Stuart, D.I., Rao, Z., Fry, E.E.
Deposit date:2014-06-23
Release date:2014-10-15
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Hepatitis A virus and the origins of picornaviruses.
Nature, 517, 2015
4QPI
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CRYSTAL STRUCTURE OF HEPATITIS A VIRUS
Descriptor:Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ...
Authors:Wang, X., Ren, J., Gao, Q., Hu, Z., Sun, Y., Li, X., Rowlands, D.J., Yin, W., Wang, J., Stuart, D.I., Rao, Z., Fry, E.E.
Deposit date:2014-06-23
Release date:2014-10-15
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Hepatitis A virus and the origins of picornaviruses.
Nature, 517, 2015
7C8U
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THE CRYSTAL STRUCTURE OF COVID-19 MAIN PROTEASE IN COMPLEX WITH GC376
Descriptor:Replicase polyprotein 1ab, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid
Authors:Luan, X., Shang, W., Wang, Y., Yin, W., Jiang, Y., Feng, S., Wang, Y., Liu, M., Zhou, R., Zhang, Z., Wang, F., Cheng, W., Gao, M., Wang, H., Wu, W., Tian, R., Tian, Z., Jin, Y., Jiang, H.W., Zhang, L., Xu, H.E., Zhang, S.
Deposit date:2020-06-03
Release date:2020-06-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The crystal structure of COVID-19 main protease in complex with GC376
To Be Published
2KYM
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SOLUTION STRUCTURE OF THE BEM1P SH3-CI DOMAIN FROM L.ELONGISPORUS IN COMPLEX WITH STE20P PEPTIDE
Descriptor:Bud emergence protein 1, Peptide form Serine/threonine-protein kinase STE20
Authors:Gorelik, M., Muhandiram, R., Davidson, A.R.
Deposit date:2010-06-02
Release date:2010-06-23
Last modified:2020-02-05
Method:SOLUTION NMR
Cite:Structural and functional characterization of an unusual SH3 domain from the fungal scaffold protein, Bem1p
To be Published
6H1U
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GLNH BOUND TO ASP, MYCOBACTERIUM TUBERCULOSIS
Descriptor:Probable glutamine-binding lipoprotein GlnH (GLNBP), ASPARTIC ACID
Authors:O'Hare, H.M., Wallis, R., Lin, L.Y., Newland-Smith, Z.
Deposit date:2018-07-12
Release date:2018-08-01
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:An Aspartate-Specific Solute-Binding Protein Regulates Protein Kinase G Activity To Control Glutamate Metabolism in Mycobacteria.
MBio, 9, 2018
6H20
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GLNH BOUND TO ASN, MYCOBACTERIUM TUBERCULOSIS
Descriptor:Probable glutamine-binding lipoprotein GlnH (GLNBP), ASPARAGINE
Authors:O'Hare, H.M., Wallis, R., Lin, L.Y., Newland-Smith, Z.
Deposit date:2018-07-12
Release date:2018-08-01
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:An Aspartate-Specific Solute-Binding Protein Regulates Protein Kinase G Activity To Control Glutamate Metabolism in Mycobacteria.
MBio, 9, 2018
6H2T
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GLNH BOUND TO GLU, MYCOBACTERIUM TUBERCULOSIS
Descriptor:Probable glutamine-binding lipoprotein GlnH (GLNBP), GLUTAMIC ACID
Authors:O'Hare, H.M., Wallis, R., Lin, L.Y., Newland-Smith, Z.
Deposit date:2018-07-16
Release date:2018-07-25
Last modified:2018-08-15
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:An Aspartate-Specific Solute-Binding Protein Regulates Protein Kinase G Activity To Control Glutamate Metabolism in Mycobacteria.
MBio, 9, 2018
4CDQ
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CRYSTAL STRUCTURE OF HUMAN ENTEROVIRUS 71 IN COMPLEX WITH THE UNCOATING INHIBITOR GPP2
Descriptor:VP1, VP2, VP3, ...
Authors:DeColibus, L., Wang, X., Spyrou, J.A.B., Kelly, J., Ren, J., Grimes, J., Puerstinger, G., Stonehouse, N., Walter, T.S., Hu, Z., Wang, J., Li, X., Peng, W., Rowlands, D., Fry, E.E., Rao, Z., Stuart, D.I.
Deposit date:2013-11-05
Release date:2014-02-12
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules
Nat.Struct.Mol.Biol., 21, 2014
4CDU
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CRYSTAL STRUCTURE OF HUMAN ENTEROVIRUS 71 IN COMPLEX WITH THE UNCOATING INHIBITOR GPP3
Descriptor:VP1, VP2, VP3, ...
Authors:De Colibus, L., Wang, X., Spyrou, J.A.B., Kelly, J., Ren, J., Grimes, J., Puerstinger, G., Stonehouse, N., Walter, T.S., Hu, Z., Wang, J., Li, X., Peng, W., Rowlands, D., Fry, E.E., Rao, Z., Stuart, D.I.
Deposit date:2013-11-06
Release date:2014-02-12
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules
Nat.Struct.Mol.Biol., 21, 2014
4CDW
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CRYSTAL STRUCTURE OF HUMAN ENTEROVIRUS 71 IN COMPLEX WITH THE UNCOATING INHIBITOR GPP4
Descriptor:VP1, VP2, VP3, ...
Authors:De Colibus, L., Wang, X., Spyrou, J.A.B., Kelly, J., Ren, J., Grimes, J., Puerstinger, G., Stonehouse, N., Walter, T.S., Hu, Z., Wang, J., Li, X., Peng, W., Rowlands, D., Fry, E.E., Rao, Z., Stuart, D.I.
Deposit date:2013-11-06
Release date:2014-02-12
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules
Nat.Struct.Mol.Biol., 21, 2014
4CDX
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CRYSTAL STRUCTURE OF HUMAN ENTEROVIRUS 71 IN COMPLEX WITH THE UNCOATING INHIBITOR GPP12
Descriptor:VP1, VP2, VP3, ...
Authors:De Colibus, L., Wang, X., Spyrou, J.A.B., Kelly, J., Ren, J., Grimes, J., Puerstinger, G., Stonehouse, N., Walter, T.S., Hu, Z., Wang, J., Li, X., Peng, W., Rowlands, D., Fry, E.E., Rao, Z., Stuart, D.I.
Deposit date:2013-11-07
Release date:2014-02-12
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules.
Nat.Struct.Mol.Biol., 21, 2014
4CEW
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CRYSTAL STRUCTURE OF HUMAN ENTEROVIRUS 71 IN COMPLEX WITH THE UNCOATING INHIBITOR ALD
Descriptor:VP1, VP2, VP3, ...
Authors:De Colibus, L., Wang, X., Spyrou, J.A.B., Kelly, J., Ren, J., Grimes, J., Puerstinger, G., Stonehouse, N., Walter, T.S., Hu, Z., Wang, J., Li, X., Peng, W., Rowlands, D., Fry, E.E., Rao, Z., Stuart, D.I.
Deposit date:2013-11-12
Release date:2014-02-12
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules.
Nat.Struct.Mol.Biol., 21, 2014
4CEY
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CRYSTAL STRUCTURE OF HUMAN ENTEROVIRUS 71 IN COMPLEX WITH THE UNCOATING INHIBITOR NLD
Descriptor:VP1, VP2, VP3, ...
Authors:De Colibus, L., Wang, X., Spyrou, J.A.B., Kelly, J., Ren, J., Grimes, J., Puerstinger, G., Stonehouse, N., Walter, T.S., Hu, Z., Wang, J., Li, X., Peng, W., Rowlands, D., Fry, E.E., Rao, Z., Stuart, D.I.
Deposit date:2013-11-12
Release date:2014-02-12
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules
Nat.Struct.Mol.Biol., 21, 2014
171588
PDB entries from 2020-11-25