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4BQY
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BU of 4bqy by Molmil
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Fe(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]alanine
Descriptor: (2S)-2-{[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]amino}propanoic acid, EGL NINE HOMOLOG 1, FE (II) ION
Authors:Chowdhury, R, McDonough, M.A, Yeoh, K.K, Schofield, C.J.
Deposit date:2013-06-03
Release date:2013-06-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
ACS Chem. Biol., 8, 2013
4UWD
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BU of 4uwd by Molmil
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) D315E VARIANT in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Descriptor: EGL NINE HOMOLOG 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
Authors:Chowdhury, R, Tarhonskaya, H, Schofield, C.J.
Deposit date:2014-08-11
Release date:2014-08-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.721 Å)
Cite:Investigating the Contribution of the Active Site Environment to the Slow Reaction of Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 with Oxygen.
Biochem.J., 463, 2014
6YVT
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BU of 6yvt by Molmil
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with MD-253
Descriptor: 2-[[5-(6-methoxynaphthalen-2-yl)-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, Egl nine homolog 1, GLYCEROL, ...
Authors:Chowdhury, R, Demetriades, M, Schofield, C.J.
Deposit date:2020-04-28
Release date:2020-05-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.847 Å)
Cite:Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.
Angew.Chem.Int.Ed.Engl., 51, 2012
5OX6
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BU of 5ox6 by Molmil
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Vadadustat
Descriptor: Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ...
Authors:Chowdhury, R, Zhang, D, Schofield, C.J.
Deposit date:2017-09-06
Release date:2017-10-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.
Chem Sci, 8, 2017
5OX5
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BU of 5ox5 by Molmil
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with CCT6, a GSK1278863-related compound
Descriptor: (6-hydroxy-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl)glycine, BICARBONATE ION, Egl nine homolog 1, ...
Authors:Chowdhury, R, Thinnes, C.C, Schofield, C.J.
Deposit date:2017-09-06
Release date:2017-10-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.251 Å)
Cite:Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.
Chem Sci, 8, 2017
2YBP
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BU of 2ybp by Molmil
JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE AND HISTONE H3K36me3 PEPTIDE (30-41)
Descriptor: (2R)-2-hydroxypentanedioic acid, GLYCEROL, HISTONE H3.1T, ...
Authors:Chowdhury, R, McDonough, M.A, Schofield, C.J.
Deposit date:2011-03-09
Release date:2011-03-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep., 12, 2011
2YC0
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BU of 2yc0 by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH R-2-HYDROXYGLUTARATE
Descriptor: (2R)-2-hydroxypentanedioic acid, FE (II) ION, GLYCEROL, ...
Authors:Chowdhury, R, Clifton, I.J, Schofield, C.J.
Deposit date:2011-03-10
Release date:2011-03-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep., 12, 2011
2YBS
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BU of 2ybs by Molmil
JMJD2A COMPLEXED WITH S-2-HYDROXYGLUTARATE AND HISTONE H3K36me3 PEPTIDE (30-41)
Descriptor: (2S)-2-HYDROXYPENTANEDIOIC ACID, GLYCEROL, HISTONE H3.1T, ...
Authors:Chowdhury, R, Schofield, C.J.
Deposit date:2011-03-10
Release date:2011-03-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep., 12, 2011
2YDE
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BU of 2yde by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH S-2-HYDROXYGLUTARATE
Descriptor: (2S)-2-HYDROXYPENTANEDIOIC ACID, FE (III) ION, GLYCEROL, ...
Authors:Chowdhury, R, Clifton, I.J, Schofield, C.J.
Deposit date:2011-03-18
Release date:2011-03-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep., 12, 2011
2YBK
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BU of 2ybk by Molmil
JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE
Descriptor: (2R)-2-hydroxypentanedioic acid, CHLORIDE ION, LYSINE-SPECIFIC DEMETHYLASE 4A, ...
Authors:Chowdhury, R, McDonough, M.A, Schofield, C.J.
Deposit date:2011-03-08
Release date:2011-04-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep., 12, 2011
4AI9
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BU of 4ai9 by Molmil
JMJD2A Complexed with Daminozide
Descriptor: CHLORIDE ION, DAMINOZIDE, GLYCEROL, ...
Authors:Chowdhury, R, Schofield, C.J.
Deposit date:2012-02-08
Release date:2012-10-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
J. Med. Chem., 55, 2012
4AI8
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BU of 4ai8 by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH DAMINOZIDE
Descriptor: DAMINOZIDE, GLYCEROL, HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, ...
Authors:King, O.N.F, Chowdhury, R, Rose, N.R, McDonough, M.A, Clifton, I.J, Schofield, C.J, Kawamura, A.
Deposit date:2012-02-08
Release date:2012-10-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
J. Med. Chem., 55, 2012
4BIS
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BU of 4bis by Molmil
JMJD2A COMPLEXED WITH 8-HYDROXYQUINOLINE-4-CARBOXYLIC ACID
Descriptor: 8-hydroxyquinoline-4-carboxylic acid, CHLORIDE ION, GLYCEROL, ...
Authors:Chowdhury, R, Thinnes, C, Schofield, C.J.
Deposit date:2013-04-12
Release date:2014-02-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.493 Å)
Cite:5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.
Chem Sci, 4, 2013
4BIO
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BU of 4bio by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH 8-HYDROXYQUINOLINE-5- CARBOXYLIC ACID
Descriptor: 8-hydroxyquinoline-5-carboxylic acid, FE (III) ION, GLYCEROL, ...
Authors:Chowdhury, R, Schofield, C.J.
Deposit date:2013-04-12
Release date:2013-04-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.
Chem Sci, 4, 2013
4BQW
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BU of 4bqw by Molmil
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and 2-(4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid
Descriptor: 2-[(1-methyl-2-oxidanyl-4-oxidanylidene-quinolin-3-yl)carbonylamino]ethanoic acid, EGL NINE HOMOLOG 1, MANGANESE (II) ION
Authors:Chowdhury, R, Schofield, C.J.
Deposit date:2013-06-03
Release date:2013-06-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
ACS Chem. Biol., 8, 2013
4BQX
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BU of 4bqx by Molmil
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Descriptor: EGL NINE HOMOLOG 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
Authors:Chowdhury, R, Schofield, C.J.
Deposit date:2013-06-03
Release date:2013-06-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
ACS Chem. Biol., 8, 2013
4IE0
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BU of 4ie0 by Molmil
Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with pyridine-2,4-dicarboxylate (2,4-PDCA)
Descriptor: Alpha-ketoglutarate-dependent dioxygenase FTO, GLYCEROL, PYRIDINE-2,4-DICARBOXYLIC ACID, ...
Authors:Aik, W.S, McDonough, M.A, Schofield, C.J.
Deposit date:2012-12-13
Release date:2013-04-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structural basis for inhibition of the fat mass and obesity associated protein (FTO)
J.Med.Chem., 56, 2013
4IE5
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BU of 4ie5 by Molmil
Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with N-[(3-hydroxypyridin-2-yl)carbonyl]glycine (MD6)
Descriptor: Alpha-ketoglutarate-dependent dioxygenase FTO, GLYCEROL, N-[(3-hydroxypyridin-2-yl)carbonyl]glycine, ...
Authors:Aik, W.S, McDonough, M.A, Schofield, C.J.
Deposit date:2012-12-13
Release date:2013-04-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for inhibition of the fat mass and obesity associated protein (FTO)
J.Med.Chem., 56, 2013
4IE7
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BU of 4ie7 by Molmil
Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with citrate and rhein (RHN)
Descriptor: 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid, Alpha-ketoglutarate-dependent dioxygenase FTO, CITRATE ANION, ...
Authors:Aik, W.S, McDonough, M.A, Schofield, C.J.
Deposit date:2012-12-13
Release date:2013-04-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.6004 Å)
Cite:Structural basis for inhibition of the fat mass and obesity associated protein (FTO)
J.Med.Chem., 56, 2013
4IE6
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BU of 4ie6 by Molmil
Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Descriptor: Alpha-ketoglutarate-dependent dioxygenase FTO, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ZINC ION
Authors:Aik, W.S, McDonough, M.A, Schofield, C.J.
Deposit date:2012-12-13
Release date:2013-04-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5036 Å)
Cite:Structural basis for inhibition of the fat mass and obesity associated protein (FTO)
J.Med.Chem., 56, 2013
4IDZ
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BU of 4idz by Molmil
Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with N-oxalylglycine (NOG)
Descriptor: Alpha-ketoglutarate-dependent dioxygenase FTO, GLYCEROL, N-OXALYLGLYCINE, ...
Authors:Aik, W.S, McDonough, M.A, Schofield, C.J.
Deposit date:2012-12-13
Release date:2013-04-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Structural basis for inhibition of the fat mass and obesity associated protein (FTO)
J.Med.Chem., 56, 2013
4IE4
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BU of 4ie4 by Molmil
Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with 5-carboxy-8-hydroxyquinoline (IOX1)
Descriptor: 8-hydroxyquinoline-5-carboxylic acid, Alpha-ketoglutarate-dependent dioxygenase FTO, GLYCEROL, ...
Authors:Aik, W.S, McDonough, M.A, Schofield, C.J.
Deposit date:2012-12-13
Release date:2013-04-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5048 Å)
Cite:Structural basis for inhibition of the fat mass and obesity associated protein (FTO)
J.Med.Chem., 56, 2013
4JHT
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BU of 4jht by Molmil
Crystal Structure of AlkB in complex with 5-carboxy-8-hydroxyquinoline (IOX1)
Descriptor: 8-hydroxyquinoline-5-carboxylic acid, ACETATE ION, Alpha-ketoglutarate-dependent dioxygenase AlkB, ...
Authors:Aik, W.S, McDonough, M.A, Schofield, C.J.
Deposit date:2013-03-05
Release date:2013-06-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.
Chem Sci, 4, 2013
5A3U
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BU of 5a3u by Molmil
HIF prolyl hydroxylase 2 (PHD2/EGLN1) in complex with 6-(5-oxo-4-(1H- 1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinic acid
Descriptor: 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinic acid, EGL NINE HOMOLOG 1, MANGANESE (II) ION
Authors:Chowdhury, R, Gomez-Perez, V, Schofield, C.J.
Deposit date:2015-06-03
Release date:2015-06-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.
Plos One, 10, 2015
6QGV
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BU of 6qgv by Molmil
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with a Spiro[4.5]decanone inhibitor (JPHM-2-167)
Descriptor: 8-[(3-methylpyridin-2-yl)methyl]-3-(4-phenylphenyl)-1-pyrimidin-2-yl-1,3,8-triazaspiro[4.5]decane-2,4-dione, Egl nine homolog 1, GLYCEROL, ...
Authors:Chowdhury, R, Holt-Martyn, J.P, Rahman, M.Z, Schofield, C.J.
Deposit date:2019-01-13
Release date:2020-02-05
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors.
Medchemcomm, 10, 2019

 

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