Author results

3HCS
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF TRAF6
Descriptor:TNF receptor-associated factor 6, ZINC ION
Authors:Yin, Q., Lin, S.-C., Lamothe, B., Lu, M., Lo, Y.-C., Hura, G., Zheng, L., Rich, R.L., Campos, A.D., Myszka, D.G., Lenardo, M.J., Darnay, B.G., Wu, H.
Deposit date:2009-05-06
Release date:2009-05-26
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:E2 interaction and dimerization in the crystal structure of TRAF6.
Nat.Struct.Mol.Biol., 16, 2009
3HCT
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CRYSTAL STRUCTURE OF TRAF6 IN COMPLEX WITH UBC13 IN THE P1 SPACE GROUP
Descriptor:TNF receptor-associated factor 6, Ubiquitin-conjugating enzyme E2 N, ZINC ION
Authors:Yin, Q., Lin, S.-C., Lamothe, B., Lu, M., Lo, Y.-C., Hura, G., Zheng, L., Rich, R.L., Campos, A.D., Myszka, D.G., Lenardo, M.J., Darnay, B.G., Wu, H.
Deposit date:2009-05-06
Release date:2009-05-26
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:E2 interaction and dimerization in the crystal structure of TRAF6.
Nat.Struct.Mol.Biol., 16, 2009
3HCU
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CRYSTAL STRUCTURE OF TRAF6 IN COMPLEX WITH UBC13 IN THE C2 SPACE GROUP
Descriptor:TNF receptor-associated factor 6, Ubiquitin-conjugating enzyme E2 N, ZINC ION
Authors:Yin, Q., Lin, S.-C., Lamothe, B., Lu, M., Lo, Y.-C., Hura, G., Zheng, L., Rich, R.L., Campos, A.D., Myszka, D.G., Lenardo, M.J., Darnay, B.G., Wu, H.
Deposit date:2009-05-06
Release date:2009-05-26
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:E2 interaction and dimerization in the crystal structure of TRAF6.
Nat.Struct.Mol.Biol., 16, 2009
3KNV
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CRYSTAL STRUCTURE OF THE RING AND FIRST ZINC FINGER DOMAINS OF TRAF2
Descriptor:TNF receptor-associated factor 2, ZINC ION
Authors:Yin, Q., Wu, H.
Deposit date:2009-11-12
Release date:2009-11-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the lack of E2 interaction in the RING domain of TRAF2.
Biochemistry, 48, 2009
4L5Q
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CRYSTAL STRUCTURE OF P202 HIN1
Descriptor:Interferon-activable protein 202
Authors:Yin, Q., Tian, Y., Wu, H.
Deposit date:2013-06-11
Release date:2013-07-31
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation.
Cell Rep, 4, 2013
4L5R
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CRYSTAL STRUCTURE OF P202 HIN1 IN COMPLEX WITH 20-MER DSDNA
Descriptor:Interferon-activable protein 202, 20-mer DNA, SODIUM ION
Authors:Yin, Q., Tian, Y., Wu, H.
Deposit date:2013-06-11
Release date:2013-07-31
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (1.873 Å)
Cite:Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation.
Cell Rep, 4, 2013
4L5S
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P202 HIN1 IN COMPLEX WITH 12-MER DSDNA
Descriptor:Interferon-activable protein 202, 12-mer DNA, SULFATE ION
Authors:Yin, Q., Tian, Y., Wu, H.
Deposit date:2013-06-11
Release date:2013-08-14
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation.
Cell Rep, 4, 2013
4L5T
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CRYSTAL STRUCTURE OF THE TETRAMERIC P202 HIN2
Descriptor:Interferon-activable protein 202
Authors:Yin, Q., Tian, Y., Wu, H.
Deposit date:2013-06-11
Release date:2013-07-31
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.405 Å)
Cite:Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation.
Cell Rep, 4, 2013
3JBL
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CRYO-EM STRUCTURE OF THE ACTIVATED NAIP2/NLRC4 INFLAMMASOME REVEALS NUCLEATED POLYMERIZATION
Descriptor:NLR family CARD domain-containing protein 4
Authors:Zhang, L., Chen, S., Ruan, J., Wu, J., Tong, A.B., Yin, Q., Li, Y., David, L., Lu, A., Wang, W.L., Marks, C., Ouyang, Q., Zhang, X., Mao, Y., Wu, H.
Deposit date:2015-09-05
Release date:2015-10-21
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.
Science, 350, 2015
3J63
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UNIFIED ASSEMBLY MECHANISM OF ASC-DEPENDENT INFLAMMASOMES
Descriptor:Apoptosis-associated speck-like protein containing a CARD
Authors:Lu, A., Magupalli, V.G., Ruan, J., Yin, Q., Atianand, M.K., Vos, M., Schroder, G.F., Fitzgerald, K.A., Wu, H., Egelman, E.H.
Deposit date:2013-12-05
Release date:2014-03-26
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes.
Cell(Cambridge,Mass.), 156, 2014
5FNA
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CRYO-EM RECONSTRUCTION OF CASPASE-1 CARD
Descriptor:CASPASE-1
Authors:Li, Y., Lu, A., Schmidt, F.I., Yin, Q., Chen, S., Fu, T.M., Tong, A.B., Ploegh, H.L., Mao, Y., Wu, H.
Deposit date:2015-11-11
Release date:2016-03-30
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Molecular Basis of Caspase-1 Polymerization and its Inhibition by a Novel Capping Mechanism
Nat.Struct.Mol.Biol., 23, 2016
6OE9
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CRYSTAL STRUCTURE OF P204 HIN1 DOMAIN
Descriptor:Interferon-activable protein 204, GLYCEROL, SULFATE ION
Authors:Tian, Y., Yin, Q.
Deposit date:2019-03-27
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structural analysis of the HIN1 domain of interferon-inducible protein 204.
Acta Crystallogr.,Sect.F, 75, 2019
4F9E
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CYCLIC DI-GMP SENSING VIA THE INNATE IMMUNE SIGNALING PROTEIN STING
Descriptor:Transmembrane protein 173
Authors:Kabaleeswaran, V., Wu, H.
Deposit date:2012-05-18
Release date:2012-07-25
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING.
Mol.Cell, 46, 2012
4F9G
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CRYSTAL STRUCTURE OF STING COMPLEX WITH CYCLIC DI-GMP.
Descriptor:Transmembrane protein 173, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
Authors:Kabaleeswaran, V., Wu, H.
Deposit date:2012-05-18
Release date:2012-07-25
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING.
Mol.Cell, 46, 2012
6FWB
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CRYSTAL STRUCTURE OF MAT2A AT 1.79 ANGSTRON RESOLUTION
Descriptor:S-adenosylmethionine synthase isoform type-2, SULFATE ION, TETRAETHYLENE GLYCOL, ...
Authors:Zhou, A., Wei, Z., Bai, J., Wang, H.
Deposit date:2018-03-06
Release date:2019-03-27
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes.
Ebiomedicine, 39, 2019
3OQ9
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STRUCTURE OF THE FAS/FADD DEATH DOMAIN ASSEMBLY
Descriptor:Tumor necrosis factor receptor superfamily member 6, Protein FADD
Authors:Kabaleeswaran, V., Wu, H.
Deposit date:2010-09-02
Release date:2010-10-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (6.8 Å)
Cite:The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations.
Nat.Struct.Mol.Biol., 17, 2010
3RIU
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CRYSTAL STRUCTURE OF DROSOPHILA HEXAMERIC C3PO FORMED BY TRUNCATED TRANSLIN AND TRAX
Descriptor:Translin, Translin associated factor X, isoform B
Authors:Tian, Y., Simanshu, D.K., Patel, D.J.
Deposit date:2011-04-14
Release date:2011-05-11
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex.
Nat.Struct.Mol.Biol., 18, 2011
6MB2
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CRYO-EM STRUCTURE OF THE PYD FILAMENT OF AIM2
Descriptor:Interferon-inducible protein AIM2, Green fluorescent protein
Authors:Lu, A., Li, Y., Wu, H.
Deposit date:2018-08-29
Release date:2018-09-05
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2.
Cell Discov, 1, 2015